216
Views
6
CrossRef citations to date
0
Altmetric
Original Articles

Body Mass Index and Mortality in Elderly Subjects from the Moli-Sani Study: A Possible Mediation by Low-Grade Inflammation?

ORCID Icon, ORCID Icon, ORCID Icon, ORCID Icon, ORCID Icon, ORCID Icon, ORCID Icon, ORCID Icon, ORCID Icon, ORCID Icon & ORCID Icon show all

References

  • GBD 2015 Obesity Collaborators, Afshin A, Forouzanfar MH, Reitsma MB, et al. (2017). Health effects of overweight and obesity in 195 countries over 25 years. N Engl J Med, 6. 377, 13–27. doi:10.1056/NEJMoa1614362
  • Alam I, Ng TP, Larbi A. (2012). Does inflammation determine whether obesity is metabolically healthy or unhealthy? The aging perspective. Mediators Inflamm, 2012, 456456. doi:10.1155/2012/456456
  • Arcari A, Zito F, Di Castelnuovo A, et al., European Collaborative Group of Immidiet Project. (2008). C reactive protein and its determinants in healthy men and women from european regions at different risk of coronary disease: the IMMIDIET project. J Thromb Haemost, 6, 436–443. doi:10.1111/j.1538-7836.2007.02851.x
  • Arterburn DE, Crane PK, Sullivan SD. (2004). The coming epidemic of obesity in elderly Americans. J Am Geriatr Soc, 52, 1907–1912. doi:10.1111/j.1532-5415.2004.52517.x
  • Blokstra A, Vissink P, Venmans LMAJ, et al. (2011). Measuring the Netherlands. A monitoring study of risk factors in the general population 2009-2010. Report No 260152001/2011 Bilthoven: RIVM.
  • Bonaccio M, Di Castelnuovo A, Pounis G, et al., Moli-sani Study Investigators. (2016). A score of low-grade inflammation and risk of mortality: prospective findings from the moli-sani study. Haematologica, 101, 1434–1441. doi:10.3324/haematol.2016.144055
  • Calle EE, Thun MJ, Petrelli JM, et al. (1999). Body-mass index and mortality in a prospective cohort of U.S. Adults. N Engl J Med, 341, 1097–1105. doi:10.1056/NEJM199910073411501
  • Global BMI Mortality Collaboration, Di Angelantonio E, Bhupathiraju S, Wormser D, et al. (2016). Body-mass index and all-cause mortality: individual-participant-data meta-analysis of 239 prospective studies in four continents. Lancet, 388, 776–786, doi:10.1016/S0140-6736(16)30175-1
  • Di Castelnuovo A, de Curtis A, Costanzo S, et al., MOLI-SANI Project Investigators. (2013). Association of D-dimer levels with all-cause mortality in a healthy adult population: findings from the MOLI-SANI study. Haematologica, 98, 1476–1480. doi:10.3324/haematol.2012.083410
  • Diouf I, Charles MA, Ducimetière P, et al. (2010). Evolution of obesity prevalence in France: an age-period-cohort analysis. Epidemiol, 21, 360–365. doi:10.1097/EDE.0b013e3181d5bff5
  • Dorner TE, Rieder A. (2012). Obesity paradox in elderly patients with cardiovascular diseases. Int J Cardiol, 155, 56–65. doi:10.1016/j.ijcard.2011.01.076
  • Flegal KM, Carroll MD, Kit BK, Ogden CL. (2012). Prevalence of obesity and trends in the distribution of body mass index among US adults, 1999–2010. JAMA, 307, 491–497. doi:10.1001/jama.2012.39
  • Frasca D, Blomberg BB, Paganelli R. (2017). Aging, obesity, and inflammatory age-related diseases. Front Immunol, 8, 1745. doi:10.3389/fimmu.2017.01745
  • Grimble RF. (2003). Inflammatory response in the elderly. Curr Opin Clin Nutr Metab Care, 6, 21–29. doi:10.1097/01.mco.0000049047.06038.eb
  • Gutiérrez-Fisac JL, Guallar-Castillón P, León-Muñoz LM, et al. (2012). Prevalence of general and abdominal obesity in the adult population of Spain, 2008-2010: the ENRICA study. Obes Rev, 13, 388–392. doi:10.1111/j.1467-789X.2011.00964.x
  • Heiat A, Vaccarino V, Krumholz HM. (2001). An evidence-based assessment of federal guidelines for overweight and obesity as they apply to elderly persons. Arch Intern Med, 161, 1194–1203.
  • Hotamisligil GS. (2006). Inflammation and metabolic disorders. Nature, 444, 860–867. doi:10.1038/nature05485
  • Kalantar-Zadeh K, Block G, Horwich T, Fonarow GC. (2004). Reverse epidemiology of conventional cardiovascular risk factors in patients with chronic heart failure. J Am Coll Cardiol, 43, 1439–1444. doi:10.1016/j.jacc.2003.11.039
  • Kalantar-Zadeh K, Horwich TB, Oreopoulos A, et al. (2007). Risk factor paradox in wasting diseases. Curr Opin Clin Nutr Metab Care, 10, 433–442. doi:10.1097/MCO.0b013e3281a30594
  • Kennedy RL, Chokkalingham K, Srinivasan R. (2004). Obesity in the elderly: who should we be treating, and why, and how? Curr Opin Clin Nutr Metab Care, 7, 3–9.
  • Lerner DJ, Kannel WB. (1986). Patterns of coronary heart disease morbidity and mortality in the sexes: a 26-year follow-up of the framingham population. Am Heart J, 111, 383–390.
  • Lloyd-Jones DM, Leip EP, Larson MG, et al. (2006). Prediction of lifetime risk for cardiovascular disease by risk factor burden at 50 years of age. Circulation, 113, 791–798. doi:10.1161/CIRCULATIONAHA.105.548206
  • Mazza A, Zamboni S, Tikhonoff V, et al. (2007). Body mass index and mortality in elderly men and women from general population: the experience of Cardiovascular Study in the Elderly (CASTEL). Gerontol, 53, 36–45. doi:10.1159/000095783
  • National Health Service Information Centre. Health survey for England: 2012 trend tables. Accessed Septempber 19, 2018. Retrieved https://digital.nhs.uk/data-and-information/publications/statistical/health-survey-for-england/health-survey-for-england-2012-trend-tables
  • NCD Risk Factor Collaboration (NCD-RisC). (2016). Trends in adult body-mass index in 200 countries from 1975 to 2014: a pooled analysis of 1698 population-based measurement studies with 19·2 million participants. Lancet, 387, 1377–1396. doi:10.1016/S0140-6736(16)30054-X
  • NCD Risk Factor Collaboration (NCD-RisC). (2017). Worldwide trends in body-mass index, underweight, overweight, and obesity from 1975 to 2016: a pooled analysis of 2416 population-based measurement studies in 128·9 million children, adolescents, and adults. Lancet, 390, 2627–2642. doi:10.1016/S0140-6736(17)32129-3
  • Nigam A, Wright RS, Allison TG, et al. (2006). Excess weight at time of presentation of myocardial infarction is associated with lower initial mortality risks but higher long-term risks including recurrent re-infarction and cardiac death. Int J Cardiol, 110, 153–159. doi:10.1016/j.ijcard.2005.06.040
  • Oreopoulos A, Padwal R, Kalantar-Zadeh K, et al. (2008). Body mass index and mortality in heart failure: a meta-analysis. Am Heart J, 156, 13–22. doi:10.1016/j.ahj.2008.02.014
  • Pisani P, Faggiano F, Krogh V, et al. (1997). Relative validity and reproducibility of a food frequency dietary questionnaire for use in the Italian EPIC centres. Int J Epidemiol, 26(Suppl 1), S152–60.
  • Pounis G, Bonaccio M, Di Castelnuovo A, et al. (2016). Polyphenol intake is associated with low-grade inflammation, using a novel data analysis from the Moli-sani study. Thromb Haemost, 115, 344–352. doi:10.1160/TH15-06-0487
  • Public Health Agency of Canada and the Canadian Institute for Health Information. Obesity in Canada: a joint report from the public health agency of Canada and the Canadian institute for health information. Accessed Septempber 19, 2018. Retrieved http://www.phac-aspc.gc.ca/hp-ps/hl-mvs/oic-oac/assets/pdf/oic-oac-eng.pdf
  • Stevens J, Cai J, Pamuk ER, et al. (1998). The effect of age on the association between body-mass index and mortality. N Engl J Med, 338, 1–7. doi:10.1056/NEJM199801013380101
  • Trichopoulou A, Costacou T, Bamia C, Trichopoulos D. (2003). Adherence to a mediterranean diet and survival in a Greek population. N Engl J Med, 348, 2599–2608. doi:10.1056/NEJMoa025039
  • Whitlock G, Lewington S, Sherliker P, et al. (2009). Body-mass index and cause-specific mortality in 900,000 adults: collaborative analyses of 57 prospective studies. Lancet, 373, 1083–1096. doi:10.1016/S0140-6736(09)60318-4
  • Winter JE, MacInnis RJ, Wattanapenpaiboon N, Nowson CA. (2014). BMI and all-cause mortality in older adults: a meta-analysis. Am J Clin Nutr, 99, 875–890. doi:10.3945/ajcn.113.068122
  • Emerging Risk Factors Collaboration, Wormser D, Kaptoge S, Di Angelantonio E, et al. (2011). Separate and combined associations of body-mass index and abdominal adiposity with cardiovascular disease: collaborative analysis of 58 prospective studies. Lancet, 377, 1085–1095, doi:10.1016/S0140-6736(11)60105-0
  • Zajacova A (2008). Shape of the BMI-mortality association by cause of death using generalized additive models: NHIS 1986–2002. Population Studies Center Research Report 08–639.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.