Normal flora: diversity and functions

References

• Gordon R. The alarming history of medicine. New York: St. Martin's Press, 1993: 164.
   Google Scholar
• Savage DC. Microbial ecology of the gastrointestinal tract. Annu Rev Microbiol 1977; 31: 107–33.
   Web of Science ®Google Scholar
• Salminen S, Isolauri E, Onnela T. Gut flora in normal and disordered states. Chemotherapy 1995; 41: 5–15.
   Google Scholar
• Keane FE, Ison CA, Taylor-Robinson D. A longitudinal study of the vaginal flora over a menstrual cycle. Int J STD AIDS 1997; 8: 489–94.
   Google Scholar
• Martin HL Jr, Richardson BA, Nyange PM, Lavreys L, Hillier SL, Chohan B, Mandaliya K, Ndinya-Achola JO, Bwayo J, Kreiss J. Vaginal lactobacilli, microbial flora, and risk of human immunodeficiency virus type 1 and sexually transmitted disease acquisition. J Infect Dis 1999; 180: 1863–8.
   Google Scholar
• Marshall JC. Gastrointestinal flora and its alterations in critical illness. Curr Opin Clin Nutr Metab Care 1999; 2: 405–11.
   Google Scholar
• Priestley CJ, Jones BM, Dhar J, Goodwin L. What is normal vaginal flora? Genitourin Med 1997; 73: 23–8.
   PubMedGoogle Scholar
• Hooper LV, Bry L, Falk PG, Gordon JI. Host-microbial symbiosis in the mammalian intestine: exploring an internal ecosystem. BioEssays 1998; 20: 336–43.
   PubMed Web of Science ®Google Scholar
• Hentges DJ. The anaerobic microflora of the human body. Clin Infect Dis 1993; 16: S175–80.
   PubMed Web of Science ®Google Scholar
• Hagiage M. La flora intestinale de l'équilibre au déséquili-bre. Paris: Vigot, 1994: 25.
   Google Scholar
• Vollaard ET, Clasener HAL, van Saene HKF, Muller NF. Effect on colonization resistance: an important criterion in selecting antibiotics. DICP 1990; 24: 60–6.
   PubMedGoogle Scholar
• Reid G, Bruce AW, McGroarty JA, Cheng K-J, Costerton JW. Is there a role for lactobacilli in prevention of urogenital and intestinal infections? Clin Microbiol Rev 1990; 3: 335–44.
   Google Scholar
• Hillier SL. The role of naturally occurring and exogenously supplied lactobacilli in the human vagina. Microbial Ecology in Health and Disease 1998; 10: 193.
   Google Scholar
• Listgarten MA. Structure of the microbial flora associated with periodontal health and disease in man., A light and electron microscopic study. J Periodontol 1976; 47: 1–18.
   Google Scholar
• Stjernquist-Desatnik A, Hoist E. Tonsillar microbial flora: comparison of recurrent tonsillitis and normal tonsils. Acta Otolaryngol 1999; 119: 102–6.
   Google Scholar
• Gagliardi D, Makihara S, Corsi PR, Viana A, de T, Wiczer MV, Nakakubo S, Mimica LM. Microbial flora of the normal esophagus. Dis Esophagus 1998; 11: 248–50.
   PubMedGoogle Scholar
• Marushko IuV. The colonization resistance of the tonsils in healthy and frequently ill children. Lik Sprava 1998; 1: 115–7.
   Google Scholar
• Ahrne S, Nobaek A, Jeppsson B, Adlerberth I, Wold AE, Molin G. The normal Lactobacillus flora of healthy human rectal and oral mucosa. J Appl Microbiol 1998; 86: 88–94.
   Google Scholar
• Smith VC, Genta RM. Role of Helicobacter pylori gastritis in gastric atrophy, intestinal metaplasia, and gastric neo-plasia. Microsc Res Tech 2000; 48: 313–20.
   PubMed Web of Science ®Google Scholar
• Quartero AO, Numans ME, de Melker RA, de Wit NJ. In-practice evaluation of whole-blood Helicobacter pylori test: its usefulness in detecting peptic ulcer disease. Br J Gen Pract 20W; 50: 13–6.
   Google Scholar
• Parente F, Cucino C, Bollani S, Imbesi V, Maconi G, Bonetto S, Vago L, Porro GB. Focal gastric inflammatory infiltrates in inflammatory bowel diseases: prevalence, im-munohistochemical characteristics, and diagnostic role. Am J Gastroenterol 2000; 95: 705–11.
   PubMed Web of Science ®Google Scholar
• Salminen S, Bouley C, Boutron-Ruault M-C, Cummings JH, Franck A, Gibson GR, Isolauri E, Moreau M-C, Roberfroid M, Rowland I. Functional food science and gastrointestinal physiology and function. Br J Nutr 1998; 80: S147–71.
   Google Scholar
• Franks AH, Harmsen HJM, Raangs GC, Jansen GJ, Schut F, Welling GW. Variations of bacterial populations in hu-man feces measured by fluorescent in situ hybridization with group-specific 16S rRNA-targeted oligonucleotide probes. Appl Environ Microbiol 1998; 64: 3336–45.
   PubMed Web of Science ®Google Scholar
• Schwebke JR, Richey CM, Weiss HL. Correlation of behav-iors with microbiological changes in vaginal flora. J Infect Dis 1999; 180: 1632–6.
   Google Scholar
• Rosenstein IJ, Stafford MK, Kitchen VS, Ward H, Weber JN, Taylor-Robinson D. Effect on normal vaginal flora of three intravaginal microbicidal agents potentially active against human immunodeficiency virus type 1. J Infect Dis 1998; 177: 1386–90.
   Google Scholar
• Collins MD, Gibson GR Probiotics, prebiotics and synbi-otics: approaches for modulating the microbial ecology of the gut. Am J Clin Nutr ; : S 1999; 69: 1052S–7.
   Google Scholar
• Karvonen AV, Vesikari T, Casas IA. Lactobacillus and Lactobacillus reuteri: mother-child vinculum at birth and during early age of infants. Microbial Ecology in Health and Disease. 1998; 10: 204.
   Google Scholar
• Benno Y, Sawada K, Mitsuoka T. The intestinal microflora of infants: composition of fecal flora in breast-fed and bottle-fed infants. Microbiol Immunol 1984; 28: 975–86.
   Google Scholar
• Bezirtzogjou E, Romond C. Effect of the feeding practices on the establishment of bacterial interactions in the intestine of the newborn delivered by cesarian section. J Perinat Med 1989; 17: 139–43.
   Google Scholar
• Harmsen HJ, Gibson GR, Elfferich P, Raangs GC, Wilde-boer-Veloo AC, Argaiz A, Roberfroid MB, Welling GW. Comparison of viable cell counts and fluorescence in situ hybridization using specific rRNA-based probes for the quantification of human fecal bacteria. FEMS Microbiol Lett 2000; 183: 125–9.
   Google Scholar
• McFarland LV, Surawicz CM, Greenberg RN, Bowen KE, Melcher SA, Mulligan ME. Possible role of cross-transmis-sion between neonates and mothers with recurrent Clostrid-itun difficile infections. ARC Am J Infect Control 1999; 27: 301–3.
   Web of Science ®Google Scholar
• Harmsen HJM, Wildeboer-Veloo ACM, Raangs GC, Wa-gendorp AA, Klijn N, Bindels JG, Welling GW. Analysis of intestinal flora development in breast-fed and formula-fed infants by using molecular identification and detection meth-ods. J Pediatr Gastroenterol Nutr 2000; 30: 61–7.
   PubMed Web of Science ®Google Scholar
• Rubaltelli FF, Biadaioli R, Pecile P, Nicoletti P. Intestinal flora in breast- and bottle-fed infants. J Perinat Med 1998; 26: 186–91.
   PubMed Web of Science ®Google Scholar
• Heavey PM, Rowland IR. The gut microflora of the devel-oping infant: microbiology and metabolism. Microbial Ecol-ogy in Health and Disease 1999; 11: 75–83.
   Google Scholar
• Ducluzeau R. Development, balance and role of the micro-bial flora of the newborn. Annales Pediatriques (Paris) 1993; 40: 13–22.
   PubMedGoogle Scholar
• Norin KE, Gustafsson BE, Lindblad BS, Midtvedt T. The establishment of some microflora associated biochemical characteristics in feces from children during the first years of life. Ada Paediatr Scand 1985; 74: 207–12.
   Google Scholar
• Midtvedt AC, Carlstedt-Duke B, Norin KE, Saxerholt H, Midtvedt T. Development of five metabolic activities associ-ated with the intestinal microflora of health infants. J Pediatr Gastroenterol Nutr 1988; 7: 559–67.
   PubMed Web of Science ®Google Scholar
• Gustafsson A, Berstad A, Lund-Tonnesen S, Midtvedt T, Norin E. The effect of faecal enema on five microflora-asso-ciated characteristics in patients with antibiotic-associated diarrhoea. Scand J Gastroenterol 1999; 34: 580–6.
   Google Scholar
• Buddington RK, Williams CH, Chen SC, Witherly SA. Dietary supplement of neosugar alters the fecal flora and decreases activities of some reductive enzymes in human subjects. Am J Clin Nutr 1996; 63: 709–16.
   PubMed Web of Science ®Google Scholar
• Rolfe RD. Colonization resistance. In: Mackie RI, White BA, Isaacson RE, eds Gastrointestinal microbiology, vol 2. New York: Chapman & Hall, Inc., 1997: 501–36.
   Google Scholar
• Moreau MC, Bisetti N, Dubuquoy C. Immunomodulating properties of a strain of Bifidobacteritun used as probiotic on the faecal and cellular intestinal IgA anti-rotavirus responses in mice. In: Functional Foods Proceedings. Royal Society of Chemistry, 1998.
   Google Scholar
• Moreau M, Gaboriau-Routhiau V. The absence of gut flora, the doses of antigen ingested and aging affect the long-term peripheral tolerance induced by ovalbumin feeding in mice. Research Immunolog 1996; 147: 49–59.
   Google Scholar
• Pulverer G, Ko HL, Beuth J. Microflora-associated defense stimulating factors. Scand J Gastroenterol 1997; 32: 107–11.
   PubMed Web of Science ®Google Scholar
• Guandalini S. Enteric nervous system: intestinal absorption and secretion. J Pediatr Gastroenterol Nutr 1997; 25: S5–6.
   Web of Science ®Google Scholar
• Midtvedt T. Gastro-intestinal motility. In: Heidt PJ, Rusch V, Van der Waaij D, eds Old Herborn University Seminar Monograph, Vol 9. Herborn-Dill Inst Microecology & Biochem, 1997: 1–7.
   Google Scholar
• Husebye E. The stimulatory influence of the intestinal mi-croflora on gastro-intestinal motility and myoelectric activity of small intestine. In: Heidt PJ, Rusch V, Van der Waaij D, eds Old Herborn University Seminar Monograph, Vol 9. Herborn-Dill Inst Microecology & Biochem, 1997: 41–52.
   Google Scholar
• Conway PL. Microbial ecology of the human large intestine. In: Gibson GR, Macfarlane GT, eds. Human colonic bacte-ria: role in nutrition, physiology, and pathology. Boca Ra-ton, FL: CRC Press, 1995: 1–24.
   Google Scholar
• Buts J-P, Bernasconi P, Vaerman J-P, Dive C. Stimulation of secretory IgA and secretory component of immunogjobu-lins in small intestine of rats treated with Saccharomyces boulardii. Dig Dis Sci 1990; 36: 251–6.
   Google Scholar
• Buts J-P, de Keyser N, de Raedemaeker L. Saccharomyces boulardii enhances rat intestinal enzyme expression by endo-luminal release of polyamines. Pediatr Res 1994; 36: 522–7.
   Google Scholar
• Cummings JH. Short chain fatty acids. In: Gibson GR, Macfarlane GT, eds. Human colonic bacteria: role in nutri-tion, physiology, and pathology. Boca Raton, FL: CRC Press, 1995: 101–30.
   Google Scholar
• Clausen MR, Bonnen H, Tvede M, Mortensen PB. Colonic fermentation to short-chain fatty acids is decreased in antibi-otic-associated diarrhea. Gastroenterology 1991; 101: 1497–504.
   PubMed Web of Science ®Google Scholar
• Treem WR, Ahsan N, Kastoff G, Hyams JS. Fecal short-chain fatty acids in patients with diarrhea-predominant irri-table bowel syndrome: in vitro studies of carbohydrate fermentation. J Pediatr Gastroenterol Nutr 1996; 23: 280–6.
   PubMed Web of Science ®Google Scholar
• Sidhu H, Holmes RP, Allison MJ, Peck AB. Direct quantifi-cation of the enteric bacterium Oxalobacter formigenes in human fecal samples by quantitative competitive-template PCR. J Clin Microbiol 1999; 37: 1503–9.
   Web of Science ®Google Scholar
• Elkins CA, Savage DC. Identification of genes coding conju-gated bile salt hydrolase and transport in Lactobacillus john-sonii 100-100. J Bacteriol 1998; 80: 4344–9.
   Google Scholar
• Wilson KH. The microecology of Clostridium difficile. Clin Infect Dis 1993; 16: S214–8.
   Web of Science ®Google Scholar
• Apperloo-Renkema HZ, van der Waaij BD, van der Waaij D. Determination of colonization resistance of the digestive tract by biotyping of Enterobacteriaceae. Epidemiol Infect 1990; 105: 355–61.
   Google Scholar
• Hazenberg MP, Bakker M, Verschoor-Burggraaf A. Effects of the human intestinal flora on germ-free mice. J Appl Bacteriol 1981; 50: 95–106.
   Google Scholar
• Nord CE, Kager L. The normal flora of the gastrointestinal tract. Neth J Med 1984; 27: 249–52.
   PubMed Web of Science ®Google Scholar
• Freter R, Abrams GD. Function of various intestinal bacte-ria in converting germfree mice to the normal state. Infect Immun 1972; 6: 119–26.
   PubMed Web of Science ®Google Scholar
• Romond MB, Haddou Z, Mielcareck C, Romond C. Bifidobacteria and human health: regulatory effect of indige-nous bifidobacteria on Fscherichia coli intestinal coloniza-tion. Anaerobe 1997; 3: 131–6.
   Web of Science ®Google Scholar
• McFarland LV. Epidemiology, risk factors and treatments for antibiotic-associated diarrhea. Dig Dis 1998; 16: 292–307.
   PubMed Web of Science ®Google Scholar
• Borriello SP. Pathogenesis of Clostridium difficile infection. J Antimicrob Chemother 1998; 41: 13–9.
   PubMed Web of Science ®Google Scholar
• Guerrant RL, Steiner TS, Lima AAM, Bobak DA. How intestinal bacteria cause disease. J Infect Dis 1999; 179: S331–7.
   PubMed Web of Science ®Google Scholar
• Fekety R. Guidelines for the diagnosis and management of Clostridium difficile-associated diarrhea and colitis. Am J Gastroenterol 1997; 92: 739–50.
   PubMed Web of Science ®Google Scholar
• Boman HG. Gut microflora. ASM News 2000; 66: 57.
   Google Scholar
• Naidu AS, Bidlack WR, Clemens RA. Probiotic spectra of lactic acid bacteria (LAB). Critical Reviews in Food Science and Nutrition 1999; 38: 13–126.
   Web of Science ®Google Scholar
• Wilson KH, Perini F. Role of competition for nutrients in suppression of Clostridium difficile by the colonic microflora. Infect Immun 1988; 56: 2610–4.
   PubMed Web of Science ®Google Scholar
• Sweeney NJ, Klemm P, McCormick BA, MollerNielsen E, Utley M, Schembri MA, Laux DC, Cohen PS. The Es - cherichia coli K-12 gntP gene allows E. coli F-18 to occupy a distinct nutritional niche in the streptomycin-treated mouse large intestine. Infect Immun 1996; 64: 3497–503.
   Google Scholar
• Castagliuolo I, Riegler MF, Valenick L, LaMont if, Pothoulakis C. Saccharomyces boulardii protease inhibits the effects of Clostridium difficile toxins A and B in human colonic mucosa. Infect Immun 1999; 67: 302–7.
   Google Scholar
• Just I, Fritz G, Aktories K, Giry M, Popoff MR, Boquet P, Hegenbarth S, von Eichel-Streiber C. Clostridium difficile toxin B acts on the GTP-binding protein Rho. Journal of Biological Chemistry 1994; 269: 10706–12.
   Google Scholar
• Fuller R. Probiotics 2. Applications and practical aspects. London: Chapman & Hall. 1997: 21.
   Google Scholar
• Giuliano M, Barza M, Jacobus NV, Gorbach SL. Effects of broad-spectrum parenteral antibiotics on composition of intestinal microflora of humans. Antimicrob Agents Chemother 1987; 31: 202–6.
   Web of Science ®Google Scholar
• Leonard F, Andremont A, Leclerq B, Labia R, Tancrede C. Use of fl-lactamase-producing anaerobes to prevent ceftriax-one from degrading intestinal resistance to colonization. J Infect Dis 1989; 160: 274–80.
   Google Scholar
• Herias MV, Midtvedt T, Hanson LA, Wold AE. Increased antibody production against gut-colonizing Escherichia coli in the presence of the anaerobic bacterium Peptostreptococ-cus. Scand J Immunol 1998; 48: 277–82.
   Web of Science ®Google Scholar
• Boureau H, Decre D, Carher JP, Guichet C, Bourlioux P. Identification of a Clostridium cocleatum strain involved in an anti-Clostridium difficile barrier effect and determination of its mucin-degrading enzymes. Res Microbiol 1993; 144: 405–10.
   Google Scholar
• Bourlioux P. What is currently known about the molecular mechanisms of colonisation resistance. Anaerobe 1997; 3: 179–84.
   PubMed Web of Science ®Google Scholar
• Wong WC, Hentges DJ, Dougherty SH. Adequacy of the human faecal microbiota associated mouse as a model for studying the ecology of the human intestinal tract. Microbial Ecology in Health and Disease 1996; 9: 187–98.
   Google Scholar
• Rolfe RD. Interactions among microorganisms of the indige-nous intestinal flora and their influence on the host Rev Infect Dis 1984; 6: S73–9.
   Google Scholar
• Silverman H, Romano J, Elmer G. The vitamin book. New York: Bantam Books, 1999.
   Google Scholar
• Umesaki Y, Okada Y, Matsumoto S, Imaoka A, Setoyama H. Segmented filamentous bacteria are indigenous intestinal bacteria that activate intraepithelial lymphocytes and induce MHC class II molecules and fucosyl asialo GM1 glycolipids on the small intestinal epithelial cells in the ex-germ-free mouse. Microbiol Immunol 1995; 39: 555–62.
   Google Scholar
• Kindon H, Pothoulakis C, Thim L, Lynch-Devaney K, Podolsky DK. Trefoil peptide protection of intestinal epithe-lial barrier function: cooperative interaction with mucin glycoprotein. Gastroenterology 1995; 109: 516–23.
   Google Scholar
• Carlstedt-Duke B, Hoverstad T, Lingaas E, Norin KE, Saxerholt H, Steinbakk M, Midtvedt T. Influence of antibi-otics on intestinal mucin in healthy subjects. Eur J Clin Microbiol 1986; 5: 634–8.
   Google Scholar
• Hoskins LC, Agustines M, McKee WB, Boulding ET, Kri-aris M, Niedermeyer G. Mucin degradation in human colon ecosystems. J Clin Invest 1985; 75: 944–53.
   PubMed Web of Science ®Google Scholar
• Pothoulakis C, Castagliuolo I, LaMont JT. Nerves and intestinal mast cells modulate responses to enterotoxins. News Physiol Sci 1998; 13: 58–63.
   Google Scholar
• Bry L, Falk PG, Midvedt T, Gordon J. A model for host-microbial interactions in an open mammalian ecosys-tem. Science 1996; 273: 1380–3.
   PubMed Web of Science ®Google Scholar
• Mitsuoka T, Hayakawa K, Kimura N. Die faekalflora bei menschen. Ill. Mitteilung: die zusammensetzung der lakto-bazillenflora der verschiedenen altersgruppen. Zentralbl Bak-teriol Orig A 1975; 232: 499–511.
   Google Scholar
• Valenti WM, Trude11 RG, Bentley ND. Factors predisposing to oropharyngeal colonization with gram-negative bacilli in the aged. N Engl J Med 1978; 298: 1108–11.
   Google Scholar
• McFarland LV, Surawicz CM, Stamm WE. Risk factors for Clostridium difficile carriage and C. difficile-associated di-arrhea in a cohort of hospitali7ed patients. J Infect Dis 1990; 162: 678–84.
   Google Scholar
• Benno Y, Endo K, Mizutani T, Namba Y, Komori T, Mitsuoka T. Comparison of fecal microblora of elderly persons in rural and urban areas of Japan. Appl Environ Microbiol 1989; 55: 1100–5.
   PubMed Web of Science ®Google Scholar
• Sepp E, Loivukene K, Koljalg S, Naaber P, Mikelsaar M, Bjorksten B. Comparison of intestinal microflora of Esto-nian and Swedish neonates. Microbial Ecology in Health and Disease 1998; 10: 203.
   Google Scholar
• Bouvee-Oudenhoven IM, Termont DS, Weerkamp AH, Faassen-Peters MA, Van der Meer R. Dietary calcium in-hibits the intestinal colonization and translocation of Salmonella in rats. Gastroenterology 1997; 113: 550–7.
   Google Scholar
• Gibson GR Dietary modulation of the human gut mi-croflora using prebiotics. Br J Nutr 1998; 80: S209–12.
   Web of Science ®Google Scholar
• Bouhnik Y, Vahedi K, Achour L, Attar A, Salfati J, Pochart P, Marteau P, Flourie B, Bornet F, Rambaud J-C. Short-chain fructo-oligosaccharide administration dose-depen-dently increases fecal bifidobacteria in healthy humans. J Nutr 1999; 129: 113–6.
   Google Scholar
• Kuda T, Goto H, Yokoyama M, Fujii T. Fermentable dietary fiber in dried products of brown algae and their effects on cecal microflora and levels of plasma lipid in rats. Fisheries Science 1998; 64: 582–8.
   Web of Science ®Google Scholar
• May T, Mackie RI, Fahey GC Jr, Cremin JC, Garleb KA. Effect of fiber source on short-chain fatty acid production and on the growth and toxin production by Clostridium difficile. Scand J Gastroenterol 1994; 29: 916–22.
   Google Scholar
• Elmer GW, Martin SW, Horner KL, McFarland LV, Levy RH. Survival of Saccharomyces boulardii in the rat gas-trointestinal tract and effects of dietary fiber. Microbial Ecology in Health and Disease 1999; 11: 29–34.
   Google Scholar
• Ward PB, Young GP. Dynamics of Clostridium difficile infection. Control using diet. Adv Exp Med Biol 1997; 412: 63–75.
   Web of Science ®Google Scholar
• Hara H, Orita N, Hatano S, Ichikawa H, Hara Y, Mat-sumoto N, Kimura Y, Terada A, Mitsuoka T. Effect of tea polyphenols on fecal flora and fecal metabolic products of pigs. J Vet Med Sci 1995; 57: 45–9.
   Google Scholar
• Dal Nogare AR, Toews GB, Pierce AK. Increased salivary elastase precedes gram-negative bacillary colonization in postoperative patients. Am Rev Respir Dis 1987; 135: 671–5.
   Google Scholar
• Drossman DA, McKee DC, Sandler RS, Mitchell CM, Cramer EM, Lowman BC, Burger AL. Psychosocial factors in the irritable bowel syndrome. A multivariate study of patients and nonpatients with irritable bowel syndrome. Gastroenterology 1988; 95: 701–8.
   Google Scholar
• Bochkov IA, Lizko NN, Semina NA, Borunov NL, Lurko LP. Peculiarities of cosmonauts fecal flora. Aviakosm Ekolog Med 1998; 32: 25–8.
   Google Scholar
• Lidbeck A, Nord CE. Lactobacilli and the normal human anaerobic microflora. Clin Infect Dis 1993; 16: S181–7.
   PubMed Web of Science ®Google Scholar
• Tetteroo GW, Wagenvoort JH, Bruining HA. Bacteriology of selective decontamination: efficacy and rebound coloniza-tion. J Antimicrob Chemother 1994; 34: 139–48.
   Google Scholar
• Lingnau W, Berger J, Javorsky F, Lejeune P, Mutz N, Benzer H. Selective intestinal decontamination in multiple trauma patients: prospective, controlled trial. J Trauma 1997; 42: 687–94.
   PubMedGoogle Scholar
• Lingnau W, Berger J, Javorsky F, Fille M, Allerberger F, Benzer H. Changing bacterial ecology during a five year period of selective intestinal decontamination. J Hosp Infect 1998; 39: 195–206.
   PubMed Web of Science ®Google Scholar
• Terg R, Llano K, Cobas SM, Brotto C, Barrios A, Levi D, Wasen W, Bartellini MA. Effects of oral ciprofloxacin on aerobic gram-negative fecal flora in patients with cirrhosis: results of short- and long-term administration, with daily and weekly dosages. J Hepatol 1998; 29: 437–42.
   Web of Science ®Google Scholar
• Thijm HA, van der Waaij D. The effect of three frequently applied antibiotics on the colonization resistance of the digestive tract of mice. J Hyg (Lond) 1979; 82: 397–405.
   PubMedGoogle Scholar
• Barza M, Giuliano M, Jacobus NV, Gorbach SL. Effect of broad-spectrum parenteral antibiotics on 'colonization resis-tance' of intestinal microflora of humans. Antimicrob Agents Chemother 1987; 31: 723–7.
   PubMed Web of Science ®Google Scholar
• Van Nispen CHM, Hoepelman AIM, Rozenberg-Arska M, Verhoef J, Purkins L, Willavize SA. A double-blind, placebo-controlled, parallel group study of oral trovafloxacin on bowel microflora in healthy male volun-teers. Am J Surg ; : S 1998; 176: 27S–31.
   Google Scholar
• Vollaard ET, Clasener HA, van Griethuysen AT, Janssen Al, Sanders-Reijmers AT. Influence of amoxycillin, erythromycin and roxithromycin on colonization resistance and on appear-ance of secondary colonization in healthy volunteers. J An-timicrob Chemother 1987; 20: 131–8.
   Google Scholar
• Vollaard ET, Clasener HA, Janssen AT. Co-trimoxazole im-pairs colonization resistance in healthy volunteers. J Antimi-crob Chemother 1992; 30: 685–91.
   Google Scholar
• Thomakos N, Maraki S, Liakakos T, Macheras A, Kanavaki S, Marinis E, Sehas M, Margioris AN, Samonis G. Effect of cefamandole, cefuroxime and cefoxitin on yeast fecal flora of surgical patients. Chemotherapy 1998; 44: 324–7.
   Google Scholar
• Van de Leur JJJPM, Vollaard ET, Janssen AJHM, Doffer-hoff ASM. Influence of low dose ciprofloxacin on microbial colonization of the digestive tract on healthy volunteers during normal and during impaired colonization resistance. Scand J Infect Dis 1997; 29: 297–303.
   Google Scholar
• Edlund C, Barkholt L, Olsson-Liljequist B, Nord CE Effect of vancomycin on intestinal flora of patients who previously received antimicrobial therapy. Clin Infect Dis 1997; 25: 729–32.
   PubMed Web of Science ®Google Scholar
• Van der Auwera P, Pensart N, Korten V, Murray BE, Leclercq R. Influence of oral glycopeptides on the fecal flora of human volunteers: selection of highly glycopeptide-resis-tant enterococci. J Infect Dis 1996; 173: 1129–36.
   PubMed Web of Science ®Google Scholar
• Hashimoto S, Igimi H, Uchida K, Satoh T, Benno Y, Takeuchi N. Effects of beta-lactam antibiotics on intestinal microflora and bile acid metabolism in rats. Lipids 1996; 31: 601–9.
   PubMed Web of Science ®Google Scholar
• Larson HE, Borriello SP. Quantitative study of antibiotic-in-duced susceptibility to Clostridium difficile enterocecitis in hamsters. Antimicrob Agents Chemother 1990; 34: 1348–53.
   PubMed Web of Science ®Google Scholar
• Papasouliotis K, Sparkes AH, Gruffydd-Jones TJ, Cripps PJ, Harper ET. Use of the breath hydrogen test to assess the effect of age on orocecal transit time and carbohydrate assimilation in cats. Am J Vet Res 1998; 59: 1299–302.
   Google Scholar
• Bonten MJM, Nathan C, Weinsein RA Recovery of noso-comial fecal flora from frozen stool specimens and rectal swabs. Comparison of preservatives for epidemiological studies. Diagn Microbiol Infect Dis 1997; 27: 103–6.
   Web of Science ®Google Scholar
• Bernhardt H, Wellmer A, Zimmermann K, Knoke M. Growth of Candida albicans in normal and altered faecal flora in the model of continuous flow culture. Mycoses 1995; 38: 265–70.
   PubMed Web of Science ®Google Scholar
• Macfarlane GT, Macfarlane S, Gibson GR Validation of a three-stage compound continuous culture system for investi-gating the effect of retention time on the ecology and metabolism of bacteria in the human colon. Microb Ecol 1998; 35: 180–7.
   PubMed Web of Science ®Google Scholar
• Kontula P, Jaskari J, Nollet L, De Smet I, von Wright A, Poutanen K, Mattila-Sandholm T. The colonization of a simulator of the human intestinal microbial ecosystem by a probiotic strain fed on a fermented oat bran product: effects on the gastrointestinal microbiota. Appl Microbiol Biotech-nol 1998; 50: 246–52.
   Google Scholar
• Corthier G, Muller MC, L'Haridon R. Selective enumera-tion of Bacteroides vulgatus and B. distasonis organisms in the predominant human fecal flora by using monoclonal antibodies. Appl Environ Microbiol 1996; 62: 735–8.
   Google Scholar
• Corthier G, Delorme C, Ehrlich SD, Renault P. Use of luciferase genes as biosensors to study bacterial physiology in the digestive tract. Appl Environ Microbiol 1998; 64: 2721–2.
   PubMed Web of Science ®Google Scholar
• Bergeron MG, Ouellette M. Preventing antibiotic resistance through rapid genotypic identification of bacteria and of their antibiotic resistance genes in the clinical microbiology laboratory. J Clin Microbiol 1998; 36: 2169–72.
   PubMed Web of Science ®Google Scholar
• Dore J, Sghir A, HannequartGramet G, Corthier G, Pochart P. Design and evaluation of a 16S rRNA-targeted oligonu-cleotide probe for specific detection and quantitation of human faecal Bacteroides populations. Systematic and Ap-plied Microbiology 1998; 21: 65–71.
   Google Scholar
• Langendijk PS, Schut F, Jansen GJ, Raangs GC, Kamphuis GR, Wilkinson MHF, Welling GW. Quantitative fluores-cence in situ hybridization of Bifidobacterium spp. with genus-specific 16S rRNA-targeted probes and its application in fecal samples. Appl Environ Microbiol 1995; 61: 3069–75.
   Google Scholar
• Wilson KH, Blitchington RB. Human colonic biota studied by ribosomal DNA sequence analysis. Appl Environ Micro-biol 1996; 62: 2273–778.
   PubMed Web of Science ®Google Scholar
• Welling GW, Elfferich P, Raangs GC, Wildeboer-Veloo AC, Jansen GJ, Degener JE. 16S ribosomal RNA-targeted oligonucleotide probes for monitoring of intestinal tract bacteria. Scand J Gastroenterol Suppl 1997; 222: 17–9.
   Google Scholar
• CoBinder E, Lindholm A, Midtvedt T, Norin E The useful-ness of microbial-associated characteristics (MACs) for stud-ies of microbial intestinal functions in different species. Microbial Ecology in Health and Disease 1998; 10: 203–4.
   Google Scholar
• Goldin BR, Gorbach SL. The effect of milk and lactobacil-lus feeding on human intestinal bacterial enzyme activity. Am J Clin Nutr 1984; 39: 756–61.
   PubMed Web of Science ®Google Scholar
• Onderdonk AB, Cisneros RL, Bartlett JG. Clostridium diffi-cile in gnotobiotic mice. Infect Immun 1980; 28: 277–82.
   PubMed Web of Science ®Google Scholar
• Umesaki Y, Sakata T, Yajima T. Abrupt induction of GDP-fucose:asialo GM1 fucosyltransferase in the small in-testine after conventionalization of germ-free mice. Biochem Biophys Res Common 1982; 105: 439–43.
   Google Scholar
• Wilson KH, Sheagren JN, Freter R, Weatherbee L, Lyerly D. Gnotobiotic models for study of the microbial ecology of Clostridium difficile and Escherichia coli. J Infect Dis 1986; 153: 547–51.
   Google Scholar
• Marteau P, Vaerman J-P, Dehennin J-P, Bord S, Brassart D, Pochart P, Desjeux J-F, Rambaud J-C. Effects of intrajeju-nal perfusion and chronic ingestion of Lactobacillus johnsonii strain La1 on serum concentrations and jejunal secretions of immunoglobulins and serum proteins in healthy humans. Gastroenterol Clin Biol 1997; 21: 293–8.
   Google Scholar
• Heimdahl A, Nord CE. Effect of phenoxymethylpenicillin and clindamycin on the oral, throat and faecal microflora of man. Scand J Infect Dis 1979; 11: 233–42.
   PubMed Web of Science ®Google Scholar
• Kaukoranta-Tolvanen S-S, Renkonen O-V, Gordin A, Tamm L, Mannisto PT. Effect of erythromycin acistrate and erythromycin stearate on human colonic microflora. Scand J Infect Dis 1989; 21: 717–20.
   Google Scholar
• Meijer-Severs GJ, van Santen E, de Vries-Hospers HG. Low-dose ciprofloxacin for selective decontamination of the digestive tract in human volunteers. Eur J Chin Microbiol Infect Dis 1990; 9: 285–7.
   Google Scholar