Immune cell profiling of preeclamptic pregnant and postpartum women by single-cell RNA sequencing

References

• Poon LC, Shennan A, Hyett JA, et al. The international federation of gynecology and obstetrics (FIGO) initiative on pre-eclampsia: A pragmatic guide for first-trimester screening and prevention. Int J Gynaecol Obstet. 2019;145(Suppl 1):1–33. doi:10.1002/ijgo.12802
   PubMed Web of Science ®Google Scholar
• Laresgoiti-Servitje E. A leading role for the immune system in the pathophysiology of preeclampsia. J Leukoc Biol. 2013;94(2):247–257. doi:10.1189/jlb.1112603
   PubMed Web of Science ®Google Scholar
• Tsang JCH, Vong JSL, Ji L, et al. Integrative single-cell and cell-free plasma RNA transcriptomics elucidates placental cellular dynamics. Proc Natl Acad Sci U S A. 2017;114(37):E7786–e7795. doi:10.1073/pnas.1710470114.
   PubMed Web of Science ®Google Scholar
• Nelson AC, Mould AW, Bikoff EK, Robertson EJ. Single-cell RNA-seq reveals cell type-specific transcriptional signatures at the maternal-foetal interface during pregnancy. Nat Commun. 2016;7:11414. doi:10.1038/ncomms11414
   PubMed Web of Science ®Google Scholar
• Han X, Ghaemi MS, Ando K, et al. Differential dynamics of the maternal immune system in healthy pregnancy and preeclampsia. Front Immunol. 2019;10:1305. 10.3389/fimmu.2019.01305.
   PubMed Web of Science ®Google Scholar
• Lu HQ, Hu R. The role of immunity in the pathogenesis and development of pre-eclampsia. Scand J Immunol. 2019;90(5):e12756. doi:10.1111/sji.12756
   PubMed Web of Science ®Google Scholar
• Luppi P, Deloia JA. Monocytes of preeclamptic women spontaneously synthesize pro-inflammatory cytokines. Clin Immunol. 2006;118(2–3):268–275. doi:10.1016/j.clim.2005.11.001
   PubMed Web of Science ®Google Scholar
• Melgert BN, Spaans F, Borghuis T, et al. Pregnancy and preeclampsia affect monocyte subsets in humans and rats. PLoS One. 2012;7(9):e45229. doi:10.1371/journal.pone.0045229
   PubMed Web of Science ®Google Scholar
• Boij R, Mjösberg J, Svensson-Arvelund J, et al. Regulatory T-cell subpopulations in severe or early-onset preeclampsia. Am J Reprod Immunol. 2015;74(4):368–378. doi:10.1111/aji.12410
   PubMed Web of Science ®Google Scholar
• Ibrahim T, Przybyl L, Harmon AC, et al. Proliferation of endogenous regulatory T cells improve the pathophysiology associated with placental ischaemia of pregnancy. Am J Reprod Immunol. 2017;78(5):e12724. doi:10.1111/aji.12724
   Web of Science ®Google Scholar
• Laresgoiti-Servitje E, Gómez-López N, Olson DM. An immunological insight into the origins of pre-eclampsia. Hum Reprod Update. 2010;16(5):510–524. doi:10.1093/humupd/dmq007
   PubMed Web of Science ®Google Scholar
• Jabbour HN, Sales KJ, Catalano RD, Norman JE. Inflammatory pathways in female reproductive health and disease. Reproduction. 2009;138(6):903–919. doi:10.1530/rep-09-0247
   PubMed Web of Science ®Google Scholar
• Kieffer TEC, Scherjon SA, Faas MM, Prins JR. Lower activation of CD4(+) memory T cells in preeclampsia compared to healthy pregnancies persists postpartum. J Reprod Immunol. 2019;136:102613. doi:10.1016/j.jri.2019.102613
   PubMed Web of Science ®Google Scholar
• Dobin A, Davis CA, Schlesinger F, et al. STAR: ultrafast universal RNA-seq aligner. Bioinformatics. 2013;29(1):15–21. doi:10.1093/bioinformatics/bts635
   PubMed Web of Science ®Google Scholar
• Zhang JY, Wang XM, Xing X, et al. Single-cell landscape of immunological responses in patients with COVID-19. Nat Immunol. 2020;21(9):1107–1118. doi:10.1038/s41590-020-0762-x
   PubMed Web of Science ®Google Scholar
• Vishnyakova P, Elchaninov A, Fatkhudinov T, Sukhikh G. Role of the monocyte-macrophage system in normal pregnancy and preeclampsia. IJMS. 2019;20(15):3695. doi:10.3390/ijms20153695
   Google Scholar
• Samstein RM, Josefowicz SZ, Arvey A, Treuting PM, Rudensky AY. Extrathymic generation of regulatory T cells in placental mammals mitigates maternal-fetal conflict. Cell. 2012;150(1):29–38. doi:10.1016/j.cell.2012.05.031
   PubMed Web of Science ®Google Scholar
• Deshmukh H, Way SS. Immunological basis for recurrent fetal loss and pregnancy complications. Annu Rev Pathol. 2019;14:185–210. doi:10.1146/annurev-pathmechdis-012418-012743
   PubMed Web of Science ®Google Scholar
• Amaral LM, Wallace K, Owens M, LaMarca B. Pathophysiology and current clinical management of preeclampsia. Curr Hypertens Rep. 2017;19(8):61. doi:10.1007/s11906-017-0757-7
   PubMed Web of Science ®Google Scholar
• Messerli M, May K, Hansson SR, et al. Feto-maternal interactions in pregnancies: placental microparticles activate peripheral blood monocytes. Placenta. 2010;31(2):106–112. doi:10.1016/j.placenta.2009.11.011
   PubMed Web of Science ®Google Scholar
• Fukui A, Yokota M, Funamizu A, et al. Changes of NK cells in preeclampsia. Am J Reprod Immunol. 2012;67(4):278–286. doi:10.1111/j.1600-0897.2012.01120.x
   PubMed Web of Science ®Google Scholar
• Taylor EB, Sasser JM. Natural killer cells and T lymphocytes in pregnancy and pre-eclampsia. Clin Sci (Lond). 2017;131(24):2911–2917. doi:10.1042/cs20171070
   PubMed Web of Science ®Google Scholar
• Rowe JH, Ertelt JM, Xin L, Way SS. Pregnancy imprints regulatory memory that sustains anergy to fetal antigen. Nature. 2012;490(7418):102–106. doi:10.1038/nature11462
   PubMed Web of Science ®Google Scholar
• Kieffer TEC, Laskewitz A, Scherjon SA, Faas MM, Prins JR. Memory T cells in pregnancy. Front Immunol. 2019;10:625. doi:10.3389/fimmu.2019.00625
   PubMed Web of Science ®Google Scholar
• Nguyen TA, Kahn DA, Loewendorf AI. Maternal-Fetal rejection reactions are unconstrained in preeclamptic women. PLoS One. 2017;12(11):e0188250. doi:10.1371/journal.pone.0188250
   PubMed Web of Science ®Google Scholar
• Jensen F, Wallukat G, Herse F, et al. CD19 + CD5+ cells as indicators of preeclampsia. Hypertension. 2012;59(4):861–868. doi:10.1161/hypertensionaha.111.188276
   PubMed Web of Science ®Google Scholar
• Liao AH, Liu LP, Ding WP, Zhang L. Functional changes of human peripheral B-lymphocytes in pre-eclampsia. Am J Reprod Immunol. 2009;61(5):313–321. doi:10.1111/j.1600-0897.2009.00697.x
   PubMed Web of Science ®Google Scholar
• Boehm U, Klamp T, Groot M, Howard JC. Cellular responses to interferon-gamma. Annu Rev Immunol. 1997;15:749–795. doi:10.1146/annurev.immunol.15.1.749
   PubMed Web of Science ®Google Scholar
• Banerjee S, Smallwood A, Moorhead J, et al. Placental expression of interferon-gamma (IFN-gamma) and its receptor IFN-gamma R2 fail to switch from early hypoxic to late normotensive development in preeclampsia. J Clin Endocrinol Metab. 2005;90(2):944–952. doi:10.1210/jc.2004-1113
   PubMed Web of Science ®Google Scholar
• Molvarec A, Szarka A, Walentin S, et al. Serum leptin levels in relation to circulating cytokines, chemokines, adhesion molecules and angiogenic factors in normal pregnancy and preeclampsia. Reprod Biol Endocrinol. 2011;9:124. doi:10.1186/1477-7827-9-124
   PubMed Web of Science ®Google Scholar
• Miko E, Szereday L, Barakonyi A, Jarkovich A, Varga P, Szekeres-Bartho J. Immunoactivation in preeclampsia: Vdelta2+ and regulatory T cells during the inflammatory stage of disease. J Reprod Immunol. 2009;80(1–2):100–108. doi:10.1016/j.jri.2009.01.003
   PubMed Web of Science ®Google Scholar
• Mansouri R, Akbari F, Vodjgani M, Mahboudi F, Kalantar F, Mirahmadian M. Serum cytokines profiles in Iranian patients with preeclampsia. Iran J Immunol. 2007;4(3):179–185.
   PubMedGoogle Scholar
• Textoris J, Ivorra D, Ben Amara A, et al. Evaluation of current and new biomarkers in severe preeclampsia: a microarray approach reveals the VSIG4 gene as a potential blood biomarker. PLoS One. 2013;8(12):e82638. doi:10.1371/journal.pone.0082638
   PubMed Web of Science ®Google Scholar
• Guo F, Zhang B, Yang H, et al. Systemic transcriptome comparison between early- and late-onset pre-eclampsia shows distinct pathology and novel biomarkers. Cell Prolif. 2021;54(2):e12968. doi:10.1111/cpr.12968
   PubMed Web of Science ®Google Scholar