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Original

Subtle differences in HLA DQ haplotype-associated presentation of AChR α-chain peptides may suffice to mediate myasthenia gravis

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Pages 277-288 | Accepted 05 Apr 2006, Published online: 07 Jul 2009

References

  • Appel SH, Almon RR, Levy N. Acetylcholine receptor antibodies in myasthenia gravis. N Engl J Med 1975; 293: 760–761
  • Lindstrom JM, Seybold ME, Lennon VA, Whittingham S, Duane DD. Antibody to acetylcholine receptor in myasthenia gravis. Prevalence, clinical correlates, and diagnostic value. Neurology 1976; 26: 1054–1059
  • Vincent A. Unravelling the pathogenesis of myasthenia gravis. Nat Rev Immunol 2002; 2: 797–804
  • Hohlfeld R, Toyka KV, Tzartoss SJ, Carson W, Conti-Tronconi B. Human T-helper lymphocytes in myasthenia gravis recognize the nicotinic receptor α subunit. Proc Natl Acad Sci USA 1987; 84: 5379–5383
  • Ofosu-Appiah W, Mokhtarian F, Shirazian D, Grob D. Production of anti-acetylcholine receptor-α antibody in vitro by peripheral blood lymphocytes of patients with myasthenia gravis: Role of immunoregulatory T cells and monocytes. J Lab Clin Med 1994; 124: 231–241
  • Rosenberg JS, Oshima M, Atassi MZ. B-cell activation in vitro by helper T cells specific to region α146–162 of Torpedo californica nicotinic acetylcholine receptor. J Immunol 1996; 157: 3192–3199
  • Yokoi T, Mulac-Jericevic B, Kurisaki J, Atassi MZ. T lymphocyte recognition of acetylcholine receptor: Localization of the full T-cell recognition profile on the extracellular part of the α chain of Torpedo californica acetylcholine receptor. Eur J Immunol 1987; 17: 1697–1702
  • Oshima M, Ashizawa T, Pollack MS, Atassi MZ. Autoimmune T cell recognition of human acetylcholine receptor: The sites of T cell recognition in myasthenia gravis on the extracellular part of the α subunit. Eur J Immunol 1990; 20: 2563–2569
  • Kanai T, Nomura Y, Segawa M, Takagi K, Senju S, Matsushita S, Nishimura Y. Immuno-suppressive peptides for a human T cell clone autoreactive to a unique acetylcholine receptor alpha subunit peptide presented by the disease-susceptible HLA-DQ6 in infant-onset myasthenia gravis. Hum Immunol 1997; 56: 28–38
  • Wang Z-Y, Diethelm-Okita B, Okita DK, Kaminski HJ, Howard JF, Conti-fine B. T cell recognition of muscle acetylcholine receptor in ocular myasthenia gravis. J Neuroimmunol 2000; 108: 29–39
  • Oshima M, Deitiker PR, Mosier DR, Smith RG, Atassi MZ. Responses in vitro of peripheral blood lymphocytes from patients with myasthenia gravis to stimulation with human AChR α-chain peptides: Analysis in relation to age, thymic abnormality and ethnicity. Hum Immunol 2005; 66: 32–42
  • Zhang Y, Schleup M, Frutiger S, Hughes GJ, Jeannet M, Steck A, Barkas T. Immunological heterogeneity of autoreactive T lymphocytes against the nicotinic acetylcholine receptor in myasthenia patients. Eur J Immunol 1990; 20: 2577–2583
  • Nagvekar N, Corlett L, Jacobson LW, Matsuo H, Chalkley R, Driscoll PC, Deshpande S, Spack EG, Willcox N. Scanning a DRB3*0101 (DR52a)-restricted epitope cross-presented by DR3: Overlapping natural and artificial determinants in the human acetylcholine receptor. J Immunol 1999; 162: 4079–4087
  • Berrih-Aknin S, Cohen-Kaminsky S, Lepage V, Neumann D, Bach JF, Fuchs S. T-cell antigenic sites involved in myasthenia gravis: Correlation with antibody titre and disease severity. J Autoimmun 1991; 4: 137–153
  • Nishimura Y, Kanai T, Oiso M, Tabata H, Ito H, Kira J, Chen Y-Z, Matsushita S. Molecular analysis of HLA class II-associated susceptibility to subtypes of autoimmune diseases unique to Asians. Int J Cardiol 1998; 1(66 Suppl)S93–104
  • Manfredi AA, Yuen MH, Moiola L, Protti MP, Conti-Tronconi BM. Human acetylcholine receptor presentation in myasthenia gravis. DR restriction of autoimmune T epitopes and binding of synthetic receptor sequences to DR molecules. J Immunol 1994; 152: 4165–4174
  • Horiki T, Inoko H, Moriuchi J, Ichikawa Y, Arimori S. Combinations of HLA-DPB1 and HLA-DQB1 alleles determine susceptibility to early-onset myasthenia gravis in Japan. Autoimmunity 1994; 19: 49–54
  • Shinomiya N, Nomura Y, Segawa M. A variant of childhood-onset myasthenia gravis: HLA typing and clinical characteristics in Japan. Clin Immunol 2004; 110: 154–158
  • Garchon HJ. Genetics of autoimmune myasthenia gravis, a model for antibody-mediated autoimmunity in man. J Autoimmun 2003; 21: 105–110
  • Matsuki K, Juji T, Tokunaga K, Takamizawa M, Maeda H, Soda M, Nomura Y, Segawa M. HLA antigens in Japanese patients with myasthenia gravis. J Clin Invest 1990; 86: 392–399
  • Khalil I, Berrih-Aknin S, Lepage V, Loste MN, Gajdos P, Hors J, Charron D, Degos L. Trans-encoded DQ alpha beta heterodimers confer susceptibility to myasthenia gravis disease. C R Acad Sci III 1993; 316: 652–660
  • Hjelmstrom P, Giscombe R, Lefvert AK, Pirskanen R, Kockum I, Landin-Olsson M, Sanjeevi CB. Different HLA-DQ are positively and negatively associated in Swedish patients with myasthenia gravis. Autoimmunity 1995; 22: 59–65
  • Vieira ML, Caillat-Zucman S, Gajdos P, Cohen-Kaminsky S, Casteur A, Bach J-F. Identification by genomic typing of non-DR3 HLA class II genes associated with myasthenia gravis. J Neuroimmunol 1993; 47: 115–122
  • Baggi F, Antozzi C, Andreetta F, Confaloniri P, Ciusani E, Begovich AB, Erlich HA, Cornelio A, Mantegazza R. Identification of a novel HLA class II association with DQB1*0502 in an Italian myasthenic population. Ann NY Acad Sci 1998; 841: 355–359
  • Hjelmstrom P, Giscombe R, Lefvert AK, Pirskanen R, Kockum I, Landin-Olsson M, Sanjeevi CB. Polymorphic amino acid domains of the HLA-DQ molecules are associated with disease heterogeneity in myasthenia gravis. J Neuroimmunol 1996; 65: 125–131
  • Suzuki S, Kuwana M, Yasuoka H, Tanaka K, Fukuuchi Y, Kawakami Y. Heterogeneous immunogenetic background in Japanese adults with myasthenia gravis. J Neurol Sci 2001; 189: 59–64
  • Pera C, Delfino L, Longo A, Pistillo MP, Ferrara GB. Novel associations among HLA-DQA1 and -DQB1 alleles, revealed by high-resolution sequence-based typing (SBT). Tissue Antigens 2000; 55: 275–279
  • Oshima M, Ohtani M, Deitiker PR, Smith RG, Mosier DR, Atassi MZ. Suppression by mAbs against DQB1 peptides of in vitro proliferation of AChR-specific T cells from myasthenia gravis patients. Autoimmunity 2005; 38: 161–169
  • Olerup O, Aldener A, Fogdell A. HLA-DQB1 and -DQA1 typing by PCR amplification with sequence-specific primers (PCR-SSP) in 2 hours. Tissue Antigens 1993; 41: 119–134
  • Zar JH. Biostatistical Analysis3rd ed. Prentice Hall, Englewood Cliffs, NJ 1996
  • Imanishi T, Akaza T, Kimura A, Tokunaga K, Gojobori T. Allele and haplotype frequencies for HLA and complement loci in various ethnic groups. HLA 1991, K Tsuji, M Aizawa, M Sasazuki. Proceedings of the Eleventh International Histocompatibility Workshop and Conference, Oxford Science Publications, Oxford 1992; 1: 1065–1220
  • Tsuneto LT, Probst CM, Hutz MH, Salzano FM, Rodriguez-Delfin LA, Zago MA, Hill K, Hurtado AM, Ribeiro-dod-Santos AKC, Petzl-Erler ML. HLA class II diversity in seven Amerindian populations. Clues about the origins of the Ache. Tissue Antigens 2003; 62: 512–526
  • Gorodezky C, Alaez C, Vazquez-Garcia MN, de la Rosa G, Infante E, Balladares S, Toribio R, Perez-Luque E, Munoz L. The genetic structure of Mexican Mestizos of different locations: Tracking back their origins through MHC genes, blood group systems, and microsatellites. Hum Immunol 2001; 62: 979–991
  • Hollenbach JA, Thomson G, Cao K, Fernandez-Vina M, Erlich HA, Bugawan TL, Winkler C, Winter M, Klitz W. HLA diversity, differentiation, and haplotype evolution in Mesoamerican natives. Hum Immunol 2001; 6: 378–390
  • Alaez C, Infante E, Pujol J, Duran C, Navarro JL, Gorodezky C. Molecular analysis of HLA-DRB1, DQA1, DQB1, DQ promoter polymorphism and extended class I/class II haplotypes in the Seri Indians from Northwest Mexico. Tissue Antigens 2002; 59: 388–396
  • Shenoy M, Oshima M, Atassi MZ, Christadoss P. Suppression of experimental autoimmune myasthenia gravis by epitope-specific neonatal tolerance to synthetic region α146–162 of acetylcholine receptor. Clin Immunol Immunopathol 1993; 66: 230–238
  • Oshima M, Pachner AR, Atassi MZ. Profile of the regions of acetylcholine receptor α chain recognized by T-lymphocytes and by antibodies in EAMG-susceptible and non-susceptible mouse strains after different periods of immunization with the receptor. Mol Immunol 1994; 31: 833–843
  • Noda M, Furutani Y, Takahashi H, Toyosato M, Tanabe T, Shimizu S, Kikyotani S, Kayano T, Hirose T, Inayama S, Numa S. Cloning and sequence analysis of calf cDNA and human genomic DNA encoding α-subunit precursor of muscle acetylcholine receptor. Nature 1983; 305: 818–823

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