TGF-β1 Mediates the EndoMt in High Glucose-Treated Human Retinal Microvascular Endothelial Cells

References

• Nawaz I, Rezzola S, Cancarini A, et al. Human vitreous in proliferative diabetic retinopathy: characterization and translational implications. progress in retinal and eye research. Prog Retinal Eye Res. 2019;72:100756. doi:10.1016/j.preteyeres.2019.03.002.
   PubMed Web of Science ®Google Scholar
• Shu D, Lovicu F. Myofibroblast transdifferentiation: the dark force in ocular wound healing and fibrosis. progress in retinal and eye research. Prog Retinal Eye Res. 2017;60:44–65. doi:10.1016/j.preteyeres.2017.08.001.
   PubMed Web of Science ®Google Scholar
• Abu El-Asrar A, De Hertogh G, van den Eynde K, et al. Myofibroblasts in proliferative diabetic retinopathy can originate from infiltrating fibrocytes and through endothelial-to-mesenchymal transition (EndoMT). Exp Eye Res. 2015;132:179–189. doi:10.1016/j.exer.2015.01.023.
   PubMed Web of Science ®Google Scholar
• Roy S, Amin S, Roy S. Retinal fibrosis in diabetic retinopathy. Exp Eye Res. 2016;142:71–75. doi:10.1016/j.exer.2015.04.004.
   PubMed Web of Science ®Google Scholar
• Pérez L, Muñoz-Durango N, Riedel CA, et al. Endothelial-to-mesenchymal transition: cytokine-mediated pathways that determine endothelial fibrosis under inflammatory conditions. Cytokine Growth Factor Rev. 2017;33:41–54. doi:10.1016/j.cytogfr.2016.09.002.
   PubMed Web of Science ®Google Scholar
• Piera-Velazquez S, Jimenez S. Endothelial to mesenchymal transition: role in physiology and in the pathogenesis of human diseases. Physiol Rev. 2019;99(2):1281–1324. doi:10.1152/physrev.00021.2018.
   PubMed Web of Science ®Google Scholar
• Zhao J, Patel J, Kaur S, et al. Sox9 and Rbpj differentially regulate endothelial to mesenchymal transition and wound scarring in murine endovascular progenitors. Nat Commun. 2021;12(1):2564. doi:10.1038/s41467-021-22717-9.
   PubMed Web of Science ®Google Scholar
• Wu M, Li T, Li G, et al. LncRNA DANCR deficiency promotes high glucose-induced endothelial to mesenchymal transition in cardiac microvascular cells via the FoxO1/DDAH1/ADMA signaling pathway. Eur J Pharmacol. 2023;950:175732. doi:10.1016/j.ejphar.2023.175732.
   PubMed Web of Science ®Google Scholar
• Li Y, Zhao Y, Song L, et al. High glucose levels contribute to vascular fibrosis via the activation of the endothelial-to-mesenchymal transition in periodontitis. J Periodontal Res. 2023;58(2):225–236. doi:10.1111/jre.13084.
   PubMed Web of Science ®Google Scholar
• Lu L, Li X, Zhong Z, et al. KMT5A downregulation participated in High Glucose-mediated EndMT via Upregulation of ENO1 Expression in Diabetic Nephropathy. Int J Biol Sci. 2021;17(15):4093–4107. doi:10.7150/ijbs.62867.
   PubMed Web of Science ®Google Scholar
• Li J, Qu X, Yao J, et al. Blockade of endothelial-mesenchymal transition by a Smad3 inhibitor delays the early development of streptozotocin-induced diabetic nephropathy. Diabetes. 2010;59(10):2612–2624. doi:10.2337/db09-1631.
   PubMed Web of Science ®Google Scholar
• Gu S, Liu Y, Zou J, et al. Retinal pigment epithelial cells secrete miR-202-5p-containing exosomes to protect against proliferative diabetic retinopathy. Exp Eye Res. 2020;201:108271. doi:10.1016/j.exer.2020.108271.
   PubMed Web of Science ®Google Scholar
• Dong Y, Wang B, Du M, et al. Targeting epsins to inhibit fibroblast growth factor signaling while potentiating transforming growth factor-β signaling constrains endothelial-to-mesenchymal transition in atherosclerosis.National center for biotechnology information. Circulation. 2023;147(8):669–685. doi:10.1161/CIRCULATIONAHA.122.063075.
   PubMed Web of Science ®Google Scholar
• Gerhardinger C, Dagher Z, Sebastiani P, Park Y, Lorenzi M. The Transforming Growth Factor-β Pathway is a Common Target of drugs That Prevent Experimental Diabetic Retinopathy. Diabetes. 2009;58(7):1659–1667. doi:10.2337/db08-1008.
   PubMed Web of Science ®Google Scholar
• Dagher Z, Gerhardinger C, Vaz J, et al. The Increased Transforming Growth Factor-β Signaling Induced by diabetes protects retinal vessels. Am J Pathol. 2017;187(3):627–638. doi:10.1016/j.ajpath.2016.11.007.
   PubMed Web of Science ®Google Scholar
• Shao K, Xi L, Cang Z, Chen C, Huang S. Knockdown of NEAT1 exerts suppressive effects on diabetic retinopathy progression via inactivating TGF-β1 and VEGF signaling pathways. J Cell Physiol. 2020;235(12):9361–9369. doi:10.1002/jcp.29740.
   PubMed Web of Science ®Google Scholar
• Liu L, Jiao J, Wang Y, et al. TGF-beta1 gene polymorphism in association with diabetic retinopathy susceptibility: a systematic review and meta-analysis. PLoS One. 2014;9(4):e94160. doi:10.1371/journal.pone.0094160.
   PubMed Web of Science ®Google Scholar
• Wheeler S, Lee N. Emerging roles of transforming growth factor β signaling in Diabetic Retinopathy. J Cell Physiol. 2017;232(3):486–489. doi:10.1002/jcp.25506.
   PubMed Web of Science ®Google Scholar
• Yao H, Wei S, Xiang Y, et al. βKangfuxin oral liquid attenuates bleomycin-induced pulmonary fibrosis via the TGF-1/Smad pathway. Evid Based Complementary Altern Med: eCAM. 2019;2019:5124026. doi:10.1155/2019/5124026.
   PubMed Web of Science ®Google Scholar
• Yu L, Bian X, Zhang C, et al. Ginkgolic acid improves bleomycin-induced pulmonary fibrosis by inhibiting SMAD4 SUMOylation. oxidative medicine and cellular longevity. Oxid Med Cell Longev. 2022;2022:1–18. doi:10.1155/2022/8002566.
   Web of Science ®Google Scholar
• Liu R, Desai L. Reciprocal regulation of TGF-β and reactive oxygen species: a perverse cycle for fibrosis. Redox Biol. 2015;6:565–577. doi:10.1016/j.redox.2015.09.009.
   PubMed Web of Science ®Google Scholar
• Veréb Z, Lumi X, Andjelic S, et al. Functional and molecular characterization of ex vivo cultured epiretinal membrane cells from human proliferative diabetic retinopathy. Biomed Res Int. 2013;2013:1–14. doi:10.1155/2013/492376.
   Web of Science ®Google Scholar
• Zhang D, Qin H, Leng Y, et al. LncRNA MEG3 overexpression inhibits the development of diabetic retinopathy by regulating TGF-β1 and VEGF. Exp Ther Med. 2018;16:2337–2342. doi:10.3892/etm.2018.6451.
   PubMed Web of Science ®Google Scholar
• Kim K, Park J-M, Kong T, et al. Retinal angiogenesis effects of TGF-β1 and paracrine factors secreted from human placental stem cells in response to a pathological environment. Cell Transplant. 2016;25(6):1145–1157. doi:10.3727/096368915x688263.
   PubMed Web of Science ®Google Scholar
• Cao Y, Feng B, Chen S, Chu Y, Chakrabarti S. Mechanisms of endothelial to mesenchymal transition in the retina in diabetes. Invest Ophthalmol Vis Sci. 2014;55(11):7321–7331. doi:10.1167/iovs.14-15167.
   PubMed Web of Science ®Google Scholar
• Wilhelmi T, Xu X, Tan X, et al. Serelaxin alleviates cardiac fibrosis through inhibiting endothelial-to-mesenchymal transition via RXFP1. Theranostics. 2020;10(9):3905–3924. doi:10.7150/thno.38640.
   PubMed Web of Science ®Google Scholar
• Weiss A, Attisano L. The TGFbeta superfamily signaling pathway. Wiley Interdisciplinary Rev. 2013;2(1):47–63. doi:10.1002/wdev.86.
   Google Scholar
• Doerr M, Morrison J, Bergeron L, Coomber B, Viloria-Petit A. Differential effect of hypoxia on early endothelial-mesenchymal transition response to transforming growth beta isoforms 1 and 2. Microvasc Res. 2016;108:48–63. doi:10.1016/j.mvr.2016.08.001.
   PubMed Web of Science ®Google Scholar
• Van Geest R, Lesnik-Oberstein SY, Tan HS, et al. A shift in the balance of vascular endothelial growth factor and connective tissue growth factor by bevacizumab causes the angiofibrotic switch in proliferative diabetic retinopathy. British J Ophthalmol. 2012;96(4):587–590. doi:10.1136/bjophthalmol-2011-301005.
   PubMed Web of Science ®Google Scholar
• Peng W, Zhou X, Xu T, et al. BMP-7 ameliorates partial epithelial-mesenchymal transition by restoring SnoN protein level via Smad1/5 pathway in diabetic kidney disease. Cell Death Dis. 2022;13(3):254. doi:10.1038/s41419-022-04529-x.
   PubMed Web of Science ®Google Scholar
• Wu L, Yang S, Li H, et al. TSPAN4-positive migrasome derived from retinal pigmented epithelium cells contributes to the development of proliferative vitreoretinopathy. J Nanobiotechnol. 2022;20(1):519. doi:10.1186/s12951-022-01732-y.
   PubMed Web of Science ®Google Scholar
• Singh V, Santhiago MR, Barbosa FL, et al. Effect of TGFβ and PDGF-B blockade on corneal myofibroblast development in mice. Exp Eye Res. 2011;93(6):810–817. doi:10.1016/j.exer.2011.09.012.
   PubMed Web of Science ®Google Scholar
• Shiju T, Sampaio L, Martinez V, Hilgert G, Wilson S. Transforming growth factor beta-3 localization in the corneal response to epithelial-stromal injury and effects on corneal fibroblast transition to myofibroblasts. Exp Eye Res. 2023;235:109631. doi:10.1016/j.exer.2023.109631.
   PubMed Web of Science ®Google Scholar