Gastrointestinal Host–Microbial Interactions in Mammals and Fish: Comparative Studies in Man, Mice, Rats, Pigs, Horses, Cows, Elks, Reindeers, Salmon and Cod

REFERENCES

• Hooper LV, Midtvedt T, Gordon JI. How host-microbial interactions shape the nutrient environment of the mammalian intestine. Ann Rev Nutr 2002; 22: 283–307.
   Google Scholar
• Stevens CE, Hume ID. Contributions of microbes in vertebrate gastrointestinal tract to production and conservation of nutrients. Physiol Rev 1998; 78: 393–427.
   PubMed Web of Science ®Google Scholar
• Midtvedt T, Bjørneklett A, Carlstedt-Duke B, Gustafsson BE, Hoverstad T, Lingaas E, et al. The influence of antibiotics upon microflora-associated characteristics in man and mammals. In: Wostmann BS, Pleasants JR, Pollard M, Teah BA, Wagner M, eds. Germfree Research: Microflora Control and its Applica-tion to the Biomedical Sciences. New York: Alan R Liss, 1985: 241–4.
   Google Scholar
• Cardona ME, de Vive Vanay V, Midtvedt T, Norin E. Effect of probiotics on five biochemical microflora-associated character-istics, in vitro and in vivo. Scand J Nutr 2002; 46: 73–9.
   Google Scholar
• Norin KE. Influence of antibiotics on some intestinal micro-flora associated characteristics. Anaerobe 1997; 3: 145–8.
   Web of Science ®Google Scholar
• Steinbakk M, Lingaas E, Carlstedt-Duke B, Hoverstad T, Midtvedt AC, Norin KE, et al. Faecal concentration of ten antibiotics and influence on some microflora-associated char-acteristics (MACs). Microb Ecol Health Dis 1992; 5: 269–76.
   Google Scholar
• Björnhag G. Comparative aspects of digestion in the hindgut of mammals. The colonic separator mechanism (CSM) (a review). Dtsch Tierärztl Wochenschr 1987; 94: 33–6.
   Google Scholar
• Björnhag G. Adaptations in the large intestine allowing small animals to eat fibrous food. In: Chivers DJ, Langer P, eds. The Digestive System in Mammals: Food, Form and Function. Cambridge: Cambridge University Press, 1994: 287–312.
   Google Scholar
• Kleiber M. Body size and metabolic rate. Physiol Rev 1947; 27: 511–41.
   PubMed Web of Science ®Google Scholar
• Darveau CA, Suarez RK, Andrews RD, Hochachka PW. Allometric cascade as a unifying principle of body mass effects on metabolism. Nature 2002; 417: 166–70.
   PubMed Web of Science ®Google Scholar
• Schmidt-Nielsen K. Animal Physiology: Adaptation and En-vironment, 4th edn. New York: Cambridge University Press, 1990: 141, 192, 317.
   Google Scholar
• Sperber I, Bjömhag G, Ridderstrale Y. Function of proximal colon in lemming and rat. Swedish J Agric Res 1983; 13:243–56.
   Google Scholar
• Ebino KY, Amao H, Suwa T, Kuwabara Y, Saito TR, Takahashi KW. Coprophagy in the germfree mouse. Jikken Dobutsu 1987; 36: 33–7.
   Web of Science ®Google Scholar
• Cummings JH. Short chain fatty acids in the human colon. Gut 1981; 22: 763–79.
   PubMed Web of Science ®Google Scholar
• McNeil NI. The contribution of the large intestine to energy supplies in man. Am J Clin Nutr 1984; 39: 338–42.
   PubMed Web of Science ®Google Scholar
• Rerat A, Fiszlewicz M, Giusi A, Vaugelade P. Influence of meal frequency on postprandial variations in the production and absorption of volatile fatty acids in the digestive tract of conscious pigs. J Anim Sci 1987; 64: 448–56.
   PubMed Web of Science ®Google Scholar
• Sperber I, Björnhag G, Holtenius K. A separation mechanism and fluid flow in the large intestine of the equine. In: Pferde-heilkunde. Europäische Konferenz tiber die Ernährung des Pferdes, 1992. Hannover: Tierärzliche Hochshule, 1992: 29–32.
   Google Scholar
• Mathiesen SD, Aagnes Utsi TH, Sormo W. Forage chemistry and the digestive system in reindeer (Rangifer tarandus tarandus) in northern Norway and on South Georgia. Rangifer 1999; 19: 91–101.
   Google Scholar
• Horsely RW. A review of bacterial flora of teleosts and elasmobranches, including methods for its analysis. J Fish Biol 1976; 10: 529–53.
   Web of Science ®Google Scholar
• Sugita H, Oshima K, Tamura M, Deguchi Y Bacterial flora in the gastrointestine of freshwater fishes in the river. Bull Jap Soc Scient Fish 1982; 49: 1387–95.
   Google Scholar
• Cahill MM. Bacterial flora of fishes: a review Microb Ecol 1990; 19: 21–41.
   Google Scholar
• Kaushik SJ. Environmental effects on feed utilization. Fish Physiol Biochem 1986; 2: 131–40.
   PubMed Web of Science ®Google Scholar
• Midtvedt T. Microbial functional activities. In: Hanson LA, Yolken RH, eds. Probiotics, Other Nutritional Factors, and Intestinal Microflora, Nestle Nutrition Workshop, 1997. Phi-ladelphia: Lippincott-Raven Publishers, 1999: 79–96.
   Google Scholar
• Gustafsson BE, Swenander-Lanke L. Bilirubin and urobilins in germfree, ex-germfree and conventional rats. J Exp Med 1960; 112: 975–81.
   PubMed Web of Science ®Google Scholar
• Midtvedt T, Gustafsson BE. Microbial conversion of bilirubin to urobilins in vitro and in vivo. Acta Pathol Microbiol Scand [B] 1981; 89: 57–60.
   PubMedGoogle Scholar
• Fahmy K, Gray CH, Nicholson DC. The reduction of bile pigments by faecal and intestinal bacteria. Biochim Biophys Acta 1972; 264: 85–97.
   PubMedGoogle Scholar
• Saxerholt H. The normal microflora and bilirubin. In: Grubb R, Midtvedt T, Norin E, eds. The Regulatory and Protective Role of the Normal Microflora. Proceedings of the 5th Bengt E Gustafsson Symposium, 1988, Stockholm, Sweden. London: Macmillan Press, 1989: 169–99.
   Google Scholar
• Neutra MR, Forstner JF. Gastrointestinal mucus: synthesis, secretion and function. In: Johnson LR, ed. Physiology of the Gastrointestinal Tract. New York: Raven Press, 1987:975–1009.
   Google Scholar
• Norin KE, Gustafsson BE, Midtvedt T. Strain differences in faecal tryptic activity of germ-free and conventional rats. Lab Anim 1986; 20: 67–9.
   Google Scholar
• Norin KE. The normal microflora and intestinal enzymes. In: Grubb R, Midtvedt T, Norin E, eds. The regulatory and protective role of the normal microflora: Bengt E Gustafsson 5th Symposium, 1988, Stockholm, Sweden. London: MacMil-lan Press, 1989: 219–37.
   Google Scholar
• Welling GW, Helmus G, de Vries-Hospers HG, Tonk RH, van der Waaij D, Haralambie E, Linzenmeier G. Rationale for use of P-aspartylglycine as indicator of colonization resistance. Prog Clin Biol Res 1985; 181: 155–8.
   Google Scholar
• Araneo BA, Cebra JJ, Beuth J, Fuller R, Heidt PJ, Midvedt T, et al. Problems and priorities for controlling opportunistic pathogens with new antimicrobial strategies; an overview of current literature. Zentralbl Bakteriol 1996; 283: 431–65.
   Google Scholar
• von Engelhardt W, Bartels S, Kirschberger S, Meyer HD, Busch R. Role of short-chain fatty acids in the hind gut. Vet Q 1998; 20(Suppl 3): S52–9.
   Google Scholar
• Bergman EN. Energy contributions of volatile fatty acids from the gastrointestinal tract in various species. Physiol Rev 1990; 70: 567–90.
   PubMed Web of Science ®Google Scholar
• Gustafsson BE. Lightweight stainless steel systems for rearing germfree animals. Ann NY Acad Sci 1959; 78: 17–21.
   PubMed Web of Science ®Google Scholar
• Mandel L. Manipulation of animals under germ-free condi-tions. In: Lefkovits I, Tlaskalova H, Sterzl J, eds. Immunology Methods Manual, Gnotobiological Models. New York: Aca-demic Press, 1997: 1531–5.
   Google Scholar
• Travnicek J, Kovaru F, Mandel L, Stozicky V, Kruml J. The delivery of piglets for germ-free rearing by caesarian section in a closed system. Acta Vet Brno 1975; 44: 297–306.
   Google Scholar
• Collinder E, Cardona ME, Kozakova H, Norin E, Stern S, Midtvedt T. Biochemical intestinal parameters in pigs reared outdoors and indoors, and in germ-free pigs. J Vet Med A Physiol Pathol Clin Med 2002; 49: 203–9.
   Google Scholar
• Siigur U, Norin KE, Allgood G, Schlagheck T, Midtvedt T. Effect of olestra on faecal water and short-chain fatty acids. Microb Ecol Health Dis 1996; 9: 9–17.
   Web of Science ®Google Scholar
• Collinder E, Lindholm A, Midtvedt T, Norin E. Six intestinal microflora-associated characteristics in sport horses. Equine Vet J 2000; 32: 222–7.
   Web of Science ®Google Scholar
• Sadzikowski MR, Sperry JF, Wilkins TD. Cholesterol-reducing bacterium from human feces. Appl Environ Microbiol 1977; 34: 355–62.
   PubMed Web of Science ®Google Scholar
• Freier TA, Beitz DC, Li L, Hartman PA. Characterization of Eubacterium coprostanoligenes sp. nov., a cholesterol-reducing anaerobe. Int J Syst Bacteriol 1994; 44: 137–42.
   PubMedGoogle Scholar
• Kellogg TF. On the site of the microbiological reduction of cholesterol to coprostanol in the rat. Lipids 1973; 8: 658–9.
   PubMed Web of Science ®Google Scholar
• Collinder E, Berge GN, Gronvold B, Lindholm A, Midtvedt T, Norin E. Influence of bacitracin on microbial functions in the gastrointestinal tract of horses. Equine Vet J 2000; 32: 345–50.
   Web of Science ®Google Scholar
• Ashes JR, Gulati SK, Cook LJ, Mills SC, Scott TW. Ruminal hydrogenation of cholesterol. J Lipid Res 1978; 19: 244–9.
   PubMed Web of Science ®Google Scholar
• Sansom BF, Gleed PT. The ingestion of sow's faeces by suckling piglets. Br J Nutr 1981; 46: 451–6.
   PubMed Web of Science ®Google Scholar
• Smith LS. Digestive functions in teleost fishes. In: Halver JE, ed. Fish Nutrition. London: Academic Press, 1989: 331–421.
   Google Scholar
• Kamel Y, Sakata T, Kakimoto D. Microflora in the alimentary tract of Tilapia: characterization and distribution of anaerobic bacteria. J Gen Appl Microbiol 1985; 31: 115–24.
   Google Scholar
• Sakata T. Microflora in the digestive tract of fish and shell-fish. In: Lesel R, ed. International Symposium on Microbiology in Po ecilotherms,1989,Paris.ElsevierSciencePublishers,1989:171–6.
   Google Scholar
• Midtvedt T, Frederichsen P. Influence of antibiotics on micro-bial intestinal transformation of cholesterol to coprostanol in man. Scand J Gastroenterol 1977; 12: 669–72.
   PubMed Web of Science ®Google Scholar
• Midtvedt T, Lingaas E, Carlstedt-Duke B, Hoverstad T, Midtvedt AC, Saxerholt H, et al. Intestinal microbial conver-sion of cholesterol to coprostanol in man. Influence of antibiotics. APMIS 1990; 98: 839–44.
   Google Scholar
• Korpela JT, Hämäläinen E, Adlercreutz H. Effect of oxyte-tracycline on bacterial intestinal metabolism of neutral sterols and on serum lipids. Scand J Gastroenterol 1984; 19: 401–4.
   PubMed Web of Science ®Google Scholar
• Wilkins TD, Hackman AS. Two patterns of neutral steroid conversion in the feces of normal North Americans. Cancer Res 1974; 34: 2250–4.
   PubMed Web of Science ®Google Scholar
• Midtvedt AC, Midtvedt T. Conversion of cholesterol to copros-tanol by the intestinal microflora during the first two years of human life. J Pediatr Gastroenterol Nutr 1993; 17: 161–8.
   PubMed Web of Science ®Google Scholar
• Vitek L, Kotal P, Jirsa M, Malina J, Cerna M, Chmelar D, et al. Intestinal colonization leading to fecal urobilinoid excretion may play a role in the pathogenesis of neonatal jaundice. J Pediatr Gastroenterol Nutr 2000; 30: 294–8.
   Web of Science ®Google Scholar
• Midtvedt AC, Carlstedt-Duke B, Norin KE, Saxerholt H, Midtvedt T. Development of five metabolic activities associated with the intestinal microflora of healthy infants. J Pediatr Gastroenterol Nutr 1988; 7: 559–67.
   PubMed Web of Science ®Google Scholar
• Smith JE, Erickson HH, Debowes RM, Clark M. Changes in circulating equine erythrocytes induced by brief, high-speed exercise. Equine Vet J 1989; 21: 444–6.
   Web of Science ®Google Scholar
• Saxerholt H, Carlstedt-Duke B, Hoverstad T, Lingaas E, Norin KE, Steinbakk M. Influence of antibiotics on the faecal excretion of bile pigments in healthy subjects. Scand J Gastro-enterol 1986; 21: 991–6.
   PubMed Web of Science ®Google Scholar
• Coates ME, Fuller R. The gnotobiotic animal in the study of gut microbiology. In: Clarke RTJ, Bauchop T, eds. Microbial Ecology of the Gut. London: Academic Press, 1977: 311–46.
   Google Scholar
• Strandberg K, Sedvall G, Midtvedt T, Gustafsson BE. Effect of some biologically active amines on the cecum wall of germfree rats. Proc Soc Exp Biol Med 1966; 121: 699–702.
   PubMed Web of Science ®Google Scholar
• Gustafsson BE, Midtvedt T, Strandberg K. Effects of microbial contamination on the cecum enlargement of germfree rats. Scand J Gastroenterol 1970; 5: 309–14.
   PubMed Web of Science ®Google Scholar
• Hoskins LC, Agustines M, McKee WB, Boulding ET, Kyriaris M, Niedermeyer G. Mucin degradation in human colon ecosystems. Isolation and properties of fecal strains that degrade ABH blood group antigens and oligosaccharides from mucin glycoproteins. J Clin Invest 1985; 75: 944–53.
   Google Scholar
• Carlstedt-Duke B, Midtvedt T, Nord CE, Gustafsson BE. Isolation and characterization of a mucin-degrading strain of Peptostreptococcus from rat intestinal tract. APMIS [B] 1986; 94: 293–300.
   Google Scholar
• Carlstedt-Duke B. The normal microflora and mucin. In: Grubb R, Midtvedt T, Norin E, eds. The Regulatory and Protective Role of the Normal Microflora: Bengt E Gustafsson 5th Symposium, 1988, Stockholm, Sweden. London: MacMil-lan Press, 1989: 219–37.
   Google Scholar
• Corfield AP, Myerscough N, Longman R, Sylvester P, Arul S, Pignatelli M. Mucins and mucosal protection in the gastro-intestinal tract: new prospects for mucins in the pathology of gastrointestinal disease. Gut 2000; 47: 589–94.
   PubMed Web of Science ®Google Scholar
• Carlstedt-Duke B, Hoverstad T, Lingaas E, Norin KE, Saxerholt H, Steinbakk M, et al. Influence of antibiotics on intestinal mucin in healthy subjects. Eur J Clin Microbiol 1986; 5: 634–8.
   Google Scholar
• Ramare F, Hautefort I, Verhe F, Raibaud P, Iovanna J. Inactivation of tryptic activity by a human-derived strain of Bacteroides distasonis in the large intestines of gnotobiotic rats and mice. Appl Environ Microbiol 1996; 62: 1434–6.
   Google Scholar
• Wostmann BS, Larkin C, Moriarty A, Bruckner-Kardoss E. Dietary intake, energy metabolism, and excretory losses of adult male germfree Wistar rats. Lab Anim Sci 1983; 33: 46–50.
   Google Scholar
• Rantzer D, Kiela P, Thaela MJ, Svendsen J, Ahrén B, Karlsson S, et al. Pancreatic exocrine secretion during the first days after weaning in pigs. J Anim Sci 1997; 75: 1324–31.
   Google Scholar
• Smith RR. Nutritional energetics. In: Halver JE, ed. Fish Nutrition. London: Academic Press, 1989: 1–29.
   Google Scholar
• Gustafsson BE, Norin KE. Development of germfree animal characteristics in conventional rats in antibiotics. Acta Pathol Microbiol Scand [B] 1977; 85: 1–8.
   Google Scholar
• Bezirtzoglou E, Chen J, Norin KE, Midtvedt T. Influence of roxitromycin on the fecal tryptic activity in conventional rats. Microecology and Therapy 1995; 23: 102–6.
   Google Scholar
• Norin KE, Carlstedt-Duke B, Hoverstad T, Lingaas E, Saxerholt H, Steinbakk M, et al. Faecal tryptic activity in humans: influence of antibiotics on microbial intestinal degra-dation. Microb Ecol Health Dis 1988; 1: 65–8.
   Google Scholar
• Collinder E, Cardona ME, Berge GN, Norin E, Stern S, Midtvedt T. Influence of zinc bacitracin and Bacillus licheni-formis on microbial functions in weaned piglets. Vet Res Commun 2003 (in press).
   Google Scholar
• Bar W, Welling GW, Kurrle E. Effects of selective oral antimicrobial prophylaxis and systemic antibiotics on the fecal flora and fecal beta-aspartylglycine concentration in patients with acute leukemia. APMIS 1989; 97: 705–14.
   Google Scholar
• Koopman JP, Kennis HM, Lankhorst A, Welling GW, Hectors MP, Nagengast E 'Normalization' of germfree mice after direct and indirect contact with mice having a 'normal' intestinal microflora. Lab Anim 1986; 20: 286–90.
   PubMed Web of Science ®Google Scholar
• Midtvedt T, Carlstedt-Duke B, Hoverstad T, Midtvedt AC, Norin KE, Saxerholt H. Establishment of a biochemically active intestinal ecosystem in ex-germfree rats. Appl Environ Microbiol 1992; 53: 2866–71.
   Google Scholar
• Hoverstad T. Studies of short-chain fatty acid absorption in man. Scand J Gastroenterol 1986; 21: 257–60.
   PubMed Web of Science ®Google Scholar
• Stevens CE, Hume ID. Microbial fermentation and synthesis of nutrients and the absorption of end products. In: Stevens CE, Hume ID, eds. Comparative Physiology of the Vertebrate Digestive System, 2nd edn. New York: Cambridge University Press, 1995: 188–228.
   Google Scholar
• Hoverstad T, Midtvedt T. Short-chain fatty acids in germfree mice and rats. J Nutr 1986; 116: 1772–6.
   PubMed Web of Science ®Google Scholar
• Cardona ME, Midtvedt T, Norin E. Probiotics in gnotobiotic mice: short-chain fatty acids production in vitro and in vivo. Scand J Lab Anim Sci 2001; 28: 75–84.
   Google Scholar
• Midtvedt T. In vivo models for short chain fatty acid production. In: Binder HJ, Cummings J, Soergel K, eds. Short-chain Fatty Acids. Falk Symposium 73, 1993, Stras-bourg, France. London: Kluwer Academic, 1994: 61–8.
   Google Scholar
• Rajendran VW, Binder HJ. Short chain fatty acid stimulation of electroneutral Na-C1 absorption: role of apical SCFA-HCO3 and SCFA-C1 exchanges. In: Binder HJ, Cummings J, Soergel K, eds. Short-chain Fatty Acids. Falk Symposium 73, 1993, Strasbourg, France. London: Kluwer Academic, 1994: 104–15.
   Google Scholar
• Zaharia V, Varzescu M, Djavadi I, Newman E, Egnor RW, Alexander-Chacko J, et al. Effects of short chain fatty acids on colonic Na + absorption and enzyme activity. Comp Biochem Physiol A Mol Integr Physiol 2001; 128: 335–47.
   Google Scholar
• Leschelle X, Delpal S, Goubern M, Blottiere HM, Blachier F. Butyrate metabolism upstream and downstream acetyl-CoA synthesis and growth control of human colon carcinoma cells. Eur J Biochem 2000; 267: 6435–42.
   Google Scholar
• Mortensen PB, Clausen MR. Short-chain fatty acids in the human colon: relation to gastrointestinal health and disease. Scand J Gastroenterol Suppl 1996; 216: 132–48.
   PubMedGoogle Scholar
• Hoverstad T, Carlstedt-Duke B, Lingaas E, Midtvedt T, Norin KE, Saxerholt H, et al. Influence of ampicillin, clindamycin, and metronidazole on faecal excretion of short-chain fatty acids in healthy subjects. Scand J Gastroenterol 1986; 21: 621–6.
   PubMed Web of Science ®Google Scholar
• Hoverstad T, Carlstedt-Duke B, Lingaas E, Norin E, Saxerholt H, Steinbakk M, et al. Influence of oral intake of seven different antibiotics on faecal short-chain fatty acid excretion in healthy subjects. Scand J Gastroenterol 1986; 21: 997–1003.
   PubMed Web of Science ®Google Scholar
• Hintz HF, Argenzio RA, Schryver HF. Digestion coefficients, blood glucose levels and molar percentage of volatile acids in intestinal fluid of ponies fed varying forage-grain ratios. J Anim Sci 1971; 33: 992–5.
   Google Scholar
• Johansson G, Midtvedt T, Gustafsson JA. The effect of a shift from a mixed to a lacto-vegetarian diet on some microflora related variables in feces - with special emphasis on the relation to cancer risk. Acta Chir Scand Suppl 1991; 562: 51–5.
   Google Scholar
• Midtvedt AC, Midtvedt T. Production of short chain fatty acids by the intestinal microflora during the first 2 years of human life. J Pediatr Gastroenterol Nutr 1992; 15: 395–403.
   Web of Science ®Google Scholar
• Christensen J. Motility of the colon. In: Johnson LR, ed. Physiology of the Gastrointestinal Tract, 2nd edn. New York: Raven Press, 1987: 666.
   Google Scholar
• Withers PC. Digestion. In: Withers PC, ed. Comparative Animal Physiology. New York: Saunders College Publishing, 1992: 925.
   Google Scholar