REFERENCES
- Welch W Mammilian stress response: cell physiology, structure/function of stress proteins, and im-plications for medicine and disease. Physiol Rev. 1992;72:1063–1081.
- Kaufmann S. Heat shock proteins and the immune response. Immunol Today. 1990;11:129–133.
- Udono H, Srivastava P. Heat shock protein 70-associated peptides elicit specific cancer immunity. J Exp Med. 1991;178:1391–1396.
- Multhoff G, Botzler C, Jennen L, Schmidt L, EllwartJ, Issels R. Heat shock protein 72 on tumor cells. J Immunol. 1997;158:4341–4350.
- Trieb K, Lechleitner T, Lang S, Windhager R, Kotz R, Dirnhofer S. Heat shock protein 72 expres-sion in osteosarcomas correlates with good response to neoadjuvant chemotherapy. Hum Pathol 1998;10:1050–1055.
- Lindquist S. The heat-shock response. Annu Rev Biochem. 1986;55:1151–1191.
- Schreiber H. Tumor immunology. In: Paul WE, ed. Fundamental Immunology, 3d ed. New York: Raven; 1993.
- Trieb K, Lechleitner T, Lang S, Windhager R, Kotz R, Dirnhofer S. Evaluation of HLA-DR expression and T lymphocyte infiltration in osteosarcoma. Pathol Res Pract. 1998;194:679–684.
- Chen L, Linsley PS, Hellstri5m KE. Costimulation of T cells for tumor immunity. Immunol Today. 1993;14:483–486.
- Bentzen SM, Poulsen HS, Kaae S, et al. Prognostic factors in osteosarcomas: a regression analysis. Cancer 1988;62:194–202.
- Davies AM, Bell RS, Goodwin PJ. Prognostic factors in osteosarcoma: a critical review. J Clin Oncol 1994;12:423–431.
- Petrilli AS, Gentil FC, Epelman S, et al. Increased survival, limb preservation, and prognostic factors for osteosarcoma. Cancer 1991;68:733–737.
- Londei M, Grubeck-Loebenstein B, de Berardinis P, Greenall C, Feldmann M. Efficient propagation and cloning of human T cells in the absence of antigen by means of OKT3, interleukin 2, and antigen-presenting cells. Scand J Immunol. 1988;27:35–46.
- Grubeck-Loebenstein B, Trieb K, Sztankay A, Holier W, Anderl H, Wick G. Retrobulbar T cells from patients with Graves' ophthalmopathy are CD8+ and specifically recognize autologous fibroblasts. J Clin Invest. 1994;93: 2738–2743.
- Wei y Zhao X, Kariya Y Fukata H, Teshigawara K, Uchida A. Induction of autologous tumor killing by heat treatment of fresh human tumor cells: involvement of yt5T cells and heat shock protein 70. Cancer Res. 1996;56:1104–1110.
- Multhoff G, Botzler C, Wiesnet M, EiBner G, Issels R. CD3- large granular lymphocytes recognize a heat-inducible immunogenic determinant associated with the 72-kD heat shock protein on human sarcoma cells. Blood. 1995;86: 1374–1382.
- Suto R, Srivastava P. A mechanism for specific immunogenicity of heat shock protein-chaperoned peptides. Science. 1995;269:1585–1589.
- Ferrarini M, Heltai S, Zocchi RS, Rugarli C. Unusual expression and localization of heat-shock pro-teins in human tumor cells. Int J Cancer 1992;51:613–618.
- de Nagel D, Pierce S. A case for chaperones in antigen processing. Immunol Today. 1992;13:86–91.
- Dickson" Hyperthermia in the treatment of cancer. Lancet. 1979;1:202–205.
- Hafstri5mL, Mattsson J. Regional chemotherapy for malignant melanoma. Cancer Treat Rev. 1993;19: 17–28.
- Feyerabend T, Steeves R, Wiedemann E, Richter E, Robins HI. Rationale and clinical status of lo-cal hyperthermia, radiation, and chemotherapy in locally advanced malignancies. Anticancer Res. 1997;17:2895–2898.
- Trieb K, Sztankay A, Amberger A, Lechner H, Grubeck-Loebenstein B. Hyperthermia inhibits pro-liferation and stimulates the expression of differentiation markers in thyroid carcinoma cells. Cancer Lett. 1994;87:65–71.