Cell-free DNA predicts all-cause mortality of sepsis-induced acute kidney injury

References

• Singer M, Deutschman CS, Seymour CW, et al. The third international consensus definitions for sepsis and septic shock (sepsis-3). JAMA. 2016;315(8):1–9. doi: 10.1001/jama.2016.0287.
   Web of Science ®Google Scholar
• Mayr VD, Dunser MW, Greil V, et al. Causes of death and determinants of outcome in critically ill patients. Crit Care. 2006;10(6):R154. doi: 10.1186/cc5086.
   PubMed Web of Science ®Google Scholar
• Kuwabara S, Goggins E, Okusa MD. The pathophysiology of sepsis-associated AKI. Clin J Am Soc Nephrol. 2022;17(7):1050–1069. doi: 10.2215/CJN.00850122.
   PubMed Web of Science ®Google Scholar
• Hoste EA, Bagshaw SM, Bellomo R, et al. Epidemiology of acute kidney injury in critically ill patients: the multinational AKI-EPI study. Intensive Care Med. 2015;41(8):1411–1423. doi: 10.1007/s00134-015-3934-7.
   PubMed Web of Science ®Google Scholar
• Uchino S, Kellum JA, Bellomo R, et al. Acute renal failure in critically ill patients: a multinational, multicenter study. JAMA. 2005;294(7):813–818. doi: 10.1001/jama.294.7.813.
   PubMed Web of Science ®Google Scholar
• Kellum JA, Chawla LS, Keener C, et al. The effects of alternative resuscitation strategies on acute kidney injury in patients with septic shock. Am J Respir Crit Care Med. 2016;193(3):281–287. doi: 10.1164/rccm.201505-0995OC.
   PubMed Web of Science ®Google Scholar
• Fiorentino M, Tohme FA, Wang S, et al. Long-term survival in patients with septic acute kidney injury is strongly influenced by renal recovery. PLOS One. 2018;13(6):e0198269. doi: 10.1371/journal.pone.0198269.
   PubMed Web of Science ®Google Scholar
• Harris DG, Koo G, McCrone MP, et al. Recurrent kidney injury in critically ill surgical patients is common and associated with worse outcomes. J Trauma Acute Care Surg. 2014;76(6):1397–1401. doi: 10.1097/TA.0000000000000241.
   PubMed Web of Science ®Google Scholar
• Kellum JA, Sileanu FE, Bihorac A, et al. Recovery after acute kidney injury. Am J Respir Crit Care Med. 2017;195(6):784–791. doi: 10.1164/rccm.201604-0799OC.
   PubMed Web of Science ®Google Scholar
• Aucamp J, Bronkhorst AJ, Badenhorst C, et al. The diverse origins of circulating cell-free DNA in the human body: a critical re-evaluation of the literature. Biol Rev Camb Philos Soc. 2018;93(3):1649–1683. doi: 10.1111/brv.12413.
   PubMed Web of Science ®Google Scholar
• Saukkonen K, Lakkisto P, Pettila V, et al. Cell-free plasma DNA as a predictor of outcome in severe sepsis and septic shock. Clin Chem. 2008;54(6):1000–1007. doi: 10.1373/clinchem.2007.101030.
   PubMed Web of Science ®Google Scholar
• Clementi A, Virzi GM, Brocca A, et al. The role of cell-free plasma DNA in critically ill patients with sepsis. Blood Purif. 2016;41(1–3):34–40. doi: 10.1159/000440975.
   PubMed Web of Science ®Google Scholar
• Duvvuri B, Lood C. Cell-free DNA as a biomarker in autoimmune rheumatic diseases. Front Immunol. 2019;10:502. doi: 10.3389/fimmu.2019.00502.
   PubMed Web of Science ®Google Scholar
• Gogenur M, Burcharth J, Gogenur I. The role of total cell-free DNA in predicting outcomes among trauma patients in the intensive care unit: a systematic review. Crit Care. 2017;21(1):14. doi: 10.1186/s13054-016-1578-9.
   PubMedGoogle Scholar
• Wu TL, Zhang D, Chia JH, et al. Cell-free DNA: measurement in various carcinomas and establishment of normal reference range. Clin Chim Acta. 2002;321(1–2):77–87. doi: 10.1016/s0009-8981(02)00091-8.
   PubMed Web of Science ®Google Scholar
• Brusca SB, Elinoff JM, Zou Y, et al. Plasma cell-free DNA predicts survival and maps specific sources of injury in pulmonary arterial hypertension. Circulation. 2022;146(14):1033–1045. doi: 10.1161/CIRCULATIONAHA.121.056719.
   PubMed Web of Science ®Google Scholar
• Polina IA, Ilatovskaya DV, DeLeon-Pennell KY. Cell free DNA as a diagnostic and prognostic marker for cardiovascular diseases. Clin Chim Acta. 2020;503:145–150. doi: 10.1016/j.cca.2020.01.013.
   PubMed Web of Science ®Google Scholar
• Kidney Disease: improving Global Outcomes (KDIGO) Acute Kidney Injury Work Group. KDIGO clinical practice guideline for acute kidney injury. Kidney Int Suppl. 2012;2:1–138.
   Web of Science ®Google Scholar
• Vincent JL, Moreno R, Takala J, et al. The SOFA (sepsis-related organ failure assessment) score to describe organ dysfunction/failure. On behalf of the working group on sepsis-related problems of the european society of intensive care medicine. Intensive Care Med. 1996;22(7):707–710. doi: 10.1007/BF01709751.
   PubMed Web of Science ®Google Scholar
• Arai Y, Yamashita K, Mizugishi K, et al. Serum neutrophil extracellular trap levels predict thrombotic microangiopathy after allogeneic stem cell transplantation. Biol Blood Marrow Transplant. 2013;19(12):1683–1689. doi: 10.1016/j.bbmt.2013.09.005.
   PubMed Web of Science ®Google Scholar
• Qi Y, Uchida T, Yamamoto M, et al. Perioperative elevation in cell-free DNA levels in patients undergoing cardiac surgery: possible contribution of neutrophil extracellular traps to perioperative renal dysfunction. Anesthesiol Res Pract. 2016;2016:2794364. doi: 10.1155/2016/2794364.
   PubMedGoogle Scholar
• Avriel A, Paryente WM, Almog Y, et al. Admission cell free DNA levels predict 28-day mortality in patients with severe sepsis in intensive care. PLOS One. 2014;9(6):e100514. doi: 10.1371/journal.pone.0100514.
   PubMed Web of Science ®Google Scholar
• Tan EM, Schur PH, Carr RI, et al. Deoxybonucleic acid (DNA) and antibodies to DNA in the serum of patients with systemic lupus erythematosus. J Clin Invest. 1966;45(11):1732–1740. doi: 10.1172/JCI105479.
   PubMed Web of Science ®Google Scholar
• Leon SA, Shapiro B, Sklaroff DM, et al. Free DNA in the serum of cancer patients and the effect of therapy. Cancer Res. 1977;37(3):646–650.
   PubMed Web of Science ®Google Scholar
• Saukkonen K, Lakkisto P, Varpula M, et al. Association of cell-free plasma DNA with hospital mortality and organ dysfunction in intensive care unit patients. Intensive Care Med. 2007;33(9):1624–1627. doi: 10.1007/s00134-007-0686-z.
   PubMed Web of Science ®Google Scholar
• Wijeratne S, Butt A, Burns S, et al. Cell-free plasma DNA as a prognostic marker in intensive treatment unit patients. Ann N Y Acad Sci. 2004;1022(1):232–238. doi: 10.1196/annals.1318.036.
   PubMedGoogle Scholar
• Pisetsky DS. The origin and properties of extracellular DNA: from PAMP to DAMP. Clin Immunol. 2012;144(1):32–40. doi: 10.1016/j.clim.2012.04.006.
   PubMed Web of Science ®Google Scholar
• Denning NL, Aziz M, Gurien SD, et al. DAMPs and NETs in sepsis. Front Immunol. 2019;10:2536. doi: 10.3389/fimmu.2019.02536.
   PubMed Web of Science ®Google Scholar
• Branzk N, Lubojemska A, Hardison SE, et al. Neutrophils sense microbe size and selectively release neutrophil extracellular traps in response to large pathogens. Nat Immunol. 2014;15(11):1017–1025. doi: 10.1038/ni.2987.
   PubMed Web of Science ®Google Scholar
• Saffarzadeh M, Juenemann C, Queisser MA, et al. Neutrophil extracellular traps directly induce epithelial and endothelial cell death: a predominant role of histones. PLOS One. 2012;7(2):e32366. doi: 10.1371/journal.pone.0032366.
   PubMed Web of Science ®Google Scholar
• Villanueva E, Yalavarthi S, Berthier CC, et al. Netting neutrophils induce endothelial damage, infiltrate tissues, and expose immunostimulatory molecules in systemic lupus erythematosus. J Immunol. 2011;187(1):538–552. doi: 10.4049/jimmunol.1100450.
   PubMed Web of Science ®Google Scholar
• Brill A, Fuchs TA, Chauhan AK, et al. von Willebrand factor-mediated platelet adhesion is critical for deep vein thrombosis in mouse models. Blood. 2011;117(4):1400–1407. doi: 10.1182/blood-2010-05-287623.
   PubMed Web of Science ®Google Scholar
• Fuchs TA, Brill A, Duerschmied D, et al. Extracellular DNA traps promote thrombosis. Proc Natl Acad Sci U S A. 2010;107(36):15880–15885. doi: 10.1073/pnas.1005743107.
   PubMed Web of Science ®Google Scholar
• Martinod K, Demers M, Fuchs TA, et al. Neutrophil histone modification by peptidylarginine deiminase 4 is critical for deep vein thrombosis in mice. Proc Natl Acad Sci U S A. 2013;110(21):8674–8679. doi: 10.1073/pnas.1301059110.
   PubMed Web of Science ®Google Scholar
• Massberg S, Grahl L, von Bruehl ML, et al. Reciprocal coupling of coagulation and innate immunity via neutrophil serine proteases. Nat Med. 2010;16(8):887–896. doi: 10.1038/nm.2184.
   PubMed Web of Science ®Google Scholar
• Iba T, Levy JH, Warkentin TE, et al. Diagnosis and management of sepsis-induced coagulopathy and disseminated intravascular coagulation. J Thromb Haemost. 2019;17(11):1989–1994. doi: 10.1111/jth.14578.
   PubMed Web of Science ®Google Scholar
• Hotchkiss RS, Sherwood ER. Immunology. Getting sepsis therapy right. Science. 2015;347(6227):1201–1202. doi: 10.1126/science.aaa8334.
   PubMed Web of Science ®Google Scholar
• Na SJ, Oh DK, Park S, et al. Clinical characteristics and outcomes of neutropenic sepsis: a multicenter cohort study. Shock. 2022;57(5):659–665. doi: 10.1097/SHK.0000000000001907.
   PubMed Web of Science ®Google Scholar