2,169
Views
0
CrossRef citations to date
0
Altmetric
Clinical Study

HBx-induced PLA2R overexpression mediates podocyte pyroptosis through the ROS-NLRP3 signaling pathway

, , , , &
Article: 2170808 | Received 01 Aug 2022, Accepted 13 Jan 2023, Published online: 25 Jan 2023

References

  • Nguyen MH, Wong G, Gane E, et al. Hepatitis B virus: advances in prevention, diagnosis, and therapy. Clin Microbiol Rev. 2020:33(2):19–46.
  • Cheng ST, Hu JL, Ren JH, et al. Dicoumarol, an NQO1 inhibitor, blocks cccDNA transcription by promoting degradation of HBx. J Hepatol. 2021;74(3):522–534.
  • Zhang Y, Fang L, Ma X. [Hepatitis B virus infection and pathogenesis of glomerulonephritis]. Zhonghua Bing Li Xue Za Zhi. 1995;24(6):341–344.
  • Zhao W, Ma Y, Wang M, et al. Expression of Foxp3 in renal tissue of patients with HBV-associated glomerulonephritis and their clinical and pathological characteristics. Exp Ther Med. 2017;14(5):4928–4934.
  • Ren J, Wang L, Chen Z, et al. Gene expression profile of transgenic mouse kidney reveals pathogenesis of hepatitis B virus associated nephropathy. J Med Virol. 2006;78(5):551–560.
  • Beck LH Jr, Bonegio RG, Lambeau G, et al. M-type phospholipase A2 receptor as target antigen in idiopathic membranous nephropathy. N Engl J Med. 2009;361(1):11–21.
  • Xie Q, Li Y, Xue J, et al. Renal phospholipase A2 receptor in hepatitis B virus-associated membranous nephropathy. Am J Nephrol. 2015;41(4-5):345–353.
  • Xu X, Zhu X, Yuan S[, et al. Role of M-type phospholipase A2 receptor and its antibody in hepatitis B virus-associated membranous nephropathy. Zhong Nan Da Xue Bao Yi Xue Ban. 2016;41(10):1064–1068.
  • Nikolopoulou A, Teixeira C, Cook HT, et al. Membranous nephropathy associated with viral infection. Clin Kidney J. 2021;14(3):876–883.
  • Dong H, Xu Y, Xu T, et al. The Role of HBx gene mutations in PLA 2R positive hepatitis-B-associated membranous nephropathy. Biomed Environ Sci. 2020;33(4):269–272.
  • Zhang MY, Jiang YX, Yang YC, et al. Cigarette smoke extract induces pyroptosis in human bronchial epithelial cells through the ROS/NLRP3/caspase-1 pathway. Life Sci. 2021;269:119090.
  • Gao Y, Ma Y, Xie D, et al. ManNAc protects against podocyte pyroptosis via inhibiting mitochondrial damage and ROS/NLRP3 signaling pathway in diabetic kidney injury model. Int Immunopharmacol. 2022;107:108711.
  • Yu Y, Dong H, Sun J, et al. Hepatitis B virus X mediates podocyte pyroptosis by regulating the ROS/NLRP3 signaling pathway in hepatitis B virus-associated glomerulonephritis. Iran J Basic Med Sci. 2022;25(1):103–109.
  • Liu J, Liang W, Jing W, et al. Countdown to 2030: eliminating hepatitis B disease, China. Bull World Health Organ. 2019;97(3):230–238.
  • Polaris Observatory C. Global prevalence, treatment, and prevention of hepatitis B virus infection in 2016: a modelling study. Lancet Gastroenterol Hepatol. 2018;3:383–403.
  • Cui H, Li QL, Chen J, et al. Hepatitis B virus X protein modifies invasion, proliferation and the inflammatory response in an HTR-8/SVneo cell model. Oncol Rep. 2015;34:2090–2098.
  • Shan H, Wang B, Zhang X, et al. CUL4B facilitates HBV replication by promoting HBx stabilization. Cancer Biol Med. 2021;19(1):120–131.
  • Xie WH, Ding J, Xie XX, et al. Hepatitis B virus X protein promotes liver cell pyroptosis under oxidative stress through NLRP3 inflammasome activation. Inflamm Res. 2020;69(7):683–696.
  • Kupin WL. Viral-associated GN: hepatitis B and other viral infections. Clin J Am Soc Nephrol. 2017;12(9):1529–1533.
  • Combes B, Shorey J, Barrera A, et al. Glomerulonephritis with deposition of Australia antigen-antibody complexes in glomerular basement membrane. Lancet. 1971;2(7718):234–237.
  • Abrahamson DR, Hudson BG, Stroganova L, et al. Cellular origins of type IV collagen networks in developing glomeruli. J Am Soc Nephrol. 2009;20(7):1471–1479.
  • Yang YT, Du Y, Yuan WJ, et al. [Role of histone demethylase KDM6B in HBx-mediated podocyte-macrophage transdifferentiation]. Zhonghua Yi Xue Za Zhi. 2021;101(12):866–871.
  • He P, Liu D, Zhang B, et al. Hepatitis B virus X protein reduces podocyte adhesion via downregulation of alpha3beta1 integrin. Cell Physiol Biochem. 2017;41(2):689–700.
  • Lei XY, Chen XX, Sun YH, et al. Hepatitis B virus X protein decreases nephrin expression and induces podocyte apoptosis via activating STAT3. Exp Ther Med. 2019;17(5):4223–4229.
  • Zhang Y, Wu Q, Zhong L, et al. Echinacoside promotes the proliferation of human renal tubular epithelial cells by blocking the HBX/TREM2mediated NFkappaB signalling pathway. Mol Med Rep. 2020;22:1137–1144.
  • Yang Y, Wang X, Zhang Y, et al. Hepatitis B virus X protein and proinflammatory cytokines synergize to enhance TRAIL-induced apoptosis of renal tubular cells by upregulation of DR4. Int J Biochem Cell Biol. 2018;97:62–72.
  • Wang X, Wang L, Zhu N, et al. Hepatitis B virus X protein modulates renal tubular epithelial cell-induced T-cell and macrophage responses. Immunol Cell Biol. 2016;94(3):266–273.
  • Skoberne A, Behnert A, Teng B, et al. Serum with phospholipase A2 receptor autoantibodies interferes with podocyte adhesion to collagen. Eur J Clin Invest. 2014;44(8):753–765.
  • Xie J, Liu L, Mladkova N, et al. The genetic architecture of membranous nephropathy and its potential to improve non-invasive diagnosis. Nat Commun. 2020;11(1):1600.
  • Xu X, Nie S, Ding H, et al. Environmental pollution and kidney diseases. Nat Rev Nephrol. 2018;14(5):313–324.
  • Xu X, Wang G, Chen N, et al. Long-Term exposure to air pollution and increased risk of membranous nephropathy in China. J Am Soc Nephrol. 2016;27:3739–3746.
  • Glassock RJ. The pathogenesis of membranous nephropathy: evolution and revolution. Curr Opin Nephrol Hypertens. 2012;21(3):235–242.
  • Chi JN, Lai TS, Wu CF, et al. The relationship of anti-phospholipase A2 receptor antibody and C5a complement with disease activity and short-term outcome in idiopathic membranous nephropathy. J Formos Med Assoc. 2019;118(5):898–906.
  • Li C, Li P, Guo W, et al. The optimal anti-phospholipase A2 receptor cutoff for the diagnosis of idiopathic membranous nephropathy: a single-center retrospective study. Korean J Intern Med. 2021;37(1):154–166.
  • Guo N, Cao Y, Dai H, et al. Anti-phospholipase A2 receptor (anti-PLA2R) antibody in diagnosis and treatment of idiopathic membranous nephropathy: a single-center observational study in China. Med Sci Monit. 2019;25:9364–9368.
  • Yang L, Wu Y, Lin S, et al. sPLA2-IB and PLA2R mediate insufficient autophagy and contribute to podocyte injury in idiopathic membranous nephropathy by activation of the p38MAPK/mTOR/ULK1(ser757) signaling pathway. FASEB J. 2020:1–16.
  • Chiou TT, Chau YY, Chen JB, et al. Rapamycin attenuates PLA2R activation-mediated podocyte apoptosis via the PI3K/AKT/mTOR pathway. Biomed Pharmacother. 2021;144:112349.
  • Ponticelli C, Glassock RJ. Glomerular diseases: membranous nephropathy–a modern view. Clin J Am Soc Nephrol. 2014;9(3):609–616.
  • Shi J, Zhao Y, Wang K, et al. Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death. Nature. 2015;526(7575):660–665.
  • Cheng Q, Pan J, Zhou ZL, et al. Caspase-11/4 and gasdermin D-mediated pyroptosis contributes to podocyte injury in mouse diabetic nephropathy. Acta Pharmacol Sin. 2021;42(6):954–963.
  • Zheng T, Tan Y, Qiu J, et al. Alternative polyadenylation trans-factor FIP1 exacerbates UUO/IRI-induced kidney injury and contributes to AKI-CKD transition via ROS-NLRP3 axis. Cell Death Dis. 2021;12(6):512.
  • Gao C, Chen J, Fan F, et al. RIPK2-Mediated autophagy and negatively regulated ROS-NLRP3 inflammasome signaling in GMCs stimulated with high glucose. Mediators Inflamm. 2019;2019:6207563. 2019:
  • Fu R, Guo C, Wang S, et al. Podocyte activation of NLRP3 inflammasomes contributes to the development of proteinuria in lupus nephritis. Arthritis Rheumatol. 2017;69:1636–1646.
  • Meyer-Schwesinger C, Tomas NM, Dehde S, et al. A novel mouse model of phospholipase A2 receptor 1-associated membranous nephropathy mimics podocyte injury in patients. Kidney Int. 2020;97(5):913–919.