114
Views
0
CrossRef citations to date
0
Altmetric
Original Articles

Songorine inhibits oxidative stress-related inflammation through PI3K/AKT/NRF2 signaling pathway to alleviate lipopolysaccharide-induced septic acute lung injury

, , , , &
Pages 152-160 | Received 09 Mar 2023, Accepted 04 Nov 2023, Published online: 17 Nov 2023

References

  • Cecconi M, Evans L, Levy M, et al. Sepsis and septic shock. Lancet. 2018;392(10141):75–87. doi: 10.1016/S0140-6736(18)30696-2.
  • Kong Q, Wu X, Qiu Z, et al. Protective effect of dexmedetomidine on acute lung injury via the upregulation of tumour necrosis factor-α-Induced protein-8-like 2 in septic mice. Inflammation. 2020;43(3):833–846. doi: 10.1007/s10753-019-01169-w.
  • Park I, Kim M, Choe K, et al. Neutrophils disturb pulmonary microcirculation in sepsis-induced acute lung injury. Eur Respir J. 2019;53(3):1800786. doi: 10.1183/13993003.00786-2018.
  • Sapoznikov A, Gal Y, Falach R, et al. Early disruption of the alveolar-capillary barrier in a ricin-induced ARDS mouse model: neutrophil-dependent and -independent impairment of junction proteins. Am J Physiol Lung Cell Mol Physiol. 2019;316(1):L255–L268. doi: 10.1152/ajplung.00300.2018.
  • Guo Y, Liu Y, Zhao S, et al. Oxidative stress-induced FABP5 S-glutathionylation protects against acute lung injury by suppressing inflammation in macrophages. Nat Commun. 2021;12(1):7094. doi: 10.1038/s41467-021-27428-9.
  • Nesterova YV, Povetieva TN, Suslov NI, et al. Anti-inflammatory activity of diterpene alkaloids from aconitum baikalense. Bull Exp Biol Med. 2014;156(5):665–668. doi: 10.1007/s10517-014-2421-4.
  • Khan H, Nabavi SM, Sureda A, et al. Therapeutic potential of songorine, a diterpenoid alkaloid of the genus aconitum. Eur J Med Chem. 2018;153:29–33. doi: 10.1016/j.ejmech.2017.10.065.
  • Zhang L, Siyiti M, Zhang J, et al. Anti-inflammatory and anti-rheumatic activities in vitro of alkaloids separated from aconitum soongoricum stapf. Exp Ther Med. 2021;21(5):493. doi: 10.3892/etm.2021.9924.
  • Li Y, Feng YF, Liu XT, et al. Songorine promotes cardiac mitochondrial biogenesis via Nrf2 induction during sepsis. Redox Biol. 2021;38:101771. doi: 10.1016/j.redox.2020.101771.
  • Yuan H, Liu Y, Huang K, et al. Therapeutic mechanism and key active ingredients of shenfu injection in sepsis: a network pharmacology and molecular docking approach. Evid Based Complement Alternat Med. 2022;2022:9686149–9686114. doi: 10.1155/2022/9686149.
  • Li ST, Dai Q, Zhang SX, et al. Ulinastatin attenuates LPS-induced inflammation in mouse macrophage RAW264.7 cells by inhibiting the JNK/NF-κB signaling pathway and activating the PI3K/akt/Nrf2 pathway. Acta Pharmacol Sin. 2018;39(8):1294–1304. doi: 10.1038/aps.2017.143.
  • Li J, Deng SH, Li J, et al. Obacunone alleviates ferroptosis during lipopolysaccharide-induced acute lung injury by upregulating Nrf2-dependent antioxidant responses. Cell Mol Biol Lett. 2022;27(1):29. doi: 10.1186/s11658-022-00318-8.
  • Yan T, Yu X, Sun X, et al. A new steroidal saponin, furotrilliumoside from trillium tschonoskii inhibits lipopolysaccharide-induced inflammation in Raw264.7 cells by targeting PI3K/akt, MARK and Nrf2/HO-1 pathways. Fitoterapia. 2016;115:37–45. doi: 10.1016/j.fitote.2016.09.012.
  • Reddy NM, Potteti HR, Vegiraju S, et al. PI3K-AKT signaling via Nrf2 protects against hyperoxia-induced acute lung injury, but promotes inflammation post-injury independent of Nrf2 in mice. PLoS One. 2015;10(6):e0129676. doi: 10.1371/journal.pone.0129676.
  • Abd El-Ghafar OAM, Hassanein EHM, Sayed AM, et al. Acetovanillone prevents cyclophosphamide-induced acute lung injury by modulating PI3K/akt/mTOR and Nrf2 signaling in rats. Phytother Res. 2021;35(8):4499–4510. doi: 10.1002/ptr.7153.
  • Armstead BE, Lee CS, Chen Y, et al. Application of single cell multiomics points to changes in chromatin accessibility near calcitonin receptor like receptor and a possible role for adrenomedullin in the post-shock lung. Front Med. 2023;10:1003121. doi: 10.3389/fmed.2023.1003121.
  • Wei WY, Zhang N, Li LL, et al. Pioglitazone alleviates cardiac fibrosis and inhibits endothelial to mesenchymal transition induced by pressure overload. Cell Physiol Biochem. 2018;45(1):26–36. doi: 10.1159/000486220.
  • Jiang J, Huang K, Xu S, et al. Targeting NOX4 alleviates sepsis-induced acute lung injury via attenuation of redox-sensitive activation of CaMKII/ERK1/2/MLCK and endothelial cell barrier dysfunction. Redox Biol. 2020;36:101638. doi: 10.1016/j.redox.2020.101638.
  • Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 2001;25(4):402–408. doi: 10.1006/meth.2001.1262.
  • Chistiakov DA, Killingsworth MC, Myasoedova VA, et al. CD68/macrosialin: not just a histochemical marker. Lab Invest. 2017;97(1):4–13. doi: 10.1038/labinvest.2016.116.
  • Lagu T, Rothberg MB, Shieh MS, et al. Hospitalizations, costs, and outcomes of severe sepsis in the United States 2003 to 2007. Crit Care Med. 2012;40(3):754–761. doi: 10.1097/CCM.0b013e318232db65.
  • Kumar V. Pulmonary innate immune response determines the outcome of inflammation during pneumonia and sepsis-associated acute lung injury. Front Immunol. 2020;11:1722. doi: 10.3389/fimmu.2020.01722.
  • Zhong W, Qian K, Xiong J, et al. Curcumin alleviates lipopolysaccharide induced sepsis and liver failure by suppression of oxidative stress-related inflammation via PI3K/AKT and NF-κB related signaling. Biomed Pharmacother. 2016;83:302–313. doi: 10.1016/j.biopha.2016.06.036.
  • Wang Y, Shen Z, Zhao S, et al. Sipeimine ameliorates PM2.5-induced lung injury by inhibiting ferroptosis via the PI3K/akt/Nrf2 pathway: a network pharmacology approach. Ecotoxicol Environ Saf. 2022;239:113615. doi: 10.1016/j.ecoenv.2022.113615.
  • Wang Y, Zhao S, Jia N, et al. Pretreatment with rosavin attenuates PM2.5-induced lung injury in rats through antiferroptosis via PI3K/akt/Nrf2 signaling pathway. Phytother Res. 2023;37(1):195–210. doi: 10.1002/ptr.7606.
  • Liu B, Wang Z, He R, et al. Buformin alleviates sepsis-induced acute lung injury via inhibiting NLRP3-mediated pyroptosis through an AMPK-dependent pathway. Clin Sci. 2022;136(4):273–289. doi: 10.1042/CS20211156.
  • Zyuz’kov GN, Zhdanov VV, Miroshnichenko LA, et al. Involvement of PI3K, MAPK ERK1/2 and p38 in functional stimulation of mesenchymal progenitor cells by alkaloid songorine. Bull Exp Biol Med. 2015;159(1):58–61. doi: 10.1007/s10517-015-2889-6.
  • Kulkarni HS, Lee JS, Bastarache JA, et al. Update on the features and measurements of experimental acute lung injury in animals: an official American thoracic society workshop report. Am J Respir Cell Mol Biol. 2022;66(2):e1–e14. doi: 10.1165/rcmb.2021-0531ST.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.