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RESEARCH ARTICLE

TNF-α stimulated exosome derived from fibroblast-like synoviocytes isolated from rheumatoid arthritis patients promotes HUVEC migration, invasion and angiogenesis by targeting the miR-200a-3p/KLF6/VEGFA axis

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Article: 2282939 | Received 16 Aug 2023, Accepted 08 Nov 2023, Published online: 17 Nov 2023

References

  • Smolen JS, Aletaha D, McInnes IB. Rheumatoid arthritis. Lancet. 2016;388(10055):1–10. doi:10.1016/S0140-6736(16)30173-8
  • Fearon U, Canavan M, Biniecka M, et al. Hypoxia, mitochondrial dysfunction and synovial invasiveness in rheumatoid arthritis. Nat Rev Rheumatol. 2016;12(7):385–397. doi:10.1038/nrrheum.2016.69
  • Colombo M, Raposo G, Théry C. Biogenesis, secretion, and intercellular interactions of exosomes and other extracellular vesicles. Annu Rev Cell Dev Biol. 2014;30(1):255–289. doi:10.1146/annurev-cellbio-101512-122326
  • Zhang L, Qin Z, Sun H, et al. Nanoenzyme engineered neutrophil-derived exosomes attenuate joint injury in advanced rheumatoid arthritis via regulating inflammatory environment. Bioact Mater. 2022;18:1–14.
  • Withrow J, Murphy C, Liu Y, et al. Extracellular vesicles in the pathogenesis of rheumatoid arthritis and osteoarthritis. Arthritis Res Ther. 2016;18(1):286. doi:10.1186/s13075-016-1178-8
  • Tan W, Chen N, Qiu Y, et al. Exosomal Dvl3 promoted the aggressive phenotypic transformation of RA-FLS via wnt pathway. Autoimmunity. 2022;55(5):285–293. doi:10.1080/08916934.2022.2067984
  • Chen Z, Wang H, Xia Y, et al. Therapeutic potential of mesenchymal Cell-Derived miRNA-150-5p-Expressing exosomes in rheumatoid arthritis mediated by the modulation of MMP14 and VEGF. J Immunol. 2018;201(8):2472–2482. doi:10.4049/jimmunol.1800304
  • Chang L, Kan L. Mesenchymal stem Cell-Originated exosomal circular RNA circFBXW7 attenuates cell proliferation, migration and inflammation of Fibroblast-Like synoviocytes by targeting miR-216a-3p/HDAC4 in rheumatoid arthritis. J Inflamm Res. 2021;14:6157–6171. doi:10.2147/JIR.S336099
  • Ren J, Zhang F, Zhu S, et al. Exosomal long non-coding RNA TRAFD1-4:1 derived from fibroblast-like synoviocytes suppresses chondrocyte proliferation and migration by degrading cartilage extracellular matrix in rheumatoid arthritis. Exp Cell Res. 2023;422(2):113441. doi:10.1016/j.yexcr.2022.113441
  • Li W, Li Y, Li P, et al. miR-200a-3p- and miR-181-5p-Mediated HOXB5 upregulation promotes HCC progression by transcriptional activation of EGFR. Front Oncol. 2022;12:822760. doi:10.3389/fonc.2022.822760
  • Yu J, Chen J, Yang H, et al. Overexpression of miR‑200a‑3p promoted inflammation in sepsis‑induced brain injury through ROS‑induced NLRP3. Int J Mol Med. 2019;44(5):1811–1823.
  • Yang J, Xu H, Chen K, et al. Platelets-Derived miR-200a-3p modulate the expression of ET-1 and VEGFA in endothelial cells by targeting MAPK14. Front Physiol. 2022;13:893102. doi:10.3389/fphys.2022.893102
  • Fu Q, Pan H, Tang Y, et al. MiR-200a-3p aggravates DOX-Induced cardiotoxicity by targeting PEG3 through SIRT1/NF-κB signal pathway. Cardiovasc Toxicol. 2021;21(4):302–313. doi:10.1007/s12012-020-09620-3
  • Ranjan P, Kumari R, Goswami SK, et al. Myofibroblast-Derived exosome induce cardiac endothelial cell dysfunction. Front Cardiovasc Med. 2021;8:676267. doi:10.3389/fcvm.2021.676267
  • Wei K, Korsunsky I, Marshall JL, et al. Notch signalling drives synovial fibroblast identity and arthritis pathology. Nature. 2020;582(7811):259–264. doi:10.1038/s41586-020-2222-z
  • Aletaha D, Neogi T, Silman AJ, 3rd, et al. 2010 Rheumatoid arthritis classification criteria: an American college of rheumatology/european league against rheumatism collaborative initiative. Arthritis Rheum. 2010;62(9):2569–2581. doi:10.1002/art.27584
  • Yates AG, Pink RC, Erdbrügger U, et al. In sickness and in health: the functional role of extracellular vesicles in physiology and pathology in vivo: part II: pathology: part II: pathology. J Extracell Vesicles. 2022;11(1):e12190. doi:10.1002/jev2.12190
  • Sharma K, Zhang Y, Paudel KR, et al. The emerging role of Pericyte-Derived extracellular vesicles in vascular and neurological health. Cells. 2022;11(19):3108. doi:10.3390/cells11193108
  • Sharma V, Nikolajeff F, Kumar S. Employing nanoparticle tracking analysis of salivary neuronal exosomes for early detection of neurodegenerative diseases. Transl Neurodegener. 2023;12(1):7. doi:10.1186/s40035-023-00339-z
  • Nakao Y, Fukuda T, Zhang Q, et al. Exosomes from TNF-α-treated human gingiva-derived MSCs enhance M2 macrophage polarization and inhibit periodontal bone loss. Acta Biomater. 2021;122:306–324. doi:10.1016/j.actbio.2020.12.046
  • Li L, Zhan M, Li M. Circular RNA circ_0130438 suppresses TNF-α-induced proliferation, migration, invasion and inflammation in human fibroblast-like MH7A synoviocytes by regulating miR-130a-3p/KLF9 axis. Transpl Immunol. 2022;72:101588. doi:10.1016/j.trim.2022.101588
  • Zhang Y, Daaka Y. PGE2 promotes angiogenesis through EP4 and PKA Cγ pathway. Blood. 2011;118(19):5355–5364. doi:10.1182/blood-2011-04-350587
  • Gualtierotti R, Solimeno LP, Peyvandi F. Hemophilic arthropathy: current knowledge and future perspectives. J Thromb Haemost. 2021;19(9):2112–2121. doi:10.1111/jth.15444
  • Carmeliet P, Jain RK. Angiogenesis in cancer and other diseases. Nature. 2000;407(6801):249–257. doi:10.1038/35025220
  • Lee KJ, Lim D, Yoo YH, et al. Paired Ig-like type 2 Receptor-Derived agonist ligands ameliorate inflammatory reactions by downregulating β1 integrin activity. Mol Cells. 2016;39(7):557–565. doi:10.14348/molcells.2016.0079
  • Chen M, Li MH, Zhang N, et al. Pro-angiogenic effect of exosomal microRNA-103a in mice with rheumatoid arthritis via the downregulation of hepatocyte nuclear factor 4 alpha and activation of the JAK/STAT3 signaling pathway. J Biol Regulat Homeos Agents. 2021;35:629–640.
  • Wu Y, Sun K, Tu Y, et al. Mir-200a-3p regulates epithelial-mesenchymal transition and inflammation in chronic rhinosinusitis with nasal polyps by targeting zeb1 via erk/p38 pathway. Int Forum Allergy Rhinol. 2023.
  • Lee UE, Ghiassi-Nejad Z, Paris AJ, et al. Tumor suppressor activity of KLF6 mediated by downregulation of the PTTG1 oncogene. FEBS Lett. 2010;584(5):1006–1010. doi:10.1016/j.febslet.2010.01.049
  • Garrido-Martín EM, Blanco FJ, Roquè M, et al. Vascular injury triggers krüppel-like factor 6 mobilization and cooperation with specificity protein 1 to promote endothelial activation through upregulation of the activin receptor-like kinase 1 gene. Circ Res. 2013;112(1):113–127. doi:10.1161/CIRCRESAHA.112.275586
  • Yang Y, Yu H, Yang C, et al. Krüppel-like factor 6 mediates pulmonary angiogenesis in rat experimental hepatopulmonary syndrome and is aggravated by bone morphogenetic protein 9. Biol Open. 2019;8(6):bio040121.
  • Carmeliet P. Angiogenesis in life, disease and medicine. Nature. 2005;438(7070):932–936. doi:10.1038/nature04478
  • Cheng X, Liu Z, Zhang H, et al. Inhibition of LOXL1-AS1 alleviates oxidative low-density lipoprotein induced angiogenesis via downregulation of miR-590-5p mediated KLF6/VEGF signaling pathway. Cell Cycle. 2021;20(17):1663–1680. doi:10.1080/15384101.2021.1958484
  • Roskoski R.Jr. Vascular endothelial growth factor (VEGF) and VEGF receptor inhibitors in the treatment of renal cell carcinomas. Pharmacol Res. 2017;120:116–132. doi:10.1016/j.phrs.2017.03.010
  • Ge H, Shrestha A, Liu C, et al. MicroRNA 148a-3p promotes thrombospondin-4 expression and enhances angiogenesis during tendinopathy development by inhibiting krüppel-like factor 6. Biochem Biophys Res Commun. 2018;502(2):276–282. doi:10.1016/j.bbrc.2018.05.167
  • Gallardo-Vara E, Blanco FJ, Roqué M, et al. Transcription factor KLF6 upregulates expression of metalloprotease MMP14 and subsequent release of soluble endoglin during vascular injury. Angiogenesis. 2016;19(2):155–171. doi:10.1007/s10456-016-9495-8