MiR-526b-3p enhances sensitivity of head and neck squamous cell carcinoma cells to radiotherapy via suppressing exosomal LAMP3-mediated autophagy

References

• Moskovitz J, Moy J, Ferris RL. Immunotherapy for head and neck squamous cell carcinoma. Curr Oncol Rep. 2018;20(2):1. PubMed PMID: 29502288; PubMed Central PMCID: PMCPMC5835060. eng.
   PubMed Web of Science ®Google Scholar
• Kitamura N, Sento S, Yoshizawa Y, et al. Current trends and future prospects of molecular targeted therapy in head and neck squamous cell carcinoma. Int J Mol Sci. 2020;22(1):240. PubMed PMID: 33383632; PubMed Central PMCID: PMCPMC7795499. eng.
   PubMed Web of Science ®Google Scholar
• Qiu X, You Y, Huang J, et al. LAMP3 and TP53 overexpression predicts poor outcome in laryngeal squamous cell carcinoma. Int J Clin Exp Pathol. 2015;8(5):5519–12. PubMed PMID: 26191259; PubMed Central PMCID: PMCPMC4503130. eng.
   PubMed Web of Science ®Google Scholar
• Sun R, Wang X, Zhu H, et al. Prognostic value of LAMP3 and TP53 overexpression in benign and malignant gastrointestinal tissues. Oncotarget. 2014;5(23):12398–12409. PubMed PMID: 25362357; PubMed Central PMCID: PMCPMC4322976. eng.
   PubMedGoogle Scholar
• Liu S, Yue J, Du W, et al. LAMP3 plays an oncogenic role in osteosarcoma cells partially by inhibiting TP53. Cell Mol Biol Lett. 2018;23(1):33. PubMed PMID: 30008754; PubMed Central PMCID: PMCPmc6042264. eng.
   PubMedGoogle Scholar
• Yang C, Shen S, Zheng X, et al. Long noncoding RNA HAGLR acts as a microRNA-143-5p sponge to regulate epithelial-mesenchymal transition and metastatic potential in esophageal cancer by regulating LAMP3. Faseb J. 2019;33(9):10490–10504. PubMed PMID: 31311326; eng.
   PubMed Web of Science ®Google Scholar
• Wu H, Li J, Chen J, et al. Efficacy of radiation exposure in laryngeal squamous cell carcinoma is mediated by the LAMP3/LAMC2/tenascin-C pathway. Exp Biol Med (Maywood). 2019;244(13):1070–1080.
   PubMed Web of Science ®Google Scholar
• Nagelkerke A, Bussink J, van der Kogel AJ, et al. The PERK/ATF4/LAMP3-arm of the unfolded protein response affects radioresistance by interfering with the DNA damage response. Radiother Oncol. 2013;108(3):415–421. PubMed PMID: 23891100; eng.
   PubMed Web of Science ®Google Scholar
• Nagelkerke A, Sweep FC, Stegeman H, et al. Hypoxic regulation of the PERK/ATF4/LAMP3-arm of the unfolded protein response in head and neck squamous cell carcinoma. Head Neck. 2015;37(6):896–905. PubMed PMID: 24634103; eng.
   PubMed Web of Science ®Google Scholar
• Levy JMM, Towers CG, Thorburn A. Targeting autophagy in cancer. Nat Rev Cancer. 2017;17(9):528–542. PubMed PMID: 28751651; PubMed Central PMCID: PMCPMC5975367. eng.
   PubMed Web of Science ®Google Scholar
• Onorati AV, Dyczynski M, Ojha R, et al. Targeting autophagy in cancer. Cancer. 2018;124(16):3307–3318. PubMed PMID: 29671878; PubMed Central PMCID: PMCPMC6108917. eng.
   PubMed Web of Science ®Google Scholar
• Li X, He S, Ma B. Autophagy and autophagy-related proteins in cancer. Mol Cancer. 2020;19(1):12. PubMed PMID: 31969156; PubMed Central PMCID: PMCPMC6975070. eng.
   PubMed Web of Science ®Google Scholar
• Kim J, Kang H, Son B, et al. NRBF2-mediated autophagy contributes to metabolite replenishment and radioresistance in glioblastoma. Exp Mol Med. 2022;54(11):1872–1885.
   PubMed Web of Science ®Google Scholar
• Ikeh KE, Lamkin EN, Crompton A, et al. REV1 inhibition enhances radioresistance and autophagy. Cancers (Basel). 2021;13(21):5290.
   PubMed Web of Science ®Google Scholar
• Sun Y, Chen K, Lin G, et al. Silencing c-Jun inhibits autophagy and abrogates radioresistance in nasopharyngeal carcinoma by activating the PI3K/AKT/mTOR pathway. Ann Transl Med. 2021;9(13):1085–1085. PubMed PMID: 34422997; PubMed Central PMCID: PMCPmc8339856. eng.
   PubMed Web of Science ®Google Scholar
• Tanaka Y, Guhde G, Suter A, et al. Accumulation of autophagic vacuoles and cardiomyopathy in LAMP-2-deficient mice. Nature. 2000;406(6798):902–906. PubMed PMID: 10972293; eng.
   PubMed Web of Science ®Google Scholar
• Eskelinen EL, Illert AL, Tanaka Y, et al. Role of LAMP-2 in lysosome biogenesis and autophagy. Mol Biol Cell. 2002;13(9):3355–3368. PubMed PMID: 12221139; PubMed Central PMCID: PMCPmc124165. eng.
   PubMed Web of Science ®Google Scholar
• Pennati M, Lopergolo A, Profumo V, et al. miR-205 impairs the autophagic flux and enhances cisplatin cytotoxicity in castration-resistant prostate cancer cells. Biochem Pharmacol. 2014;87(4):579–597. PubMed PMID: 24370341; eng.
   PubMed Web of Science ®Google Scholar
• Zhang Z, Lin M, Wang J, et al. Calycosin inhibits breast cancer cell migration and invasion by suppressing EMT via BATF/TGF-β1. Aging (Albany NY). 2021;13(12):16009–16023. PubMed PMID: 34096887; PubMed Central PMCID: PMCPmc8266341. eng.
   PubMedGoogle Scholar
• Zhang Y, Yuan Y, Zhang Y, et al. SNHG7 accelerates cell migration and invasion through regulating miR-34a-Snail-EMT axis in gastric cancer. Cell Cycle. 2020;19(1):142–152. PubMed PMID: 31814518; PubMed Central PMCID: PMCPMC6927713. eng.
   PubMed Web of Science ®Google Scholar
• Nagelkerke A, Sieuwerts AM, Bussink J, et al. LAMP3 is involved in tamoxifen resistance in breast cancer cells through the modulation of autophagy. Endocr Relat Cancer. 2014;21(1):101–112. PubMed PMID: 24434718; eng.
   PubMed Web of Science ®Google Scholar
• Digomann D, Linge A, Dubrovska A. SLC3A2/CD98hc, autophagy and tumor radioresistance: a link confirmed. Autophagy. 2019;15(10):1850–1851. PubMed PMID: 31276435; PubMed Central PMCID: PMCPMC6735542. eng.
   PubMed Web of Science ®Google Scholar
• Naseri Z, Oskuee RK, Jaafari MR, et al. Exosome-mediated delivery of functionally active miRNA-142-3p inhibitor reduces tumorigenicity of breast cancer in vitro and in vivo. Int J Nanomedicine. 2018;13:7727–7747. PubMed PMID: 30538455; PubMed Central PMCID: PMCPMC6251455. eng.
   PubMed Web of Science ®Google Scholar
• Jiang M, Zhang W, Zhang R, et al. Cancer exosome-derived miR-9 and miR-181a promote the development of early-stage MDSCs via interfering with SOCS3 and PIAS3 respectively in breast cancer. Oncogene. 2020;39(24):4681–4694. PubMed PMID: 32398867; eng.
   PubMed Web of Science ®Google Scholar
• Chen X, Liu Y, Zhang Q, et al. Exosomal miR-590-3p derived from cancer-associated fibroblasts confers radioresistance in colorectal cancer. Mol Ther Nucleic Acids. 2021;24:113–126. PubMed PMID: 33738143; PubMed Central PMCID: PMCPMC7943971. eng.
   PubMedGoogle Scholar
• Chen X, Liu J, Zhang Q, et al. Exosome-mediated transfer of miR-93-5p from cancer-associated fibroblasts confer radioresistance in colorectal cancer cells by downregulating FOXA1 and upregulating TGFB3. J Exp Clin Cancer Res. 2020;39(1):65. PubMed PMID: 32293494; PubMed Central PMCID: PMCPMC7158087. eng.
   PubMed Web of Science ®Google Scholar
• Jønson L, Christiansen J, Hansen TVO, et al. IMP3 RNP safe houses prevent miRNA-directed HMGA2 mRNA decay in cancer and development. Cell Rep. 2014;7(2):539–551. PubMed PMID: 24703842; eng.
   PubMed Web of Science ®Google Scholar
• Bryan K, Terrile M, Bray IM, et al. Discovery and visualization of miRNA-mRNA functional modules within integrated data using bicluster analysis. Nucleic Acids Res. 2014;42(3):e17–e17. PubMed PMID: 24357407; PubMed Central PMCID: PMCPMC3919560. eng.
   PubMed Web of Science ®Google Scholar
• Wang D, Cao X, Zhang Y, et al. LAMP3 expression correlated with poor clinical outcome in human ovarian cancer. Tumour Biol. 2017;39(3):1010428317695014. PubMed PMID: 28349821; eng.
   Google Scholar
• Maiuri MC, Zalckvar E, Kimchi A, et al. Self-eating and self-killing: crosstalk between autophagy and apoptosis. Nat Rev Mol Cell Biol. 2007;8(9):741–752. PubMed PMID: 17717517; eng.
   PubMed Web of Science ®Google Scholar
• Li YJ, Lei YH, Yao N, et al. Autophagy and multidrug resistance in cancer. Chin J Cancer. 2017;36(1):52. PubMed PMID: 28646911; PubMed Central PMCID: PMCPMC5482965. eng.
   PubMedGoogle Scholar
• Chen B, Sang Y, Song X, et al. Exosomal miR-500a-5p derived from cancer-associated fibroblasts promotes breast cancer cell proliferation and metastasis through targeting USP28. Theranostics. 2021;11(8):3932–3947. PubMed PMID: 33664871; PubMed Central PMCID: PMCPmc7914354. eng.
   PubMed Web of Science ®Google Scholar
• Shi L, Wang Z, Geng X, et al. Exosomal miRNA-34 from cancer-associated fibroblasts inhibits growth and invasion of gastric cancer cells in vitro and in vivo. Aging (Albany NY). 2020;12(9):8549–8564. PubMed PMID: 32391804; PubMed Central PMCID: PMCPmc7244055. eng.
   PubMedGoogle Scholar
• Chen KB, Yang W, Xuan Y, et al. miR-526b-3p inhibits lung cancer cisplatin-resistance and metastasis by inhibiting STAT3-promoted PD-L1. Cell Death Dis. 2021;12(8):748. PubMed PMID: 34321456; PubMed Central PMCID: PMCPmc8319181. eng.
   PubMed Web of Science ®Google Scholar
• Liu JH, Li WT, Yang Y, et al. MiR-526b-3p attenuates breast cancer stem cell properties and chemoresistance by targeting HIF-2α/notch signaling. Front Oncol. 2021;11:696269. PubMed PMID: 35004266; PubMed Central PMCID: PMCPmc8733566. eng.
   PubMed Web of Science ®Google Scholar