155
Views
0
CrossRef citations to date
0
Altmetric
Research Article

Increasing expression of dual-specificity phosphatase 12 mitigates oxygen-glucose deprivation/reoxygenation-induced neuronal apoptosis and inflammation through inactivation of the ASK1-JNK/p38 MAPK pathway

, , , , , , & show all
Article: 2345919 | Received 21 Sep 2023, Accepted 17 Apr 2024, Published online: 09 May 2024

References

  • Mosconi MG, Paciaroni M. Treatments in ischemic stroke: current and future. Eur Neurol. 2022;85(5):349–366. doi:10.1159/000525822
  • Balch MHH, Nimjee SM, Rink C, et al. Beyond the brain: the systemic pathophysiological response to acute ischemic stroke. J Stroke. 2020;22(2):159–172. doi:10.5853/jos.2019.02978
  • Liang TY, Peng SY, Ma M, et al. Protective effects of sevoflurane in cerebral ischemia reperfusion injury: a narrative review. Med Gas Res. 2021;11(4):152–154.
  • Zhang Q, Jia M, Wang Y, et al. Cell death mechanisms in cerebral Ischemia-Reperfusion injury. Neurochem Res. 2022;47(12):3525–3542. doi:10.1007/s11064-022-03697-8
  • Jurcau A, Simion A. Neuroinflammation in cerebral ischemia and ischemia/reperfusion injuries: from pathophysiology to therapeutic strategies. Int J Mol Sci. 2021;23(1):14. doi:10.3390/ijms23010014
  • Mo Z, Zeng Z, Liu Y, et al. Activation of wnt/Beta-Catenin signaling pathway as a promising therapeutic candidate for cerebral ischemia/reperfusion injury. Front Pharmacol. 2022;13:914537. doi:10.3389/fphar.2022.914537
  • Wang L, Liu Y, Zhang X, et al. Endoplasmic reticulum stress and the unfolded protein response in cerebral ischemia/reperfusion injury. Front Cell Neurosci. 2022;16:864426. doi:10.3389/fncel.2022.864426
  • Huang CY, Tan TH. DUSPs, to MAP kinases and beyond. Cell Biosci. 2012;2(1):24. doi:10.1186/2045-3701-2-24
  • MacKeigan JP, Murphy LO, Blenis J. Sensitized RNAi screen of human kinases and phosphatases identifies new regulators of apoptosis and chemoresistance. Nat Cell Biol. 2005;7(6):591–600. doi:10.1038/ncb1258
  • Cain EL, Braun SE, Beeser A. Characterization of a human cell line stably over-expressing the candidate oncogene, dual specificity phosphatase 12. PLoS One. 2011;6(4):e18677. doi:10.1371/journal.pone.0018677
  • Li WM, Zhao YF, Zhu GF, et al. Dual specific phosphatase 12 ameliorates cardiac hypertrophy in response to pressure overload. Clin Sci (Lond). 2017;131(2):141–154. doi:10.1042/CS20160664
  • Cho SSL, Han J, James SJ, et al. Dual-Specificity phosphatase 12 targets p38 MAP kinase to regulate macrophage response to intracellular bacterial infection. Front Immunol. 2017;8:1259. doi:10.3389/fimmu.2017.01259
  • Hui Z, Jie H, Fan GH. Expression of DUSP12 reduces lung vascular endothelial cell damage in a murine model of lipopolysaccharide-induced acute lung injury via the apoptosis signal-regulating kinase 1 (ASK1)-jun N-Terminal kinase activation (JNK) pathway. Med Sci Monit. 2021;27:e930429.
  • Huang Z, Wu LM, Zhang JL, et al. Dual specificity phosphatase 12 regulates hepatic lipid metabolism through inhibition of the lipogenesis and apoptosis signal-regulating kinase 1 pathways. Hepatology. 2019;70(4):1099–1118. doi:10.1002/hep.30597
  • Ogier JM, Nayagam BA, Lockhart PJ. ASK1 inhibition: a therapeutic strategy with multi-system benefits. J Mol Med (Berl). 2020;98(3):335–348. doi:10.1007/s00109-020-01878-y
  • Obsilova V, Honzejkova K, Obsil T. Structural insights support targeting ASK1 kinase for therapeutic interventions. Int J Mol Sci. 2021;22(24):13395. doi:10.3390/ijms222413395
  • Rusnak L, Fu H. Regulation of ASK1 signaling by scaffold and adaptor proteins. Adv Biol Regul. 2017;66:23–30. doi:10.1016/j.jbior.2017.10.003
  • Cheon SY, Kim EJ, Kim JM, et al. Cell Type-Specific mechanisms in the pathogenesis of ischemic stroke: the role of apoptosis signal-regulating kinase 1. Oxid Med Cell Longev. 2018;2018:2596043–2596049.
  • Shiizaki S, Naguro I, Ichijo H. Activation mechanisms of ASK1 in response to various stresses and its significance in intracellular signaling. Adv Biol Regul. 2013;53(1):135–144. doi:10.1016/j.jbior.2012.09.006
  • Li F, Mao Q, Wang J, et al. Salidroside inhibited cerebral ischemia/reperfusion-induced oxidative stress and apoptosis via Nrf2/Trx1 signaling pathway. Metab Brain Dis. 2022;37(8):2965–2978. doi:10.1007/s11011-022-01061-x
  • Qiu T, Wang T, Zhou J, et al. DUSP12 protects against hepatic ischemia-reperfusion injury dependent on ASK1-JNK/p38 pathway in vitro and in vivo. Clin Sci (Lond). 2020;134(17):2279–2294. doi:10.1042/CS20191272
  • Boldorini R, Clemente N, Alchera E, et al. DUSP12 acts as a novel endogenous protective signal against hepatic ischemia-reperfusion damage by inhibiting ASK1 pathway. Clin Sci (Lond). 2021;135(1):161–166. doi:10.1042/CS20201091
  • Cheng J, Ji M, Jing H, et al. DUSP12 ameliorates myocardial ischemia-reperfusion injury through HSPB8-induced mitophagy. J Biochem Mol Toxicol. 2023;37(5):e23310. doi:10.1002/jbt.23310
  • Wang J, Ren B, Yang Y, et al. C1q/tumor necrosis factor-related protein-9 exerts antioxidant and anti-inflammatory effects on oxygen-glucose deprivation/reoxygenation-stimulated neurons by modulating the Akt-GSK-3beta-Nrf2 Cascade via AdipoR1. Int Immunopharmacol. 2023;118:110045. doi:10.1016/j.intimp.2023.110045
  • Sharda PR, Bonham CA, Mucaki EJ, et al. The dual-specificity phosphatase hYVH1 interacts with Hsp70 and prevents heat-shock-induced cell death. Biochem J. 2009;418(2):391–401. doi:10.1042/BJ20081484
  • Zhang H, Feng Y, Si Y, et al. Shank3 ameliorates neuronal injury after cerebral ischemia/reperfusion via inhibiting oxidative stress and inflammation. Redox Biol. 2024;69:102983. doi:10.1016/j.redox.2023.102983
  • Li X, Fu J, Guan M, et al. Biochanin a attenuates spinal cord injury in rats during early stages by inhibiting oxidative stress and inflammasome activation. Neural Regen Res. 2024;19(9):2050–2056. doi:10.4103/1673-5374.390953
  • Su L, Lu H, Zhang D, et al. Total paeony glycoside relieves neuroinflammation to exert antidepressant effect via the interplay between NLRP3 inflammasome, pyroptosis and autophagy. Phytomedicine. 2024;128:155519. doi:10.1016/j.phymed.2024.155519
  • Luo L, Wang S, Liu W, et al. Narirutin attenuates cerebral ischemia-reperfusion injury by suppressing the TXNIP/NLRP3 pathway. Neurochem Res. 2024;49(3):692–705. doi:10.1007/s11064-023-04062-z
  • Tang S, Lai N, Xu L. Neuronal pyroptosis mediated by STAT3 in early brain injury after subarachnoid hemorrhage. Brain Res. 2024;1822:148666. doi:10.1016/j.brainres.2023.148666
  • Zhang Y, Ye P, Zhu H, et al. Neutral polysaccharide from gastrodia elata alleviates cerebral ischemia-reperfusion injury by inhibiting ferroptosis-mediated neuroinflammation via the NRF2/HO-1 signaling pathway. CNS Neurosci Ther. 2024;30(3):e14456. doi:10.1111/cns.14456
  • Yang F, Lian Q, Zhang X, et al. Aucubin provides protection against cerebral ischaemia-reperfusion injury by suppressing neuronal apoptosis, oxidative stress, and inflammation through the modulation of the AKT-GSK-3beta-Nrf2 signal cascade. Toxicol Appl Pharmacol. 2024;483:116829. doi:10.1016/j.taap.2024.116829
  • Liu C, Chen H, Tao X, et al. ALKBH5 protects against stroke by reducing endoplasmic reticulum stress-dependent inflammation injury via the STAT5/PERK/EIF2alpha/CHOP signaling pathway in an m(6)A-YTHDF1-dependent manner. Exp Neurol. 2024;372:114629. doi:10.1016/j.expneurol.2023.114629
  • Xu W, Zhang L, Zhang Y, et al. TRAF1 exacerbates myocardial ischemia reperfusion injury via ASK1-JNK/p38 signaling. J Am Heart Assoc. 2019;8(21):e012575. doi:10.1161/JAHA.119.012575
  • Qin JJ, Mao W, Wang X, et al. Caspase recruitment domain 6 protects against hepatic ischemia/reperfusion injury by suppressing ASK1. J Hepatol. 2018;69(5):1110–1122. doi:10.1016/j.jhep.2018.06.014
  • Chen J, Wang Q, Zhou W, et al. GPCR kinase 2-interacting protein-1 protects against ischemia-reperfusion injury of the spinal cord by modulating ASK1/JNK/p38 signaling. Faseb J. 2018;18:fj201800548.
  • Tesch GH, Ma FY, Nikolic-Paterson DJ. ASK1: a new therapeutic target for kidney disease. Am J Physiol Renal Physiol. 2016;311(2):F373–81. doi:10.1152/ajprenal.00208.2016