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Renal Failure Volume 40, 2018 - Issue 1
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Laboratory Study

3,3′-Diindolylmethane ameliorates renal fibrosis through the inhibition of renal fibroblast activation in vivo and in vitro

Zun-En XiaDepartment of Clinical Laboratory, Renmin Hospital of Wuhan University, Wuhan, China; View further author information
,
Juan-Li XiDepartment of Gastroenterology, Wuhan Third Hospital, Wuhan, China; View further author information
&
Lei ShiDepartment of Oncology, Renmin Hospital of Wuhan University, Wuhan, ChinaCorrespondence[email protected]
View further author information
Pages 447-454 | Received 24 May 2017, Accepted 10 Jun 2018, Published online: 12 Aug 2018

References

  • Schelling JR. Tubular atrophy in the pathogenesis of chronic kidney disease progression. Pediatr Nephrol. 2016;31:693–706.
  • Liu Y. Cellular and molecular mechanisms of renal fibrosis. Nat Rev Nephrol. 2011;7:684–696.
  • Sun YB, Qu X, Caruana G, et al. The origin of renal fibroblasts/myofibroblasts and the signals that trigger fibrosis. Differentiation. 2016;92:102–107.
  • Zhou X, Zhang J, Xu C, et al. Curcumin ameliorates renal fibrosis by inhibiting local fibroblast proliferation and extracellular matrix deposition. J Pharmacol Sci. 2014;126:344–350.
  • Meng XM, Nikolic-Paterson DJ, Lan HY. TGF-β: the master regulator of fibrosis. Nat Rev Nephrol. 2016;12:325–338.
  • Zhang Y, Wang S, Liu S, et al. Role of Smad signaling in kidney disease. Int Urol Nephrol. 2015;47:1965–1975.
  • Lan HY. Smad7 as a therapeutic agent for chronic kidney diseases. Front Biosci. 2008;13:4984–4992.
  • McGuire KP, Ngoubilly N, Neavyn M, et al. 3,3'-Diindolylmethane and paclitaxel act synergistically to promote apoptosis in HER2/Neu human breast cancer cells. J Surg Res. 2006;132:208–213.
  • Ye Y, Fang Y, Xu W, et al. 3,3'-Diindolylmethane induces anti-human gastric cancer cells by the miR-30e-ATG5 modulating autophagy. Biochem Pharmacol. 2016;115:77–84.
  • Tomar S, Nagarkatti M, Nagarkatti PS. 3,3′-Diindolylmethane attenuates LPS-mediated acute liver failure by regulating miRNAs to target IRAK4 and suppress Toll-like receptor signalling. Br J Pharmacol. 2015;172:2133–2147.
  • Kunimasa K, Kobayashi T, Kaji K, et al. Antiangiogenic effects of indole-3-carbinol and 3,3'-diindolylmethane are associated with their differential regulation of ERK1/2 and Akt in tube-forming HUVEC. J Nutr. 2010;140:1–6.
  • Zhang Z, Gao Z, Hu W, et al. 3,3′-Diindolylmethane ameliorates experimental hepatic fibrosis via inhibiting miR-21 expression. Br J Pharmacol. 2013;170:649–660.
  • Zong J, Deng W, Zhou H, et al. 3,3'-Diindolylmethane protects against cardiac hypertrophy via 5'-adenosine monophosphate-activated protein kinase-alpha2. PLOS One. 2013;8:e53427.
  • Li J, Zhang W, Jiao R, et al. DIM attenuates TGF-beta1-induced myofibroblast differentiation in neonatal rat cardiac fibroblasts. Int J Clinical Experimental Pathol. 2015;8:5121–5128.
  • Eddy AA, Lopez-Guisa JM, Okamura DM, et al. Investigating mechanisms of chronic kidney disease in mouse models. Pediatr Nephrol. 2012;27:1233–1247.
  • Debelle FD, Nortier JL, De, et al. Aristolochic acids induce chronic renal failure with interstitial fibrosis in salt-depleted rats. J Am Soc Nephrol. 2002;13:431–436.
  • Yan Y, Ma L, Zhou X, et al. Src inhibition blocks renal interstitial fibroblast activation and ameliorates renal fibrosis. Kidney Int. 2016;89:68–81.
  • Jiang L, Xu L, Mao J, et al. Rheb/mTORC1 signaling promotes kidney fibroblast activation and fibrosis. J Am Soc Nephrol. 2013;24:1114–1126.
  • Meng XM, Tang PM, Li J, et al. TGF-β/Smad signaling in renal fibrosis. Front Physiol. 2015;6:82
  • Liu FY, Li XZ, Peng YM, et al. Arkadia regulates TGF-beta signaling during renal tubular epithelial to mesenchymal cell transition. Kidney International 2008;73:588–594.
  • Ebisawa T, Fukuchi M, Murakami G, et al. Smurf1 interacts with transforming growth factor-beta type I receptor through Smad7 and induces receptor degradation. J Biol Chem. 2001;276:12477–12480.
  • Sato M, Muragaki Y, Saika S, et al. Targeted disruption of TGF-beta1/Smad3 signaling protects against renal tubulointerstitial fibrosis induced by unilateral ureteral obstruction. J Clin Invest. 2003;112:1486–1494.
  • Tang H, Su H, Fan D, et al. MAD2B-mediated SnoN downregulation is implicated in fibroblast activation and tubulointerstitial fibrosis. Am J Physiol Renal Physiol. 2016;311:F207–F216.
  • Meng XM, Huang XR, Chung AC, et al. Smad2 protects against TGF-beta/Smad3-mediated renal fibrosis. J Am Soc Nephrol. 2010;21:1477–1487.

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