344
Views
22
CrossRef citations to date
0
Altmetric
ORIGINAL RESEARCH

Assessment of Wound Healing in the Alloxan-Induced Diabetic Rabbit Ear Model

, BE, , BE, , PhD, , MB, BCh, BAO & , MPH, MS, PhD
Pages 261-269 | Received 12 Feb 2008, Accepted 20 May 2008, Published online: 09 Jul 2009

REFERENCES

  • Darby I A, Bisucci T, Hewitson T D, MacLellan D G. Apoptosis is increased in a model of diabetes-impaired wound healing in genetically diabetic mice. Int J Biochem Cell Biol 1997; 29(1)191–200
  • Zimny S, Schatz H, Pfohl M. Determinants and estimation of healing times in diabetic foot ulcers. J Diabetes Complicat 2002; 16(3)327–332
  • Loots M A, Lamme E N, Zeegelaar J, et al. Differences in cellular infiltrate and extracellular matrix of chronic diabetic and venous ulcers versus acute wounds. J Invest Dermatol 1998; 111(3)850–857
  • Lerman O Z, Galiano R D, Armour M, et al. Cellular dysfunction in the diabetic fibroblast: impairment in migration, vascular endothelial growth factor production, and response to hypoxia. Am J Pathol 2003; 162(1)303–312
  • Blakytny R, Jude E B, Martin Gibson J, et al. Lack of insulin-like growth factor 1 (IGF1) in the basal keratinocyte layer of diabetic skin and diabetic foot ulcers. J Pathol 2000; 190(3)589–594
  • Yamasaki K, Edington H D, McClosky C, et al. Reversal of impaired wound repair in iNOS-deficient mice by topical adenoviral-mediated iNOS gene transfer. J Clin Invest 1998; 101(3)967–971
  • Cechowska-Pasko M, Palka J, Bankowski E. Decrease in the glycosaminoglycan content in the skin of diabetic rats. The role of IGF-I, IGF-binding proteins and proteolytic activity. Mol Cell Biochem 1996; 154(1)1–8
  • Onodera H, Ikeuchi D, Nagayama S, et al. Weakness of anastomotic site in diabetic rats is caused by changes in the integrity of newly formed collagen. Dig Surg 2004; 21(2)146–151
  • Ortolan E V, Spadella C T, Caramori C, et al. Microscopic, morphometric and ultrastructural analysis of anastomotic healing in the intestine of normal and diabetic rats. Exp Clin Endocrinol Diabetes 2008; 116(2)198–202
  • Franzen L E, Roberg K. Impaired connective tissue repair in streptozotocin-induced diabetes shows ultrastructural signs of impaired contraction. J Surg Res 1995; 58(2)407–414
  • Gottrup F, Andreassen T T. Healing of incisional wounds in stomach and duodenum: the influence of experimental diabetes. J Surg Res 1981; 31(1)61–68
  • Loots M A, Lamme E N, Mekkes J R, et al. Cultured fibroblasts from chronic diabetic wounds on the lower extremity (non-insulin-dependent diabetes mellitus) show disturbed proliferation. Arch Dermatol Res 1999; 291(2–3)93–99
  • Martin A, Komada M R, Sane D C. Abnormal angiogenesis in diabetes mellitus. Med Res Rev 2003; 23(2)117–145
  • Jorneskog G, Brismar K, Fagrell B. Skin capillary circulation severely impaired in toes of patients with IDDM, with and without late diabetic complications. Diabetologia 1995; 38(2)474–480
  • Williams S B, Goldfine A B, Timimi F K, et al. Acute hyperglycemia attenuates endothelium-dependent vasodilation in humans in vivo. Circulation 1998; 97(17)1695–1701
  • Akbari C M, Saouaf R, Barnhill D F, et al. Endothelium-dependent vasodilatation is impaired in both microcirculation and macrocirculation during acute hyperglycemia. J Vasc Surg 1998; 28(2)687–694
  • Creager M A, Luscher T F, Cosentino F, et al. Diabetes and vascular disease: pathophysiology, clinical consequences, and medical therapy; part I. Circulation 2003; 108(12)1527–1532
  • Makimattila S, Virkamaki A, Groop P H, et al. Chronic hyperglycemia impairs endothelial function and insulin sensitivity via different mechanisms in insulin-dependent diabetes mellitus. Circulation 1996; 94(6)1276–1282
  • Terashi H, Izumi K, Deveci M, et al. High glucose inhibits human epidermal keratinocyte proliferation for cellular studies on diabetes mellitus. Int Wound J 2005; 2(2)298–304
  • Spravchikov N, Sizyakov G, Gartsbein M, et al. Glucose effects on skin keratinocytes: implications for diabetes skin complications. Diabetes 2001; 50(7)1627–1635
  • Cosentino F, Hishikawa K, Katusic Z S, et al. High glucose increases nitric oxide synthase expression and superoxide anion generation in human aortic endothelial cells. Circulation 1997; 96(1)25–28
  • Squadrito G L, Pryor W A. The formation of peroxynitrite in vivo from nitric oxide and superoxide. Chem Biol Interact 1995; 96(2)203–206
  • Kampfer H, Pfeilschifter J, Frank S. Expression and activity of arginase isoenzymes during normal and diabetes-impaired skin repair. J Invest Dermatol 2003; 121(6)1544–1551
  • Schaffer M R, Tantry U, Efron P A, et al. Diabetes-impaired healing and reduced wound nitric oxide synthesis: a possible pathophysiologic correlation. Surgery 1997; 121(3)513–519
  • Davidson J M. Experimental animal wound models. Wounds 2001; 13(1)9–23
  • Sullivan S R, Underwood R A, Gibran N S, et al. Validation of a model for the study of multiple wounds in the diabetic mouse (db/db). Plast Reconstr Surg 2004; 113(3)953–960
  • Garcia Y, Breen A, Burugapalli K, et al. Stereological methods to assess tissue response for tissue-engineered scaffolds. Biomaterials 2007; 28(2)175–186
  • Mayhew T M, Burton G J. Stereology and its impact on our understanding of human placental functional morphology. Microsc Res Tech 1997; 38(1–2)195–205
  • Cooney R, Hynes S O, Sharif F, et al. Effect of gene delivery of NOS isoforms on intimal hyperplasia and endothelial regeneration after balloon injury. Gene Ther 2007; 14(3)396–404
  • Mayhew T M. Stereology and the Placenta: Where's the Point? A Review. Placenta 2006; 27(14)S17–S25
  • Mandarim-de-Lacerda C A. Stereological tools in biomedical research. An Acad Bras Cienc 2003; 75(2)469–486
  • Cruz-Orive L M, Weibel E R. Recent stereological methods for cell biology: a brief survey. Am J Physiol 1990; 258: L148–L156, (4 Pt. 1)
  • Dong F. Stereological analysis of the effects of alpha-MSH and cAMP on the morphology of melanoma cells in vitro. PhD dissertation, University of Hong Kong. 1995
  • Howell K, Hopkins N, McLoughlin P. Combined confocal microscopy and stereology: a highly efficient and unbiased approach to quantitative structural measurement in tissues. Exp Physiol 2002; 87(6)747–756
  • Mayhew T M. The new stereological methods for interpreting functional morphology from slices of cells and organs. Exp Physiol 1991; 76(3)639–665
  • Goldstein S, Moerman E J, Soeldner J S, et al. Chronologic and physiologic age affect replicative life-span of fibroblasts from diabetic, prediabetic, and normal donors. Science 1978; 199(4330)781–782
  • Brown D L, Kao W W, Greenhalgh D G. Apoptosis down-regulates inflammation under the advancing epithelial wound edge: delayed patterns in diabetes and improvement with topical growth factors. Surgery 1997; 121(2)372–380
  • Galeano M, Deodato B, Altavilla D, et al. Adeno-associated viral vector-mediated human vascular endothelial growth factor gene transfer stimulates angiogenesis and wound healing in the genetically diabetic mouse. Diabetologia 2003; 46(2)546–555
  • Herse P. Effects of hyperglycaemia on ocular development in rabbit: refraction and biometric changes. Ophthalmic Physiol Opt 2005; 25(2)97–104

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.