The protective effect of teprenone in TNBS-induced ulcerative colitis rats by modulating the gut microbiota and reducing inflammatory response

References

• Mak WY, Zhao M, Ng SC, et al. The epidemiology of inflammatory bowel disease: east meets west. J Gastroenterol Hepatol. 2020;35(3):380–389. doi: 10.1111/jgh.14872.
   PubMed Web of Science ®Google Scholar
• Shawki S, Ashburn J, Signs SA, et al. Colon cancer: inflammation-associated cancer. Surg Oncol Clin N Am. 2018;27(2):269–287. doi: 10.1016/j.soc.2017.11.003.
   PubMed Web of Science ®Google Scholar
• Saez A, Herrero-Fernandez B, Gomez-Bris R, et al. Pathophysiology of inflammatory bowel disease: innate immune system. Int J Mol Sci. 2023;24(2):1526. doi: 10.3390/ijms24021526.
   PubMed Web of Science ®Google Scholar
• Qu Y, Li X, Xu F, et al. Kaempferol alleviates murine experimental colitis by restoring gut microbiota and inhibiting the LPS-TLR4-NF-κB axis. Front Immunol. 2021;12:679897. doi: 10.3389/fimmu.2021.679897.
   PubMed Web of Science ®Google Scholar
• Liu Y, Yang M, Tang L, et al. TLR4 regulates RORγt+ regulatory T-cell responses and susceptibility to colon inflammation through interaction with Akkermansia muciniphila. Microbiome. 2022;10(1):98. doi: 10.1186/s40168-022-01296-x.
   PubMed Web of Science ®Google Scholar
• Dejban P, Nikravangolsefid N, Chamanara M, et al. The role of medicinal products in the treatment of inflammatory bowel diseases (IBD) through inhibition of TLR4/NF-kappaB pathway. Phytother Res. 2021;35(2):835–845. doi: 10.1002/ptr.6866.
   PubMed Web of Science ®Google Scholar
• Ruiz E, Penrose HM, Heller S, et al. Bacterial TLR4 and NOD2 signaling linked to reduced mitochondrial energy function in active inflammatory bowel disease. Gut Microbes. 2020;11(3):350–363. doi: 10.1080/19490976.2019.1611152.
   PubMed Web of Science ®Google Scholar
• Shi YJ, Gong HF, Zhao QQ, et al. Critical role of toll-like receptor 4 (TLR4) in dextran sulfate sodium (DSS)-induced intestinal injury and repair. Toxicol Lett. 2019;315:23–30. doi: 10.1016/j.toxlet.2019.08.012.
   PubMed Web of Science ®Google Scholar
• Wang Y, Wang W, Yang H, et al. Intraperitoneal injection of 4-hydroxynonenal (4-HNE), a lipid peroxidation product, exacerbates colonic inflammation through activation of toll-like receptor 4 signaling. Free Radic Biol Med. 2019;131:237–242. doi: 10.1016/j.freeradbiomed.2018.11.037.
   PubMed Web of Science ®Google Scholar
• Chen YX, Zhang XQ, Yu CG, et al. Artesunate exerts protective effects against ulcerative colitis via suppressing toll-like receptor 4 and its downstream nuclear factor-κB signaling pathways. Mol Med Rep. 2019;20(2):1321–1332. doi: 10.3892/mmr.2019.10345.
   PubMed Web of Science ®Google Scholar
• Bing X, Xuelei L, Wanwei D, et al. EGCG maintains Th1/Th2 balance and mitigates ulcerative colitis induced by dextran sulfate sodium through TLR4/MyD88/NF-κB signaling pathway in rats. Can J Gastroenterol Hepatol. 2017;2017:3057268–3057269. doi: 10.1155/2017/3057268.
   PubMed Web of Science ®Google Scholar
• Rafa H, Benkhelifa S, AitYounes S, et al. All-Trans retinoic acid modulates TLR4/NF-κB signaling pathway targeting TNF-α and nitric oxide synthase 2 expression in colonic mucosa during ulcerative colitis and colitis associated cancer. Mediators Inflamm. 2017;2017:7353252–7353216. doi: 10.1155/2017/7353252.
   PubMed Web of Science ®Google Scholar
• Li Y, Yang S, Lun J, et al. Inhibitory effects of the Lactobacillus rhamnosus GG effector protein HM0539 on inflammatory response through the TLR4/MyD88/NF-кB axis. Front Immunol. 2020;11:551449. doi: 10.3389/fimmu.2020.551449.
   PubMed Web of Science ®Google Scholar
• Chen GL, Zhang Y, Wang WY, et al. Partners of patients with ulcerative colitis exhibit a biologically relevant dysbiosis in fecal microbial metacommunities. World J Gastroenterol. 2017;23(25):4624–4631. doi: 10.3748/wjg.v23.i25.4624.
   PubMed Web of Science ®Google Scholar
• Machiels K, Joossens M, Sabino J, et al. A decrease of the butyrate-producing species Roseburia hominis and Faecalibacterium prausnitzii defines dysbiosis in patients with ulcerative colitis. Gut. 2014;63(8):1275–1283. doi: 10.1136/gutjnl-2013-304833.
   PubMed Web of Science ®Google Scholar
• Zhao C, Wang J, Xiao Q. Efficacy of teprenone for prevention of NSAID-Induced gastrointestinal injury: a systematic review and Meta-Analysis. Front Med (Lausanne). 2021;8:647494. doi: 10.3389/fmed.2021.647494.
   PubMed Web of Science ®Google Scholar
• Sun Y, Dong H, Zhan A, et al. Protection of teprenone against hypoxia and reoxygenation stress in stomach and intestine of Lateolabrax maculatus. Fish Physiol Biochem. 2020;46(2):575–584. doi: 10.1007/s10695-019-00732-4.
   PubMed Web of Science ®Google Scholar
• Esmaeili Z, Niaz Q, Saffari PM, et al. Evaluation of the effect of heat shock protein 70 targeted drugs on cirrhotic cardiomyopathy in biliary cirrhotic rats. Life Sci. 2021;273:119261. doi: 10.1016/j.lfs.2021.119261.
   PubMed Web of Science ®Google Scholar
• Ohkawara T, Nishihira J, Takeda H, et al. Protective effect of geranylgeranylacetone on trinitrobenzene sulfonic acid-induced colitis in mice. Int J Mol Med. 2006;17(2):229–234. doi: 10.3892/ijmm.17.2.229.
   PubMed Web of Science ®Google Scholar
• Kim B. Western blot techniques. Methods Mol Biol. 2017;1606:133–139. doi: 10.1007/978-1-4939-6990-6_9.
   PubMedGoogle Scholar
• Fischer AH, Jacobson KA, Rose J, et al. Hematoxylin and eosin staining of tissue and cell sections. CSH Protoc. 2008;2008:pdb.prot4986. doi: 10.1101/pdb.prot4986.
   PubMedGoogle Scholar
• El-Baz AM, Khodir AE, Adel El-Sokkary MM, et al. The protective effect of Lactobacillus versus 5-aminosalicylic acid in ulcerative colitis model by modulation of gut microbiota and Nrf2/HO-1 pathway. Life Sci. 2020;256:117927. doi: 10.1016/j.lfs.2020.117927.
   PubMed Web of Science ®Google Scholar
• Lu J, Dong B, Chen A, et al. Escherichia coli promotes DSS-induced murine colitis recovery through activation of the TLR4/NF-κB signaling pathway. Mol Med Rep. 2019;19(3):2021–2028. doi: 10.3892/mmr.2019.9848.
   PubMed Web of Science ®Google Scholar
• Zhao J, Fan Y, Ye W, et al. The protective effect of teprenone on Aspirin-related gastric mucosal injuries. Gastroenterol Res Pract. 2019;2019:6532876–6532877. doi: 10.1155/2019/6532876.
   PubMed Web of Science ®Google Scholar
• Nakase H, Sato N, Mizuno N, et al. The influence of cytokines on the complex pathology of ulcerative colitis. Autoimmun Rev. 2022;21(3):103017. doi: 10.1016/j.autrev.2021.103017.
   PubMed Web of Science ®Google Scholar
• Ohkawara T, Nishihira J, Takeda H, et al. Geranylgeranylacetone protects mice from dextran sulfate sodium-induced colitis. Scand J Gastroenterol. 2005;40(9):1049–1057. doi: 10.1080/00365520510023161.
   PubMed Web of Science ®Google Scholar
• Rashidian A, Muhammadnejad A, Dehpour AR, et al. Atorvastatin attenuates TNBS-induced rat colitis: the involvement of the TLR4/NF-kB signaling pathway. Inflammopharmacology. 2016;24(2–3):109–118. doi: 10.1007/s10787-016-0263-6.
   PubMed Web of Science ®Google Scholar
• Hu LH, Liu JY, Yin JB. Eriodictyol attenuates TNBS-induced ulcerative colitis through repressing TLR4/NF-kB signaling pathway in rats. Kaohsiung J Med Sci. 2021;37(9):812–818. doi: 10.1002/kjm2.12400.
   PubMed Web of Science ®Google Scholar
• Tao JH, Duan JA, Zhang W, et al. Polysaccharides from Chrysanthemum morifolium ramat ameliorate colitis rats via regulation of the metabolic profiling and NF-κ B/TLR4 and IL-6/JAK2/STAT3 signaling pathways. Front Pharmacol. 2018;9:746. doi: 10.3389/fphar.2018.00746.
   PubMed Web of Science ®Google Scholar
• Duan C, Xu X, Lu X, et al. RIP3 knockdown inhibits necroptosis of human intestinal epithelial cells via TLR4/MyD88/NF-κB signaling and ameliorates murine colitis. BMC Gastroenterol. 2022;22(1):137. doi: 10.1186/s12876-022-02208-x.
   PubMed Web of Science ®Google Scholar
• Lin JC, Wu JQ, Wang F, et al. QingBai decoction regulates intestinal permeability of dextran sulphate sodium-induced colitis through the modulation of notch and NF-κB signalling. Cell Prolif. 2019;52(2):e12547. doi: 10.1111/cpr.12547.
   PubMed Web of Science ®Google Scholar
• Kawamoto A, Nagata S, Anzai S, et al. Ubiquitin D is upregulated by synergy of notch signalling and TNF-α in the inflamed intestinal epithelia of IBD patients. J Crohns Colitis. 2019;13(4):495–509. doi: 10.1093/ecco-jcc/jjy180.
   PubMed Web of Science ®Google Scholar
• Martini E, Krug SM, Siegmund B, et al. Mend your fences: the epithelial barrier and its relationship with mucosal immunity in inflammatory bowel disease. Cell Mol Gastroenterol Hepatol. 2017;4(1):33–46. doi: 10.1016/j.jcmgh.2017.03.007.
   PubMed Web of Science ®Google Scholar
• Kuo WT, Zuo L, Odenwald MA, et al. The tight junction protein ZO-1 is dispensable for barrier function but critical for effective mucosal repair. Gastroenterology. 2021;161(6):1924–1939. doi: 10.1053/j.gastro.2021.08.047.
   PubMed Web of Science ®Google Scholar
• Tan Y, Peng L, Wen L, et al. Correlations of inflammatory cytokines in the intestinal mucosa, serum inflammation, oxidative stresses and immune changes with vitamin deficiency in ulcerative colitis patients. Cell Mol Biol (Noisy-le-Grand). 2022;68(7):101–106. doi: 10.14715/cmb/2022.68.7.17.
   PubMed Web of Science ®Google Scholar
• Chami B, Martin NJJ, Dennis JM, et al. Myeloperoxidase in the inflamed colon: a novel target for treating inflammatory bowel disease. Arch Biochem Biophys. 2018;645:61–71. doi: 10.1016/j.abb.2018.03.012.
   PubMed Web of Science ®Google Scholar
• Viladomiu M, Metz ML, Lima SF, et al. Adherent-invasive E. coli metabolism of propanediol in Crohn’s disease regulates phagocytes to drive intestinal inflammation. Cell Host Microbe. 2021;29(4):607–619.e8. doi: 10.1016/j.chom.2021.01.002.
   PubMed Web of Science ®Google Scholar
• Zhang J, Hoedt EC, Liu Q, et al. Elucidation of Proteus mirabilis as a key bacterium in Crohn’s disease inflammation. Gastroenterology. 2021;160(1):317–330.e11. doi: 10.1053/j.gastro.2020.09.036.
   PubMed Web of Science ®Google Scholar
• Fiorillo L, Cervino G, Laino L, et al. Porphyromonas gingivalis, periodontal and systemic implications: a systematic review. Dent J (Basel). 2019;7(4):114. doi: 10.3390/dj7040114.
   PubMedGoogle Scholar