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Original Article

Tumor-associated Glycans and Tregs in Immunogenicity of an Autologous Cell-based Vaccine

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References

  • Antony PA, Restifo NP. (2002). Do CD4+ CD25+ immunoregulatory T cells hinder tumor immunotherapy? J Immunother, 25(3), 202–206.
  • Aslakson CJ, Miller FR. (1992). Selective events in the metastatic process defined by analysis of the sequential dissemination of subpopulations of a mouse mammary tumor. Cancer Res, 52(6), 1399–1405.
  • Bright JD, Schultz HN, Byrne JA, Bright RK. (2013). Injection site and regulatory T cells influence durable vaccine-induced tumor immunity to an over-expressed self tumor associated antigen. Oncoimmunology, 2(7), e25049.
  • Camara NO, Ng WF, Hernandes-Fuentes M, et al. (2002). Human CD4(+)CD25(+) T cells regulate CD8(+) T-cell activation. Transplant Proc, 34(7), 2858–2860.
  • Caramalho I, Lopes-Carvalho T, Ostler D, et al. (2003). Regulatory T cells selectively express toll-like receptors and are activated by lipopolysaccharide. J Exp Med, 197(4), 403–411.
  • Chang C, Wu SY, Kang YW, et al. (2015). High levels of regulatory T cells in blood are a poor prognostic factor in patients with diffuse large B-cell lymphoma. Am J Clin Pathol, 144(6), 935–944.
  • Chodon T, Koya RC, Odunsi K. (2015). Active Immunotherapy of Cancer. Immunological Investigations, 44(8), 817–836.
  • Cooney CA, Jousheghany F, Yao-Borengasser A, et al. (2011). Chondroitin sulfates play a major role in breast cancer metastasis: a role for CSPG4 and CHST11 gene expression in forming surface P-selectin ligands in aggressive breast cancer cells. Breast Cancer Res, 13(3), R58.
  • Couldrey C, Green JE. (2000). Metastases: the glycan connection. Breast Cancer Res, 2(5), 321–323.
  • Dillman RO, Barth NM, VanderMolen LA, et al. (2001). Treatment of kidney cancer with autologous tumor cell vaccines of short-term cell lines derived from renal cell carcinoma. Cancer Biother Radiopharm, 16(1), 47–54.
  • Dranoff G, Jaffee E, Lazenby A, et al. (1993). Vaccination with irradiated tumor cells engineered to secrete murine granulocyte-macrophage colony-stimulating factor stimulates potent, specific, and long-lasting anti-tumor immunity. Proc Natl Acad Sci USA, 90(8), 3539–3543.
  • Garin MI, Chu CC, Golshayan D, et al. (2007). Galectin-1: a key effector of regulation mediated by CD4+CD25+ T cells. Blood, 109(5), 2058–2065.
  • Golgher D, Jones E, Powrie F, et al. (2002). Depletion of CD25+ regulatory cells uncovers immune responses to shared murine tumor rejection antigens. Eur J Immunol, 32(11), 3267–3275.
  • Gorelik E, Galili U, Raz A. (2001). On the role of cell surface carbohydrates and their binding proteins (lectins) in tumor metastasis. Cancer Metastasis Rev, 20(3–4), 245–277.
  • Greene JM, Schneble EJ, Jackson DO, et al. (2016). A phase I/IIa clinical trial in stage IV melanoma of an autologous tumor-dendritic cell fusion (dendritoma) vaccine with low dose interleukin-2. Cancer Immunol Immunother, 65(4), 383–392.
  • Hakomori S. (1989). Aberrant glycosylation in tumors and tumor-associated carbohydrate antigens. Adv Cancer Res, 52, 257–331.
  • Harris JE, Ryan L, Hoover HC, Jr, et al. (2000). Adjuvant active specific immunotherapy for stage II and III colon cancer with an autologous tumor cell vaccine: Eastern Cooperative Oncology Group Study E5283. J Clin Oncol, 18(1), 148–157.
  • Herman D, Leakey TI, Behrens A, et al. (2015). CHST11 gene expression and DNA methylation in breast cancer. Int J Oncol, 46(3), 1243–1251.
  • Hua W, Yuan A, Zheng W, et al. (2016). Accumulation of FoxP3+ T regulatory cells in the tumor microenvironment of human colorectal adenomas. Pathol Res Pract, 212(2), 106–112.
  • Inoue M, Ton SM, Ogawa H, Tanizawa O. (1991). Expression of Tn and sialyl-Tn antigens in tumor tissues of the ovary. Am J Clin Pathol, 96(6), 711–716.
  • Javed A, Sato S, Sato T. (2016). Autologous melanoma cell vaccine using monocyte-derived dendritic cells (NBS20/eltrapuldencel-T). Future Oncol, 12(6), 751–762.
  • Jeschke U, Karsten U, Wiest I, et al. (2006). Binding of galectin-1 (gal-1) to the Thomsen-Friedenreich (TF) antigen on trophoblast cells and inhibition of proliferation of trophoblast tumor cells in vitro by gal-1 or an anti-TF antibody. Histochem Cell Biol, 126(4), 437–444.
  • Jonuleit H, Schmitt E, Kakirman H, et al. (2002). Infectious tolerance: human CD25(+) regulatory T cells convey suppressor activity to conventional CD4(+) T helper cells. J Exp Med, 196(2), 255–260.
  • Kawaguchi T. (2005). Cancer metastasis: characterization and identification of the behavior of metastatic tumor cells and the cell adhesion molecules, including carbohydrates. Curr Drug Targets Cardiovasc Haematol Disord, 5(1), 39–64.
  • Kawaguchi T, Takazawa H, Imai S, et al. (2006). Expression of Vicia villosa agglutinin (VVA)-binding glycoprotein in primary breast cancer cells in relation to lymphatic metastasis: is atypical MUC1 bearing Tn antigen a receptor of VVA? Breast Cancer Res Treat, 98(1), 31–43.
  • Kim SJ, Ha GH, Kim SH, Kang CD. (2014). Combination of cancer immunotherapy with clinically available drugs that can block immunosuppressive cells. Immunological Investigations, 43(6), 517–534.
  • Kircheis R, Kupcu Z, Wallner G, et al. (2000). Interleukin-2 gene-modified allogeneic melanoma cell vaccines can induce cross-protection against syngeneic tumors in mice. Cancer Gene Ther, 7(6), 870–878.
  • Klages K, Mayer CT, Lahl K, et al. (2010). Selective depletion of Foxp3+ regulatory T cells improves effective therapeutic vaccination against established melanoma. Cancer Res, 70(20), 7788–7799.
  • Korourian S, Siegel E, Kieber-Emmons T, Monzavi-Karbassi B. (2008). Expression analysis of carbohydrate antigens in ductal carcinoma in situ of the breast by lectin histochemistry. BMC Cancer, 8, 136.
  • Ladisch S, Becker H, Ulsh L. (1992). Immunosuppression by human gangliosides: I. Relationship of carbohydrate structure to the inhibition of T cell responses. Biochim Biophys Acta, 1125(2), 180–188.
  • Liu T, Soong L, Liu G, et al. (2009). CD44 expression positively correlates with Foxp3 expression and suppressive function of CD4+ Treg cells. Biol Direct, 4, 40.
  • McKallip R, Li R, Ladisch S. (1999). Tumor gangliosides inhibit the tumor-specific immune response. J Immunol, 163(7), 3718–3726.
  • Ogawa H, Ghazizadeh M, Araki T. (1996). Tn and sialyl-Tn antigens as potential prognostic markers in human ovarian carcinoma. Gynecol Obstet Invest, 41(4), 278–283.
  • Ophir E, Bobisse S, Coukos G, et al. (2016). Personalized approaches to active immunotherapy in cancer. Biochim Biophys Acta, 1865(1), 72–82.
  • Parmiani G, Pilla L, Maccalli C, Russo V. (2011). Autologous versus allogeneic cell-based vaccines? Cancer J, 17(5), 331–336.
  • Reed W, Bryne M, Clausen H, et al. (1994). Simple mucins (T, sialosyl-T, Tn and sialosyl-Tn) are not diagnostic for malignant breast lesions. Anticancer Res, 14(2B), 609–615.
  • Sakaguchi S, Sakaguchi N, Asano M, et al. (1995). Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J Immunol, 155(3), 1151–1164.
  • Sakaguchi S, Yamaguchi T, Nomura T, Ono M. (2008). Regulatory T cells and immune tolerance. Cell, 133(5), 775–787.
  • Soliman H, Mediavilla-Varela M, Antonia SJ. (2015). A GM-CSF and CD40L bystander vaccine is effective in a murine breast cancer model. Breast Cancer (Dove Med Press), 7, 389–397.
  • Steplewska-Mazur K, Gabriel A, Zajecki W, et al. (2000). Breast cancer progression and expression of blood group-related tumor-associated antigens. Hybridoma, 19(2), 129–133.
  • Tanaka H, Tanaka J, Kjaergaard J, Shu S. (2002). Depletion of CD4+ CD25+ regulatory cells augments the generation of specific immune T cells in tumor-draining lymph nodes. J Immunother, 25(3), 207–217.
  • Termeer C, Benedix F, Sleeman J, et al. (2002). Oligosaccharides of Hyaluronan activate dendritic cells via toll-like receptor 4. J Exp Med, 195(1), 99–111.
  • Thornton AM, Shevach EM. (1998). CD4+CD25+ immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production. J Exp Med, 188(2), 287–296.
  • Vacchelli E, Semeraro M, Enot DP, et al. (2015). Negative prognostic impact of regulatory T cell infiltration in surgically resected esophageal cancer post-radiochemotherapy. Oncotarget, 6(25), 20840–20850.
  • Wang J, Lu ZH, Gabius HJ, et al. (2009). Cross-linking of GM1 ganglioside by galectin-1 mediates regulatory T cell activity involving TRPC5 channel activation: possible role in suppressing experimental autoimmune encephalomyelitis. J Immunol, 182(7), 4036–4045.
  • Wittke S, Baxmann S, Fahlenkamp D, Kiessig ST. (2016). Tumor heterogeneity as a rationale for a multi-epitope approach in an autologous renal cell cancer tumor vaccine. Onco Targets Ther, 9, 523–537.
  • Wolf AM, Wolf D, Steurer M, et al. (2003). Increase of regulatory T cells in the peripheral blood of cancer patients. Clin Cancer Res, 9(2), 606–612.

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