Mechanism of dexmedetomidine protection against cisplatin induced acute kidney injury in rats

References

• Pickkers P, Darmon M, Hoste E, et al. Acute kidney injury in the critically ill: an updated review on pathophysiology and management. Intensive Care Med. 2021;47(8):1–9. doi:10.1007/s00134-021-06454-7.
   PubMed Web of Science ®Google Scholar
• Kellum JA, Romagnani P, Ashuntantang G, et al. Acute kidney injury. Nat Rev Dis Primers. 2021;7(1):52. doi:10.1038/s41572-021-00284-z.
   PubMed Web of Science ®Google Scholar
• Kim D-H, Choi H-I, Park JS, et al. Farnesoid X receptor protects against cisplatin-induced acute kidney injury by regulating the transcription of ferroptosis-related genes. Redox Biol. 2022;54:102382. doi:10.1016/j.redox.2022.102382.
   PubMed Web of Science ®Google Scholar
• Volarevic V, Djokovic B, Jankovic MG, et al. Molecular mechanisms of cisplatin-induced nephrotoxicity: a balance on the knife edge between renoprotection and tumor toxicity. J Biomed Sci. 2019;26(1):25. doi:10.1186/s12929-019-0518-9.
   PubMed Web of Science ®Google Scholar
• Wang Z, Wu J, Hu Z, et al. Dexmedetomidine alleviates Lipopolysaccharide-Induced acute kidney injury by inhibiting p75NTR-mediated oxidative stress and apoptosis. Oxid Med Cell Longev. 2020;2020:5454210–5454213. doi:10.1155/2020/5454210.
   PubMed Web of Science ®Google Scholar
• Hao Y, Miao J, Liu W, et al. Formononetin protects against cisplatin‑induced acute kidney injury through activation of the PPARalpha/Nrf2/HO‑1/NQO1 pathway. Int J Mol Med. 2021;47(2):511–522. doi:10.3892/ijmm.2020.4805.
   PubMed Web of Science ®Google Scholar
• Tang C, Livingston MJ, Safirstein R, et al. Cisplatin nephrotoxicity: new insights and therapeutic implications. Nat Rev Nephrol. 2023;19(1):53–72. doi:10.1038/s41581-022-00631-7.
   PubMed Web of Science ®Google Scholar
• Chen Y, Feng X, Hu X, et al. Dexmedetomidine ameliorates acute stress-induced kidney injury by attenuating oxidative stress and apoptosis through inhibition of the ROS/JNK signaling pathway. Oxid Med Cell Longev. 2018;2018:4035310. doi:10.1155/2018/4035310.
   PubMed Web of Science ®Google Scholar
• Chen Y, Luan L, Wang C, et al. Dexmedetomidine protects against lipopolysaccharide-induced early acute kidney injury by inhibiting the iNOS/NO signaling pathway in rats. Nitric Oxide. 2019;85:1–9. doi:10.1016/j.niox.2019.01.009.
   PubMed Web of Science ®Google Scholar
• Si Y, Bao H, Han L, et al. Dexmedetomidine attenuation of renal ischaemia-reperfusion injury requires sirtuin 3 activation. Br J Anaesth. 2018;121(6):1260–1271. doi:10.1016/j.bja.2018.07.007.
   PubMed Web of Science ®Google Scholar
• Qiu R, Yao W, Ji H, et al. Dexmedetomidine restores septic renal function via promoting inflammation resolution in a rat sepsis model. Life Sci. 2018;204:1–8. doi:10.1016/j.lfs.2018.05.001.
   PubMed Web of Science ®Google Scholar
• Wang C, Yuan W, Hu A, et al. Dexmedetomidine alleviated sepsis‑induced myocardial ferroptosis and septic heart injury. Mol Med Rep. 2020;22(1):175–184. doi:10.3892/mmr.2020.11114.
   PubMed Web of Science ®Google Scholar
• Cui Y, Zhang Y, Zhao X, et al. ACSL4 exacerbates ischemic stroke by promoting ferroptosis-induced brain injury and neuroinflammation. Brain Behav Immun. 2021;93:312–321. doi:10.1016/j.bbi.2021.01.003.
   PubMed Web of Science ®Google Scholar
• Tao W-H, Shan X-S, Zhang J-X, et al. Dexmedetomidine attenuates Ferroptosis-Mediated renal ischemia/reperfusion injury and inflammation by inhibiting ACSL4 via alpha2-AR. Front Pharmacol. 2022;13:782466. doi:10.3389/fphar.2022.782466.
   PubMed Web of Science ®Google Scholar
• Yu W, Lyu J, Jia L, et al. Dexmedetomidine ameliorates hippocampus injury and cognitive dysfunction induced by hepatic ischemia/reperfusion by activating SIRT3-Mediated mitophagy and inhibiting activation of the NLRP3 inflammasome in young rats. Oxid Med Cell Longev. 2020;2020:7385458–7385417. doi:10.1155/2020/7385458.
   PubMed Web of Science ®Google Scholar
• Cho I, Koo BN, Kim SY, et al. Neuroprotective effect of dexmedetomidine against postoperative cognitive decline via NLRP3 inflammasome signaling pathway. Int J Mol Sci. 2022;23(15):8806.
   PubMed Web of Science ®Google Scholar
• Sun L, Ma W, Gao W, et al. Propofol directly induces caspase-1-dependent macrophage pyroptosis through the NLRP3-ASC inflammasome. Cell Death Dis. 2019;10(8):542. doi:10.1038/s41419-019-1761-4.
   PubMedGoogle Scholar
• Li S, Sun Y, Song M, et al. NLRP3/caspase-1/GSDMD-mediated pyroptosis exerts a crucial role in astrocyte pathological injury in mouse model of depression. JCI Insight. 2021;6(23):e146852. doi:10.1172/jci.insight.146852.
   PubMed Web of Science ®Google Scholar
• de Vasconcelos NM, Van Opdenbosch N, Van Gorp H, et al. Single-cell analysis of pyroptosis dynamics reveals conserved GSDMD-mediated subcellular events that precede plasma membrane rupture. Cell Death Differ. 2019;26(1):146–161. doi:10.1038/s41418-018-0106-7.
   PubMed Web of Science ®Google Scholar
• Yao F, Jin Z, Zheng Z, et al. HDAC11 promotes both NLRP3/caspase-1/GSDMD and caspase-3/GSDME pathways causing pyroptosis via ERG in vascular endothelial cells. Cell Death Discov. 2022;8(1):112. doi:10.1038/s41420-022-00906-9.
   PubMed Web of Science ®Google Scholar
• Jiang S, Zhang H, Li X, et al. Vitamin D/VDR attenuate cisplatin-induced AKI by down-regulating NLRP3/caspase-1/GSDMD pyroptosis pathway. J Steroid Biochem Mol Biol. 2021;206:105789. doi:10.1016/j.jsbmb.2020.105789.
   PubMed Web of Science ®Google Scholar
• Al-Kharashi L, Attia H, Alsaffi A, et al. Pentoxifylline and thiamine ameliorate rhabdomyolysis-induced acute kidney injury in rats via suppressing TLR4/NF-kappaB and NLRP-3/caspase-1/gasdermin mediated-pyroptosis. Toxicol Appl Pharmacol. 2023;461:116387. doi:10.1016/j.taap.2023.116387.
   PubMed Web of Science ®Google Scholar
• Altındağ F, Ergen H. Sinapic acid alleviates cisplatin-induced acute kidney injury by mitigating oxidative stress and apoptosis. Environ Sci Pollut Res Int. 2023;30(5):12402–12411. doi:10.1007/s11356-022-22940-x.
   PubMed Web of Science ®Google Scholar
• Lempiainen J, Finckenberg P, Mervaala EE, et al. Dexmedetomidine preconditioning ameliorates kidney ischemia-reperfusion injury. Pharmacol Res Perspect. 2014;2(3):e00045.
   PubMedGoogle Scholar
• Chai Y, Zhu K, Li C, et al. Dexmedetomidine alleviates cisplatin‑induced acute kidney injury by attenuating endoplasmic reticulum stress‑induced apoptosis via the alpha2AR/PI3K/AKT pathway. Mol Med Rep. 2020;21(3):1597–1605.
   PubMed Web of Science ®Google Scholar
• Hu J, Gu W, Ma N, et al. Leonurine alleviates ferroptosis in cisplatin-induced acute kidney injury by activating the Nrf2 signalling pathway. Br J Pharmacol. 2022;179(15):3991–4009. doi:10.1111/bph.15834.
   PubMed Web of Science ®Google Scholar
• Shen X, Wang H, Weng C, et al. Caspase 3/GSDME-dependent pyroptosis contributes to chemotherapy drug-induced nephrotoxicity. Cell Death Dis. 2021;12(2):186. doi:10.1038/s41419-021-03458-5.
   PubMed Web of Science ®Google Scholar
• Yang J, Liu Z, Wang C, et al. Mechanism of gasdermin D recognition by inflammatory caspases and their inhibition by a gasdermin D-derived peptide inhibitor. Proc Natl Acad Sci U S A. 2018;115(26):6792–6797. doi:10.1073/pnas.1800562115.
   PubMed Web of Science ®Google Scholar
• Shi J, Zhao Y, Wang K, et al. Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death. Nature. 2015;526(7575):660–665. doi:10.1038/nature15514.
   PubMed Web of Science ®Google Scholar
• Yang Y, Adebali O, Wu G, et al. Cisplatin-DNA adduct repair of transcribed genes is controlled by two circadian programs in mouse tissues. Proc Natl Acad Sci U S A. 2018;115(21):E4777–E85.
   PubMed Web of Science ®Google Scholar
• Linkermann A, Chen G, Dong G, et al. Regulated cell death in AKI. J Am Soc Nephrol. 2014;25(12):2689–2701. doi:10.1681/ASN.2014030262.
   PubMed Web of Science ®Google Scholar
• Sami DH, Soliman AS, Khowailed AA, et al. 7-hydroxycoumarin modulates Nrf2/HO-1 and microRNA-34a/SIRT1 signaling and prevents cisplatin-induced oxidative stress, inflammation, and kidney injury in rats. Life Sci. 2022;310:121104. doi:10.1016/j.lfs.2022.121104.
   PubMed Web of Science ®Google Scholar
• Ko J-W, Shin N-R, Jung T-Y, et al. Melatonin attenuates cisplatin-induced acute kidney injury in rats via induction of anti-aging protein, klotho. Food Chem Toxicol. 2019;129:201–210. doi:10.1016/j.fct.2019.04.049.
   PubMed Web of Science ®Google Scholar
• Gu J, Sun P, Zhao H, et al. Dexmedetomidine provides renoprotection against ischemia-reperfusion injury in mice. Crit Care. 2011;15(3):R153. doi:10.1186/cc10283.
   PubMed Web of Science ®Google Scholar
• Zhong Y, Li YP, Yin YQ, et al. Dexmedetomidine inhibits pyroptosis by down-regulating miR-29b in myocardial ischemia reperfusion injury in rats. Int Immunopharmacol. 2020;86:106768. doi:10.1016/j.intimp.2020.106768.
   PubMed Web of Science ®Google Scholar
• Liu Y, Zhang T, Zhou Y, et al. Visualization of perforin/gasdermin/complement-formed pores in real cell membranes using atomic force microscopy. Cell Mol Immunol. 2019;16(6):611–620. doi:10.1038/s41423-018-0165-1.
   PubMed Web of Science ®Google Scholar
• Huang Y, Xu W, Zhou R. NLRP3 inflammasome activation and cell death. Cell Mol Immunol. 2021;18(9):2114–2127. doi:10.1038/s41423-021-00740-6.
   PubMed Web of Science ®Google Scholar
• Wang C, Yang T, Xiao J, et al. NLRP3 inflammasome activation triggers gasdermin D-independent inflammation. Sci Immunol. 2021;6(64):eabj3859. doi:10.1126/sciimmunol.abj3859.
   PubMed Web of Science ®Google Scholar