Induction of cardiac autoimmunity in Chagas heart disease: A case for molecular mimicry

References

• Moncayo A. Chagas disease: Current epidemiological trends after the interruption of vectorial and transfusional transmission in the Southern Cone countries. Mem Inst Oswaldo Cruz 2003; 98: 577–591
   PubMed Web of Science ®Google Scholar
• Moncayo A. Progress towards interruption of transmission of Chagas disease. Mem Inst Oswaldo Cruz 1999; 94(1)401–404
   Google Scholar
• Kirchhoff LV, Weiss LM, Wittner M, Tanowitz HB. Parasitic diseases of the heart. Front Biosci 2004; 9: 706–723
   PubMed Web of Science ®Google Scholar
• Urbina JA, Docampo R. Specific chemotherapy of Chagas disease: Controversies and advances. Trends Parasitol 2003; 19: 495–501
   PubMed Web of Science ®Google Scholar
• Prata A. Chagas' disease. Infect Dis Clin North Am 1994; 8: 61–77
   PubMed Web of Science ®Google Scholar
• Tanowitz HB, Kirchhoff LV, Simon D, Morris SA, Weiss LM, Wittner M. Chagas' disease. Clin Microbiol Rev 1992; 5: 400–419
   PubMed Web of Science ®Google Scholar
• Kierszenbaum F. Chronic Chagasic tissue lesions in the absence of Trypanosoma cruzi: A proposed mechanism. Parasitol Today 1996; 12: 414–415
   Google Scholar
• Kalil J, Cunha-Neto E. Autoimmunity in Chagas' disease cardiomyopathy: Fulfilling the criteria at last?. Parasitol Today 1996; 12: 396–399
   PubMedGoogle Scholar
• Kierszenbaum F. Chagas' disease and the autoimmunity hypothesis. Clin Microbiol Rev 1999; 12: 210–223
   PubMed Web of Science ®Google Scholar
• Engman DM, Leon JS. Pathogenesis of Chagas heart disease: Role of autoimmunity. Acta Trop 2002; 81: 123–132
   PubMed Web of Science ®Google Scholar
• Leon JS, Engman DM. The significance of autoimmunity in the pathogenesis of Chagas heart disease. Front Biosci 2003; 8: e315–e322
   Google Scholar
• Cunha-Neto E, Iwai LK, Bilate AMB, Fonseca SG, Kalil J. Autoimmunity in Chagas' disease. Infections and autimmunity, EY Shoenfeld, NR Rose. Elsiever, Northamsterdam 2004; 451–468
   Google Scholar
• Nitz N, Gomes C, Rosa AC, D'Souza-Ault MR, Moreno F, Lauria-Pires L, Nascimento RJ, Teixeira ARL. Heritable integration of kDNA minicircle sequences from Trypanosoma cruzi into the avian genome: Insights into human Chagas disease. Cell 2004; 118: 175–186
   Google Scholar
• De Souza W. Basic cell biology of Trypanosoma cruzi. Curr Pharm Des 2002; 8: 269–285
   Google Scholar
• Lopes MD, Macedo V. Incidencia elevada de transmicao materno-infantil da doenca de Chagas entre irmaos. Revista da Sociedade Brasileira de Medicina Tropical 1991; 24: 48–49
   Google Scholar
• Jorg M. Enfermedad de Chagas con puerta de entrada en el tracto digestivo. Centro Medico Publicacion Medica, Argentina 1992; 5: 71–88
   Google Scholar
• 2005., Ministério da Saúde, Secretaria de vigilância em saúde. Doença de Chagas Aguda relacionada à ingestão de caldo de cana em Santa Catarina. NOTA TÉCNICA
   Google Scholar
• Nickerson P, Orr P, Schroeder ML, Sekla L, Johnston JB. Transfusion-associated Trypanosoma cruzi infection in a non-endemic area. Ann Int Med 1989; 111: 851–853
   PubMed Web of Science ®Google Scholar
• Leiby DA, Read EJ, Lenes BA, Yund AJ, Stumpf RJ, Kirchhoff LV, Dodd RY. Seroepidemiology of Trypanosoma cruzi, etiologic agent of Chagas' disease, in US blood donors. J Infect Dis 1997; 176: 1047–1052
   Google Scholar
• Leiby DA, Herron RM, Jr, Read EJ, Lenes BA, Stumpf RJ. Trypanosoma cruzi in Los Angeles and Miami blood donors: Impact of evolving donor demographics on seroprevalence and implications for transfusion transmission. Transfusion 2002; 42: 549–555
   PubMed Web of Science ®Google Scholar
• Chocacir PR, Sabbage E, Amato Neto V. Transpante de rim: Nova modalidade de transmicao de doenca de Chagas. Revista Instituto de Medicina de Sao Paulo 1981; 23
   Google Scholar
• Mendoza I, Camardo J, Moleiro F, Castellanos A, Medina V, Gomez J, Acquatella H, Casal H, Tortoledo F, Puigbo J. Sustained ventricular tachycardia in chronic Chagasic myocarditis: Electrophysiologic and pharmacologic characteristics. Am J Cardiol 1986; 57: 423–427
   Google Scholar
• Rodriguez-Salas LA, Klein E, Acquatella H, Catalioti F, Davalos VV, Gomez-Mancebo JR, Gonzalez H, Bosch F, Puigbo JJ. Echocardiographic and clinical predictors of mortality in chronic Chagas' disease. Echocardiography 1998; 15: 271–278
   PubMed Web of Science ®Google Scholar
• Bocchi EA. Update on indications and results of the surgical treatment of heart failure. Arq Bras Cardiol 1994; 63: 523–530
   Google Scholar
• Bocchi EA, Fiorelli A. The paradox of survival results after heart transplantation for cardiomyopathy caused by Trypanosoma cruzi. First guidelines group for heart transplantation of the Brazilian society of cardiology. Ann Thorac Surg 2001; 71: 1833–1838
   PubMed Web of Science ®Google Scholar
• Zicker F, Smith PG, Almeida Netto JC, Oliveira RM, Zicker EMS. Physical activity, opportunity for reinfection, and sibling history of heart disease as risk factors for Chagas' cardiomyopathy. Am J Trop Med Hyg 1990; 43: 498–505
   PubMed Web of Science ®Google Scholar
• Layrisse Z, Acquatella H, Piccone C, Catalioti C, Gomez JR. HLA-Dw22 and Chagas disease. Hum Immunol 1988; 23: 116
   Google Scholar
• Fernandez-Mestre MT, Layrisse Z, Montagnani S, Acquatella H, Catalioti F, Matos M, Balbas O, Makhatadze N, Dominguez E, Herrera F, Madrigal A. Influence of the HLA Class II polymorphism in chronic Chagas'disease. Parasite Immunol 1998; 20: 197–203
   Google Scholar
• Deghaide NH, Dantas RO, Donadi EA. HLA class I and II profiles of patients presenting with Chagas'disease. Dig Dis Sci 1998; 43: 246–252
   PubMed Web of Science ®Google Scholar
• Colorado IA, Acquatella H, Catalioti F, Fernandez MT, Layrisse Z. HLA class II DRB1, DQB1, DPB1 polymorphism and cardiomyopathy due to Trypanosoma cruzi chronic infection. Hum Immunol 2000; 61: 320–325
   PubMed Web of Science ®Google Scholar
• Faé KC, Drigo SA, Cunha-Neto E, Ianni B, Mady C, Kalil J, Goldberg AC. HLA and β-myosin heavy chain do not influence susceptibility to Chagas' disease cardiomyopathy. Microbes Infect 2000; 2: 745–751
   Google Scholar
• Calzada JE, Nieto A, López-Nevot MA, Martín J. Lack of association between NRAMP1 gene polymorphisms and Trypanosoma cruzi infection. Tissue Antigens 2001; 57: 353–357
   Google Scholar
• Rodríguez-Pérez JM, Cruz-Robles D, Hernández-Pacheco G, Pérez-Hernández N, Murguía LE, Granados J, Reyes PA, Vargas-Alarcón G. Tumor necrosis factor-alpha promoter polymorphism in Mexican patients with Chagas' disease. Immunol Lett 2005; 98: 97–102
   Google Scholar
• Beraún Y, Nieto A, Collado MD, González A, Martín J. Polymorphisms at tumor necrosis factor (TNF) loci are not associated with Chagas' disease. Tissue Antigens 1998; 52: 81–83
   Google Scholar
• Drigo SA, Cunha-Neto E, Ianni B, Cardoso MRA, Braga PE, Faé KC, Lopes V, Paula Buck P, Mady C, Kalil J, Goldberg AC. TNF gene polymorphisms are associated with reduced survival in severe Chagas' disease cardiomyopathy patients Microbes Infect 2005., in press
   Google Scholar
• Cunha-Neto E, Rizzo LV, Albuquerque F, Abel L, Guilherme L, Bocchi E, Bacal F, Carrara D, Ianni B, Mady C, Kalil J. Cytokine production profile of heart-infiltrating T cells in Chagas' disease cardiomyopathy. Braz J Med Biol Res 1998; 31: 133–137
   PubMed Web of Science ®Google Scholar
• Cunha-Neto E, Abel L, Rizzo LV, Goldberg A, Mady C, Ianni B, Hammer J, Simigaglia F, Kalil J. Checkpoints for autoimmunity-induced heart tissue damage in human Chagas' disease: A multistep process?. Mem Inst Oswaldo Cruz 1998; 93(I)40–41
   Google Scholar
• Gomes JA, Bahia-Oliveira LM, Rocha MO, Martins-Filho OA, Gazzinelli G, Correa-Oliveira R. Evidence that development of severe cardiomyopathy in human Chagas' disease is due to a Th1-specific immune response. Infect Immun 2003; 71: 1185–1193
   PubMed Web of Science ®Google Scholar
• Abel LC, Rizzo LV, Ianni B, Albuquerque F, Bacal F, Carrara D, Bocchi EA, Teixeira HC, Mady C, Kalil J, Cunha-Neto E. Chronic Chagas' disease cardiomyopathy patients display an increased IFN-γ response to Trypanosoma cruzi infection. J Autoimmun 2001; 17: 99–107
   PubMed Web of Science ®Google Scholar
• Ferreira R, Ianni B, Abel LCJ, Buck P, Mady C, Kalil J, Cunha-Neto E. Increased plasma levels of tumor necrosis factor-alpha in asymptomatic/“indeterminate” and Chagas disease cardiomyopathy patients. Mem Inst Oswaldo Cruz 2003; 98: 407–411
   PubMed Web of Science ®Google Scholar
• Camargo MM, Almeida IC, Pereira ME, Ferguson MA, Travassos LR, Gazzinelli RT. Glycosylphosphatidylinositol-anchored mucin-like glycoproteins isolated from Trypanosoma cruzi trypomastigotes initiate the synthesis of proinflammatory cytokines by macrophages. J Immunol 1997; 158: 5890–5901
   Google Scholar
• DosReis GA, Freire-de-Lima CG, Nunes MP, Lopes MF. The importance of aberrant T-cell responses in Chagas disease. Trends Parasitol 2005; 21: 237–243
   Google Scholar
• Higuchi ML, De Morais CF, Pereira BA, Lopes EA, Stolf N, Bellotti G, Pileggi F. The role of active myocarditis in the development of heart failure in chronic Chagas' disease: A study based on endomyocardial biopsies. Clin Cardiol 1987; 10: 665–670
   PubMed Web of Science ®Google Scholar
• Higuchi Mde L, Gutierrez PS, Aiello VD, Palomino S, Bocchi E, Kalil J, Bellotti G, Pileggi F. Immunohistochemical characterization of infiltrating cells in human chronic Chagasic myocarditis: Comparison with myocardial rejection process. Virchows Arch A Pathol Anat Histopathol 1993; 423: 157–160
   PubMedGoogle Scholar
• Tostes JS, Lopes ER, Pereira FE, Chapadeiro E. Human chronic Chagasic myocarditis: Quantitative study of CD4+ and CD8+ lymphocytes in inflammatory exudates. Rev Soc Bras Med Trop 1994; 27: 127–134
   Google Scholar
• Reis MM, Higuchi Mde L, Benvenuti LA, Aiello VD, Gutierrez PS, Bellotti G, Pileggi F. An in situ quantitative immunohistochemical study of cytokines and IL-2R+ in chronic human Chagasic myocarditis: Correlation with the presence of myocardial Trypanosoma cruzi antigens. Clin Immunol Immunopathol 1997; 83: 165–172
   PubMed Web of Science ®Google Scholar
• Reis DD, Jones EM, Tostes S, Lopes ER, Chapadeiro E, Gazzinelli G, Colley DG, McCurley TL. Expression of major histocompatibility complex antigens and adhesion molecules in hearts of patients with chronic Chagas' disease. Am J Trop Med Hyg 1993; 49: 192–200
   Google Scholar
• Soares MB, Silva-Mota KN, Lima RS, Bellintani MC, Pontes-de-Carvalho L, Ribeiro-dos-Santos R. Modulation of Chagasic cardiomyopathy by interleukin-4: Dissociation between inflammation and tissue parasitism. Am J Pathol 2001; 159: 703–709
   Google Scholar
• Cunha-Neto E, Dzau VJ, Allen PD, Stamatiou D, Benvenutti L, Higuchi ML, Koyama NS, Silva JS, Kalil J, Liew CC. Cardiac gene expression profiling provides evidence for cytokinopathy as a molecular mechanism in Chagas' disease cardiomyopathy. Am J Pathol 2005; 167: 305–313
   PubMed Web of Science ®Google Scholar
• Mukherjee S, Belbin TJ, Spray DC, Iacobas DA, Weiss LM, Kitsis RN, Wittner M, Jelicks LA, Scherer PE, Ding A, Tanowitz HB. Microarray analysis of changes in gene expression in a murine model of chronic Chagasic cardiomyopathy. Parasitol Res 2003; 91: 187–196
   PubMed Web of Science ®Google Scholar
• Garg N, Popov VL, Papaconstantinou J. Profiling gene transcription reveals a deficiency of mitochondrial oxidative phosphorylation in Trypanosoma cruzi-infected murine hearts: Implications in Chagasic myocarditis development. Biochim Biophys Acta 2003; 1638: 106–120
   PubMed Web of Science ®Google Scholar
• Vyatkina G, Bhatia V, Gerstner A, Papaconstantinou J, Garg N. Impaired mitochondrial respiratory chain and bioenergetics during Chagasic cardiomyopathy development. Biochim Biophys Acta 2004; 1689: 162–173
   PubMed Web of Science ®Google Scholar
• Higuchi MD, Reis MM, Aiello VD, Benvenuti LA, Gutierrez PS, Bellotti G, Pileggi F. Association of an increase in CD8+T cells with the presence of Trypanosoma cruzi antigens in chronic, human, Chagasic myocarditis. Am J Trop Med Hyg 1997; 56: 485–489
   PubMed Web of Science ®Google Scholar
• Jones EM, Colley DG, Tostes S, Lopes ER, Vnencak-Jones CL, McCurley TL. Amplification of a Trypanosoma cruzi DNA sequence from inflammatory lesions in human Chagasic cardiomyopathy. Am J Trop Med Hyg 1993; 48: 348–357
   PubMed Web of Science ®Google Scholar
• Freitas JM, Lages-Silva E, Crema E, Pena SD, Macedo AM. Real time PCR strategy for the identification of major lineages of Trypanosoma cruzi directly in chronically infected human tissues. Int J Parasitol 2005; 35: 411–417
   PubMed Web of Science ®Google Scholar
• Sartori AM, Shikanai-Yasuda MA, Amato N, Lopes MH. Follow-up of 18 patients with human immunodeficiency virus infection and chronic Chagas' disease, with reactivation of Chagas' disease causing cardiac disease in three patients. Clin Infect Dis 1998; 26: 177–179
   PubMed Web of Science ®Google Scholar
• Riarte A, Luna C, Sabatiello R, Sinagra A, Schiavelli R, De Rissio A, Maiolo E, Garcia MM, Jacob N, Pattin M, Lauricella M, Segura EL, Vazquez M. Chagas' disease in patients with kidney transplants: 7 years of experience 1989–1996. Clin Infect Dis 1999; 29: 561–567
   PubMed Web of Science ®Google Scholar
• Pereira JB, Wilcox HP, Coura JR. The evolution of chronic Chagasic cardiopathy. I. The influence of parasitemia. Rev Soc Bras Med Trop 1992; 25: 101–108
   Google Scholar
• Palomino SA, Aiello VD, Higuchi ML. Systematic mapping of hearts from chronic Chagasic patients: The association between the occurrence of histopathological lesions and Trypanosoma cruzi antigens. Ann Trop Med Parasitol 2000; 94: 571–579
   Web of Science ®Google Scholar
• Elias FE, Vigliano CA, Laguens RP, Levin MJ, Berek C. Analysis of the presence of Trypanosoma cruzi in the heart tissue of three patients with chronic Chagas' heart disease. Am J Trop Med Hyg 2003; 68: 242–247
   PubMed Web of Science ®Google Scholar
• Anez N, Carrasco H, Parada H, Crisante G, Rojas A, Fuenmayor C, Gonzalez N, Percoco G, Borges R, Guevara P, Ramirez JL. Myocardial parasite persistence in chronic Chagasic patients. Am J Trop Med Hyg 1999; 60: 726–732
   PubMed Web of Science ®Google Scholar
• Olivares-Villagomez D, McCurley TL, Vnencak-Jones CL, Correa-Oliveira R, Colley DG, Carter CE. Polymerase chain reaction amplification of three different Trypanosoma cruzi DNA sequences from human Chagasic cardiac tissue. Am J Trop Med Hyg 1998; 59: 563–570
   PubMed Web of Science ®Google Scholar
• Higuchi ML, De Brito T, Reis MM, Bellotti G, Pereira-Barretto AC, Pileggi F. Correlation between T. cruzi parasitism and myocardial inflammatory infiltrate in human chronic Chagasic myocarditis: Light microscopy and immunohistochemical findings. Cardiovasc Pathol 1993; 2: 101–105
   PubMed Web of Science ®Google Scholar
• Palomino SA, Aiello VD, Higuchi ML. Systematic mapping of hearts from chronic Chagasic patients: The association between the occurrence of histopathological lesions and Trypanosoma cruzi antigens. Ann Trop Med Parasitol 2000; 94: 571–579
   Web of Science ®Google Scholar
• Torres CM. Patologia de la miocarditis crónica en la enfermedad de Chagas. An 5a Reun Soc Argent Pat Reg Norte 1929; 2: 902–916
   Google Scholar
• Cunha-Neto E, Coelho V, Guilherme L, Fiorelli A, Stolf N, Kalil J. Autoimmunity in Chagas' disease. Identification of cardiac myosin-B13 Trypanosoma cruzi protein crossreactive T cell clones in heart lesions of a chronic Chagas' cardiomyopathy patient. J Clin Investig 1996; 98: 1709–1712
   PubMed Web of Science ®Google Scholar
• Fonseca SG, Moins-Teisserenc H, Clave E, Ianni B, Nunes VL, Mady C, Iwai LK, Sette A, Sidney J, Marin ML, Goldberg AC, Guilherme L, Charron D, Toubert A, Kalil J, Cunha-Neto E. Identification of multiple HLA-A*0201-restricted cruzipain and FL-160 CD8+ epitopes recognized by T cells from chronically Trypanosoma cruzi-infected patients. Microbes Infect 2005; 7: 688–697
   PubMed Web of Science ®Google Scholar
• Minoprio P, Burlen O, Pereira P, Guilbert B, Andrade L, Hontebeyrie-Joskowicz M, Coutinho A. Most B cells in acute Trypanosoma cruzi infection lack parasite specificity. Scand J Immunol 1988; 28: 553–561
   Google Scholar
• Minoprio P. Parasite polyclonal activators: New targets for vaccination approaches?. Int J Parasitol 2001; 31: 588–591
   Google Scholar
• Barr SC, Dennis VA, Klei TR, Norcross NL. Antibody and lymphoblastogenic responses of dogs experimentally infected with Trypanosoma cruzi isolates from North American mammals. Vet Immunol Immunopathol 1991; 29: 267–283
   Google Scholar
• Barr SC. Anti-heart tissue antibodies during experimental infections with pathogenic and non-pathogenic Trypanosoma cruzi isolates in dogs. Int J Parasitol 1993; 23: 961–967
   Google Scholar
• Amorim DS. Chagas' heart disease: Experimental models. Heart Vessels Suppl 1985; 1: 236–239
   Google Scholar
• Ramirez LE, Lages-Silva E, Soares Junior JM, Chapadeiro E. The hamster (Mesocricetus auratus) as experimental model in Chagas' disease: Parasitological and histopathological studies in acute and chronic phases of Trypanosoma cruzi infection. Rev Soc Bras Med Trop 1994; 27: 163–169
   PubMedGoogle Scholar
• Bilate AM, Salemi VM, Ramires FJ, de Brito T, Silva AM, Umezawa ES, Mady C, Kalil J, Cunha-Neto E. The Syrian hamster as a model for the dilated cardiomyopathy of Chagas' disease: A quantitative echocardiographical and histopathological analysis. Microbes Infect 2003; 5: 1116–1124
   PubMedGoogle Scholar
• Colmanetti FH, Teixeira Vde P, Rodrigues ML, Chica JE, Reis MG, Dos Santos VM. Myocardiocyte ultrastructure and morphometrical analysis in hamsters experimentally infected with Trypanosoma cruzi. Ultrastruct Pathol 2005; 29: 139–147
   PubMed Web of Science ®Google Scholar
• Postan M, McDaniel JP, Dvorak JA. Comparative studies of the infection of Lewis rats with four Trypanosoma cruzi clones. Trans R Soc Trop Med Hyg 1987; 81: 415–419
   Google Scholar
• Junqueira LF, Jr, Beraldo PS, Chapadeiro E, Jesus PC. Cardiac autonomic dysfunction and neuroganglionitis in a rat model of chronic Chagas' disease. Cardiovasc Res 1992; 26: 324–329
   Google Scholar
• Revelli S, Davila H, Ferro ME, Romero-Piffiguer M, Musso O, Valenti J, Bernabo J, Falcoff E, Wietzerbin J, Bottasso O. Acute and chronic experimental Trypanosoma cruzi infection in the rat. Response to systemic treatment with recombinant rat interferon-gamma. Microbiol Immunol 1995; 39: 275–281
   Google Scholar
• Marcipar IS, Risso MG, Silber AM, Revelli S, Marcipar AJ. Antibody maturation in Trypanosoma cruzi-infected rats. Clin Diagn Lab Immunol 2001; 8: 802–805
   Google Scholar
• Piaggio E, Roggero E, Pitashny M, Wietzerbin J, Bottasso OA, Revelli SS. Treatment with benznidazole and its immunomodulating effects on Trypanosoma cruzi-infected rats. Parasitol Res 2001; 87: 539–547
   Google Scholar
• Camargos ER, Machado CR, Teixeira AL, Jr, Rocha LL, Ferreira AJ, Almeida AP, Barton M, Teixeira MM. Role of endothelin during experimental Trypanosoma cruzi infection in rats. Clin Sci (Lond) 2002; 103(48)64S–67S
   Google Scholar
• Cossio PM, Bustuoabad O, Paterno E, Iotti R, Casanova MB, Podesta MR, Bolomo N, Arana RM, de Pasqualini CD. Experimental myocarditis induced in Swiss mice by homologous heart immunization resembles chronic experimental Chagas' heart disease. Clin Immunol Immunopathol 1984; 33: 165–175
   PubMedGoogle Scholar
• McCormick TS, Rowland EC. Trypanosoma cruzi: Cross-reactive anti-heart autoantibodies produced during infection in mice. Exp Parasitol 1989; 69: 393–401
   Google Scholar
• Laguens RP, Cabeza Meckert PM, Chambo JG. Immunologic studies on a murine model of Chagas disease. Medicina (Buenos Aires) 1989; 49: 197–202
   Google Scholar
• Hontebeyrie-Joskowicz M. Autoimmunity in Chagas disease: The mouse model. Parasitol Today 1997; 13(156-7)157, author reply 157
   Google Scholar
• Costa SC. Mouse as a model for Chagas disease: Does mouse represent a good model for Chagas disease?. Mem Inst Oswaldo Cruz 1999; 94(1)269–272
   Google Scholar
• Bustamante JM, Rivarola HW, Fernandez AR, Enders JE, Fretes R, Palma JA, Paglini-Oliva PA. Trypanosoma cruzi reinfections in mice determine the severity of cardiac damage. Int J Parasitol 2002; 32: 889–896
   PubMed Web of Science ®Google Scholar
• Andersson J, Orn A, Sunnemark D. Chronic murine Chagas' disease: The impact of host and parasite genotypes. Immunol Lett 2003; 86: 207–212
   PubMed Web of Science ®Google Scholar
• Leon JS, Wang K, Engman DM. Captopril ameliorates myocarditis in acute experimental Chagas disease. Circulation 2003a; 107: 2264–2269
   PubMed Web of Science ®Google Scholar
• Vasconcelos JR, Hiyane MI, Marinho CR, Claser C, Machado AM, Gazzinelli RT, Bruna-Romero O, Alvarez JM, Boscardin SB, Rodrigues MM. Protective immunity against Trypanosoma cruzi infection in a highly susceptible mouse strain after vaccination with genes encoding the amastigote surface protein-2 and trans-sialidase. Hum Gene Ther 2004; 15: 878–886
   PubMed Web of Science ®Google Scholar
• Dumonteil E, Escobedo-Ortegon J, Reyes-Rodriguez N, Arjona-Torres A, Ramirez-Sierra MJ. Immunotherapy of Trypanosoma cruzi infection with DNA vaccines in mice. Infect Immun 2004; 72: 46–53
   PubMed Web of Science ®Google Scholar
• Pontes de Carvalho L, Santana CC, Soares MB, Oliveira GG, Cunha-Neto E, Ribeiro Dos Santos R. Experimental chronic Chagas' disease myocarditis is an autoimmune disease preventable by induction of immunological tolerance to myocardial antigens. J Autoimmun 2002; 18: 131–138
   Google Scholar
• Leon JS, Godsel LM, Wang K, Engman DM. Cardiac myosin autoimmunity in acute Chagas heart disease. Infect Immun 2001; 69: 5643–5649
   Google Scholar
• Tibbetts RS, McCormick TS, Rowland EC, Miller SD, Engman DM. Cardiac antigen-specific autoantibody production is associated with cardiomyopathy in Trypanosoma cruzi-infected mice. J Immunol 1994; 152: 1493–1499
   PubMedGoogle Scholar
• Tekiel VS, Mirkin GA, Gonzalez Cappa SM. Chagas' disease: Reactivity against homologous tissues induced by different strains of Trypanosoma cruzi. Parasitology 1997; 115: 495–502
   PubMed Web of Science ®Google Scholar
• Tekiel V, Losavio A, Jones M, Muchnik S, Gonzalez-Cappa SM. Changes in the mouse sciatic nerve action potential after epineural injection of sera from Trypanosoma cruzi infected mice. Parasite Immunol 2001; 23: 533–539
   PubMed Web of Science ®Google Scholar
• Ternynck T, Bleux C, Gregoire J, Avrameas S, Kanellopoulos-Langevin C. Comparison between autoantibodies arising during Trypanosoma cruzi infection in mice and natural autoantibodies. J Immunol 1990; 144: 1504–1511
   Google Scholar
• Laguens RP, Meckert PC, Chambo JG. Antiheart antibody-dependent cytotoxicity in the sera of mice chronically infected with Trypanosoma cruzi. Infect Immun 1988; 56: 993–997
   PubMedGoogle Scholar
• Acosta AM, Santos-Buch CA. Autoimmune myocarditis induced by Trypanosoma cruzi. Circulation 1985; 71: 1255–1261
   Google Scholar
• Rizzo LV, Cunha-Neto E, Teixeira AR. Autoimmunity in Chagas' disease: Specific inhibition of reactivity of CD4+T cells against myosin in mice chronically infected with Trypanosoma cruzi. Infect Immun 1989; 57: 2640–2644
   PubMedGoogle Scholar
• Dos Santos RR, Rossi MA, Laus JL, Silva JS, Savino W, Mengel J. Anti-CD4 abrogates rejection and reestablishes long-term tolerance to syngeneic newborn hearts grafted in mice chronically infected with Trypanosoma cruzi. J Exp Med 1992; 175: 29–39
   PubMedGoogle Scholar
• Tarleton RL, Zhang L, Downs MO. ‘Autoimmune rejection’ of neonatal heart transplants in experimental Chagas disease is a parasite-specific response to infected host tissue. Proc Natl Acad Sci USA 1997; 94: 3932–3937
   PubMed Web of Science ®Google Scholar
• Benoist C, Mathis D. Autoimmunity provoked by infection: How good is the case for T cell epitope mimicry?. Nat Immunol 2001; 2: 797–801
   PubMed Web of Science ®Google Scholar
• Al-Sabbagh A, Garcia CA, Diaz-Bardales BM, Zaccarias C, Sakurada JK, Santos LM. Evidence for cross-reactivity between antigen derived from Trypanosoma cruzi and myelin basic protein in experimental Chagas disease. Exp Parasitol 1998; 89: 304–311
   Google Scholar
• Ribeiro-Dos-Santos R, Mengel JO, Postol E, Soares RA, Ferreira-Fernandez E, Soares MB, Pontes-De-Carvalho LC. A heart-specific CD4+T-cell line obtained from a chronic Chagasic mouse induces carditis in heart-immunized mice and rejection of normal heart transplants in the absence of Trypanosoma cruzi. Parasite Immunol 2001; 23: 93–101
   PubMedGoogle Scholar
• Motran CC, Fretes RE, Cerban FM, Rivarola HW, Vottero de Cima E. Immunization with the C-terminal region of Trypanosoma cruzi ribosomal P1 and P2 proteins induces long-term duration cross-reactive antibodies with heart functional and structural alterations in young and aged mice. Clin Immunol 2000; 97: 89–94
   Google Scholar
• Kyu B, Matsumori A, Sato Y, Okada I, Chapman NM, Tracy S. Cardiac persistence of cardioviral RNA detected by polymerase chain reaction in a murine model of dilated cardiomyopathy. Circulation 1992; 86: 522–530
   PubMedGoogle Scholar
• Rose NR, Hill SL. Autoimmune myocarditis. Int J Cardiol 1996; 54: 171–175
   PubMedGoogle Scholar
• Cunningham MW. Pathogenesis of group A streptococcal infections. Clin Microbiol Rev 2000; 13: 470–511
   PubMed Web of Science ®Google Scholar
• Cunningham MW. Streptococcus-induced myocarditis in mice. Autoimmunity 2001; 34: 193–197
   PubMed Web of Science ®Google Scholar
• Cunningham MW. Autoimmunity and molecular mimicry in the pathogenesis of post-streptococcal heart disease. Front Biosci 2003; 8: s533–s543
   Web of Science ®Google Scholar
• Cunha-Neto E, Duranti M, Gruber A, Zingales B, de Messias I, Stolf N, Bellotti G, Patarroyo ME, Pilleggi F, Kalil J. Autoimmunity in Chagas' disease cardiomyopathy: Biological relevance of a cardiac myosin-specific epitope crossreactive to an immunodominant Trypanosoma cruzi antigen. Proc Natl Acad Sci USA 1995; 92: 3541–3545
   PubMed Web of Science ®Google Scholar
• Leon JS, Wang K, Engman DM. Myosin autoimmunity is not essential for cardiac inflammation in acute Chagas' disease. J Immunol 2003b; 171: 4271–4277
   PubMed Web of Science ®Google Scholar
• Giordanengo L, Maldonado C, Rivarola HW, Iosa D, Girones N, Fresno M, Gea S. Induction of antibodies reactive to cardiac myosin and development of heart alterations in cruzipain-immunized mice and their offspring. Eur J Immunol 2000a; 30: 3181–3189
   Google Scholar
• Oliveira M, Bijovsky A, Carvalho T, Souza W, Alves M, Colli W. A monoclonal antibody to Trypanosoma cruzi trypomastigotes recognizes a myosin tail epitope. Parasitol Res 2001; 87: 1043–1049
   Google Scholar
• Neu N, Klieber R, Fruhwirth M, Berger P. Cardiac myosin-induced myocarditis as a model of postinfectious autoimmunity. Eur Heart J 1991; 12(D)117–120
   Google Scholar
• Neu N, Pummerer C, Rieker T, Berger P. T cells in cardiac myosin-induced myocarditis. Clin Immunol Immunopathol 1993; 68: 107–110
   Google Scholar
• Wang Z, Liao Y, Dong J, Li S, Wang J, Tu Y. Myosin-induced autoimmune myocarditis in BALB/C mice. J Tongji Med Univ 1999; 19: 112–114
   Google Scholar
• Stull LB, DiIulio NA, Yu M, McTiernan CF, Ratliff NB, Tuohy VK, Moravec CS. Alterations in cardiac function and gene expression during autoimmune myocarditis in mice. J Mol Cell Cardiol 2000; 32: 2035–2049
   Google Scholar
• Kohno K, Takagaki Y, Aoyama N, Yokoyama H, Takehana H, Izumi T. A peptide fragment of beta cardiac myosin heavy chain (beta-CMHC) can provoke autoimmune myocarditis as well as the corresponding alpha cardiac myosin heavy chain (alpha-CMHC) fragment. Autoimmunity 2001; 34: 177–185
   PubMed Web of Science ®Google Scholar
• Godsel LM, Wang K, Schodin BA, Leon JS, Miller SD, Engman DM. Prevention of autoimmune myocarditis through the induction of antigen-specific peripheral immune tolerance. Circulation 2001; 103: 1709–1714
   PubMed Web of Science ®Google Scholar
• Cihakova D, Sharma RB, Fairweather D, Afanasyeva M, Rose NR. Animal models for autoimmune myocarditis and autoimmune thyroiditis. Methods Mol Med 2004; 102: 175–193
   Google Scholar
• Giordanengo L, Fretes R, Diaz H, Cano R, Bacile A, Vottero-Cima E, Gea S. Cruzipain induces autoimmune response against skeletal muscle and tissue damage in mice. Muscle Nerve 2000b; 23: 1407–1413
   Google Scholar
• Sterin-Borda L, Giordanengo L, Joensen L, Gea S. Cruzipain induces autoantibodies against cardiac muscarinic acetylcholine receptors. Functional and pathological implications. Eur J Immunol 2003; 33: 2459–2468
   Google Scholar
• Leon JS, Daniels MD, Toriello KM, Wang K, Engman DM. A cardiac myosin-specific autoimmune response is induced by immunization with Trypanosoma cruzi proteins. Infect Immun 2004; 72: 3410–3417
   PubMed Web of Science ®Google Scholar
• Koberle F. Chagas' disease and Chagas' syndromes: The pathology of American trypanosomiasis. Adv Parasitol 1968; 6: 63–116
   PubMedGoogle Scholar
• Ribeiro dos Santos R, Marquez JO, Von Gal Furtado CC, Ramos de Oliveira JC, Martins AR, Koberle F. Antibodies against neurons in chronic Chagas' disease. Tropenmed Parasitol 1979; 30: 19–23
   Google Scholar
• Junqueira JL, Beraldo PS, Chapadeiro E, Jesus PC. Cardiac autonomic dysfunction and neuroganglionitis in a rat model of chronic Chagas' disease. Cardiovasc Res 1992; 26: 324–329
   Google Scholar
• Marin-Neto JA, Bromberg-Marin G, Pazin-Filho A, Simoes MV, Maciel BC. Cardiac autonomic impairment and early myocardial damage involving the right ventricle are independent phenomena in Chagas' disease. Int J Cardiol 1998; 65: 261–269
   PubMed Web of Science ®Google Scholar
• Borda E, Pascual J, Cossio P, De LV, Arana R, Sterin-Borda L. A circulating IgG in Chagas' disease which binds to beta-adrenoceptors of myocardium and modulates their activity. Clin Exp Immunol 1984; 57: 679–686
   PubMedGoogle Scholar
• Pascual J, Borda E, Sterin-Borda L. Chagasic IgG modifies the activity of sarcolemmal ATPases through a beta adrenergic mechanism. Life Sci 1987; 40: 313–319
   Google Scholar
• Sterin-Borda L, Perez LC, Wald M, Cremaschi G, Borda E. Antibodies to beta 1 and beta 2 adrenoreceptors in Chagas' disease. Clin Exp Immunol 1988; 74: 349–354
   Google Scholar
• Sterin-Borda L, Gorelik G, Borda ES. Chagasic IgG binding with cardiac muscarinic cholinergic receptors modifies cholinergic-mediated cellular transmembrane signals. Clin Immunol Immunopathol 1991; 61: 387–397
   Google Scholar
• Goin JC, Borda E, Segovia A, Sterin-Borda L. Distribution of antibodies against beta-adrenoceptors in the course of human Trypanosoma cruzi infection. Proc Soc Exp Biol Med 1991; 197: 186–192
   Google Scholar
• Goin JC, Perez LC, Borda E, Sterin-Borda L. Modification of cholinergic-mediated cellular transmembrane signals by the interaction of human Chagasic IgG with cardiac muscarinic receptors. Neuroimmunomodulation 1994; 1: 284–291
   Google Scholar
• Goin JC, Borda E, Leiros CP, Storino R, Sterin-Borda L. Identification of antibodies with muscarinic cholinergic activity in human Chagas' disease: Pathological implications. J Auton Nerv Syst 1994; 47: 45–52
   Google Scholar
• Goin JC, Leiros CP, Borda E, Sterin-Borda L. Interaction of human Chagasic IgG with the second extracellular loop of the human heart muscarinic acetylcholine receptor: Functional and pathological implications. FASEB J 1997; 11: 77–83
   PubMed Web of Science ®Google Scholar
• Costa RP, Gollob KJ, Fonseca LL, Rocha MO, Chaves AC, Medrano-Mercado N, Araujo-Jorge TC, Antas PR, Colley DG, Correa-Oliveira R, Gazzinelli G, Carvalho-Parra J, Dutra WO. T-cellrepertoire analysis in acute and chronic human Chagas' disease: Differential frequencies of Vβ5 expressing T cells. Scand J Immunol 2000; 51: 511–519
   Google Scholar
• Kaplan D, Ferrari I, Bergami PL, Mahler E, Levitus G, Chiale P, Hoebeke J, Van Regenmortel MH, Levin MJ. Antibodies to ribosomal P proteins of Trypanosoma cruzi in Chagas disease possess functional autoreactivity with heart tissue and differ from anti-P autoantibodies in lupus. Proc Natl Acad Sci USA 1997; 94: 10301–10306
   PubMed Web of Science ®Google Scholar
• De OS, Pedrosa RC, Nascimento JH, Campos de Carvalho AC, Masuda MO. Sera from chronic Chagasic patients with complex cardiac arrhythmias depress electrogenesis and conduction in isolated rabbit hearts. Circulation 1997; 96: 2031–2037
   Google Scholar
• Jahns R, Boivin V, Siegmund C, Inselmann G, Lohse MJ, Boege F. Autoantibodies activating human beta1-adrenergic receptors are associated with reduced cardiac function in chronic heart failure. Circulation 1999; 99: 649–654
   PubMed Web of Science ®Google Scholar
• Chiale PA, Rosenbaum MB, Elizari MV, Hjalmarson A, Magnusson Y, Wallukat G, Hoebeke J. High prevalence of antibodies against beta 1- and beta 2-adrenoceptors in patients with primary electrical cardiac abnormalities. J Am Coll Cardiol 1995; 26: 864–869
   Google Scholar
• Girones N, Rodriguez CI, Carrasco-Marin E, Hernaez RF, de Rego JL, Fresno M. Dominant T-and B-cell epitopes in an autoantigen linked to Chagas' disease. J Clin Investig 2001; 107: 985–993
   PubMed Web of Science ®Google Scholar
• Girones N, Rodriguez CI, Basso B, Bellon JM, Resino S, Munoz-Fernandez MA, Gea S, Moretti E, Fresno M. Antibodies to an epitope from the Cha human autoantigen are markers of Chagas' disease. Clin Diagn Lab Immunol 2001; 8: 1039–1043
   PubMedGoogle Scholar
• Tibbetts RS, McCormick TS, Rowland EC, Miller SD, Engman DM. Cardiac antigen-specific autoantibody production is associated with cardiomyopathy in Trypanosoma cruzi-infected mice. J Immunol 1994; 152: 1493–1499
   PubMedGoogle Scholar
• McCormick TS, Rowland EC. Trypanosoma cruzi: Recognition of a 43-kDa muscle glycoprotein by autoantibodies present during murine infection. Exp Parasitol 1993; 77: 273–281
   Google Scholar
• Tekiel VS, Mirkin GA, Gonzalez Cappa SM. Chagas' disease: Reactivity against homologous tissues induced by different strains of Trypanosoma cruzi. Parasitology 1997; 115: 495–502
   PubMed Web of Science ®Google Scholar
• Gea S, Ordonez P, Cerban F, Iosa D, Chizzolini C, Vottero-Cima E. Chagas' disease cardioneuropathy: Association of anti-Trypanosoma cruzi and anti-sciatic nerve antibodies. Am J Trop Med Hyg 1993; 49: 581–588
   PubMed Web of Science ®Google Scholar
• Bach-Elias M, Bahia D, Teixeira DC, Cicarelli RM. Presence of autoantibodies against small nuclear ribonucleoprotein epitopes in Chagas' patients' sera. Parasitol Res 1998; 84: 796–799
   Google Scholar
• Bosetto MC, Peixoto MS, de Castro LI, Cicarelli RM. Presence of autoantibodies against HeLa small nuclear ribonucleoproteins in Chagasic and non-Chagasic cardiac patients. Braz J Med Biol Res 2004; 37: 37–45
   Google Scholar
• Giordanengo L, Gea S, Barbieri G, Rabinovich GA. Anti-galectin-1 autoantibodies in human Trypanosoma cruzi infection: Differential expression of this beta-galactoside-binding protein in cardiac Chagas' disease. Clin Exp Immunol 2001; 124: 266–273
   PubMedGoogle Scholar
• Aiello VD, Reis MM, Benvenuti LA, Higuchi ML, Ramires JA, Halperin JA. A possible role for complement in the pathogenesis of chronic Chagasic cardiomyopathy. J Pathol 2002; 197: 224–229
   Google Scholar
• de la Vega MT, Damilano G, Diez C. Leukocyte migration inhibition test with heart antigens in American trypanosomiasis. J Parasitol 1976; 62: 129–130
   Google Scholar
• Toledo BM, Amato NV, Mendes E, Mota I. In vitro cellular immunity in Chagas' disease. Clin Exp Immunol 1979; 38: 376–380
   Google Scholar
• Todd CW, Todd NR, Guimaraes AC. Do lymphocytes from Chagasic patients respond to heart antigens?. Infect Immun 1983; 40: 832–835
   Google Scholar
• Mosca W, Plaja J, Hubsch R, Cedillos R. Longitudinal study of immune response in human Chagas' disease. J Clin Microbiol 1985; 22: 438–441
   Google Scholar
• Teixeira AR, Teixeira G, Macedo V, Prata A. Trypanosoma cruzi-sensitized T-lymphocyte mediated 51CR release from human heart cells in Chagas' disease. Am J Trop Med Hyg 1978; 27: 1097–1107
   PubMed Web of Science ®Google Scholar
• Acosta AM, Sadigursky M, Santos-Buch CA. Anti-striated muscle antibody activity produced by Trypanosoma cruzi. Proc Soc Exp Biol Med 1983; 172: 364–369
   Google Scholar
• Santos-Buch CA, Acosta AM, Zweerink HJ, Sadigursky M, Andersen OF, von Kreuter BF, Brodskyn CI, Sadigursky C, Cody RJ. Primary muscle disease: Definition of a 25-kDa polypeptide myopathic specific Chagas antigen. Clin Immunol Immunopathol 1985; 37: 334–350
   PubMedGoogle Scholar
• Vermelho AB, de Meirelles MD, Pereira MC, Pohlentz G, Barreto-Bergter E. Heart muscle cells share common neutral glycosphingolipids with Trypanosoma cruzi. Acta Trop 1997; 64: 131–143
   PubMed Web of Science ®Google Scholar
• Kerner N, Liegeard P, Levin MJ, Hontebeyrie-Joskowicz M. Trypanosoma cruzi: Antibodies to a MAP-like protein in chronic Chagas' disease cross-react with mammalian cytoskeleton. Exp Parasitol 1991; 73: 451–459
   PubMedGoogle Scholar
• Bonfa V, Tavares AV, Regenmortel MV, Cosermelli W, Levin MT. The importance of one aminoacid substitution in the anti-P response in Chagas' disease. Mem Inst Oswaldo Cruz 1992; 87: 172
   Google Scholar
• Bonfa E, Viana VS, Barreto AC, Yoshinari NH, Cossermelli W. Autoantibodies in Chagas' disease. An antibody cross-reactive with human and Trypanosoma cruzi ribosomal proteins. J Immunol 1993; 150: 3917–3923
   PubMedGoogle Scholar
• Levin MJ, Mesri E, Benarous R, Levitus G, Schijman A, Levy-Yeyati P, Chiale PA, Ruiz AM, Khan A, Rosenbaum MB, Torres HN, Segura EL. Identification of major Trypanosoma cruzi antigenic determinants in chronic Chagas' heart disease. Am J Trop Med Hyg 1989; 41: 530–538
   PubMedGoogle Scholar
• Levitus G, Hontebeyrie-Joskowicz M, Van RM, Levin MJ. Humoral autoimmune response to ribosomal P proteins in chronic Chagas heart disease. Clin Exp Immunol 1991; 85: 413–417
   PubMed Web of Science ®Google Scholar
• Ferrari I, Levin MJ, Wallukat G, Elies R, Lebesgue D, Chiale P, Elizari M, Rosenbaum M, Hoebeke J. Molecular mimicry between the immunodominant ribosomal protein P0 of Trypanosoma cruzi and a functional epitope on the human beta 1- adrenergic receptor. J Exp Med 1995; 182: 59–65
   PubMed Web of Science ®Google Scholar
• Masuda MO, Levin M, De Oliveira SF, Dos Santos Costa PC, Bergami PL, Dos Santos Almeida NA, Pedrosa RC, FerrSari I, Hoebeke J, Campos de Carvalho AC. Functionally active cardiac antibodies in chronic Chagas' disease are specifically blocked by Trypanosoma cruzi antigens. FASEB J 1998; 12: 1551–1558
   Google Scholar
• Cunha-Neto E, Duranti M, Gruber A, Zingales B, De Messias I, Stolf N, Bellotti G, Patarroyo ME, Pilleggi F, Kalil J. Autoimmunity in Chagas disease cardiopathy: Biological relevance of a cardiac myosin-specific epitope crossreactive to an immunodominant Trypanosoma cruzi antigen. Proc Natl Acad Sci USA 1995; 92: 3541–3545
   PubMed Web of Science ®Google Scholar
• Gruber A, Zingales B. Trypanosoma cruzi: Characterization of two recombinant antigens with potential application in the diagnosis of Chagas' disease. Exp Parasitol 1993; 76: 1–12
   Google Scholar
• Abel LC, Kalil J, Cunha NE. Molecular mimicry between cardiac myosin and Trypanosoma cruzi antigen B13: Identification of a B13-driven human T cell clone that recognizes cardiac myosin. Braz J Med Biol Res 1997; 30: 1305–1308
   PubMedGoogle Scholar
• Abel LC, Iwai LK, Viviani W, Bilate AM, Fae KC, Ferreira RC, Goldberg AC, Juliano L, Juliano MA, Ianni B, Mady C, Gruber A, Hammer J, Sinigaglia F, Kalil J, Cunha-Neto E. T cell epitope characterization in tandemly repetitive Trypanosoma cruzi B13 protein. Microbes Infect 2005, in press
   Google Scholar
• Iwai LK, Juliano MA, Juliano L, Kalil J, Cunha-Neto E. T-cell molecular mimicry in Chagas disease: Identification and partial structural analysis of multiple cross-reactive epitopes between Trypanosoma cruzi B13 and cardiac myosin heavy chain. J Autoimmun 2005; 24: 111–117
   PubMedGoogle Scholar
• de Scheerder IK, de Buyzere ML, Delanghe JR, Clement DL, Wieme RJ. Anti-myosin humoral immune response following cardiac injury. Autoimmunity 1989; 4: 51–58
   PubMed Web of Science ®Google Scholar
• Nomura Y, Yoshinaga M, Haraguchi T, Oku S, Noda T, Miyata K, Umebayashi Y, Taira A. Relationship between the degree of injury at operation and the change in antimyosin antibody titer in the postpericardiotomy syndrome. Pediatr Cardiol 1994; 15: 116–120
   PubMed Web of Science ®Google Scholar
• Zinkernagel RM. Anti-infection immunity and autoimmunity. Ann NY Acad Sci 2002; 958: 3–6
   Google Scholar
• Tarleton RL. Parasite persistence in the aetiology of Chagas disease. Int J Parasitol 2001; 31: 550–554
   PubMed Web of Science ®Google Scholar
• Ablashi DV, Lapps W, Kaplan M, Whitman JE, Richert JR, Pearson GR. Human Herpesvirus-6 (HHV-6) infection in multiple sclerosis: A preliminary report. Mult Scler 1998; 4: 490–496
   PubMed Web of Science ®Google Scholar
• el-Zayadi AR, Selim OE, Hamdy H, Dabbous H, Ahdy A, Moniem SA. Association of chronic hepatitis C infection and diabetes mellitus. Trop Gastroenterol 1998; 19: 141–144
   PubMedGoogle Scholar
• Neumann DA, Lane JR, Allen GS, Herskowitz A, Rose NR. Viral myocarditis leading to cardiomyopathy: Do cytokines contribute to pathogenesis?. Clin Immunol Immunopathol 1993; 68: 181–190
   PubMedGoogle Scholar
• Cunha-Neto E, Moliterno R, Coelho V, Guilherme L, Bocchi E, Higuchi Mde L, Stolf N, Pileggi F, Steinman L, Kalil J. Restricted heterogeneity of T cell receptor variable alpha chain transcripts in hearts of Chagas' disease cardiomyopathy patients. Parasite Immunol 1994; 16: 171–179
   PubMedGoogle Scholar
• Rose NR, Bona C. Defining criteria for autoimmune diseases (Witebsky's postulates revisited). Immunol Today 1993; 14: 426–430
   PubMedGoogle Scholar
• Gattass CR, Lima MT, Nobrega AF, Barcinski MA, Dos Reis GA. Do self-heart-reactive T cells expand in Trypanosoma cruzi-immune hosts?. Infect Immun 1988; 56: 1402–1405
   Google Scholar
• Pontes-De-Carvalho L, Santana CC, Soares MB, Oliveira GG, Cunha-Neto E, Ribeiro-Dos-Santos R. Experimental chronic Chagas' disease myocarditis is an autoimmune disease preventable by induction of immunological tolerance to myocardial antigens. J Autoimmun 2002; 18: 131–138
   Google Scholar
• Mijares A, Verdot L, Peineau N, Vray B, Hoebeke J, Argibay J. Antibodies from Trypanosoma cruzi infected mice recognize the second extracellular loop of the beta 1-adrenergic and M2-muscarinic receptors and regulate calcium channels in isolated cardiomyocytes. Mol Cell Biochem 1996; 163–164, 107–112
   Google Scholar
• Mijares A, Lebesgue D, Argibay J, Hoebeke J. Anti-peptide antibodies sensitive to the 'active' state of the b2-adrenergic receptor. FEBS Lett 1996; 399: 188–191
   PubMed Web of Science ®Google Scholar
• Leiros CP, Sterin-Borda L, Borda ES, Goin JC, Hosey MM. Desensitization and sequestration of human M2 muscarinic acetylcholine receptors by autoantibodies from patients with Chagas' disease. J Biol Chem 1997; 272: 12989–12993
   Google Scholar
• Sterin-Borda L, Goin JC, Bilder CR, Iantorno G, Hernando AC, Borda E. Interaction of human Chagasic IgG with human colon muscarinic acetylcholine receptor: Molecular and functional evidence. Gut 2001; 49: 699–705
   Google Scholar
• Hernandez CC, Barcellos LC, Gimenez LE, Cabarcas RA, Garcia S, Pedrosa RC, Nascimento JH, Kurtenbach E, Masuda MO, Campos de Carvalho AC. Human Chagasic IgGs bind to cardiac muscarinic receptors and impair L-type Ca2+ currents. Cardiovasc Res 2003; 58: 55–65
   PubMed Web of Science ®Google Scholar
• Santos-Buch CA, Teixeira AR. The immunology of experimental Chagas' disease 3. Rejection of allogeneic heart cells in vitro. J Exp Med 1974; 140: 38–53
   Google Scholar
• Snary D, Flint JE, Wood JN, Scott MT, Chapman MD, Dodd J, Jessell TM, Miles MA. A monoclonal antibody with specificity for Trypanosoma cruzi, central and peripheral neurones and glia. Clin Exp Immunol 1983; 54: 617–624
   Google Scholar
• Wood JN, Hudson L, Jessell TM, Yamamoto M. A monoclonal antibody defining antigenic determinants on subpopulations of mammalian neurones and Trypanosoma cruzi parasites. Nature 1982; 296: 34–38
   PubMedGoogle Scholar
• Petry K, Voisin P, Baltz T. Complex lipids as common antigens to Trypanosoma cruzi, T. dionisii, T. vespertilionis and nervous tissue (astrocytes, neurons). Acta Trop 1987; 44: 381–386
   Google Scholar
• Petry K, Eisen H. Chagas disease: A model for the study of autoimmune diseases. Parasitol Today 1989; 5: 111–115
   PubMedGoogle Scholar
• Petry K, Voisin P, Baltz T, Labouesse J. Epitopes common to trypanosomes (T. cruzi, T. dionisii and T. vespertilionis (Schizotrypanum)): Astrocytes and neurons. J Neuroimmunol 1987; 16: 237–252
   Google Scholar
• Petry K, Eisen H. Chemical characterization of epitopes common to Trypanosoma cruzi and mammalian nervous cells. Mem Inst Oswaldo Cruz 1988; 83(1)498–501
   Google Scholar
• McCormick TS, Rowland EC. Trypanosoma cruzi: Cross-reactive anti-heart autoantibodies produced during infection in mice. Exp Parasitol 1989; 69: 393–401
   Google Scholar
• Laucella SA, Velazquez E, Dasso M, de Titto E. Trypanosoma cruzi and mammalian heart cross-reactive antigens. Acta Trop 1996; 61: 223–238
   Google Scholar
• Laucella SA, de Titto EH, Segura EL. Epitopes common to Trypanosoma cruzi and mammalian tissues are recognized by sera from Chagas' disease patients: Prognosis value in Chagas disease. Acta Trop 1996; 62: 151–162
   PubMedGoogle Scholar
• Giordanengo L, Guinazu N, Stempin C, Fretes R, Cerban F, Gea S. Cruzipain, a major Trypanosoma cruzi antigen, conditions the host immune response in favor of parasite. Eur J Immunol 2002; 32: 1003–1011
   Web of Science ®Google Scholar
• Oliveira MF, Bijovsky AT, Carvalho TU, de Souza W, Alves MJ, Colli W. A monoclonal antibody to Trypanosoma cruzi trypomastigotes recognizes a myosin tail epitope. Parasitol Res 2001; 87: 1043–1049
   Google Scholar
• Zwirner NW, Malchiodi EL, Chiaramonte MG, Fossati CA. A lytic monoclonal antibody to Trypanosoma cruzi bloodstream trypomastigotes which recognizes an epitope expressed in tissues affected in Chagas' disease. Infect Immun 1994; 62: 2483–2489
   Google Scholar
• Vermelho AB, de Meirelles MD, Pereira MC, Pohlentz G, Barreto-Bergter E. Heart muscle cells share common neutral glycosphingolipids with Trypanosoma cruzi. Acta Trop 1997; 64: 131–143
   PubMed Web of Science ®Google Scholar
• Kerner N, Liegeard P, Levin MJ, Hontebeyrie-Joskowicz M. Trypanosoma cruzi: Antibodies to a MAP-like protein in chronic Chagas' disease cross-react with mammalian cytoskeleton. Exp Parasitol 1991; 73: 451–459
   PubMedGoogle Scholar
• Al-Sabbagh A, Garcia CA, Diaz-Bardales BM, Zaccarias C, Sakurada JK, Santos LM. Evidence for cross-reactivity between antigen derived from Trypanosoma cruzi and myelin basic protein in experimental Chagas disease. Exp Parasitol 1998; 89: 304–311
   Google Scholar
• Hernandez-Munain C, De DJ, Alcina A, Fresno M. A Trypanosoma cruzi membrane protein shares an epitope with a lymphocyte activation antigen and induces crossreactive antibodies. J Exp Med 1992; 175: 1473–1482
   Google Scholar
• Van Voorhis WC, Eisen H. Fl-160. A surface antigen of Trypanosoma cruzi that mimics mammalian nervous tissue. J Exp Med 1989; 169: 641–652
   PubMed Web of Science ®Google Scholar
• Van Voorhis WC, Schlekewy L, Trong HL. Molecular mimicry by Trypanosoma cruzi: The F1-160 epitope that mimics mammalian nerve can be mapped to a 12-amino acid peptide. Proc Natl Acad Sci USA 1991; 88: 5993–5997
   PubMed Web of Science ®Google Scholar
• Van Voorhis WC, Barrett L, Koelling R, Farr AG. FL-160 proteins of Trypanosoma cruzi are expressed from a multigene family and contain two distinct epitopes that mimic nervous tissues. J Exp Med 1993; 178: 681–694
   PubMed Web of Science ®Google Scholar
• Bergami PL, Scaglione J, Levin M. Antigen against the carboxyl-terminal of the Trypanosoma cruzi ribosomal P proteins are pathogenic. FASEB J 2001; 5: 2602–2612
   Google Scholar
• Lopez Bergami P, Cabeza Meckert P, Kaplan D, Levitus G, Elias F, Quintana F, Van Regenmortel M, Laguens R, Levin MJ. Immunization with recombinant Trypanosoma cruzi ribosomal P2beta protein induces changes in the electrocardiogram of immunized mice. FEMS Immunol Med Microbiol 1997; 18: 75–85
   PubMedGoogle Scholar
• Mahler E, Sepulveda P, Jeannequin O, Liegeard P, Gounon P, Wallukat G, Eftekhari P, Levin MJ, Hoebeke J, Hontebeyrie M. A monoclonal antibody against the immunodominant epitope of the ribosomal P2beta protein of Trypanosoma cruzi interacts with the human beta 1-adrenergic receptor. Eur J Immunol 2001; 31: 2210–2216
   Google Scholar
• Ferrari I, Lorenzi H, Santos MR, Brandariz S, Requena JM, Schijman A, Vázquez M, da Silveira JF, Ben-Dov C, Medrano C, Ghío S, SLópez Bergami P, Cano I, Zingales B, Urmenyi TP, Rondinelli E, González A, Cortes A, Lopez MC, Thomas MC, Alonso C, et al. Towards the physical map of the Trypanosoma cruzi nuclear genome: Construction of YAC and BAC libraries of the reference clone T. cruzi CL-Brener. Mem Inst Oswaldo Cruz 1997; 92: 843–852
   Web of Science ®Google Scholar
• Cremaschi G, Zwirner NW, Gorelik G, Malchiodi EL, Chiaramonte MG, Fossati CA, Sterin-Borda L. Modulation of cardiac physiology by an anti-Trypanosoma cruzi monoclonal antibody after interaction with myocardium. FASEB J 1995; 9: 1482–1488
   Google Scholar
• Motran CC, Cerban FM, Rivarola W, Iosa D, Vottero DC. Trypanosoma cruzi: Immune response and functional heart damage induced in mice by the main linear B-cell epitope of parasite ribosomal P proteins. Exp Parasitol 1998; 88: 223–230
   Google Scholar