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Inhalation Toxicology
International Forum for Respiratory Research
Volume 15, 2003 - Issue 6
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Research Article

Modeling the Retention and Clearance of Manmade Vitreous Fibers in the Rat Lung

C. L. Tran Institute of Occupational Medicine, Edinburgh, Scotland
,
A. D. Jones Institute of Occupational Medicine, Edinburgh, Scotland
,
B. G. Miller Institute of Occupational Medicine, Edinburgh, Scotland
&
K. Donaldson Institute of Occupational Medicine, Edinburgh, Scotland
Pages 553-587 | Published online: 01 Oct 2008

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  • Tran, C. L., Buchanan, D., Miller, B. G., Jones, A. D., and Donaldson, K. 2000a. Mathematical modeling to predict the responses to poorly soluble particles in rat lungs, lnhal. Toxicol. 12(suppl. 3): 403-409.
  • Tran, C. L., Graham, M. K., and Buchanan, D. 2001. A biomathematical model for rodent and human lung describing exposure, dose, and response to inhaled silica. Edinburgh: Institute of Occupational Medicine. IOM Report TM/01/04.
  • Vincent, J. H., Johnston, A. M., Jones, A. D., Bolton, R. E., and Addison, J. 1985. Kinetics of deposition and clearance of inhaled mineral dusts during chronic exposure. Br. J. Ind. Med. 42:707-715.
  • Vincent, J. H., Jones, A. D., Johnston, A. R., Bolton, R. E., and Cowie, H. 1987. Accumulation of inhaled mineral dust in the lung and associated lymph nodes: implications to exposure and dose in occupational lung disease. Ann. Occup. Hyg. 31:375-393.
  • Yu, C. P., Zhang, L., Oberdörster, G., Mast, R. W., Glass, L. R., and Utell, M. J. 1994a. Clearance of refractory ceramic fibres (RCF) from the rat lung: Development of a model. Environ. Res. 65:243253.
  • Yu, C. P., Zhang, Z., Oberdörster, G., Mast, R. W., Glass, L. R., and Utell, M. J. 1994b. Deposition modelling of refractory ceramic fibers in the lung. J. Aerosol Sci. 25:407-417.
  • Yu, C. P., Ding, Y. J., Zhang, L., Oberdörster, G., Mast, R. W., Glass, L. R., and Utell, M. J. 1995. Deposition and clearance modeling of inhaled kaolin refractory ceramic fibers (RCF) in hamstersComparison between species, lnhal. Toxicol. 7:165-177.
  • Yu, C. P., Dai. Y. T., Boymel, P. M., Zoitos, B. K., Oberdörster, G., and Utell, M. J. 1998 A clearance model of man-made vitreous fibres (MMVFs) in the rat lung, lnhal. Toxicol. 10:253-274.
  • Yu, C. P., Dai. Y. T., and Ding, Y. J. 1998 A retention model of man-made vitreous fibres (MMVFs) inhaled by rats. Aerosol Sci. Technol. 29:152-162.
  • Zoltos, B. K., De-Meringo, A., Rouyer, E., Thélohan, S., Bauer, J., Law, B., Boymel, P. M., Olson, J. R., Christensen, V. R., Guldberg, M., Koenig, A. R., and Perander, M. 1997. In vitro measurement of fiber dissolution rate relevant to biopersistence at neutral pH: An interlaboratory round robin. lnhal. Toxicol. 9:525-540.

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