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Research Article

FUNCTIONS AND MECHANISMS OF ACTION OF THE ADENOVIRUS E3 PROTEINS

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Pages 75-111 | Published online: 03 Aug 2009

REFERENCES

  • M., Andersson, A., McMichael, P. A., Peterson. Reduced allorecognition of adenovirus-2 infected cells. J. Immunol.. 138: 3960–3966, 1987
  • M., Andersson, S., Pääbo, T., Nilsson, P. A., Peterson. Impaired intracellular transport of class I MHC antigens as a possible means for adenoviruses to evade immune surveillance. Cell. 43: 215–222, 1985, [CROSSREF]
  • W. A., Andiman, G., Miller. Persistent infection with adenovirus types 5 and 6 in lymphoid cells from humans and woolly monkeys. J Infect. Dis.. 145: 83–88, 1982
  • A., Ashkenazi. Targeting death and decoy receptors of the tumour-necrosis factor superfamily. Nat. Rev. Cancer. 2: 420–430, 2002, [CSA], [CROSSREF]
  • D. C., Beier, J. H., Cox, D. R., Vining, P., Cresswell, V. H., Engelhard. Association of human class I MHC alleles with the adenovirus E3/19 K protein. J. Immunol.. 152: 3862–3872, 1994
  • C., Benedict, P., Norris, T., Prigozy, J. L., Bodmer, J. A., Mahr, C., Garnett, F., Martinon, J., Tschopp, L. R., Gooding, C. F., Ware. Three adenovirus E3 proteins cooperate to evade apoptosis by tumor necrosis factor-related apoptosis-inducing ligand receptor-1 and-2. J. Biol. Chem.. 276: 3270–3278, 2001, [CROSSREF]
  • E. M., Bennett, J. R., Bennink, J. W., Yewdell, F. M., Brodsky. Cutting edge: Adenovirus E19 has two mechanisms for affecting class I MHC expression. J. Immunol.. 162: 5049–5052, 1999
  • A. J., Bett, V., Krougliak, F. L., Graham. DNA sequence of the deletion/insertion in early region 3 of Ad5 dl309. Virus Res.. 39: 75–82, 1995, [CROSSREF]
  • B. M., Bhat, H. A., Brady, W.S.M., Wold. Virus deletion mutants that affect a 3′ splice site in the E3 transcription unit of adenovirus 2. Mol. Cell. Biol.. 5: 2405–2413, 1985
  • M., Bouvier. Accessory proteins and the assembly of human class I MHC molecules: A molecular and structural perspective. Mol. Immunol.. 39: 697–706, 2003, [CSA], [CROSSREF]
  • J. T., Bruder, T., Jie, D. L., McVey, I., Kovesdi. Expression of gp19 K increases the persistence of transgene expression from an adenovirus vector in the mouse lung and liver. J. Virol.. 71: 7623–7628, 1997, [CSA]
  • H.-G., Burgert, Z., Ruzsics, S., Obermeier, A., Hilgendorf, M., Windheim, A., Elsing. Subversion of host defense mechanisms by adenoviruses. Curr. Top. Microbiol. Immunol.. 269: 273–318, 2002, [CSA]
  • H.-G., Burgert, S., Kvist. An adenovirus type 2 glycoprotein blocks cell surface expression of human histocompatibility class I antigens. Cell. 41: 987–997, 1985, [CROSSREF]
  • H.-G., Burgert, S., Kvist. The E3/19 K protein of adenovirus type 2 binds to the domains of histocompatibility antigens required for CTL recognition. EMBO J.. 6: 2019–2026, 1987, [CSA]
  • H.-G., Burgert, J. L., Maryanski, S., Kvist. “E3/19 K” protein of adenovirus type 2 inhibits lysis of cytolytic T lymphocytes by blocking cell-surface expression of histocompatibility class I antigens. Proc. Natl. Acad. Sci. USA. 84: 1356–1360, 1987, [CSA]
  • D. P., Cahill, L. T., da Costa, E. B., Carson-Walter, K. W., Kinzler, B., Vogelstein, C., Lengauer. Characterization of MAD2B and other mitotic spindle checkpoint genes. Genomics. 58: 181–187, 1999, [CSA], [CROSSREF]
  • C. R., Carlin, A. E., Tollefson, H. A., Brady, B. L., Hoffman, W.S.M., Wold. Epidermal growth factor receptor is down-regulated by a 10,400 MW protein encoded by the E3 region of adenovirus. Cell. 57: 135–144, 1989, [CROSSREF]
  • S. R., Carlsson, J., Roth, F., Piller, M., Fukuda. Isolation and characterization of human lysosomal membrane glycoproteins, h-lamp-1 and h-lamp-2. Major sialoglycoproteins carrying polylactosaminoglycan. J. Biol. Chem.. 15: 18911–18919, 1988
  • G., Chen, D. V., Goeddel. TNF-R1 signaling: A beautiful pathway. Science. 296: 1634–1635, 2002, [CROSSREF]
  • J., Chen, G., Fang. MAD2B is an inhibitor of the anaphase-promoting complex. Genes Dev.. 15: 1765–1770, 2001, [CROSSREF]
  • P., Chen, J., Tian, I., Kovesdi, J. B., Bruder. Interaction of the adenovirus 14.7 K protein with FLICE inhibits Fas ligand-induced apoptosis. J. Biol. Chem.. 273: 5815–5820, 1998, [CROSSREF]
  • L. T., Chow, T. R., Broker, J. B., Lewis. Complex splicing patterns of RNAs from the early regions of adenovirus-2. J. Mol. Biol.. 134: 265–303, 1979, [CROSSREF]
  • Y., Chu, K., Sperber, L., Mayer, M. T., Hsu. Persistent infection of human adenovirus type 5 in human monocyte cell lines. Virology. 188: 793–800, 1992, [CSA], [CROSSREF]
  • C., Cladaras, B., Bhat, W. S., Wold. Mapping the 5′ ends, 3′ ends, and splice sites of mRNAs from the early E3 transcription unit of adenovirus 5. Virology. 140: 44–54, 1985, [CSA], [CROSSREF]
  • C., Cladaras, W. S., Wold. DNA sequence of the early E3 transcription unit of adenovirus 5. Virology. 140: 28–43, 1985, [CSA], [CROSSREF]
  • J. H., Cox, J. R., Bennink, J. W., Yewdell. Retention of adenovirus E19 glycoprotein in the endoplasmic reticulum is essential to its ability to block antigen presentation. J. Exp. Med.. 174: 1629–1637, 1991, [CROSSREF]
  • J. H., Cox, J. W., Yewdell, L. C., Eisenlohr, P. R., Johnson, J. R., Bennink. Antigen presentation requires transport of MHC class I molecules from the endoplasmic reticulum. Science. 247: 715–718, 1990
  • T., Derfuss, E., Meinl. Herpesviral proteins regulating apoptosis. Curr. Top. Microbiol. Immunol.. 269: 257–272, 2002, [CSA]
  • F., Deryckere, H.-G., Burgert. Tumor necrosis factor α induces the adenovirus early 3 promoter by activation of NF-κB. J. Biol. Chem.. 271: 30249–30255, 1996, [CROSSREF]
  • F., Deryckere, C., Ebenau-Jehle, W. S., Wold, H.-G., Burgert. Tumor necrosis factor alpha increases expression of adenovirus E3 proteins. Immunobiology. 193: 186–192, 1995
  • A., Devin, A., Cook, Y., Lin, Y., Rodriguez, M., Kelliher, Z., Liu. The distinct roles of TRAF2 and RIP in IKK activation by TNF-R1: TRAF2 recruits IKK to TNF-R1 while RIP mediates IKK activation. Immunity. 12: 419–429, 2000, [CSA], [CROSSREF]
  • T., Dimitrov, P., Krajcsi, T. W., Hermiston, A. E., Tollefson, M., Hannink, W.S.M., Wold. Adenovirus E3-10.4 K/14.5 K protein complex inhibits tumor necrosis factor-induced translocation of cytosolic phospholipase A2 to membranes. J. Virol.. 71: 2830–2837, 1997, [CSA]
  • K., Doronin, M., Kuppuswamy, K., Toth, A. E., Tollefson, P., Krajcsi, V., Krougliak, W.S.M., Wold. Tissue-specific, tumor-selective, replication-competent adenovirus vector for cancer gene therapy. J. Virol.. 75: 3314–3324, 2001, [CSA], [CROSSREF]
  • K., Doronin, K., Toth, M., Kuppuswamy, P., Krajcsi, A. E., Tollefson, W.S.M., Wold. Overexpression of the ADP (E3-11.6 K) protein increases cell lysis and spread of adenovirus. Virology. 305: 378–387, 2003, [CSA], [CROSSREF]
  • K., Doronin, K., Toth, M., Kuppuswamy, P., Ward, A. E., Tollefson, W.S.M., Wold. Tumor-specific, replication-competent adenovirus vectors overexpressing the Adenovirus Death Protein. J. Virol.. 74: 6147–6155, 2000, [CSA], [CROSSREF]
  • N., Durepaire, J. P., Rogez, M., Verdier, S., Rogez, P., Weinbreck, F., Denis. Detection of adenovirus DNA by polymerase chain reaction in peripheral blood lymphocytes from HIV-infected patients and a control group: Preliminary results. J. Acquir. Immune. Defic. Syndr. Hum. Retrovirol.. 14: 189–190, 1997, [CSA]
  • S., Efrat, G., Fejer, M., Brownlee, M. S., Horwitz. Prolonged survival of pancreatic islet allografts mediated by adenovirus immunoregulatory transgenes. Proc. Natl. Acad. Sci. USA. 92: 6947–6951, 1995, [CSA]
  • S., Efrat, D., Serreze, A., Svetlanov, C. M., Post, E. A., Johnson, K., Herold, M., Horwitz. Adenovirus early region 3 (E3) immunomodulatory genes decrease the incidence of autoimmune diabetes in NOD mice. Diabetes. 50: 980–984, 2001
  • B., Elangovan, D. L., Lichtenstein, A. E., Tollefson, W.S.M., Wold. The YxxΦ motif present in the cytoplasmic tail of RID β interacts with the μ2 subunit of the AP2 complex. Manuscript in preparation. 2003
  • A., Elsing, H.-G., Burgert. The adenovirus E3/10.4 K-14.5 K proteins down-modulate the apoptosis receptor Fas/Apo-1 by inducing its internalization. Proc. Natl. Acad. Sci. USA. 95: 10072–10077, 1998, [CSA], [CROSSREF]
  • H., Everett, G., McFadden. Poxviruses and apoptosis: A time to die. Curr. Opin. Microbiol.. 5: 395–402, 2002, [CSA], [CROSSREF]
  • D., Feuerbach, S., Etteldorf, C., Ebenau-Jehle, J., Abastado, D., Madden, H.-G., Burgert. Identification of amino acids within the MHC molecule important for the interaction with the adenovirus protein E3-19 K. J. Immunol.. 153: 1626–1636, 1994
  • P., Flomenberg, E., Gutierrez, K. T., Hogan. Identification of class I MHC regions which bind to the adenovirus E3-19 k protein. Mol. Immunol.. 31: 1277–1284, 1994, [CSA], [CROSSREF]
  • P., Flomenberg, E., Gutierrez, V., Piaskowski, J. T., Casper. Detection of adenovirus DNA in peripheral blood mononuclear cells by polymerase chain reaction assay. J. Med. Virol.. 51: 182–188, 1997, [CSA], [CROSSREF]
  • P., Flomenberg, V., Piaskowski, R. L., Truitt, J. T., Casper. Human adenovirus-specific CD8 + T-cell responses are not inhibited by E3-19 K in the presence of gamma interferon. J. Virol.. 70: 6314–6322, 1996, [CSA]
  • J. P., Fox, C. D., Brandt, F. E., Wassermann, C. E., Hall, I., Spigland, A., Kogon, L. R., Elveback. The virus watch program: A continuing surveillance of viral infections in metropolitan New York families. VI. Observations of adenovirus infections: virus excretion patterns, antibody response, efficiency of surveillance, patterns of infections, and relation to illness. Am. J. Epidemiol.. 89: 25–50, 1969
  • J. P., Fox, C. E., Hall, M. K., Cooney. The Seattle Virus Watch. VII. Observations of adenovirus infections. Am. J. Epidemiol.. 105: 362–386, 1977
  • J. M., Friedman, M. S., Horwitz. Inhibition of tumor necrosis factor alpha-induced NF-κB activation by the adenovirus E3-10.4/14.5 K complex. J. Virol.. 76: 5515–5521, 2002, [CSA], [CROSSREF]
  • R., Gabathuler, S., Kvist. The endoplasmic reticulum retention signal of the E3/19 K protein of adenovirus type 2 consists of three separate amino acid segments at the carboxy terminus. J. Cell. Biol.. 111: 1803–1810, 1990, [CROSSREF]
  • R., Gabathuler, F., Levy, S., Kvist. Requirements for the association of adenovirus type 2 E3/19 K wild-type and mutant proteins with HLA antigens. J. Virol.. 64: 3679–3685, 1990
  • M., Gantzer, E., Spitz, N., Accard, R., Rooke. Constitutive expression of the adenovirus E3-14.7 K protein does not prolong adenovirus vector DNA persistence but protects mice against lipopolysaccharide-induced acute hepatitis. Hum. Gene Ther.. 13: 921–933, 2002, [CSA], [CROSSREF]
  • J., Garcia, F., Wu, R., Gaynor. Upstream regulatory regions required to stabilize binding to the TATA sequence in an adenovirus early promoter. Nucleic Acids Res.. 15: 8367–8385, 1987
  • C. T., Garnett, D., Erdman, W., Xu, L. R., Gooding. Prevalence and quantitation of species C adenovirus DNA in human mucosal lymphocytes. J. Virol.. 76: 10608–10616, 2002, [CSA]
  • K., Ghosh, H. P., Ghosh. Role of the membrane anchoring and cytoplasmic domains in intracellular transport and localization of viral glycoproteins. J. Biochem. Cell Biol.. 77: 165–178, 1999, [CSA], [CROSSREF]
  • H. S., Ginsberg, R. L., Horswood, R. M., Chanock, G. A., Prince. Role of early genes in pathogenesis of adenovirus pneumonia. Proc. Nat. Acad. Sci. USA. 87: 6191–6195, 1990, [CSA]
  • H. S., Ginsberg, U., Lundholm-Beauchamp, R. L., Horswood, B., Pernis, W.S.M., Wold, R. M., Chanock, G. A., Prince. Role of early region 3 (E3) in pathogenesis of adenovirus disease. Proc. Natl. Acad. Sci. USA. 86: 3823–3827, 1989, [CSA]
  • H. S., Ginsberg, L. L., Moldawer, P. B., Sehgal, M., Redington, P. L., Kilian, R. M., Chanock, G. A., Prince. A mouse model for investigating the molecular pathogenesis of adenovirus pneumonia. Proc. Natl. Acad. Sci. USA. 88: 1651–1655, 1991, [CSA]
  • L. R., Gooding, L., Aquino, P. J., Duerksen-Hughes, D., Day, T. M., Horton, S. P., Yei, W.S.M., Wold. The E1B 19,000-molecular-weight protein of group C adenoviruses prevents tumor necrosis factor cytolysis of human cells but not of mouse cells. J. Virol.. 65: 3083–3094, 1991, [CSA]
  • L. R., Gooding, L. W., Elmore, A. E., Tollefson, H. A., Brady, W.S.M., Wold. A 14,700 MW protein from the E3 region of adenovirus inhibits cytolysis by tumor necrosis factor. Cell. 53: 341–346, 1988, [CROSSREF]
  • L. R., Gooding, T. S., Ranheim, A. E., Tollefson, L., Aquino, P., Duerksen-Hughes, T. M., Horton, W.S.M., Wold. The 10,400- and 14,500-dalton proteins encoded by region E3 of adenovirus function together to protect many but not all mouse cell lines against lysis by tumor necrosis factor. J. Virol.. 65: 4114–4123, 1991, [CSA]
  • L. R., Gooding, I. O., Sofola, A. E., Tollefson, P., Duerksen-Hughes, W.S.M., Wold. The adenovirus E3-14.7 K protein is a general inhibitor of tumor necrosis factor-mediated cytolysis. J. Immunol.. 145: 3080–3086, 1990
  • A., Grunhaus, S., Cho, M. S., Horwitz. Association of vaccinia virus-expressed adenovirus E3-19 K glycoprotein with class I MHC and its effects on virulence in a murine pneumonia model. Virology. 200: 535–546, 1994, [CSA], [CROSSREF]
  • K., Hattula, J., Peränen. FIP-2, a coiled-coil protein, links Huntingtin to Rab8 and modulates cellular morphogenesis. Curr. Biol.. 10: 1603–1606, 2000, [CROSSREF]
  • J., Hausmann, D., Ortmann, M., Witt, E., Veit, W., Seidel. Adenovirus death protein, a transmembrane protein encoded in the E3 region, is palmitoylated at the cytoplasmic tail. Virology. 244: 343–351, 1998, [CSA], [CROSSREF]
  • L. K., Hawkins, W.S.M., Wold. A 12,500 MW protein is coded by region E3 of adenovirus. Virology. 188: 486–494, 1992, [CSA], [CROSSREF]
  • J., Herisse, G., Courtois, F., Galibert. Nucleotide sequence of the EcoRI D fragment of adenovirus 2 genome. Nucleic Acids Res.. 8: 2173–2192, 1980
  • J., Herisse, F., Galibert. Nucleotide sequence of the EcoRI E fragment of adenovirus 2 genome. Nucleic Acids Res.. 9: 1229–1240, 1981
  • T. W., Hermiston, R. A., Tripp, T., Sparer, L. R., Gooding, W.S.M., Wold. Deletion mutation analysis of the adenovirus type 2 E3-gp19 K protein: Identification of sequences within the endoplasmic reticulum lumenal domain that are required for class I antigen binding and protection from adenovirus-specific cytotoxic T lymphocytes. J. Virol.. 67: 5289–5298, 1993, [CSA]
  • P., Hoffman, P., Rajakumar, B., Hoffman, R., Heuertz, W. S., Wold, C. R., Carlin. Evidence for intracellular down-regulation of the epidermal growth factor (EGF) receptor during adenovirus infection by an EGF-independent mechanism. J. Virol.. 66: 197–203, 1992, [CSA]
  • P., Hoffman, M. B., Yaffe, B. L., Hoffman, S., Yei, W.S.M., Wold, C., Carlin. Characterization of the adenovirus E3 protein that down-regulates the epidermal growth factor receptor. Evidence for intermolecular disulfide bonding and plasma membrane localization. J. Biol. Chem.. 267: 13480–13487, 1992
  • T. M., Horton, T. S., Ranheim, L., Aquino, D. I., Kusher, S. K., Saha, C. F., Ware, W.S.M., Wold, L. R., Gooding. Adenovirus E3 14.7 K protein functions in the absence of other adenovirus proteins to protect transfected cells from tumor necrosis factor cytolysis. J. Virol.. 65: 2629–2639, 1991, [CSA]
  • J., Horvath, L., Palkonyay, J., Weber. Group C adenovirus DNA sequences in human lymphoid cells. J. Virol.. 59: 189–192, 1986, [CSA]
  • M., Horwitz. Adenovirus immunoregulatory genes and their cellular targets. Virology. 279: 1–8, 2001, [CSA], [CROSSREF]
  • H. C., Hurst, N. C., Jones. Identification of factors that interact with the E1A- inducible adenovirus E3 promoter. Genes Dev.. 1: 1132–1146, 1987
  • Y., Ilan, G., Droguett, N. R., Chowdhury, Y., Li, K., Sengupta, N. R., Thummala, A., Davidson, J. R., Chowdhury, M. S., Horwitz. Insertion of the adenoviral E3 region into a recombinant viral vector prevents antiviral humoral and cellular immune responses and permits long-term gene expression. Proc. Natl. Acad. Sci. USA. 94: 2587–2592, 1997, [CSA], [CROSSREF]
  • M. R., Jackson, T., Nilsson, P. A., Peterson. Identification of a consensus motif for retention of transmembrane proteins in the endoplasmic reticulum. EMBO J.. 9: 3153–3162, 1990, [CSA]
  • W. A., Jefferies, H.-G., Burgert. E3/19 K from adenovirus 2 is an immunosubversive protein that binds to a structural motif regulating the intracellular transport of major histocompatibility complex class I proteins. J. Exp. Med.. 172: 1653–1664, 1990, [CROSSREF]
  • O., Kampe, D., Bellgrau, U., Hammerling, P., Lind, S., Pääbo, L., Severinsson, P. A., Peterson. Complex formation of class I transplantation antigens and a viral glycoprotein. J. Biol. Chem.. 258: 10594–10598, 1983
  • J. M., Kaplan, D., Armentano, T. E., Sparer, S. G., Wynn, P. A., Peterson, S. C., Wadsworth, K. K., Couture, S. E., Pennington, J. A., St George, L. R., Gooding, A. E., Smith. Characterization of factors involved in modulating persistence of transgene expression from recombinant adenovirus in the mouse lung. Hum. Gene Ther.. 8: 45–56, 1997, [CSA]
  • M., Karin, Y., Ben. Neriah, Phosphorylation meets ubiquitination: The control of NF-[κ]B activity. Annu. Rev. Immunol.. 18: 621–663, 2000, [CSA], [CROSSREF]
  • M., Karin, A., Lin. NF-kappaB at the crossroads of life and death. Nat. Immunol.. 3: 221–227, 2002, [CROSSREF]
  • T. J., Kelly, Jr., A. M., Lewis, Jr.. Use of nondefective adenovirus-simian virus 40 hybrids for mapping the simian virus 40 genome, J. Virol.. 12: 643–652, 1973
  • H.-J., Kim, M. P., Foster. Characterization of Ad5 E3-14.7 K, an adenoviral inhibitor of apoptosis: Structure, oligometric state, and metal binding. Protein Science. 11: 1117–1128, 2002, [CSA], [CROSSREF]
  • T., Kirchhausen. Adaptors for clathrin-mediated traffic. Annu. Rev. Cell Dev. Biol.. 15: 705–732, 1999, [CSA], [CROSSREF]
  • H., Korner, U., Fritzsche, H.-G., Burgert. Tumor necrosis factor alpha stimulates expression of adenovirus early region 3 proteins: Implications for viral persistence. Proc. Natl. Acad. Sci. USA. 89: 11857–11861, 1992, [CSA]
  • R., Kornfeld, W.S.M., Wold. Structures of the oligosaccharides of the glycoprotein coded by early region E3 of adenovirus 2. J. Virol.. 40: 440–449, 1981
  • M., Kornuc, S., Kliewer, J., Garcia, D., Harrich, C., Li, R., Gaynor. Adenovirus early region 3 promoter regulation by E1A/E1B is independent of alterations in DNA binding and gene activation of CREB/ATF and AP1. J. Virol.. 64: 2004–2013, 1990
  • P., Krajcsi, T., Dimitrov, T. W., Hermiston, A. E., Tollefson, T. S., Ranheim, S. B., Vande Pol, A. H., Stephenson, W.S.M., Wold. The adenovirus E3-14.7 K protein and the E3-10.4 K/14.5 K complex of proteins, which independently inhibit tumor necrosis factor (TNF)-induced apoptosis, also independently inhibit TNF-induced release of arachidonic acid. J. Virol.. 70: 4904–4913, 1996, [CSA]
  • P., Krajcsi, A. E., Tollefson, C. W., Anderson, A. R., Stewart, C. R., Carlin, W.S.M., Wold. The E3-10.4 K protein of adenovirus is an integral membrane protein that is partially cleaved between Ala22 and Ala23 and has a Ccyt orientation, Virology. 187: 131–144, 1992, [CSA], [CROSSREF]
  • P., Krajcsi, A. E., Tollefson, C. W., Anderson, W.S.M., Wold. The adenovirus E3 14.5-kilodalton protein, which is required for downregulation of the epidermal growth factor receptor and prevention of tumor necrosis factor cytolysis, is an integral membrane protein oriented with its C terminus in the cytoplasm. J. Virol.. 66: 1665–1673, 1992, [CSA]
  • P., Krajcsi, A. E., Tollefson, W.S.M., Wold. The E3-14.5 K integral membrane protein of adenovirus that is required for downregulation of the EGF receptor and for prevention of TNF cytolysis is O-glycosylated but not N-glycosylated.. Virology. 188: 570–579, 1992, [CSA], [CROSSREF]
  • P., Krajcsi, W.S.M., Wold. The adenovirus E3-14.5 K protein which is required for prevention of TNF cytolysis and for downregulation of the EGF receptor contains phosphoserine. Virology. 187: 492–498, 1992, [CSA], [CROSSREF]
  • E., Kuivinen, B. L., Hoffman, P. A., Hoffman, C. R., Carlin. Structurally related class I and class II receptor protein tyrosine kinases are down-regulated by the same E3 protein coded for by human group C adenoviruses. J. Cell. Biol.. 120: 1271–1279, 1993, [CROSSREF]
  • S., Kvist, L., Ostberg, H., Persson, L., Philipson, P. A., Peterson. Molecular association between transplantation antigens and cell surface antigen in adenovirus-transformed cell line. Proc. Natl. Acad. Sci. USA. 75: 5674–5678, 1978
  • M. G., Lee, M. A., Abina, H., Haddada, M., Perricaudet. The constitutive expression of the immunomodulatory gp19k protein in E1–:E3– adenoviral vectors strongly reduces the host cytotoxic T cell response against the vector. Gene Therapy. 2: 256–262, 1995
  • R., Li, A. W., Murray. Feedback control of mitosis in budding yeast. Cell. 66: 519–531, 1991, [CROSSREF]
  • Y., Li, J., Kang, J., Friedman, L., Tarassishin, J., Ye, A., Kovalenko, D., Wallach, M. S., Horwitz. Identification of a cell protein (FIP-3) as a modulator of NF-κB activity and as a target of an adenovirus inhibitor of tumor necrosis factor α-induced apoptosis. Proc. Natl. Acad. Sci. USA. 96: 1042–1047, 1999, [CSA], [CROSSREF]
  • Y., Li, J., Kang, M. S., Horwitz. Interaction of an adenovirus 14.7-kilodalton protein inhibitor of tumor necrosis factor alpha cytolysis with a new member of the GTPase superfamily of signal transducers, J. Virol.. 71: 1576–1582, 1997, [CSA]
  • Y., Li, J., Kang, M. S., Horwitz. Interaction of an adenovirus E3 14.7-kilodalton protein with a novel tumor necrosis factor alpha-inducible cellular protein containing leucine zipper domains. Mol. Cell. Biol.. 18: 1601–1610, 1998
  • Y., Li, W. S., Wold. Identification and characterization of a 30K protein (Ad4E3-30K) encoded by the E3 region of human adenovirus type 4, Virology. 273: 127–138, 2000
  • D. L., Lichtenstein, P., Krajcsi, D. J., Esteban, A. E., Tollefson, W.S.M., Wold. The adenovirus RIDß subunit contains a tyrosine residue that is critical for RID-mediated receptor internalization and inhibition of Fas- and TRAIL-induced apoptosis. J. Virol.. 76: 11329–11342, 2002, [CSA], [CROSSREF]
  • S., Lukashok, L., Tarassishin, Y., Li, M., Horwitz. An adenovirus inhibitor of tumor necrosis factor alpha-induced apoptosis complexes with dynein and a small GTPase. J. Virol.. 74: 4705–4709, 2000, [CSA], [CROSSREF]
  • M., MacFarlane. TRAIL-induced signalling and apoptosis. Toxicol. Lett.. 139: 89–97, 2003, [CSA]
  • J. A., Mahr, J. M., Boss, L. R., Gooding. The adenovirus E3 promoter is sensitive to activation signals in human T cells. J. Virol.. 77: 1112–1119, 2003, [CSA]
  • J. A., Mahr, L. R., Gooding. Immune evasion by adenoviruses. Immunol. Rev.. 168: 121–130, 1999, [CSA]
  • A. L., McNees, C. T., Garnett, L. R., Gooding. The adenovirus E3 RID complex protects some cultured human T and B lymphocytes from Fas-induced apoptosis. J. Virol.. 76: 9716–9723, 2002, [CSA], [CROSSREF]
  • F., Mercurio, B. W., Murray, A., Shevchenko, B. L., Bennett, D. B., Young, J. W., Li, G., Pascual, A., Motiwala, H., Zhu, M., Mann, A. M., Manning. IkappaB kinase (IKK)-associated protein 1, a common component of the heterogeneous IKK complex. Mol. Cell Biol.. 19: 1526–1538, 1999
  • A. R., Moise, J. R., Grant, T. Z., Vitalis, W. A., Jefferies. Adenovirus E3-6.7 K maintains calcium homeostasis and prevents apoptosis and arachidonic acid release. J. Virol.. 76: 1578–1587, 2002, [CSA], [CROSSREF]
  • J. E., Morin, M. D., Lubeck, J. E., Barton, A. J., Conley, A. R., Davis, P. P., Hung. Recombinant adenovirus induces antibody response to hepatitis B virus surface antigen in hamsters. Proc. Natl. Acad. Sci. USA. 84: 4626–4630, 1987, [CSA]
  • Y., Murakumo, T., Roth, H., Ishii, D., Rasio, S., Numata, C. M., Croce, R., Fishel. A human REV7 homolog that interacts with the polymerase zeta catalytic subunit hREV3 and the spindle assembly checkpoint protein hMAD2. J. Biol. Chem.. 275: 4391–4397, 2000, [CROSSREF]
  • K. K., Nelson, J., Schlondorff, C. P., Blobel. Evidence for an interaction of the metalloprotease-disintegrin tumour necrosis factor alpha convertase (TACE) with mitotic arrest deficient 2 (MAD2), and of the metalloprotease-disintegrin MDC9 with a novel MAD2-related protein, MAD2beta. Biochem. J.. 343: 673–680, 1999, [CROSSREF]
  • T., Nilsson, M., Jackson, P. A., Peterson. Short cytoplasmic sequences serve as retention signals for transmembrane proteins in the endoplasmic reticulum. Cell. 58: 707–718, 1989, [CROSSREF]
  • S., Pääbo, B. M., Bhat, W.S.M., Wold, P. A., Peterson. A short sequence in the COOH-terminus makes an adenovirus membrane glycoprotein a resident of the endoplasmic reticulum. Cell. 50: 311–317, 1987, [CROSSREF]
  • S., Pääbo, F., Weber, O., Kampe, W., Schaffner, P. A., Peterson. Association between transplantation antigens and a viral membrane protein synthesized from a mammalian expression vector. Cell. 33: 445–453, 1983, [CROSSREF]
  • S., Pääbo, F., Weber, T., Nilsson, W., Schaffner, P. A., Peterson. Structural and functional dissection of an MHC class I antigen- binding adenovirus glycoprotein. EMBO J.. 5: 1921–1927, 1986
  • D. L., Pacini, E. J., Dubovi, W. A., Clyde, Jr.. A new animal model for human respiratory tract disease due to adenovirus. J. Infect. Dis.. 150: 92–97, 1984
  • H., Persson, M., Jansson, L., Philipson. Synthesis and genomic site for an adenovirus type 2 early glycoprotein. J. Mol. Biol.. 136: 375–394, 1980, [CROSSREF]
  • H., Persson, H., Jornvall, J., Zabielski. Multiple mRNA species for the precursor to an adenovirus-encoded glycoprotein: identification and structure of the signal sequence. Proc. Natl. Acad. Sci. USA. 77: 6349–6353, 1980
  • H., Persson, B., Oberg, L., Philipson. Purification and characterization of an early protein (E14 K) from adenovirus type 2-infected cells. J. Virol.. 28: 119–139, 1978
  • C. M., Pfleger, A., Salic, E., Lee, M. W., Kirschner. Inhibition of Cdh1-APC by the MAD2-related protein MAD2L2: A novel mechanism for regulating Cdh1. Genes Dev.. 15: 1759–1764, 2001, [CROSSREF]
  • W., Poller, S., Schneider-Rasp, U., Liebert, F., Merklein, P., Thalheimer, A., Haack, R., Schwaab, C., Schmitt, H. H., Brackmann. Stabilization of transgene expression by incorporation of E3 region genes into an adenoviral factor IX vector and by transient anti-CD4 treatment of the host. Gene Ther.. 3: 521–530, 1996
  • M., Ramachandra, A., Rahman, A., Zou, M., Vaillancourt, J. A., Howe, D., Antelman, B., Sugarman, G. W., Demers, H., Engler, D., Johnson, P., Shabram. Re-engineering adenovirus regulatory pathways to enhance oncolytic specificity and efficacy. Nature Biotech.. 19: 1035–1041, 2001, [CSA], [CROSSREF]
  • T. S., Ranheim, J., Shisler, T. M., Horton, L. J., Wold, L. R., Gooding, W.S.M., Wold. Characterization of mutants within the gene for the adenovirus E3 14.7-kilodalton protein which prevents cytolysis by tumor necrosis factor. J. Virol.. 67: 2159–2167, 1993, [CSA]
  • F. C., Rawle, B. B., Knowles, R. P., Ricciardi, V., Brahmacheri, P., Duerksen-Hughes, W.S.M., Wold, L. R., Gooding. Specificity of the mouse cytotoxic T lymphocyte response to adenovirus 5. E1A is immunodominant in H-2b, but not in H-2d or H-2k mice. J. Immunol.. 146: 3977–3984, 1991
  • F. C., Rawle, A. E., Tollefson, W.S.M., Wold, L. R., Gooding. Mouse anti-adenovirus cytotoxic T lymphocytes. Inhibition of lysis by E3 gp19 K but not E3 14.7 K. J. Immunol.. 143: 2031–2037, 1989
  • D. M., Rothwarf, E., Zandi, G., Natoli, M., Karin. IKK-gamma is an essential regulatory subunit of the IkappaB kinase complex. Nature. 395: 297–300, 1998, [CROSSREF]
  • U., Sartorius, I., Schmitz, P. H., Krammer. Molecular mechanisms of death- receptor-mediated apoptosis. Chembiochem.. 2: 20–29, 2001, [CSA], [CROSSREF]
  • A., Scaria, A. E., Tollefson, S. K., Saha, W.S.M., Wold. The E3-11.6 K protein of adenovirus is an Asn-glycosylated integral membrane protein that localizes to the nuclear membrane. Virology. 191: 743–753, 1992, [CSA], [CROSSREF]
  • D. B., Schowalter, J. C., Tubb, M., Liu, C. B., Wilson, M. A., Kay. Heterologous expression of adenovirus E3-gp19 K in an E1a-deleted adenovirus vector inhibits MHC I expression in vitro, but does not prolong transgene expression in vivo. Gene Ther.. 4: 351–360, 1997, [CROSSREF]
  • A., Schurmann, A., Brauers, S., Massmann, W., Becker, H. G., Joost. Cloning of a novel family of mammalian GTP-binding proteins (RagA, RagBs, RagB1) with remote similarity to the Ras-related GTPases. J. Biol. Chem.. 270: 28982–28988, 1995, [CROSSREF]
  • K., Schwamborn, R., Weil, G., Courtois, S. T., Whiteside, A., Israël. Phorbol esters and cytokines regulate the expression of the NEMO-related protein, a molecule involved in a NF-kappa B-independent pathway. J. Biol. Chem.. 275: 22780–22789, 2000, [CROSSREF]
  • M., Sester, H.-G., Burgert. Conserved cysteine residues within the E3/19 K protein of adenovirus type 2 are essential for binding to major histocompatibility complex antigens. J. Virol.. 68: 5423–5432, 1994, [CSA]
  • L., Severinsson, I., Martens, P. A., Peterson. Differential association between two human MHC class I antigens and an adenoviral glycoprotein. J. Immunol.. 137: 1003–1009, 1986
  • T., Shenk. Adenoviridae: The viruses and their replication. D. M., Knipe, P. M., Howley. Fields Virology. Philadelphia, Lippincott, Williams & Wilkins. 2265–2300, 2001
  • J., Shisler, C., Yang, B., Walter, C. F., Ware, L. R., Gooding. The adenovirus E3-10.4 K/14.5 K complex mediates loss of cell surface Fas (CD95) and resistance to Fas-induced apoptosis. J. Virol.. 71: 8299–8306, 1997, [CSA]
  • C., Signas, M. G., Katze, H., Persson, L., Philipson. An adenovirus glycoprotein binds heavy chains of class I transplantation antigens from man and mouse. Nature. 299: 175–178, 1982, [CROSSREF]
  • L., Silver, C. W., Anderson. Interaction of human adenovirus serotype 2 with human lymphoid cells. Virology. 165: 377–387, 1988, [CSA], [CROSSREF]
  • T., Sparer, R. A., Tripp, D. L., Dillehay, T. W., Hermiston, W.S.M., Wold, L. R., Gooding. The role of adenovirus early region 3 proteins (gp19 K, 10.4 K, 14.5 K, and 14.7 K) in a murine pneumonia model. J. Virol.. 70: 2431–2439, 1996, [CSA]
  • T. E., Sparer, L. R., Gooding. Suppression of MHC class I antigen presentation by human adenoviruses. Curr. Top. Microbiol. Immunol.. 232: 135–147, 1998, [CSA]
  • T. E., Sparer, S. G., Wynn, D. J., Clark, J. M., Kaplan, L. M., Cardoza, S. C., Wadsworth, A. E., Smith, L. R., Gooding. Generation of cytotoxic T lymphocytes against immunorecessive epitopes after multiple immunizations with adenovirus vectors is dependent on haplotype. J. Virol.. 71: 2277–2284, 1997, [CSA]
  • M. K., Spriggs, B. H., Koller, T., Sato, P. J., Morrissey, W. C., Fanslow, O., Smithies, R. F., Voice, M. B., Widmer, C. R., Maliszewski. Beta 2-microglobulin–, CD8+ T-cell-deficient mice survive inoculation with high doses of vaccinia virus and exhibit altered IgG responses. Proc. Natl. Acad. Sci. USA. 89: 6070–6074, 1992, [CSA]
  • A. R., Stewart, A. E., Tollefson, P., Krajcsi, S. P., Yei, W.S.M., Wold. The adenovirus E3 10.4 K and 14.5 K proteins, which function to prevent cytolysis by tumor necrosis factor and to down-regulate the epidermal growth factor receptor, are localized in the plasma membrane. J. Virol.. 69: 172–181, 1995, [CSA]
  • K., Suzuki, R., Alemany, M., Yamamoto, D. T., Curiel. The presence of the adenovirus E3 region improves the oncolytic potency of conditionally replicative adenoviruses. Clin. Cancer Res.. 8: 3348–3359, 2002, [CSA]
  • K., Tada, T., Okazaki, S., Sakon, T., Kobarai, K., Kurosawa, S., Yamaoka, H., Hashimoto, T. W., Mak, H., Yagita, K., Okumura, W. C., Yeh, H., Nakano. Critical roles of TRAF2 and TRAF5 in tumor necrosis factor-induced NF-kappa B activation and protection from cell death. J. Biol. Chem.. 276: 36530–36534, 2001, [CROSSREF]
  • M. M., Taketo, M., Sonoshita. Phospolipase A2 and apoptosis. Biochim. Biophys. Acta. 1585: 72–76, 2002
  • Y., Tanaka, S. S., Tevethia. Differential effect of adenovirus 2 E3/19 K glycoprotein on the expression of H-2Kb and H-2Db class I antigens and H-2Kb- and H- 2Db-restricted SV40-specific CTL-mediated lysis. Virology. 165: 357–366, 1988, [CSA], [CROSSREF]
  • T. E., Thorne, C., Voelkel-Johnson, W. M., Casey, L. W., Parks, S. M., Laster. The activity of cytosolic phospholipase A2 is required for the lysis of adenovirus-infected cells by tumor necrosis factor. J. Virol.. 70: 8502–8507, 1996, [CSA]
  • A. E., Tollefson, T. W., Hermiston, D. L., Lichtenstein, C. F., Colle, R. A., Tripp, T., Dimitrov, K., Toth, C. E., Wells, P. C., Doherty, W.S.M., Wold. Forced degradation of Fas inhibits apoptosis in adenovirus-infected cells. Nature. 392: 726–730, 1998, [CROSSREF]
  • A. E., Tollefson, P., Krajcsi, M. H., Pursley, L. R., Gooding, W.S.M., Wold. A 14,500 MW protein is coded by region E3 of group C human adenoviruses. Virology. 175: 19–29, 1990, [CSA], [CROSSREF]
  • A. E., Tollefson, P., Krajcsi, S. P., Yei, C. R., Carlin, W.S.M., Wold. A 10,400- molecular-weight membrane protein is coded by region E3 of adenovirus. J. Virol.. 64: 794–801, 1990, [CSA]
  • A. E., Tollefson, J. S., Ryerse, A., Scaria, T. W., Hermiston, W.S.M., Wold. The E3-11.6 kDa Adenovirus Death Protein (ADP) is required for efficient cell death: Characterization of cells infected with adp mutants. Virology. 220: 152–162, 1996, [CSA], [CROSSREF]
  • A. E., Tollefson, A., Scaria, T. W., Hermiston, J. S., Ryerse, L. J., Wold, W.S.M., Wold. The adenovirus death protein (E3-11.6 K) is required at very late stages of infection for efficient cell lysis and release of adenovirus from infected cells. J. Virol.. 70: 2296–2306, 1996, [CSA]
  • A. E., Tollefson, A., Scaria, S. K., Saha, W.S.M., Wold. The 11,600-MW protein encoded by region E3 of adenovirus is expressed early but is greatly amplified at late stages of infection. J. Virol.. 66: 3633–3642, 1992, [CSA]
  • A. E., Tollefson, A., Scaria, B., Ying, W.S.M., Wold. Mutations within the adenovirus death protein (ADP) alter the Kinetics of cell death of adenovirus infected cells. J. Virol. 77: 7764–7778, 2003, [CSA], [CROSSREF]
  • A. E., Tollefson, A. R., Stewart, S. P., Yei, S. K., Saha, W.S.M., Wold. The 10,400- and 14,500-dalton proteins encoded by region E3 of adenovirus form a complex and function together to down-regulate the epidermal growth factor receptor. J. Virol.. 65: 3095–3105, 1991, [CSA]
  • A. E., Tollefson, K., Toth, K., Doronin, M., Kuppuswamy, O. A., Doronina, D. L., Lichtenstein, T. W., Hermiston, C. A., Smith, W.S.M., Wold. Inhibition of TRAIL- induced apoptosis and forced internalization of TRAIL receptor 1 by adenovirus proteins. J. Virol.. 75: 8875–8887, 2001, [CSA]
  • A. E., Tollefson, W.S.M., Wold. Identification and gene mapping of a 14,700-molecular-weight protein encoded by region E3 of group C adenoviruses. J. Virol.. 62: 33–39, 1988, [CSA]
  • K., Toth, M., Kuppuswamy, K., Doronin, O., Doronina, D. L., Lichtenstein, A. E., Tollefson, W.S.M., Wold. Construction and characterization of E1-minus replication-defective adenovirus vectors that express E3 proteins from the E1 region. Virology. 301: 99–108, 2002, [CSA], [CROSSREF]
  • J., Tufariello, S., Cho, M. S., Horwitz. The adenovirus E3 14.7-kilodalton protein which inhibits cytolysis by tumor necrosis factor increases the virulence of vaccinia virus in a murine pneumonia model. J. Virol.. 68: 453–462, 1994, [CSA]
  • J. M., Tufariello, S., Cho, M. S., Horwitz. Adenovirus E3 14.7-kilodalton protein, an antagonist of tumor necrosis factor cytolysis, increases the virulence of vaccinia virus in severe combined immunodeficient mice. Proc. Natl. Acad. Sci. USA. 91: 10987–10991, 1994, [CSA]
  • J., van der Veen, M., Lambriex. Relationship of adenovirus to lymphocytes in naturally infected human tonsils and adenoids. Infect. Immun.. 7: 604–609, 1973
  • M. G., von Herrath, S., Efrat, M.B.A., Oldstone, M. S., Horwitz. Expression of adenovirus E3 transgenes in β cells prevents autoimmune diabetes. Proc. Natl. Acad. Sci. USA. 94: 9808–9813, 1997, [CSA], [CROSSREF]
  • R. E., Wallace. Susceptibility of human lymphoblasts (RPMI 7466) to viral infections in vitro. Proc. Soc Exp. Biol Med.. 130: 702–710, 1969
  • E. W., Wang, M. O., Scott, R. P., Ricciardi. An adenovirus mRNA which encodes a 14,700-Mr protein that maps to the last open reading frame of region E3 is expressed during infection. J. Virol.. 62: 1456–1459, 1988, [CSA]
  • S., Wen, R. M., Driscoll, D. B., Schneider, D. A., Dichek. Inclusion of the E3 region in an adenoviral vector decreases inflammation and neointima formation after arterial gene transfer. Arterioscler. Thromb. Vasc. Biol.. 21: 1777–1782, 2001, [CSA]
  • J. L., Williams, J., Garcia, D., Harrich, L., Pearson, F., Wu, R., Gaynor. Lymphoid specific gene expression of the adenovirus early region 3 promoter is mediated by NF-kappa B binding motifs. EMBO J.. 9: 4435–4442, 1990, [CSA]
  • J., Wilson-Rawls, S. K., Saha, P., Krajcsi, A. E., Tollefson, L. R., Gooding, W.S.M., Wold. A 6700 MW membrane protein is encoded by region E3 of adenovirus type 2. Virology. 178: 204–212, 1990, [CSA], [CROSSREF]
  • J., Wilson-Rawls, W.S.M., Wold. The E3-6.7 K protein of adenovirus is an Asn-linked integral membrane glycoprotein localized in the endoplasmic reticulum. Virology. 195: 6–15, 1993, [CSA], [CROSSREF]
  • W.S.M., Wold, G., Chinnadurai. Adenovirus proteins that regulate apoptosis. 200–232, A. J., Cann. DNA Virus Replication: Frontiers in Molecular Biology. Oxford, Oxford University Press. 2000
  • W.S.M., Wold, C., Cladaras, S. L., Deutscher, Q. S., Kapoor. The 19-kDa glycoprotein coded by region E3 of adenovirus. Purification, characterization, and structural analysis. J. Biol. Chem.. 260: 2424–2431, 1985
  • W.S.M., Wold, C., Cladaras, S. C., Magie, N., Yacoub. Mapping a new gene that encodes an 11,600-molecular-weight protein in the E3 transcription unit of adenovirus 2. J. Virol.. 52: 307–313, 1984, [CSA]
  • W.S.M., Wold, K., Doronin, K., Toth, M., Kuppuswamy, D. L., Lichtenstein, A. E., Tollefson. Immune responses to adenoviruses: Viral evasion mechanisms and their implications for the clinic. Curr. Opin. Immunol.. 11: 380–386, 1999, [CSA], [CROSSREF]
  • W.S.M., Wold, A. E., Tollefson, T. W., Hermiston. E3 transcription unit of adenovirus. 237–274, W., Doerfler, P., Bohm. The Molecular Repertoire of Adenoviruses. Springer-Verlag, Heidelberg 1995
  • S., Yamaoka, G., Courtois, C., Bessia, S. T., Whiteside, R., Weil, F., Agou, H. E., Kirk, R. J., Kay, A., Israël. Complementation cloning of NEMO, a component of the IkappaB kinase complex essential for NF-kappaB activation. Cell. 93: 1231–1240, 1998
  • J., Ye, X., Xie, L., Tarassishin, M., Horwitz. Regulation of the NF-κB activation pathway by isolated domains of FIP3/IKKγ, a component of the IκB-α kinase complex. J. Biol. Chem.. 275: 9882–9889, 2000, [CROSSREF]
  • B., Ying, W.S.M., Wold. Adenovirus ADP protein (E3-11.6 K), which is required for efficient cell lysis and virus release, interacts with human MAD2B. Virology. 313: 224–234, 2003, [CSA], [CROSSREF]
  • D.-C., Yu, Y., Chen, M., Seng, J., Dilley, D. R., Henderson. The addition of adenovirus type 5 region E3 enables Calydon virus 787 to eliminate distant prostate tumor xenografts. Cancer Res.. 59: 4200–4203, 1999
  • T. A., Zanardi, S., Yei, D. L., Lichtenstein, Tollefson A. E., W. S. M., Wold. Distinct domains in the adenovirus E3 RIDα protein are required for degradation of Fas and the epidermal growth factor receptor. J. Virol.. 77: 11685–11696, 2003, [CSA], [CROSSREF]
  • S. Q., Zhang, A., Kovalenko, G., Cantarella, D., Wallach. Recruitment of the IKK signalosome to the p55 TNF receptor: RIP and A20 bind to NEMO (IKKgamma) upon receptor stimulation. Immunity. 12: 301–311, 2000, [CSA], [CROSSREF]
  • Z. K., Zsengeller, S. E., Wert, W. M., Hull, X., Hu, S., Yei, B. C., Trapnell, J. A., Whitsett. Persistence of replication-deficient adenovirus-mediated gene transfer in lungs of immune-deficient (nu/nu) mice. Hum. Gene Ther.. 6: 457–467, 1995, [CSA]

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