GADD45B predicts lung squamous cell carcinoma survival and impacts immune infiltration, and T cell exhaustion

References

• Bray F, Ferlay J, Soerjomataram I, et al. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018;68(6):1–17.
   Web of Science ®Google Scholar
• Gridelli C, Rossi A, Carbone DP, et al. Non-small-cell lung cancer. Nat Rev Dis Primers. 2015;1:15009.
   PubMed Web of Science ®Google Scholar
• Gandara DR, Hammerman PS, Sos ML, et al. Squamous cell lung cancer: from tumor genomics to cancer therapeutics. Clin Cancer Res. 2015;21(10):2236–2243.
   PubMed Web of Science ®Google Scholar
• Chen Z, Fillmore CM, Hammerman PS, et al. Non-small-cell lung cancers: a heterogeneous set of diseases. Nat Rev Cancer. 2014;14(8):535–546.
   PubMed Web of Science ®Google Scholar
• Perez-Moreno P, Brambilla E, Thomas R, et al. Squamous cell carcinoma of the lung: molecular subtypes and therapeutic opportunities. Clin Cancer Res. 2012;18(9):2443–2451.
   PubMed Web of Science ®Google Scholar
• Huang J-Z, Chen M, Chen D, et al. A peptide encoded by a putative lncRNA HOXB-AS3 suppresses Colon cancer growth. Mol Cell. 2017;68(1):171–184.e6.
   PubMed Web of Science ®Google Scholar
• Sorber L, Zwaenepoel K, Deschoolmeester V, et al. Circulating cell-free nucleic acids and platelets as a liquid biopsy in the provision of personalized therapy for lung cancer patients. Lung Cancer. 2017;107:100–107.
   PubMed Web of Science ®Google Scholar
• Mony JT, Schuchert MJ. Prognostic implications of heterogeneity in intra-tumoral immune composition for recurrence in early stage lung cancer. Front Immunol. 2018;9:2298.
   PubMed Web of Science ®Google Scholar
• Liu X, Wu S, Yang Y, et al. The prognostic landscape of tumor-infiltrating immune cell and immunomodulators in lung cancer. Biomed Pharmacother. 2017;95:55–61.
   PubMed Web of Science ®Google Scholar
• Xiong Y, Wang K, Zhou H, et al. Profiles of immune infiltration in colorectal cancer and their clinical significant: a gene expression-based study. Cancer Med. 2018;7(9):4496–4508.
   PubMed Web of Science ®Google Scholar
• Liebermann DA, Tront JS, Sha X, et al. Gadd45 stress sensors in malignancy and leukemia. Crit Rev Oncog. 2011;16(1–2):129–140.
   PubMedGoogle Scholar
• Takekawa M, Saito H. A family of stress-inducible GADD45-like proteins mediate activation of the stress-responsive MTK1/MEKK4 MAPKKK. Cell. 1998;95(4):521–530.
   PubMed Web of Science ®Google Scholar
• Kigar SL, Chang L, Auger AP. Gadd45b is an epigenetic regulator of juvenile social behavior and alters local pro-inflammatory cytokine production in the rodent amygdala. Brain Behav Immun. 2015;46:60–69.
   PubMed Web of Science ®Google Scholar
• Zhao Z, Gao Y, Guan X, et al. GADD45B as a prognostic and predictive biomarker in stage II colorectal cancer. Genes. 2018;9(7):361.
   PubMed Web of Science ®Google Scholar
• Barros-Filho MC, de Mello JBH, Marchi FA, et al. GADD45B transcript is a prognostic marker in papillary thyroid carcinoma patients treated with total thyroidectomy and radioiodine therapy. Front Endocrinol (Lausanne). 2020;11:269.
   PubMed Web of Science ®Google Scholar
• Inowa T, Hishikawa K, Matsuzaki Y, et al. GADD45β determines chemoresistance and invasive growth of side population cells of human embryonic carcinoma. Stem Cells Int. 2010;2010:782967.
   PubMed Web of Science ®Google Scholar
• Myint KZ, Kongpracha P, Rattanasinganchan P, et al. Gadd45β silencing impaired viability and metastatic phenotypes in cholangiocarcinoma cells by modulating the EMT pathway. Oncology Letters. 2018;15(3):3031–3041.
   PubMed Web of Science ®Google Scholar
• Li T, Fan J, Wang B, et al. TIMER: a web server for comprehensive analysis of tumor-infiltrating immune cells. Cancer Res. 2017;77(21):e108–e110.
   PubMed Web of Science ®Google Scholar
• Li B, Li JZ. A general framework for analyzing tumor subclonality using SNP array and DNA sequencing data. Genome Biol. 2014;15(9):473.
   PubMed Web of Science ®Google Scholar
• Bhattacharya S, Dunn P, Thomas CG, et al. ImmPort, toward repurposing of open access immunological assay data for translational and clinical research. Sci Data. 2018;5:180015.
   PubMed Web of Science ®Google Scholar
• Danaher P, Warren S, Dennis L, et al. Gene expression markers of tumor infiltrating leukocytes. J Immunother Cancer. 2017;5:18.
   PubMed Web of Science ®Google Scholar
• Mermel CH, Schumacher SE, Hill B, et al. GISTIC2.0 facilitates sensitive and confident localization of the targets of focal somatic copy-number alteration in human cancers. Genome Biol. 2011;12(4):R41.
   PubMed Web of Science ®Google Scholar
• Nirmal AJ, Regan T, Shih BB, et al. Immune cell gene signatures for profiling the microenvironment of solid tumors. Cancer Immunol Res. 2018;6(11):1388–1400.
   PubMed Web of Science ®Google Scholar
• Tang Z, Kang B, Li C, et al. GEPIA2: an enhanced web server for large-scale expression profiling and interactive analysis. Nucleic Acids Res. 2019;47(W1):W556–W560.
   PubMed Web of Science ®Google Scholar
• Nagy Á, Lánczky A, Menyhárt O, et al. Validation of miRNA prognostic power in hepatocellular carcinoma using expression data of independent datasets. Sci Rep. 2018;8(1):9227.
   PubMed Web of Science ®Google Scholar
• Ru B, Wong CN, Tong Y, et al. TISIDB: an integrated repository portal for tumor-immune system interactions. Bioinformatics. 2019;35(20):4200–4202.
   PubMed Web of Science ®Google Scholar
• Uhlén M, Fagerberg L, Hallström BM, et al. Proteomics. Tissue-based map of the human proteome. Science. 2015;347(6220):1260419.
   PubMed Web of Science ®Google Scholar
• Koch A, de Meyer T, Jeschke J, et al. MEXPRESS: visualizing expression, DNA methylation and clinical TCGA data. BMC Genomics. 2015;16(1):636.
   PubMed Web of Science ®Google Scholar
• Vasaikar SV, Straub P, Wang J, et al. LinkedOmics: analyzing multi-omics data within and across 32 cancer types. Nucleic Acids Res. 2018;46(D1):D956–D963.
   PubMed Web of Science ®Google Scholar
• Sticht C, de La Torre C, Parveen A, et al. miRWalk: an online resource for prediction of microRNA binding sites. PLoS One. 2018;13(10):e0206239.
   PubMed Web of Science ®Google Scholar
• Ravelli A, Roviello G, Cretella D, et al. Tumor-infiltrating lymphocytes and breast cancer: beyond the prognostic and predictive utility. Tumour Biol. 2017;39(4):1010428317695023.
   Google Scholar
• Azimi F, Scolyer RA, Rumcheva P, et al. Tumor-infiltrating lymphocyte grade is an independent predictor of sentinel lymph node status and survival in patients with cutaneous melanoma. J Clin Oncol. 2012;30(21):2678–2683.
   PubMed Web of Science ®Google Scholar
• Ohtani H. Focus on TILs: prognostic significance of tumor infiltrating lymphocytes in human colorectal cancer. Cancer Immun. 2007;7:4.
   PubMedGoogle Scholar
• Sousa S, Määttä J. The role of tumour-associated macrophages in bone metastasis. J Bone Oncol. 2016;5(3):135–138.
   PubMed Web of Science ®Google Scholar
• Siemers NO, Holloway JL, Chang H, et al. Genome-wide association analysis identifies genetic correlates of immune infiltrates in solid tumors. PLoS One. 2017;12(7):e0179726.
   PubMed Web of Science ®Google Scholar
• Liu L, Tran E, Zhao Y, et al. Gadd45 beta and Gadd45 gamma are critical for regulating autoimmunity. J Exp Med. 2005;202(10):1341–1347.
   PubMed Web of Science ®Google Scholar
• Lu B, Ferrandino AF, Flavell RA. Gadd45beta is important for perpetuating cognate and inflammatory signals in T cells. Nat Immunol. 2004;5(1):38–44.
   PubMed Web of Science ®Google Scholar
• Sawant A, Hensel JA, Chanda D, et al. Depletion of plasmacytoid dendritic cells inhibits tumor growth and prevents bone metastasis of breast cancer cells. J Immunol. 2012;189(9):4258–4265.
   PubMed Web of Science ®Google Scholar
• Liebermann DA, Hoffman B. Myeloid differentiation (MyD) primary response genes in hematopoiesis. Blood Cells Mol Dis. 2003;31(2):213–228.
   PubMed Web of Science ®Google Scholar
• Ju S, Zhu Y, Liu L, et al. Gadd45b and Gadd45g are important for anti-tumor immune responses. Eur J Immunol. 2009;39(11):3010–3018.
   PubMed Web of Science ®Google Scholar
• Zumbrun SD, Hoffman B, Liebermann DA. Distinct mechanisms are utilized to induce stress sensor gadd45b by different stress stimuli. J Cell Biochem. 2009;108(5):1220–1231.
   PubMed Web of Science ®Google Scholar
• Wang L, Xiao X, Li D, et al. Abnormal expression of GADD45B in human colorectal carcinoma. J Transl Med. 2012;10:215.
   PubMed Web of Science ®Google Scholar
• Lee K-W, Lee SS, Hwang J-E, et al. Development and validation of a six-gene recurrence risk score assay for gastric cancer. Clin Cancer Res. 2016;22(24):6228–6235.
   PubMed Web of Science ®Google Scholar
• Li L, Cai S, Liu S, et al. Bioinformatics analysis to screen the key prognostic genes in ovarian cancer. J Ovarian Res. 2017;10(1):27.
   PubMedGoogle Scholar
• Wherry EJ. T cell exhaustion. Nat Immunol. 2011;12(6):492–499.
   PubMed Web of Science ®Google Scholar
• Wherry EJ, Kurachi M. Molecular and cellular insights into T cell exhaustion. Nat Rev Immunol. 2015;15(8):486–499.
   PubMed Web of Science ®Google Scholar
• Zarour HM. Reversing T-cell dysfunction and exhaustion in cancer. Clin Cancer Res. 2016;22(8):1856–1864.
   PubMed Web of Science ®Google Scholar
• Ribas A, Wolchok JD. Cancer immunotherapy using checkpoint blockade. Science. 2018;359(6382):1350–1355.
   PubMed Web of Science ®Google Scholar
• Anderson AC, Joller N, Kuchroo VK. Lag-3, tim-3, and TIGIT: co-inhibitory receptors with specialized functions in immune regulation. Immunity. 2016;44(5):989–1004.
   PubMed Web of Science ®Google Scholar
• Kastenmüller W, Kastenmüller K, Kurts C, et al. Dendritic cell-targeted vaccines–hope or hype? Nat Rev Immunol. 2014;14(10):705–711.
   PubMed Web of Science ®Google Scholar
• Pyfferoen L, Brabants E, Everaert C, et al. The transcriptome of lung tumor-infiltrating dendritic cells reveals a tumor-supporting phenotype and a microRNA signature with negative impact on clinical outcome. Oncoimmunology. 2017;6(1):e1253655.
   PubMed Web of Science ®Google Scholar
• Stevens D, Ingels J, van Lint S, et al. Dendritic cell-based immunotherapy in lung cancer. Front Immunol. 2020;11:620374.
   PubMed Web of Science ®Google Scholar
• Chen X, Liu Z, Huang Y, et al. Superior anti-tumor protection and therapeutic efficacy of vaccination with dendritic cell/tumor cell fusion hybrids for murine Lewis lung carcinoma. Autoimmunity. 2014;47(1):46–56.
   PubMed Web of Science ®Google Scholar
• Dudeck A, Köberle M, Goldmann O, et al. Mast cells as protectors of health. J Allergy Clin Immunol. 2019;144(4S):S4–S18.
   PubMedGoogle Scholar
• Eissmann MF, Dijkstra C, Jarnicki A, et al. IL-33-mediated mast cell activation promotes gastric cancer through macrophage mobilization. Nat Commun. 2019;10(1):2735.
   PubMedGoogle Scholar
• Komi DEA, Redegeld FA. Role of mast cells in shaping the tumor microenvironment. Clin Rev Allergy Immunol. 2020;58(3):313–325.
   PubMed Web of Science ®Google Scholar
• Jin X, Liu X, Zhang Z, et al. Identification of key pathways and genes in lung carcinogenesis. Oncol Lett. 2018;16(4):4185–4192.
   PubMed Web of Science ®Google Scholar