Mice deficient in PKC theta demonstrate impaired in vivo T cell activation and protection from T cell-mediated inflammatory diseases

References

• Osada S, Mizuno K, Saido TC, Suzuki K, Kuroki T, Ohno S. A new member of the protein kinase C family, nPKC theta, predominantly expressed in skeletal muscle. Mol Cell Biol 1992; 12: 3930–3938
   PubMed Web of Science ®Google Scholar
• Baier G, Telford D, Giampa L, Coggeshall KM, Baier-Bitterlich G, Isakov N, Altman A. Molecular cloning and characterization of PKC theta, a novel member of the protein kinase C (PKC) gene family expressed predominantly in hematopoietic cells. J Biol Chem 1993; 268: 4997–5004
   PubMed Web of Science ®Google Scholar
• Arendt CW, Albrecht B, Soos TJ, Littman DR. Protein kinase C-theta; Signaling from the center of the T-cell synapse. Curr Opin Immunol 2002; 14: 323–330
   Google Scholar
• Isakov N, Altman A. Protein kinase C(theta) in T cell activation. Annu Rev Immunol 2002; 20: 761–794
   PubMed Web of Science ®Google Scholar
• Altman A, Villalba M. Protein kinase C-theta (PKCtheta): It's all about location, location, location. Immunol Rev 2003; 192: 53–63
   PubMed Web of Science ®Google Scholar
• Pfeifhofer C, Kofler K, Gruber T, Tabrizi NG, Lutz C, Maly K, Leitges M, Baier G. Protein kinase C theta affects Ca2+ mobilization and NFAT cell activation in primary mouse T cells. J Exp Med 2003; 197: 1525–1535
   PubMed Web of Science ®Google Scholar
• Sun Z, Arendt CW, Ellmeier W, Schaeffer EM, Sunshine MJ, Gandhi L, Annes J, Petrzilka D, Kupfer A, Schwartzberg PL, Littman DR. PKC-theta is required for TCR-induced NF-kappaB activation in mature but not immature T lymphocytes. Nature 2000; 404: 402–407
   PubMed Web of Science ®Google Scholar
• Salek-Ardakani S, So T, Halteman BS, Altman A, Croft M. Differential regulation of Th2 and Th1 lung inflammatory responses by protein kinase C theta. J Immunol 2004; 173: 6440–6447
   PubMed Web of Science ®Google Scholar
• Marsland BJ, Soos TJ, Spath G, Littman DR, Kopf M. Protein kinase C theta is critical for the development of in vivo T helper (Th)2 cell but not Th1 cell responses. J Exp Med 2004; 200: 181–189
   PubMed Web of Science ®Google Scholar
• Osborn L, Kunkel S, Nabel GJ. Tumor necrosis factor alpha and interleukin 1 stimulate the human immunodeficiency virus enhancer by activation of the nuclear factor kappa B. Proc Natl Acad Sci USA 1989; 86: 2336–2340
   PubMed Web of Science ®Google Scholar
• Dignam JD, Lebovitz RM, Roeder RG. Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res 1983; 11: 1475–1489
   PubMed Web of Science ®Google Scholar
• Picarella D, Hurlbut P, Rottman J, Shi X, Butcher E, Ringler DJ. Monoclonal antibodies specific for beta 7 integrin and mucosal addressin cell adhesion molecule-1 (MAdCAM-1) reduce inflammation in the colon of scid mice reconstituted with CD45RBhigh CD4+ T cells. J Immunol 1997; 158: 2099–2106
   PubMed Web of Science ®Google Scholar
• Granelli-Piperno A. Lymphokine gene expression in vivo is inhibited by cyclosporin A. J Exp Med 1990; 171: 533–544
   PubMed Web of Science ®Google Scholar
• Granelli-Piperno A, Andrus L, Reich E. Antibodies to interleukin 2. Effects on immune responses in vitro and in vivo. J Exp Med 1984; 160: 738–750
   Google Scholar
• Powrie F, Correa-Oliveira R, Mauze S, Coffman RL. Regulatory interactions between CD45RBhigh and CD45RBlow CD4+ T cells are important for the balance between protective and pathogenic cell-mediated immunity. J Exp Med 1994; 179: 589–600
   PubMed Web of Science ®Google Scholar
• Powrie F, Coffman RL, Correa-Oliveira R. Transfer of CD4+ T cells to C.B-17 SCID mice: A model to study Th1 and Th2 cell differentiation and regulation in vivo. Res Immunol 1994; 145: 347–353
   Google Scholar
• Powrie F, Leach MW, Mauze S, Menon S, Caddle LB, Coffman RL. Inhibition of Th1 responses prevents inflammatory bowel disease in scid mice reconstituted with CD45RBhi CD4+ T cells. Immunity 1994; 1: 553–562
   PubMed Web of Science ®Google Scholar
• Zhao ML, Fritz RB. Acute and relapsing experimental autoimmune encephalomyelitis in IL-4- and alpha/beta T cell-deficient C57BL/6 mice. J Neuroimmunol 1998; 87: 171–178
   PubMed Web of Science ®Google Scholar
• Juedes AE, Hjelmstrom P, Bergman CM, Neild AL, Ruddle NH. Kinetics and cellular origin of cytokines in the central nervous system: Insight into mechanisms of myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis. J Immunol 2000; 164: 419–426
   Google Scholar
• Morrissey PJ, Charrier K. Induction of wasting disease in SCID mice by the transfer of normal CD4+/CD45RBhi T cells and the regulation of this autoreactivity by CD4+/CD45RBlo T cells. Res Immunol 1994; 145: 357–362
   PubMedGoogle Scholar
• Aranda R, Sydora BC, McAllister PL, Binder SW, Yang HY, Targan SR, Kronenberg M. Analysis of intestinal lymphocytes in mouse colitis mediated by transfer of CD4+, CD45RBhigh T cells to SCID recipients. J Immunol 1997; 158: 3464–3473
   PubMed Web of Science ®Google Scholar
• Claesson MH, Bregenholt S, Bonhagen K, Thoma S, Moller P, Grusby MJ, Leithauser F, Nissen MH, Reimann J. Colitis-inducing potency of CD4+ T cells in immunodeficient, adoptive hosts depends on their state of activation, IL-12 responsiveness, and CD45RB surface phenotype. J Immunol 1999; 162: 3702–3710
   PubMed Web of Science ®Google Scholar
• Bernard CC, Johns TG, Slavin A, Ichikawa M, Ewing C, Liu J, Bettadapura J. Myelin oligodendrocyte glycoprotein: A novel candidate autoantigen in multiple sclerosis. J Mol Med 1997; 75: 77–88
   PubMed Web of Science ®Google Scholar
• Hafler DA, Slavik JM, Anderson DE, O'Connor KC, De Jager P, Baecher-Allan C. Multiple sclerosis. Immunol Rev 2005; 204: 208–231
   PubMed Web of Science ®Google Scholar
• Mendel I, Kerlero de Rosbo N, Ben-Nun A. A myelin oligodendrocyte glycoprotein peptide induces typical chronic experimental autoimmune encephalomyelitis in H-2b mice: Fine specificity and T cell receptor V beta expression of encephalitogenic T cells. Eur J Immunol 1995; 25: 1951–1959
   PubMed Web of Science ®Google Scholar
• Barten DM, Clark RB, Ruddle NH. Presence of T cells with activated and memory phenotypes in inflammatory spinal cord lesions. J Immunol 1995; 155: 5409–5418
   Google Scholar
• Montero E, Nussbaum G, Kaye JF, Perez R, Lage A, Ben-Nun A, Cohen IR. Regulation of experimental autoimmune encephalomyelitis by CD4+, CD25+ and CD8+T cells: Analysis using depleting antibodies. J Autoimmun 2004; 23: 1–7
   PubMedGoogle Scholar
• Kuchroo VK, Das MP, Brown JA, Ranger AM, Zamvil SS, Sobel RA, Weiner HL, Nabavi N, Glimcher LH. B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: Application to autoimmune disease therapy. Cell 1995; 80: 707–718
   PubMed Web of Science ®Google Scholar
• Kohm AP, Williams JS, Bickford AL, McMahon JS, Chatenoud L, Bach JF, Bluestone JA, Miller SD. Treatment with nonmitogenic anti-CD3 monoclonal antibody induces CD4+ T cell unresponsiveness and functional reversal of established experimental autoimmune encephalomyelitis. J Immunol 2005; 174: 4525–4534
   PubMed Web of Science ®Google Scholar
• Hilliard B, Samoilova EB, Liu TS, Rostami A, Chen Y. Experimental autoimmune encephalomyelitis in NF-kappa B-deficient mice: Roles of NF-kappa B in the activation and differentiation of autoreactive T cells. J Immunol 1999; 163: 2937–2943
   PubMed Web of Science ®Google Scholar
• Salek-Ardakani S, So T, Halteman BS, Altman A, Croft M. Protein kinase Ctheta controls Th1 cells in experimental autoimmune encephalomyelitis. J Immunol 2005; 175: 7635–7641
   PubMedGoogle Scholar
• Tan SL, Zhao J, Bi C, Chen XC, Hepburn DL, Wang J, Sedgwick JD, Chintalacharuvu SR, Na S. Resistance to experimental autoimmune encephalomyelitis and impaired IL-17 production in protein kinase C{theta}-deficient mice. J Immunol 2006; 176: 2872–2879
   PubMed Web of Science ®Google Scholar