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Original

Viruses and autoimmunity

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Pages 71-77 | Published online: 07 Jul 2009

References

  • von Herrath MG, Fujinami RS, Whitton JL. Microorganisms and autoimmunity: Making the barren field fertile?. Nat Rev Microbiol 2003; 1: 151–157
  • Benoist C, Mathis D. Autoimmunity provoked by infection: How good is the case for T cell epitope mimicry?. Nat Immunol 2001; 2: 797–801
  • Rouse BT, Deshpande S. Viruses and autoimmunity: An affair but not a marriage contract. Rev Med Virol 2002; 12: 107–113
  • Oldstone MB. Molecular mimicry and immune-mediated diseases. FASEB J 1998; 12: 1255–1265
  • Whitton JL, Fujinami RS. Viruses as triggers of autoimmunity: Facts and fantasies. Curr Opin Microbiol 1999; 2: 392–397
  • Christen U, von Herrath MG. Infections and autoimmunity-good or bad?. J Immunol 2005; 174: 7481–7486
  • Christen U, von Herrath MG. Induction, acceleration or prevention of autoimmunity by molecular mimicry. Mol Immunol 2004; 40: 1113–1120
  • Olson JK, Croxford JL, Miller SD. Innate and adaptive immune requirements for induction of autoimmune demyelinating disease by molecular mimicry. Mol Immunol 2004; 40: 1103–1108
  • Panoutsakopoulou V, Cantor H. On the relationship between viral infection and autoimmunity. J Autoimmun 2001; 16: 341–345
  • Oldstone MB, Nerenberg M, Southern P, Price J, Lewicki H. Virus infection triggers insulin-dependent diabetes mellitus in a transgenic model: Role of anti-self (virus) immune response. Cell 1991; 65: 319–331
  • Ohashi PS, Oehen S, Buerki K, Pircher H, Ohashi CT, Odermatt B, Malissen B, Zinkernagel RM, Hengartner H. Ablation of “tolerance” and induction of diabetes by virus infection in viral antigen transgenic mice. Cell 1991; 65: 305–317
  • von Herrath MG, Dockter J, Oldstone MB. How virus induces a rapid or slow onset insulin-dependent diabetes mellitus in a transgenic model. Immunity 1994; 1: 231–242
  • Selin LK, Nahill SR, Welsh RM. Cross-reactivities in memory cytotoxic T lymphocyte recognition of heterologous viruses. J Exp Med 1994; 179: 1933–1943
  • Olson JK, Croxford JL, Calenoff MA, Dal Canto MC, Miller SD. A virus-induced molecular mimicry model of multiple sclerosis. J Clin Investig 2001; 108: 311–318
  • Lehmann PV, Sercarz EE, Forsthuber T, Dayan CM, Gammon G. Determinant spreading and the dynamics of the autoimmune T-cell repertoire. Immunol Today 1993; 14: 203–208
  • Miller SD, Vanderlugt CL, Begolka WS, Pao W, Yauch RL, Neville KL, Katz-Levy Y, Carrizosa A, Kim BS. Persistent infection with Theiler's virus leads to CNS autoimmunity via epitope spreading. Nat Med 1997; 3: 1133–1136
  • Croxford JL, Olson JK, Miller SD. Epitope spreading and molecular mimicry as triggers of autoimmunity in the Theiler's virus-induced demyelinating disease model of multiple sclerosis. Autoimmun Rev 2002; 1: 251–260
  • Olson JK, Girvin AM, Miller SD. Direct activation of innate and antigen-presenting functions of microglia following infection with Theiler's virus. J Virol 2001; 75: 9780–9789
  • Avery AC, Zhao ZS, Rodriguez A, Bikoff EK, Soheilian M, Foster CS, Cantor H. Resistance to herpes stromal keratitis conferred by an IgG2a-derived peptide. Nature 1995; 376: 431–434
  • Zhao ZS, Granucci F, Yeh L, Schaffer PA, Cantor H. Molecular mimicry by herpes simplex virus-type 1: Autoimmune disease after viral infection. Science 1998; 279: 1344–1347
  • Panoutsakopoulou V, Sanchirico ME, Huster KM, Jansson M, Granucci F, Shim DJ, Wucherpfennig KW, Cantor H. Analysis of the relationship between viral infection and autoimmune disease. Immunity 2001; 15: 137–147
  • Deshpande SP, Lee S, Zheng M, Song B, Knipe D, Kapp JA, Rouse BT. Herpes simplex virus-induced keratitis: Evaluation of the role of molecular mimicry in lesion pathogenesis. J Virol 2001; 75: 3077–3088
  • Verjans GM, Remeijer L, Mooy CM, Osterhaus AD. Herpes simplex virus-specific T cells infiltrate the cornea of patients with herpetic stromal keratitis: No evidence for autoreactive T cells. Invest Ophthalmol Vis Sci 2000; 41: 2607–2612
  • Olson JK, Croxford JL, Miller SD. Virus-induced autoimmunity: Potential role of viruses in initiation, perpetuation, and progression of T-cell-mediated autoimmune disease. Viral Immunol 2001; 14: 227–250
  • Toubi E, Shoenfeld Y. Toll-like receptors and their role in the development of autoimmune diseases. Autoimmunity 2004; 37: 183–188
  • Horwitz MS, Bradley LM, Harbertson J, Krahl T, Lee J, Sarvetnick N. Diabetes induced by Coxsackie virus: Initiation by bystander damage and not molecular mimicry. Nat Med 1998; 4: 781–785
  • Huster KM, Panoutsakopoulou V, Prince K, Sanchirico ME, Cantor H. T cell-dependent and -independent pathways to tissue destruction following herpes simplex virus-1 infection. Eur J Immunol 2002; 32: 1414–1419
  • Rouse BT, Suvas S. Regulatory cells and infectious agents: Detentes cordiale and contraire. J Immunol 2004; 173: 2211–2215
  • Belkaid Y, Rouse BT. Natural regulatory T cells in infectious disease. Nat Immunol 2005; 6: 353–360
  • Suvas S, Kumaraguru U, Pack CD, Lee S, Rouse BT. CD4+CD25+T cells regulate virus-specific primary and memory CD8+T cell responses. J Exp Med 2003; 198: 889–901
  • Suvas S, Azkur AK, Kim BS, Kumaraguru U, Rouse BT. CD4+CD25+ regulatory T cells control the severity of viral immunoinflammatory lesions. J Immunol 2004; 172: 4123–4132
  • Gangappa S, Deshpande SP, Rouse BT. Bystander activation of CD4(+) T cells can represent an exclusive means of immunopathology in a virus infection. Eur J Immunol 1999; 29: 3674–3682
  • Gangappa S, Deshpande SP, Rouse BT. Bystander activation of CD4+T cells accounts for herpetic ocular lesions. Invest Ophthalmol Vis Sci 2000; 41: 453–459
  • Horwitz MS, Sarvetnick N. Viruses, host responses, and autoimmunity. Immunol Rev 1999; 169: 241–253
  • Banerjee K, Deshpande S, Zheng M, Kumaraguru U, Schoenberger SP, Rouse BT. Herpetic stromal keratitis in the absence of viral antigen recognition. Cell Immunol 2002; 219: 108–118
  • Gangappa S, Babu JS, Thomas J, Daheshia M, Rouse BT. Virus-induced immunoinflammatory lesions in the absence of viral antigen recognition. J Immunol 1998; 161: 4289–4300
  • Deshpande S, Zheng M, Lee S, Banerjee K, Gangappa S, Kumaraguru U, Rouse BT. Bystander activation involving T lymphocytes in herpetic stromal keratitis. J Immunol 2001; 167: 2902–2910
  • Kurt-Jones EA, Chan M, Zhou S, Wang J, Reed G, Bronson R, Arnold MM, Knipe DM, Finberg RW. Herpes simplex virus 1 interaction with Toll-like receptor 2 contributes to lethal encephalitis. Proc Natl Acad Sci USA 2004; 101: 1315–1320
  • Zheng M, Deshpande S, Lee S, Ferrara N, Rouse BT. Contribution of vascular endothelial growth factor in the neovascularization process during the pathogenesis of herpetic stromal keratitis. J Virol 2001; 75: 9828–9835
  • Zheng M, Schwarz MA, Lee S, Kumaraguru U, Rouse BT. Control of stromal keratitis by inhibition of neovascularization. Am J Pathol 2001; 159: 1021–1029
  • Talbot PJ, Paquette JS, Ciurli C, Antel JP, Ouellet F. Myelin basic protein and human coronavirus 229E cross-reactive T cells in multiple sclerosis. Ann Neurol 1996; 39: 233–240
  • Soldan SS, Berti R, Salem N, Secchiero P, Flamand L, Calabresi PA, Brennan MB, Maloni HW, McFarland HF, Lin HC, Patnaik M, Jacobson S. Association of human herpes virus 6 (HHV-6) with multiple sclerosis: Increased IgM response to HHV-6 early antigen and detection of serum HHV-6 DNA. Nat Med 1997; 3: 1394–1397
  • Steinman L, Oldstone MB. More mayhem from molecular mimics. Nat Med 1997; 3: 1321–1322
  • Banki K, Colombo E, Sia F, Halladay D, Mattson DH, Tatum AH, Massa PT, Phillips PE, Perl A. Oligodendrocyte-specific expression and autoantigenicity of transaldolase in multiple sclerosis. J Exp Med 1994; 180: 1649–1663
  • ter Meulen V, Liebert UG. Measles virus-induced autoimmune reactions against brain antigen. Intervirology 1993; 35: 86–94
  • Munch M, Hvas J, Christensen T, Moller-Larsen A, Haahr S. The implications of Epstein–Barr virus in multiple sclerosis—a review. Acta Neurol Scand Suppl 1997; 169: 59–64
  • Stohlman SA, Hinton DR. Viral induced demyelination. Brain Pathol 2001; 11: 92–106
  • Goswami KK, Lange LS, Mitchell DN, Cameron KR, Russell WC. Does simian virus 5 infect humans?. J Gen Virol 1984; 65(Pt8)1295–1303
  • Croxford JL, Olson JK, Anger HA, Miller SD. Initiation and exacerbation of autoimmune demyelination of the central nervous system via virus-induced molecular mimicry: Implications for the pathogenesis of multiple sclerosis. J Virol 2005; 79: 8581–8590
  • Atkinson MA, Bowman MA, Campbell L, Darrow BL, Kaufman DL, Maclaren NK. Cellular immunity to a determinant common to glutamate decarboxylase and coxsackie virus in insulin-dependent diabetes. J Clin Investig 1994; 94: 2125–2129
  • Maclaren NK, Alkinson MA. Insulin-dependent diabetes mellitus: The hypothesis of molecular mimicry between islet cell antigens and microorganisms. Mol Med Today 1997; 3: 76–83
  • Karges WJ, Ilonen J, Robinson BH, Dosch HM. Self and non-self antigen in diabetic autoimmunity: Molecules and mechanisms. Mol Aspects Med 1995; 16: 79–213
  • Aydin Y, Ustun I, Erol K, Ozkaya E, Gul K, Berker D, Unal M, Delibasi T, Altundag K, Guler S. Herpes simplex type-2 encephalitis masked by diabetic ketoacidosis. J Natl Med Assoc 2005; 97: 722–724
  • Takeda N. Cardiomyopathy: Molecular and immunological aspects (review). Int J Mol Med 2003; 11: 13–16
  • Schwimmbeck PL, Dyrberg T, Drachman DB, Oldstone MB. Molecular mimicry and myasthenia gravis. An autoantigenic site of the acetylcholine receptor alpha-subunit that has biologic activity and reacts immunochemically with herpes simplex virus. J Clin Investig 1989; 84: 1174–1180
  • Eddy S, Wim R, Peter VE, Tanja R, Jan T, Werner VS. Myasthenia gravis: Another autoimmune disease associated with hepatitis C virus infection. Dig Dis Sci 1999; 44: 186–189
  • James JA, Neas BR, Moser KL, Hall T, Bruner GR, Sestak AL, Harley JB. Systemic lupus erythematosus in adults is associated with previous Epstein–Barr virus exposure. Arthritis Rheum 2001; 44: 1122–1126
  • Sekigawa I, Nawata M, Seta N, Yamada M, Iida N, Hashimoto H. Cytomegalovirus infection in patients with systemic lupus erythematosus. Clin Exp Rheumatol 2002; 20: 559–564
  • Romero Portales M, De Diego Lorenzo A, Rivera J, Garcia Monforte A, Piqueras Alcol B, Garcia Duran F, Cos Arregui E, Clemente Ricote G. Rheumatologic and autoimmune manifestations in patients with chronic hepatitis C virus infection. Rev Esp Enferm Dig 1997; 89: 591–598
  • McMurray RW, Elbourne K. Hepatitis C virus infection and autoimmunity. Semin Arthritis Rheum 1997; 26: 689–701
  • Csepregi A, Nemesanszky E, Rojkovich B, Poor G. Rheumatoid arthritis and hepatitis B virus: Evaluating the pathogenic link. J Rheumatol 2001; 28: 474–477
  • Balandraud N, Roudier J, Roudier C. Epstein-barr virus and rheumatoid arthritis. Autoimmun Rev 2004; 3: 362–367
  • Muller-Ladner U, Gay RE, Gay S. Retroviral sequences in rheumatoid arthritis synovium. Int Rev Immunol 1998; 17: 273–290

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