Advanced search
Publication Cover
Inhalation Toxicology
International Forum for Respiratory Research
Volume 14, 2002 - Issue 2
Submit an article Journal homepage
23
Views
17
CrossRef citations to date
0
Altmetric
Research Article

9-NITROCAMPTOTHECIN LIPOSOME AEROSOL: LACK OF SUBACUTE TOXICITY IN DOGS

Brian E. Gilbert Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, USA
,
Alexander Seryshev Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, Texas, USA
,
Vernon Knight Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, Texas, USA
&
Cory Brayton Center for Comparative Medicine, Baylor College of Medicine, Houston, Texas, USA
Pages 185-197 | Published online: 01 Oct 2008

  • Burke, T. G., and Gao, X. 1994. Stabilization of topotecan in low pH liposomes composed of distearoylphosphatidylcholine. J. Pharm. Sci. 83:967-969.
  • Burke, T. G., Mishra, A. K., Wani, M. C, and Wall, M. E. 1993. Lipid bilayer partitioning and stability of camptothecin drugs. Biochemistry 32:5352-5364.
  • Cortesi, R., Esposito, E., Maietti, A., Menegatti, E., and Nastruzzi, C. 1997. Formulation study for the antitumor drug camptothecin: Liposomes, micellar solutions and a microemulsion. Int. J. Pharm. 159:95-103.
  • Dancey, J., and Eisenhauer, E. A. 1996. Current perspectives on camptothecins in cancer treatment. Br. J. Cancer 74:327-338.
  • Gilbert, B. E., Wilson, S. Z., Garcon, N. M., Wyde, P. R., and Knight, V. 1993. Characterization and administration of cyclosporine liposomes as a small-particle aerosol. Transplantation 56:974-977.
  • Gilbert, B. E., Black, M. B., Waldrep, J. C, Bennick, J., Montgomery, C, and Knight, V. 1997. Cyclosporin A liposome aerosol: Lack of acute toxicity in rats with a high incidence of underlying pneumonitis. lnhal. Toxicol. 9:717-730.
  • Gilbert, B., Newman, R., Zamboni, W., Knight, V., and Verschraegen, C. 2001. Pharmacokinetics of multiple 9-nitrocamptothecin (9-NC) liposome aerosols during a phase I study: Levels of total and lactone forms, and its conversion to 9-aminocamptothecin (9-AC). Proc. Am. Soc. Clin. Oncol. 20:90b.
  • Giovanella, B. C, Natelson, E., Harris, N., Vardeman, D., and Stehlin, J. S. 1996. Protocols for the treatment of human tumor xenografts with camptothecins. Ann. NY Acad. Sci. 803:181-187.
  • Jaxel, C, Kohn, K. W., Wani, M. C, Wall, M. E., and Pommier, Y. 1989. Structure-activity study of the actions of camptothecin derivatives on mammalian topoisomerase I: Evidence for a specific receptor site and a relation to antitumor activity. Cancer Res. 49:1465-1469.
  • Knight, V., Koshkina, N. V., Waldrep, J. C, Giovanella, B. C, and Gilbert, B. E. 1999. Anti-cancer effect of 9-nitrocamptothecin liposome aerosol on human cancer xenografts in nude mice. Cancer Chemother. Pharmacol. 44:177-186.
  • Knight, V., Kleinerman, E. S., Waldrep, J. C, Giovanella, B. C, Gilbert, B. E., and Koshkina, N. V. 2000. 9-Nitrocamptothecin liposome aerosol treatment of human cancer subcutaneous xenografts and pulmonary cancer metastases in mice. Ann. NY Acad. Sci. 922:151-163.
  • Koshkina, N. V., Gilbert, B. E., Waldrep, J. C, Seryshev, A., and Knight, V. 1999. Distribution of camptothecin after delivery as a liposome aerosol or following intramuscular injection in mice. Cancer Chemother. Pharmacol. 44:187-192.
  • Koshkina, N. V., Kleinerman, E. S., Waldrep, C, Jia, S.-F., Worth, L. L., Gilbert, B. E., and Knight, V. 2000. 9-Nitrocamptothecin liposome aerosol treatment of melanoma and osteosarcoma lung metastases in mice. Clin. Cancer Res. 6:2876-2880.
  • Natelson, E. A., Giovanella, B. C, Verschraegen, C. F., Fehir, K. M., De lpolyi, P. D., Harris, N., and Stehlin, J. S. 1996. Phase I clinical and pharmacological studies of 20-(S)-camptothecin and 20-(S)-9-nitrocamptothecin as anticancer agents. Ann. NYAcad. Sci. 803:224-230.
  • Pantazis, P., Kozielski, A. J., Mendoza, J. T., Early, J. A., Hinz, H. R., and Giovanella, B. C. 1993a. Camptothecin derivatives induce regression of human ovarian carcinomas grown in nude mice and distinguish between non-tumorigenic and tumorigenic cells in vitro. Int. J. Cancer 53:863-871.
  • Pantazis, P., Kozielski, A. J., Vardeman, D. M., Petry, E. R., and Giovanella, B. C. 1993b. Efficacy of camptothecin congeners in the treatment of human breast carcinoma xenografts. Oncol. Res. 5:273-281.
  • Pantazis, P., Mendoza, J. T., DeJesus, A., Rubin, E., Kufe, D., and Giovanella, B. C. 1994. Partial characterization of human leukemia U-937 cell sublines resistant to 9-nitrocamptothecin. Eur J. Haematol. 53:135-144.
  • Sadzuka, Y., Hirotsu, S., and Hirota, S. 1999. Effective irinotecan (CPT-11)-containing liposomes: lntraliposomal conversion to the active metabolite SN-38. Jpn. J. Cancer Res. 90:226-232.
  • Stehlin, J. S., Giovanella, B. C, Natelson, E. A., De lpolyi, P. D., Coil, D., Davis, B., WoIk, D., Wallace, P., and Trojacek, A. 1999. A study of 9-nitrocamptothecin (RFS-2000) in patients with advanced pancreatic cancer. Int. J. Oncol. 14:821-831.
  • Takimoto, C. H., Wright, J., and Arbuck, S. G. 1998. Clinical applications of the camptothecins. Biochim. Biophys. Acta 1400:107-119.
  • Verschraegen, C. F., Natelson, E. A., Giovanella, B. C, Kavanagh, J. J., Kudelka, A. P., Freedman, R. S., Edwards, C. L., Ende, K., and Stehlin, J. S. 1998. A phase I clinical and pharmacological study of oral 9-nitrocamptothecin, a novel water-insoluble topoisomerase I inhibitor. Anti-Cancer Drug 9:36-44.
  • Verschraegen, C. F., Gupta, F., Loyer, E., Kavanagh, J. J., Kudelka, A. P., Freedman, R. S., Edwards, C. L., Harris, N., Steger, M., Steltz, V., Giovanella, B. C, and Stehlin, J. S. 1999. A phase II clinical and pharmacological study of oral 9-nitrocamptothecin in patients with refractory epithelial ovarian, tubal or peritoneal cancer. Anti-Cancer Drug 10:375-383.
  • Verschraegen, C. F., Jaeckle, K., Giovanella, B. C, Knight, V., and Gilbert, B. E. 2000. Alternative administration of camptothecin analogues. Ann. NY Acad. Sci. 922:237-246.
  • Wall M. E., and Wani, M. C. 1995. Camptothecin and taxol: Discovery to clinic-Thirteenth Bruce F. Cain memorial award lecture. Cancer Res. 55:753-760.
  • Wani, M. C., Nicholas, A. W., and Wall, M. E. 1986. Plant antitumor agents. 23. Synthesis and antileukemic activity of camptothecin analogues. J. Med. Chem. 29:2358-2363.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.