Advanced search
Publication Cover
Inhalation Toxicology
International Forum for Respiratory Research
Volume 14, 2002 - Issue 12
Submit an article Journal homepage
249
Views
116
CrossRef citations to date
0
Altmetric
Research Article

CARDIOVASCULAR EFFECTS ASSOCIATED WITH AIR POLLUTION: POTENTIAL MECHANISMS AND METHODS OF TESTING

Mark J. Utell Departments of Medicine and Environmental Medicine, University of Rochester Medical Center, Rochester, New York, USA
,
Mark W. Frampton Departments of Medicine and Environmental Medicine, University of Rochester Medical Center, Rochester, New York, USA
,
Wojciech Zareba Department of Medicine, University of Rochester Medical Center, Rochester, New York, USA
,
Robert B. Devlin U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, USA
&
Wayne E. Cascio Department of Medicine, University of North Carolina, and Center for Environmental Medicine and Lung Biology, Chapel Hill, North Carolina, USA
Pages 1231-1247 | Published online: 01 Oct 2008

  • Atiga, W., Calkins, H., Lawrence, J., Tomaselli, G., Smith, J., and Berger, R. 1998, Beat-to-beat repolarization lability identifies patients at risk for sudden cardiac death. J. Cardiovasc. Electrophysiol. 9:899-908.
  • Boscia, J. A., Chalupa, D., Utell, M. J., Zareba, W., Konecki, J. A., Morrow, P. E., Gibb, F. R., OberdU+00f6rster, G., Azadniv, M., Frasier, L. M., Speers, D. M., and Frampton, M. W. 2000. Airway and cardiovascular effects of inhaled ultrafine carbon particles in resting healthy nonsmoking adults. Am. J. Respir. Crit. Care Med. 161: A239.
  • Calderón-Garciduenas, L., Gambling, T. M., Acuna, H., Garcia, R., Osnaya, N., Monroy, S., Villarreal-Calderón, A., Carson, J., Koren, H. S., and Devlin, R. B. 2001. Canines as sentinel species for assessing chronic exposure to air pollutants. Part 2. Cardiac Pathol. Toxicol. Sci. 61:356-367.
  • Dekker, J. M., Crow, R. S., Folsom, A. R., Hannan, P. J., Liao, D., Swenne, C. A., and Schouten, E. G. 2000. Low heart rate variability in a 2-minute rhythm strip predicts risk of coronary heart disease and mortality from several causes: The ARIC Study, Atherosclerosis Risk in Communities. Circulation 102(11):1239-1244.
  • Devlin, R. B., Cascio, W., Kerhl, H., and Ghio, A. 2000. Changes in heart rate variability in young and elderly humans exposed to concentrated ambient air particles. Am. J. Respir. Crit. Care Med. 161: A239.
  • Frampton, M. W. 2001. Systemic and cardiovascular effects of airway injury and inflammation: Ultra-fine particle exposure in humans. Environ. Health Perspect. 109(suppl. 4):529-532.
  • Gerszten, R. E., Mach, F., Sauty, A., Rosenzweig, A., and Luster, A. D. 2000. Chemokines, leukocytes, and atherosclerosis. J. Lab. Clin. Med. 136:87-92.
  • Ghio, A. J., Kim, C., and Devlin, R. B. 2000. Concentrated ambient air particles induce mild pulmonary inflammation in healthy human volunteers. Am. J. Respir. Crit. Care Med. 162:981-988.
  • Godleski, J. J., Verrier, R. L., Koutrakis, P., and Catalano, P. 2000. Mechanisms of morbidity and mortality from exposure to ambient air particles. Res. Rep. Health Effects Inst. 91:5-88.
  • Gold, D. R., Litonjua, A., Schwartz, J., Lovett, E., Larson, A., Nearing, B., Allen, G., Verrier, M., Cherry, R., and Verrier, R. 2000. Ambient pollution and heart rate variability. Circulation 101(11):1267-1273.
  • Gordon, T., and Reibman, J. 2000. Toxiocological highlight: Cardiovascular toxicity of inhaled ambient particulate matter. Toxicol. Sci. 56:2-4.
  • Gordon, T., Nadziejko, C., Chen, L. C., and Schlesinger, R. 2000. Effects of concentrated ambient particles in rats and hamsters: An exploratory study. Research Report 93, Health Effects Institute, Cambridge, MA.
  • Kodavanti, U. P., Schladweiler, M. C., Richards, J. R., and costa, D. L. 2001. Acute lung injury from intratracheal exposure to fugitive residual oil fly ash and its constituent metals in normo-and spontaneously hypertensive rats. Inhal. Toxicol. 13(1):37-54.
  • Laman, J. D., de Smet, B. J., Schonveld, A., and van Meurs, M. 1997. CD40-CD40L interactions in atherosclerosis. Immunol. Today 18:272-277.
  • Liao, D., Greason, J., Shy, C., Williams, R., Watts, R., and Zweidinger, R. 1999. Daily variation of particulate air pollution and poor cardiac autonomic control in the elderly. Environ. Health Perspect. 107:521-525.
  • Malik, M., and Camm, A. J. 1995. Heart rate variability. Armonk, NY: Futura.
  • Maseri, A. 1997. Inflammation, arthrosclerosis, and ischemic events: Exploring the hidden side of the moon. N. Engl. J. Med. 336:1014-1016.
  • Muggenberg, B. A., Barr, E. G., Cheng, Y. S., Seagrave, J. C., Tilley, L. P., and Mauderley, J. L. 2001. Effect of inhaled residual oil fly ash on the electrocardiogram of dogs. Inhal. Toxicol. 12:189-208.
  • National heart, Lung, and Blood Institute. 2000. Morbidity and mortality chart book in cardiovascular, lung and blood diseases. www.nhlbi.nih.gov/resources/doc/00chtbk.pdf,May.
  • Peters, A., Döring, A., Wichmann, H.-E., and Koenig, W. 1997. Increased plasma viscosity during an air pollution episode: A link to mortality?. Lancet 349:1582-1587.
  • Peters, A., Liu, E. Verrier, R. L., Schwartz, J., Gold, D. R., Mittleman, M., Baliff, J., Oh, J. A., Allen, G., Monahan, K., and Dockery, D. W. 2000. Air pollution and incidence of cardiac arrhythmia. Epidemiology 11:11-17.
  • Peters, A., Dockery, D. W., Muller, J. E., and Mittleman, M. A. 2001a. Increased particulate air pollution and the triggering of myocardial infarction. Circulation 103:2810-2815.
  • Peters, A., Fröhlich, O., Döring, A., Immervoll, T. Wichmann, H.-E., Hutchinson, W., Pepys, M. and Koenig, J. 2001b. Particulate air pollution is associated with an acute phase response in men. Results for the MONICA-Augsburg Study. Eur. Heart J. 22:1198-1204.
  • Phipps, R. P. 2000. Atherosclerosis: the emerging role of inflammation and the CD40-CD40 ligand system. Proc. Natl. Acad. Sci. USA 97:6930-6932.
  • Pope, C. A. III. 2000. Epidemiology of fine particulate air pollution and human health: Biologic mechanisms and who's at risk. Environ. Health Perspect. 108(suppl 4):713-723
  • Pope, C. A. III, Dockery, D. W., Kanner, R. E., Villegas, G. M., and Schwartz, J. 1999a. Oxygen saturation, pulse rate, and particulate air pollution: A daily time-series panel study. Am. J. Respir. Crit. Care Med. 159:365-372.
  • Pope, C. A. III, Verrier, R. L., Lovett, E. G., Larson, A. C., Raizenne, M. E., Kanner, R. E., Schwartz, J., Villegas, G. M., Gold, D. R., and Dockery, D. W. 1999b. Heart rate variability associated with particulate air pollution. Am. Heart J. 138:890-899.
  • Prescott, G. J., Lee, R. J., Cohen, G. R., Elton, R. H., Lee, A. J., Fowkes, F. G., and Agius, R. M. 2000. Investigation of factors which might indicate susceptibility to particulate air pollution. Occup. Environ. Med. 57(1):53-57.
  • Quyyumi, A. A. 1998. Endothelial function in health and disease: new insights into the genesis of cardiovascular disease. Am. J. Med. 105:32S-39S.
  • Ross, R. 1999. Atherosclerosis; An inflammatory disease. N. Engl. J. Med. 340:115-126.
  • Schwartz, P., La Rovere, M., and Vanoli, E. 1992. Autonomic nervous system and sudden cardiac death. Circulation 85(suppl. 1):77-91.
  • Seaton, A. 1995. Particulate air pollution and acute health effects. Lancet 345:176-178.
  • Seaton, A., Soutar, A., Crawford, V., Elton, R., McNerlan, S. Cherrie, J., Watt, M., Agius, R., and Stout, R. 1999. Particulate air pollution and the blood. Thorax 54:1027-1032.
  • Stys, A., and Stys, T. 1998. Current clinical applications of heart rate variability. Clin. Cardiol. 21:719-724.
  • Sullivan, G.W., Sarembock, I. J., and Linden, J. 2000. The role of inflammation in vascular diseases. J. Leukocyte Biol. 67:591-602.
  • Tsuji, H., Larson, M. G., Venditti, F. J., Manders, E. S., Evans, J. C., Feldmann, C. L., and Levy, D. 1996. Impact of reduced heart rate variability on risk of cardiac events. The Framingham heart study. Circulation 94:2850-2855.
  • Warner, T. D. 2001. Endothelin and its inhibitors. Berlin: Springer.
  • Watkinson, W. P., Campen, M. J., and Costa, D. L. 1998. Cardiac arrhythmia induction after exposure to residual oil fly ash particles in a rodent model of pulmonary hypertension. Toxicol. Sci. 41:209-216.
  • Zareba, W., Locati, E., and Maison-Blanche P., eds. 2001a. Noninvasive electro-cardiology in clinical practice. Armonk, NY: Futura.
  • Zareba, W., Normura, A., and Couderc, J. P. 2000b. Cardiovascular effects of air pollution: What to measure in ECG?. Environ. Health Perspect. 109(suppl. 4):533-538.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.