Tripterygium glycosides improve abnormal lipid deposition in nephrotic syndrome rat models

References

• Engin AB. What is lipotoxicity? Adv Exp Med Biol. 2017;960:197–220.
   PubMed Web of Science ®Google Scholar
• Nishi H, Higashihara T, Inagi R. Lipotoxicity in kidney, heart, and skeletal muscle dysfunction. Nutrients. 2019;11(7):1664.
   PubMed Web of Science ®Google Scholar
• Li S, Nagothu K, Ranganathan G, et al. Reduced kidney lipoprotein lipase and renal tubule triglyceride accumulation in cisplatin-mediated acute kidney injury. Am J Physiol Renal Physiol. 2012;303(3):F437–F448.
   PubMed Web of Science ®Google Scholar
• Zhang X, Cheng Y, Zhou Q, et al. The effect of Chinese traditional medicine Huaiqihuang (HQH) on the protection of nephropathy. Oxid Med Cell Longev. 2020;2020:2153912.
   PubMed Web of Science ®Google Scholar
• Ibrahim KM, Mantawy EM, Elanany MM, et al. Protection from doxorubicin-induced nephrotoxicity by clindamycin: novel antioxidant, anti-inflammatory and anti-apoptotic roles. Naunyn-Schmiedebergs Arch Pharmacol. 2020;393(4):739–748.
   PubMed Web of Science ®Google Scholar
• Schley G, Grampp S, Goppelt-Struebe M. Inhibition of oxygen-sensing prolyl hydroxylases increases lipid accumulation in human primary tubular epithelial cells without inducing ER stress. Cell Tissue Res. 2020;381(1):125–140.
   PubMed Web of Science ®Google Scholar
• Liu S, Li X, Li H, et al. Comparison of Tripterygium wilfordii multiglycosides and tacrolimus in the treatment of idiopathic membranous nephropathy: a prospective cohort study. BMC Nephrol. 2015;16(1):200.
   PubMedGoogle Scholar
• Zhang J, Li SL, Lin W, et al. Tripterygium glycoside tablet attenuates renal function impairment in diabetic nephropathy mice by regulating triglyceride metabolism. J Pharm Biomed Anal. 2022;221:115028.
   PubMed Web of Science ®Google Scholar
• Zhang CJ, Zhu N, Long J, et al. Celastrol induces lipophagy via the LXRα/ABCA1 pathway in clear cell renal cell carcinoma. Acta Pharmacol Sin. 2021;42(9):1472–1485.
   PubMed Web of Science ®Google Scholar
• Huang RS, Guo F, Li YP, et al. Activation of AMPK by triptolide alleviates nonalcoholic fatty liver disease by improving hepatic lipid metabolism, inflammation and fibrosis. Phytomedicine. 2021;92:153739.
   PubMed Web of Science ®Google Scholar
• Moorhead JF, Chan MK, El-Nahas M, et al. Lipid nephrotoxicity in chronic progressive glomerular and tubulo-interstitial disease. Lancet. 1982;2(8311):1309–1311.
   PubMed Web of Science ®Google Scholar
• Agrawal S, Zaritsky JJ, Fornoni A, et al. Dyslipidaemia in nephrotic syndrome: mechanisms and treatment. Nat Rev Nephrol. 2018;14(1):57–70.
   PubMed Web of Science ®Google Scholar
• Lee RG, Fu W, Graham MJ, et al. Comparison of the pharmacological profiles of murine antisense oligonucleotides targeting apolipoprotein B and microsomal triglyceride transfer protein. J Lipid Res. 2013;54(3):602–614.
   PubMed Web of Science ®Google Scholar
• Thombare K, Ntika S, Wang X, et al. Long chain saturated and unsaturated fatty acids exert opposing effects on viability and function of GLP-1-producing cells: mechanisms of lipotoxicity. PLOS One. 2017;12(5):e0177605.
   PubMed Web of Science ®Google Scholar
• Brennan E, Kantharidis P, Cooper ME, et al. Pro-resolving lipid mediators: regulators of inflammation, metabolism and kidney function. Nat Rev Nephrol. 2021;17(11):725–739.
   PubMed Web of Science ®Google Scholar
• Zhang X, Li ZL, Woollard JR, et al. Obesity-metabolic derangement preserves hemodynamics but promotes intrarenal adiposity and macrophage infiltration in swine renovascular disease. Am J Physiol Renal Physiol. 2013;305(3):F265–F276.
   PubMed Web of Science ®Google Scholar
• Laudette M, Sainte-Marie Y, Cousin G, et al. Cyclic AMP-binding protein Epac1 acts as a metabolic sensor to promote cardiomyocyte lipotoxicity. Cell Death Dis. 2021;12(9):824.
   PubMed Web of Science ®Google Scholar
• Yang X, Wu Y, Li Q, et al. CD36 promotes podocyte apoptosis by activating the pyrin domain-containing-3 (NLRP3) inflammasome in primary nephrotic syndrome. Med Sci Monit. 2018;24:6832–6839.
   PubMed Web of Science ®Google Scholar
• Chorner Z, Barbeau PA, Castellani L, et al. Dietary α-linolenic acid supplementation alters skeletal muscle plasma membrane lipid composition, sarcolemmal FAT/CD36 abundance, and palmitate transport rates. Am J Physiol Regul Integr Comp Physiol. 2016;311(6):R1234–R1242.
   PubMed Web of Science ®Google Scholar
• Chen Y, Yan Q, Lv M, et al. Involvement of FATP2-mediated tubular lipid metabolic reprogramming in renal fibrogenesis. Cell Death Dis. 2020;11(11):994.
   PubMed Web of Science ®Google Scholar
• Yang X, Okamura DM, Lu X, et al. CD36 in chronic kidney disease: novel insights and therapeutic opportunities. Nat Rev Nephrol. 2017;13(12):769–781.
   PubMed Web of Science ®Google Scholar
• Hara Y, Goda K, Hirooka S, et al. Association between endoscopic milk-white mucosa, epithelial intracellular lipid droplets, and histological grade of superficial non-ampullary duodenal epithelial tumors. Diagnostics. 2021;11(5):769.
   Web of Science ®Google Scholar
• Meng X, Sun R, Wang W, et al. ADFP promotes cell proliferation in lung adenocarcinoma via Akt phosphorylation. J Cell Mol Med. 2021;25(2):827–839.
   PubMed Web of Science ®Google Scholar
• Mak KM, Ren C, Ponomarenko A, et al. Adipose differentiation-related protein is a reliable lipid droplet marker in alcoholic fatty liver of rats. Alcoholism Clin Exp Res. 2008;32(4):683–689.
   PubMed Web of Science ®Google Scholar
• Tang W, Ma W, Ding H, et al. Adenylyl cyclase 1 as a major isoform to generate cAMP signaling for apoA-1-mediated cholesterol efflux pathway. J Lipid Res. 2018;59(4):635–645.
   PubMed Web of Science ®Google Scholar
• Jin M, Feng H, Wang Y, et al. Gentiopicroside ameliorates oxidative stress and lipid accumulation through nuclear factor erythroid 2-Related factor 2 activation. Oxid Med Cell Longev. 2020;2020:2940746.
   PubMed Web of Science ®Google Scholar
• Gong T, Jiang W, Gao Z, et al. Dibromoacetic acid induced hepatotoxicity in mice through oxidative stress and Toll-Like receptor 4 signaling pathway activation. Oxid Med Cell Longev. 2019;2019:5637235.
   PubMed Web of Science ®Google Scholar
• Pompella A, Corti A. Editorial: the changing faces of glutathione, a cellular protagonist. Front Pharmacol. 2015;6:98.
   PubMed Web of Science ®Google Scholar
• Ahowesso C, Black PN, Saini N, et al. Chemical inhibition of fatty acid absorption and cellular uptake limits lipotoxic cell death. Biochem Pharmacol. 2015;98(1):167–181.
   PubMed Web of Science ®Google Scholar
• Spitz AZ, Gavathiotis E. Physiological and pharmacological modulation of BAX. Trends Pharmacol Sci. 2022;43(3):206–220.
   PubMed Web of Science ®Google Scholar
• Zhou JF, Ci XX, Ma X, et al. Pterostilbene activates the Nrf2-dependent antioxidant response to ameliorate arsenic-induced intracellular damage and apoptosis in human keratinocytes. Front Pharmacol. 2019;10:497.
   PubMed Web of Science ®Google Scholar
• Han XD, Zhou ZW, Yang W, et al. A computational and functional study elicits the ameliorating effect of the Chinese herbal formula Huo Luo Xiao Ling Dan on experimental ischemia-induced myocardial injury in rats via inhibition of apoptosis. Drug Des Devel Ther. 2015;9:1063–1102.
   PubMed Web of Science ®Google Scholar
• Xu Q, Xi H, Chen X, et al. Milk‑derived hexapeptide PGPIPN prevents and attenuates acute alcoholic liver injury in mice by reducing endoplasmic reticulum stress. Int J Mol Med. 2020;46(3):1107–1117.
   PubMed Web of Science ®Google Scholar