Sema3A inactivates the ERK/JNK signalling pathways to alleviate inflammation and oxidative stress in lipopolysaccharide-stimulated rat endothelial cells and lung tissues

References

• Ashbaugh DG, Bigelow DB, Petty TL, et al. Acute respiratory distress in adults. Lancet. 1967;2(7511):1–10.
   PubMed Web of Science ®Google Scholar
• Confalonieri M, Salton F, Fabiano F. Acute respiratory distress syndrome. Eur Respir Rev. 2017;26(144):160116.
   PubMed Web of Science ®Google Scholar
• Meyer NJ, Gattinoni L, Calfee CS. Acute respiratory distress syndrome. Lancet. 2021;398(10300):622–637.
   PubMed Web of Science ®Google Scholar
• Bellani G, Laffey JG, Pham T, et al. Epidemiology, patterns of care, and mortality for patients with acute respiratory distress syndrome in intensive care units in 50 countries. JAMA. 2016;315(8):788–800.
   PubMed Web of Science ®Google Scholar
• Marseglia L, D’Angelo G, Granese R, et al. Role of oxidative stress in neonatal respiratory distress syndrome. Free Radic Biol Med. 2019;142:132–137.
   PubMed Web of Science ®Google Scholar
• Zhai Z, Ouyang W, Yao Y, et al. Dexamethasone-loaded ROS-responsive poly(thioketal) nanoparticles suppress inflammation and oxidative stress of acute lung injury. Bioact Mater. 2022;14:430–442.
   PubMed Web of Science ®Google Scholar
• Huppert LA, Matthay MA, Ware LB. Pathogenesis of acute respiratory distress syndrome. Semin Respir Crit Care Med. 2019;40(1):31–39.
   PubMed Web of Science ®Google Scholar
• Cannavo L, Perrone S, Viola V, et al. Oxidative stress and respiratory diseases in preterm newborns. Int J Mol Sci. 2021;22(22):12504.
   Web of Science ®Google Scholar
• Avouac J, Pezet S, Vandebeuque E, et al. Semaphorins: from angiogenesis to inflammation in rheumatoid arthritis. Arthritis Rheumatol. 2021;73(9):1579–1588.
   PubMed Web of Science ®Google Scholar
• Liu L, Watanabe M, Minami N, et al. Semaphorin 3A: a potential target for prevention and treatment of nickel allergy. Commun Biol. 2022;5(1):671.
   PubMed Web of Science ®Google Scholar
• Imoto T, Kondo S, Wakisaka N, et al. Overexpression of semaphorin 3A is a marker associated with poor prognosis in patients with nasopharyngeal carcinoma. Microorganisms. 2020;8(3):423.
   PubMed Web of Science ®Google Scholar
• Rivera LB, Bergers G. Location, location, location: macrophage positioning within tumors determines pro- or antitumor activity. Cancer Cell. 2013;24(6):687–689.
   PubMed Web of Science ®Google Scholar
• Negi O, Tominaga M, Tengara S, et al. Topically applied semaphorin 3A ointment inhibits scratching behavior and improves skin inflammation in NC/nga mice with atopic dermatitis. J Dermatol Sci. 2012;66(1):37–43.
   PubMed Web of Science ®Google Scholar
• Rienks M, Carai P, Bitsch N, et al. Sema3A promotes the resolution of cardiac inflammation after myocardial infarction. Basic Res Cardiol. 2017;112(4):42.
   PubMed Web of Science ®Google Scholar
• Zhang H, Lu Y, Wu B, et al. Semaphorin 3A mitigates lipopolysaccharide-induced chondrocyte inflammation, apoptosis and extracellular matrix degradation by binding to neuropilin-1. Bioengineered. 2021;12(2):9641–9654.
   PubMed Web of Science ®Google Scholar
• D’Alessio FR. Mouse models of acute lung injury and ARDS. Methods Mol Biol. 2018;1809:341–350.
   PubMedGoogle Scholar
• Liang Z, Zhang X, Liu Y, et al. SEMA3A protects against hyperoxia-induced lung injury in a bronchopulmonary dysplasia model of newborn rat by inhibiting ERK pathway. Allergol Immunopathol (Madr). 2021;49(6):8–15.
   PubMed Web of Science ®Google Scholar
• Liu F, Yang X, Geng M, et al. Targeting ERK, an achilles’ heel of the MAPK pathway, in cancer therapy. Acta Pharm Sin B. 2018;8(4):552–562.
   PubMed Web of Science ®Google Scholar
• Sui X, Kong N, Ye L, et al. p38 and JNK MAPK pathways control the balance of apoptosis and autophagy in response to chemotherapeutic agents. Cancer Lett. 2014;344(2):174–179.
   PubMed Web of Science ®Google Scholar
• Lai JL, Liu YH, Liu C, et al. Indirubin inhibits LPS-Induced inflammation via TLR4 abrogation mediated by the NF-kB and MAPK signaling pathways. Inflammation. 2017;40(1):1–12.
   PubMed Web of Science ®Google Scholar
• Tsai YF, Chen CY, Yang SC, et al. Apremilast ameliorates acute respiratory distress syndrome by inhibiting neutrophil-induced oxidative stress. Biomed J. 2022 [Sept 11]. DOI: 10.1016/j.bj.2022.09.001
   Web of Science ®Google Scholar
• Vassiliou AG, Kotanidou A, Dimopoulou I, et al. Endothelial damage in acute respiratory distress syndrome. Int J Mol Sci. 2020;21(22):8793.
   PubMed Web of Science ®Google Scholar
• Vadasz Z, Toubi E. Semaphorins: their dual role in regulating immune-mediated diseases. Clin Rev Allergy Immunol. 2014;47(1):17–25.
   PubMed Web of Science ®Google Scholar
• Becker PM, Tran TS, Delannoy MJ, et al. Semaphorin 3A contributes to distal pulmonary epithelial cell differentiation and lung morphogenesis. PLoS One. 2011;6(11):e27449.
   PubMed Web of Science ®Google Scholar
• Sumi C, Hirose N, Yanoshita M, et al. Semaphorin 3A inhibits inflammation in chondrocytes under excessive mechanical stress. Mediators Inflamm. 2018;2018:5703651.
   PubMed Web of Science ®Google Scholar
• Adi SD, Eiza N, Bejar J, et al. Semaphorin 3A is effective in reducing both inflammation and angiogenesis in a mouse model of bronchial asthma. Front Immunol. 2019;10:550.
   PubMed Web of Science ®Google Scholar
• Liu S, Xiong X, Thomas SV, et al. Analysis for carom complex, signaling and function by database mining. Front Biosci (Landmark Ed). 2016;21(4):856–872.
   PubMedGoogle Scholar
• Szade A, Grochot-Przeczek A, Florczyk U, et al. Cellular and molecular mechanisms of inflammation-induced angiogenesis. IUBMB Life. 2015;67(3):145–159.
   PubMed Web of Science ®Google Scholar
• Xiang R, Xu Y, Zhang W, et al. Semaphorin 3A inhibits allergic inflammation by regulating immune responses in a mouse model of allergic rhinitis. Int Forum Allergy Rhinol. 2019;9(5):528–537.
   PubMed Web of Science ®Google Scholar
• Rimar D, Nov Y, Rosner I, et al. Semaphorin 3A: an immunoregulator in systemic sclerosis. Rheumatol Int. 2015;35(10):1625–1630.
   PubMed Web of Science ®Google Scholar
• Xing X, Yang J, Yang X, et al. IL-17A induces endothelial inflammation in systemic sclerosis via the ERK signaling pathway. PLoS One. 2013;8(12):e85032.
   PubMed Web of Science ®Google Scholar
• Klimontov VV, Saik OV, Korbut AI. Glucose variability: how does it work? Int J Mol Sci. 2021;22(15):7783.
   Web of Science ®Google Scholar
• El-Dessouki AM, El Fattah MA, Awad AS, et al. Zafirlukast and vincamine ameliorate tamoxifen-induced oxidative stress and inflammation: role of the JNK/ERK pathway. Life Sci. 2018;202:78–88.
   PubMed Web of Science ®Google Scholar
• Zhu H, Zhang L, Jia H, et al. Tetrahydrocurcumin improves lipopolysaccharide-induced myocardial dysfunction by inhibiting oxidative stress and inflammation via JNK/ERK signaling pathway regulation. Phytomedicine. 2022;104:154283.
   PubMed Web of Science ®Google Scholar
• Wang J, Huang J, Wang L, et al. Urban particulate matter triggers lung inflammation via the ROS-MAPK-NF-kappaB signaling pathway. J Thorac Dis. 2017;9(11):4398–4412.
   PubMed Web of Science ®Google Scholar
• Huang X, Kong G, Li Y, et al. Decitabine and 5-azacitidine both alleviate LPS induced ARDS through anti-inflammatory/antioxidant activity and protection of glycocalyx and inhibition of MAPK pathways in mice. Biomed Pharmacother. 2016;84:447–453.
   PubMed Web of Science ®Google Scholar