Different islet protein expression profiles during spontaneous diabetes development vs. allograft rejection in BB-DP rats

References

• Nerup J, Mandrup-Poulsen T, Helqvist S, Andersen HU, Pociot F, Reimers JI, Cuartero BG, Karlsen AE, Bjerre U, Lorenzen T. On the pathogenesis of IDDM. Diabetologia 1994; 37(Suppl 2)S82–S89
   PubMedGoogle Scholar
• O'Reilly LA, Hutchings PR, Crocker PR, Simpson E, Lund T, Kioussis D, Takei F, Baird J, Cooke A. Characterization of pancreatic islet cell infiltrates in NOD mice: Effect of cell transfer and transgene expression. Eur J Immunol 1991; 21: 1171–1180
   PubMed Web of Science ®Google Scholar
• Mandrup-Poulsen T. The role of interleukin-1 in the pathogenesis of insulin-dependent diabetes mellitus. Diabetologia 1996; 39: 1005–1029
   PubMed Web of Science ®Google Scholar
• Rabinovitch A. An update on cytokines in the pathogenesis of insulin-dependent diabetes mellitus. Diabetes Metab Rev 1998; 14: 129–151
   PubMed Web of Science ®Google Scholar
• Southern C, Schulster D, Green IC. Inhibition of insulin secretion by interleukin-1 beta and tumour necrosis factor-alpha via an l-arginine-dependent nitric oxide generating mechanism. FEBS Lett 1990; 276: 42–44
   PubMed Web of Science ®Google Scholar
• Eizirik DL, Flodström M, Karlsen AE, Welsh N. The harmony of the spheres: Inducible nitric oxide synthase and related genes in pancreatic beta cells. Diabetologia 1996; 39: 875–890
   PubMed Web of Science ®Google Scholar
• Hutchinson IV. Cellular mechanisms of allograft rejection. Curr Opin Immunol 1991; 3: 722–728
   PubMed Web of Science ®Google Scholar
• Kovarik J, Koulmanda M, Mandel TE. Expression of both Th1 and Th2 cytokines correlates with the histological rejection of MHC-matched and MHC-mismatched foetal pancreas allografts in mice. Immunol Cell Biol 1997; 75: 303–309
   PubMed Web of Science ®Google Scholar
• Korsgren O, Jansson L. Characterization of mixed syngeneic–allogeneic and syngeneic–xenogeneic islet-graft rejections in mice. Evidence of functional impairment of the remaining syngeneic islets in xenograft rejections. J Clin Invest 1994; 93: 1113–1119
   PubMed Web of Science ®Google Scholar
• Karlsen AE, Sparre T, Nielsen K, Nerup J, Pociot F. Proteome analysis—a novel approach to understand the pathogenesis of Type 1 diabetes mellitus. Dis Markers 2001; 17: 205–216
   PubMed Web of Science ®Google Scholar
• Andersen HU, Larsen PM, Fey SJ, Karlsen AE, Mandrup-Poulsen T, Nerup J. Two-dimensional gel electrophoresis of rat islet proteins. Interleukin 1 beta-induced changes in protein expression are reduced by l-arginine depletion and nicotinamide. Diabetes 1995; 44: 400–407
   PubMed Web of Science ®Google Scholar
• Christensen UB, Larsen PM, Fey SJ, Andersen HU, Nawrocki A, Sparre T, Mandrup-Poulsen T, Nerup J. Islet protein expression changes during diabetes development in islet syngrafts in BB-DP rats and during rejection of BB-DP islet allografts. Autoimmunity 2000; 32: 1–15
   PubMed Web of Science ®Google Scholar
• Mose Larsen P, Fey SJ, Larsen MR, Nawrocki A, Andersen HU, Kähler H, Heilmann MCV, Roepstorff P, Pociot F, Karlsen AE, Nerup J. Proteome analysis of IL-1β induced changes in protein expression in rat islets of Langerhans. Diabetes 2001; 50: 1056–1063
   PubMed Web of Science ®Google Scholar
• Sparre T, Christensen UB, Larsen PM, Fey SJ, Wrzesinski K, Roepstorff P, Mandrup-Poulsen T, Pociot F, Karlsen AE, Nerup J. IL-1β induced protein changes in diabetes prone BB rat islets of Langerhans identified by proteome analysis. Diabetologia 2002; 45: 1550–1561
   PubMed Web of Science ®Google Scholar
• Sparre T, Christensen UB, Gotfredsen CF, Larsen PM, Fey SJ, Hjerno K, Roepstorff P, Pociot F, Karlsen AE, Nerup J. Changes in expression of IL-1 beta influenced proteins in transplanted islets during development of diabetes in diabetes-prone BB rats. Diabetologia 2004; 47: 892–908
   PubMed Web of Science ®Google Scholar
• Davalli AM, Scaglia L, Zangen DH, Hollister J, Bonner-Weir S, Weir GC. Vulnerability of islets in the immediate posttransplantation period. Dynamic changes in structure and function. Diabetes 1996; 45: 1161–1167
   PubMed Web of Science ®Google Scholar
• Christensen U, Sparre T, Cooke A, Andersen H, Mandrup-Poulsen T, Nerup J. Syngeneic islet transplantation in prediabetic BB-DP rats-a synchronized model for studying beta-cell destruction during the development of IDDM. Autoimmunity 1998; 28: 91–107
   PubMed Web of Science ®Google Scholar
• Brunstedt J, Nielsen JH, Lernmark Å. The Hagedorn study group isolation of islets from mice and rats. Methods in diabetes research, (Laboratory methods, part C), J Larner, SL Pohl. Wiley & Sons, New York 1984; 1: 254–288
   Google Scholar
• Weringer EJ, Like AA. Identification of T cell subsets and class I and class II antigen expression in islet grafts and pancreatic islets of diabetic BioBreeding/Worcester rats. Am J Pathol 1988; 132: 292–303
   PubMed Web of Science ®Google Scholar
• Korsgren O, Jansson L, Sandler S, Andersson A. Hyperglycemia-induced B cell toxicity. The fate of pancreatic islets transplanted into diabetic mice is dependent on their genetic background. J Clin Invest 1990; 86: 2161–2168
   PubMed Web of Science ®Google Scholar
• O'Farrell PZ, Goodman HM, O'Farrell PH. High resolution two dimentional electrophoresis of basic as well as acidic proteins. Cell 1977; 12: 1133–1142
   PubMed Web of Science ®Google Scholar
• Fey SJ, Nawrocki A, Larsen MR, Gorg A, Roepstorff P, Skews GN, Williams R, Larsen PM. Proteome analysis of Saccharomyces cerevisiae: A methodological outline. Electrophoresis 1997; 18: 1361–1372
   PubMed Web of Science ®Google Scholar
• Bloomgarden ZT. Transplantation and islet topics. Diabetes Care 2005; 28: 213–219
   PubMed Web of Science ®Google Scholar
• Abdi R, Means TK, Luster AD. Chemokines in islet allograft rejection. Diabetes Metab Res Rev 2003; 19: 186–190
   PubMed Web of Science ®Google Scholar
• Cameron MJ, Arreaza GA, Grattan M, Meagher C, Sharif S, Burdick MD, Strieter RM, Cook DN, Delovitch TL. Differential expression of CC chemokines and the CCR5 receptor in the pancreas is associated with progression to type I diabetes. J Immunol 2000; 165: 1102–1110
   PubMed Web of Science ®Google Scholar
• Rabinovitch A, Suarez-Pinzon W, El-Sheikh A, Sorensen O, Power RF. Cytokine gene expression in pancreatic islet-infiltrating leukocytes of BB rats: Expression of Th1 cytokines correlates with beta-cell destructive insulitis and IDDM. Diabetes 1996; 45: 749–754
   PubMed Web of Science ®Google Scholar
• Andersen HU, Fey SJ, Mose Larsen P, Nawrocki A, Hejnæs KR, Mandrup-Poulsen T, Nerup J. Interleukin-1beta induced changes in the protein expression of rat islets: A computerized database. Electrophoresis 1997; 18: 2091–2103
   PubMed Web of Science ®Google Scholar
• Wallgren AC, Karlsson-Parra A, Korsgren O. The main infiltrating cell in xenograft rejection is a CD4+ macrophage and not a T lymphocyte. Transplantation 1995; 60: 594–601
   PubMed Web of Science ®Google Scholar