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The Impact of the Microbiome on Immunosenescence

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References

  • Belkaid Y, Hand TW. (2014). Role of the microbiota in immunity and inflammation. Cell, 157, 121–141. doi:10.1016/j.cell.2014.03.011
  • Benno Y, Endo K, Mizutani T, et al. (1989). Comparison of fecal microflora of elderly persons in rural and urban areas of Japan. Appl Environ Microbiol, 55, 1100–1105.
  • Biagi E, Candela M, Turroni S, et al. (2013). Ageing and gut microbes: perspectives for health maintenance and longevity. Pharmacol Res, 69, 11–20. doi:10.1016/j.phrs.2012.10.005
  • Biagi E, Nylund L, Candela M, et al. (2010). Through aging and beyond: gut microbiota and inflammatory status in seniors and centenarians. PloS One, 5, e10667. doi:10.1371/journal.pone.0010667
  • Cancro MP, Hao Y, Scholtz JL, et al. (2009). B cells and aging: molecules and mechanisms. Trends Immunol, 30, 313–318. doi:10.1016/j.it.2009.04.005
  • Castañeda-Delgado JE, Frausto-Lujan I, González-Curiel I, et al. (2017). Differences in cytokine production during aging and its relationship with antimicrobial peptides production. Immunological Inv, 46, 48–58. doi:10.1080/08820139.2016.1212873
  • Christensen HR, Frokiar H, Petska JJ. (2002). Lactobacilli differentially modulate expression of cytokines and maturation surface markers in murine dendritic cells. J Immunol, 168, 171–178.
  • Claesson MJ, Cusack S, O’Sullivan O, et al. (2011). Composition, variability, and temporal stability of the intestinal microbiota of the elderly. Proc Natl Acad Sci, 15, 4586–4591. doi:10.1073/pnas.1000097107
  • Costello EK, Lauber CL, Hamady M, et al. (2009). Bacterial community variation in human body habitats across space and time. Science, 326, 1694–1697. doi:10.1126/science.1177486
  • Dominguez-Bello MG, Costello EK, Contreras M, et al. (2010). Delivery mode shapes the acquisition and structure of the initial microbiota across multiple body habitats in newborns. Proc Natl Acad Sci, 107, 11971–11975. doi:10.1073/pnas.1002601107
  • Franceschi C, Capri M, Monti D, et al. (2007). Inflammaging and antiinflammaging: a systemic perspective on aging and longevity emerged from studies in humans. Mech Ageing Dev, 128, 92–105. doi:10.1016/j.mad.2006.11.016
  • Fuentes E, Fuentes M, Alarcon M, Palomo I. (2017). Immune system dysfunction in the elderly. Ann Braz Acad Sci, 89, 285–299. doi:10.1590/0001-3765201720160487
  • Gavini F, Cayuela C, Antoine J-M, et al. (2001). Differences in the distribution of bifidobacterial and enterobacterial species in human faecal microflora of three different (children, adults, elderly) age groups. Microb Eco Health Dis, 13, 40–45.
  • Gibson KL, Wu YC, Barnett Y, et al. (2009). B-cell diversity decreases in old age and is correlated with poor health status. Aging Cell, 8, 18–25. doi:10.1111/j.1474-9726.2008.00443.x
  • Hannet I, Erkeller-Yuksel F, Lydyard P, et al. (1992). Developmental and maturational changes in human blood lymphocyte subpopulations. Immunol Today, 13, 215–218. doi:10.1016/0167-5699(92)90157-3
  • Ivanov II, Fruto LR, Manel L, et al. (2008). Specific microbiota direct the differentiation of IL-17-producing T-helper cells in the mucosa of the small intestine. Cell Host Microbe, 4, 337–349. doi:10.1016/j.chom.2008.09.009
  • Katz MJ, Roghmann. (2016). Healthcare-associated infections in the elderly: what’s new. Curr Opin Infect Dis, 29, 388–393. doi:10.1097/QCO.0000000000000283
  • Kenyon CJ. (2010). The genetics of aging. Nature, 464, 504–512. doi:10.1038/nature08980
  • Leeansyah E, Loh L, Nixon DF, Sandberg JK. (2014). Acquisition of innate-like microbial reactivity in mucosal tissue during human fetal MAIT–cell development. Nat Commun, 5, 3143. doi:10.1038/ncomms4143
  • Lopez-Otin C, Blasco MA, Partridge L, et al. (2013). The hallmarks of aging. Cell, 153, 1194–1217. doi:10.1016/j.cell.2013.05.039
  • Macpherson AJ, Harris NL. (2004). Interactions between commensal intestinal bacteria and the immune system. Nat Rev Immunol, 4, 478–485. doi:10.1038/nri1373
  • Makivuokko H, Tiihonen K, Tynkkynen S, et al. (2010). The effect of age and non-steroidal anti-inflammatory drugs on human intestinal microbiota composition. Br J Nutr, 103, 227–234. doi:10.1017/S0007114509991553
  • Maslowski KM, Viera AT, Ng A, et al. (2009). Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43. Nature, 461, 1282–1286. doi:10.1038/nature08530
  • Mazmanian SK, Liu CH, Tzianabos AO, Kasper DL. (2005). An immunomodulatory molecule of symbiotic bacteria directs maturation of the host immune system. Cell, 122, 107–118. doi:10.1016/j.cell.2005.05.007
  • Nagpal R, Kumar M, Yadav AK, et al. (2016). Gut microbiota in health and disease: an overview focused on metabolic inflammation. Benef Microbes, 7, 181–194. doi:10.3920/bm2015.0062
  • Nagpal R, Mainali R, Ahmadi S, et al. (2018). Review: gut microbiome and aging: physiological and mechanistic insights. Nutrition Healthy Aging, 4, 267–285. doi:10.3233/NHA-170030
  • Nagpal R, Yamashiro Y. (2015). Early life gut microbial composition. J Ped Biochem, 5, 41–50. doi:10.1055/s-0035-1564573
  • Naylor K, Li G, Vallejo AN, et al. (2005). The influence of age on T cell generation and TCR diversity. J Immunol, 174, 7446–7452.
  • Nikolich-Zugich J. (2018). The twilight of immunity: emerging concepts in aging of the immune system. Nat Immunol, 19, 10–19. doi:10.1038/s41590-017-0006-x
  • Odamaki T, Kato K, Sugahara H, et al. (2016). Age-related changes in gut microbiota composition from newborn to centenarian: a cross-sectional study. BMC Microbiol, 16, 90. doi:10.1186/s12866-016-0708-5
  • Ouwehand AC, Bergsma N, Parhiala R, et al. (2008). Bifidobacterium microbiota and parameters of immune function in elderly subjects. FEMS Immunol Med Microbiol, 53, 18–25. doi:10.1111/j.1574-695X.2008.00392.x
  • Rakoff-Nahoum S, Paglino J, Eslami-Varzaneh F, et al. (2004). Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis. Cell, 118, 229–241. doi:10.1016/j.cell.2004.07.002
  • Rea MC, O’Sullivan O, Shanahan F, et al. (2012). Clostridium difficile carriage in elderly subjects and associated changes in the intestinal microbiota. J Clin Microbiol, 50, 867–875. doi:10.1128/JCM.05176-11
  • Rosenstiel P, Derer S, Till A, et al. (2008). Systematic expression profiling of innate immune genes defines a complex pattern of immunosenescence in peripheral and intestinal leukocytes. Genes Immunol, 9, 103–114. doi:10.1038/sj.gene.6364454
  • Rosner JL. (2014). Ten times more microbial cells than body cells in humans? Microbe, 9, 47.
  • Rothschild D, Weissbrod O, Barkan E, et al. (2018). Environment dominates over host genetics in shaping human gut microbiota. Nature. doi:10.1038/nature25973
  • Round JL, Mazmanian SK. (2009). The gut microbiota shapes intestinal immune responses during health and disease. Nat Rev Immunol, 9, 313–323. doi:10.1038/nri2515
  • Schwab L, Goroncy L, Palaniyandi S, et al. (2014). Neutrophil granulocytes recruited upon translocation of intestinal bacteria enhance graft-versus-host disease via tissue damage. Nat Med, 20, 648–654. doi:10.1038/nm.3517
  • Sender R, Fuchs S, Milo R, et al. (2016). Are we really vastly outnumbered? Revisiting the ratio of bacterial cells to host cells in humans. Cell, 164, 537–540. doi:10.1016/j.cell.2016.01.013
  • Shaw AC, Joshi S, Greenwood H, et al. (2010). Aging of the innate immune system. Curr Opin Immunol, 22, 507–513. doi:10.1016/j.coi.2010.05.003
  • Simon AK, Hollander GA, McMichael A. (2015). Evolution of the immune system in humans from infancy to old age. Proc R Soc B, 282, 20143085. doi:10.1098/rspb.2014.3085
  • Stiehm ER (2018). Immune function in older adults. Up to Date, July 2018. Accessed 8 March 2018.www.uptodate.com/contents/immune-function-in-older-adults.
  • Su LF, Kidd BA, Han A, et al. (2013). Virus-specific CD4+ memory phenotype T cells are abundant in unexposed adults. Immunity, 38, 373–383. doi:10.1016/j.immuni.2012.10.021
  • Turnbaugh PJ, Ley RE, Hamady M, et al. (2007). The human microbiome project. Nature, 449, 804–810. doi:10.1038/nature06244
  • Van Duin D, Mohanty S, Thomas V, et al. (2007). Age-associated defect in TLR-1/2 function. J Immunol, 178, 970–975.
  • Walker JM, Slifka MK. (2010). Longevity of T-cell memory following acute viral infection. Adv Exp Med Biol, 684, 96–107.
  • Weiskopf D, Weinberger B, Grubeck-Loebenstein B. (2009). The aging of the immune system. Transplant Int, 22, 1041–1050. doi:10.1111/j.1432-2277.2009.00927.x
  • Yoshikawa TT. (2000). Epidemiology and unique aspects of aging and infectious diseases. Clin Infect Dis, 30, 931–933. doi:10.1086/313792
  • Zapata HJ, Quagliarello VJ. (2015). The microbiota and microbiome in aging: potential implications in health and age-related diseases. Am Geriatr Soc, 63, 776–781. doi:10.1111/jgs.13310
  • Zinkernagel RM. (2000). On immunological memory. Phil Trans R Soc Lond, 355, 369–371. doi:10.1098/rstb.2000.0576

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