Advanced search
Publication Cover
Inhalation Toxicology
International Forum for Respiratory Research
Volume 15, 2003 - Issue 4
Submit an article Journal homepage
263
Views
120
CrossRef citations to date
0
Altmetric
Research Article

Controlled Exposures of Healthy and Asthmatic Volunteers to Concentrated Ambient Fine Particles in Los Angeles

Henry Gong, Jr. Rancho Los Amigos National Rehabilitation Center, Downey, California, and Keck School of Medicine, University of Southern California, Los Angeles, California, USA
,
William S. Linn Rancho Los Amigos National Rehabilitation Center, Downey, California, and Keck School of Medicine, University of Southern California, Los Angeles, California, USA
,
Constantinos Sioutas School of Engineering, University of Southern California, Los Angeles, California, USA
,
Sheryl L. Terrell Rancho Los Amigos National Rehabilitation Center, Downey, California, USA
,
Kenneth W. Clark Rancho Los Amigos National Rehabilitation Center, Downey, California, USA
,
Karen R. Anderson Rancho Los Amigos National Rehabilitation Center, Downey, California, USA
&
Lester L. Terrell Rancho Los Amigos National Rehabilitation Center, Downey, California, USA
 show all
Pages 305-325 | Published online: 01 Oct 2008

  • Alexis, N., Hu, S. C., Zeman, K., Alter, T., and Bennett, W. D. 2001. Induced sputum derives from central airways: Confirmation using a radiolabeled aerosol bolus delivery technique. Am. I. Respir. Crit. Care Med. 64:1964-1970.
  • American Thoracic Society. 1996. State of the art: Health effects of outdoor air pollution. Am. I. Respir. Crit. Care Med. 153:3-50.
  • Chai, H., Farr, R. S., Froehlich, L. A., Mathison, D. A., McLean, J. A., Rosenthal, R. R., Sheffer, A. L, Spector, S. L., and Townley, R. G. 1975. Standardization of bronchial inhalation challenge procedures. J. Allergy Clin. lmmunol. 56:323-327.
  • Clarice, R. W., Cou 11, B., Reinisch, U., Catalano, P., Killingsworth, C. R., Koutrakis, P., Kavouras, I., Murthy, G. G., Lawrence, J., Lovett, E., Wolfson, J. M., Verrier, R. L., and Codleski, J. J. 2000. Inhaled concentrated ambient particles are associated with hematologic and bronchoalveolar lavage changes in canines. Environ. Health Perspect. 108:1179-1187.
  • Dockery, D. W. 2001. Epidemiologic evidence of cardiovascular effects of participate air pollution. Environ. Health Perspect. 109(suppl. 4):483-486.
  • Fahy, J. V., Wong, H., Liu, J., and Boushey, H. A. 1996. Analysis of induced sputum after air and ozone exposures in healthy subjects. Environ. Res. 70:77-83.
  • Fung, K. 1990. Particulate carbon speciation by MnO2 oxidation. Aerosol Sci. Technol. 12:122-127.
  • Ghio, A. J., Kim, C., and Devlin, R. B. 2000. Concentrated ambient air particles induce mild pulmonary inflammation in healthy human volunteers. Am. J. Respir. Crit. Care Med. 162:981-988.
  • Gold, D., Litonjua, A., Schwartz, J., Lovett, E., Larson, A., Nearing, B., Alien, G., Verrier, M., Cherry, R., and Verrier, R. 2000. Ambient pollution and heart rate variability. Circulation 101:1267-1273.
  • Godleski, J. J., Verrier, R. L., Koutrakis, P., and Catalano, P. 2000. Mechanisms of morbidity and mortality from exposure to airborne particles. Research Report 91. Cambridge, MA: Health Effects Institute.
  • Gong, H., Jr., Sioutas, C., Linn, W. S., Clark, K. W., Terrell, S. L., Terrell, L. L., Anderson, K. R., Kim, S., and Chang, M. C. 2000. Controlled human exposures to concentrated ambient fine particles in metropolitan Los Angeles: Methodology and preliminary health-effect findings, lnhal. Toxicol. 12(suppl. 1):107-119.
  • Kim, S., Sioutas, C., Chang, M. C., Gong, H., and Linn, W. S. 2000. Factors affecting stability of the performance of ambient fine particle concentrators, lnhal. Toxicol. 12:281-298.
  • Kodavanti, U. P., Mebane, R., Ledbetter, A., Krantz, T., McGee, J., Jackson, M. C., Walsh, L., Hilliard, H., Chen, B. Y., Richards, J., and Costa, D. L. 2000. Variable pulmonary responses from exposure to concentrated ambient air particles in a rat model of bronchitis. Toxicol. Sci. 54:441-451.
  • Koutrakis, P., Sioutas, C., Ferguson, S. T., and Wolfson, J. M. 1993. Development and evaluation of a glass honeycomb denuder/filter pack system to collect atmospheric gases and particles. Environ. Sci. Technol. 27:2497-2501.
  • Liao, D., Creason, J., Shy, C., Williams, R., Watts, R., and Zweidinger, R. 1999. Daily variation of particulate air pollution and poor cardiac autonomie control in the elderly. Environ. Health Perspect. 107:521-525.
  • Linn, W. S., Gong, H., Clark, K. W., and Anderson, K. R. 1999. Day-to-day particulate exposures and health changes in Los Angeles area residents with severe lung disease. /. Air Waste Manage. Assoc. 49:PM108-PM115.
  • Lippmann, M., and Schlesinger, R. B. 2000. Toxicological bases for the setting of health-related air pollution standards. Annu. Rev. Public Health 21:309-333.
  • Marple, V. A., Rubow, K. L., and Behm, S. 1991. A micro-orifice uniform deposit impactor (MOUDI): Description, calibration, and use. Aerosol Sci. Technol. 14:434-446.
  • Marriott, H. J. L. 1983. Practical Electrocardiography, 7th ed., p. 406. Baltimore, MD: Williams & Wilkins.
  • National Asthma Education and Prevention Program. 1997. Guidelines for the diagnosis and management of asthma. Publication No. 97-4051. Bethesda, MD: National Institutes of Health.
  • O'Dell, J. W., Pfaff, J. D., Gales, M. E., and McKee, G. D. 1984. Test method: The determination of inorganic ions in water by ion chromatography-Method 300.0. Publication No. EPA-600/4-84-017. Cincinnati, OH: U.S. Environmental Protection Agency, Environmental Monitoring and Support Laboratory.
  • Peters, A., Doring, A., Wichmann, N. E., and Koenig, W. 1997. Increased plasma viscosity during an air pollution episode: A link to mortality? Lancet 349:1582-1587.
  • Petrovic, S., Urch, B., Brook, J., Datema, J., Purdham, J., Liu, L, Lukic, Z., Zimmerman, B., Tofler, C., and Downar, E. 2000. Cardiorespiratory effects of concentrated ambient PM2.5: A pilot study using controlled human exposures, lnhal. Toxicol. 12(suppl. 1):173-188.
  • Pope, C. A., Verrier, R. L., Lovett, E. G., Larson, A. C, Raizenne, M. E., Kanner, R. E., Schwarte, J., Villegas, G. M., Gold, D. R., and Dockery, D. W. 1999. Heart rate variability associated with particulate air pollution. Am. Heart J. 138:890-899.
  • Salvi, S., Blomberg, A., Rudell, B., Kelly, F. J., Sandstrom, T., Holgate, S. T., and Frew, A. J. 1999. Acute inflammatory responses in the airways and peripheral blood after short-term exposure to diesel exhaust in healthy human volunteers. Am. J. Respir. Crit. Care Med. 159:702-709.
  • Seaton, A., Soutar, A., Crawford, V., Elton, R., McNerlan, S., Cherrie, J., Watt, M., Agius, R., and Stout, R. 1999. Particulate air pollution and the blood. Thorax 54:1027-1032.
  • Sioutas, C., Koutrakis, P., and Burton, R. M. 1995a. A technique to expose animals to concentrated fine ambient aerosols. Environ. Health Perspect. 103:172-177.
  • Sioutas, C., Koutrakis, P., Ferguson, S. T., and Burton, R. M. 1995b. Development and evaluation of a prototype ambient particle generator for inhalation exposure studies, lnhal. Toxicol. 7:633-644.
  • Sioutas, C., Koutrakis, P., Godleski, J., Ferguson, S. T., Kim, C. S., and Burton, R. M. 1997. Harvard/EPA ambient fine particle concentrators for human and animal exposures. J. Aerosol. Sci. 28:1057-1061.
  • Sioutas, C., Kim, S., Chang, M. C., Terrell, L., and Gong, H. 2000. Field evaluation of a modified DataRAM MIE scattering monitor for real-time PM2.5 mass concentration measurements. Atmos. Environ. 34:4829-4838.
  • Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology. 1996. Heart rate variability: Standards of measurement, physiological interpretation, and clinical use. Circulation 93:1043-1065.
  • Thurston, G. 1996. A critical review of PM10-mortality time-series studies. J. Expos. Anal. Environ. Epidemiol. 6:3-21.
  • U.S. Environmental Protection Agency. 1996. Air quality criteria for paniculate matter. Document EPA/600/P-95/001. Washington, DC.: Office of Research and Development.
  • Vedal, S. 1997. Ambient particles and health: Lines that divide. /. Air Waste Manage. Assoc. 47:551-581.
  • Zareba, W., Nomura, A., and Couderc, J. P. 2001. Cardiovascular effects of air pollution: What to measure in ECG? Environ. Health Perspect. 109(suppl. 4):533-538.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.