Publication Cover
Inhalation Toxicology
International Forum for Respiratory Research
Volume 17, 2005 - Issue 2
97
Views
27
CrossRef citations to date
0
Altmetric
Research Article

Repeated Inhalation Challenge with Diphenylmethane-4,4′-Diisocyanate in Brown Norway Rats Leads to a Time-Related Increase of Neutrophils in Bronchoalveolar Lavage After Topical Induction

, &
Pages 67-78 | Received 28 Jun 2003, Accepted 20 Sep 2004, Published online: 06 Oct 2008

REFERENCES

  • Allmers H., Chen Z., Barbinova L., Marczynski B., Kirschmann V., Baur X. Challenge from methacholine, natural rubber latex, or 4,4′-diphenylmethane diisocyanate in workers with suspected sensitization affects exhaled nitric oxide (change in exhaled NO levels after allergen challenges). Int. Arch. Occup. Environ. Health 2000; 73: 181–186, [CSA]
  • Arts J. H. E., Dröge S. C. M., Spanhaak S., Bloksma N., Kuper C. F. Local lymph node activation and IgE responses in Brown Norway and Wistar rats after dermal application of sensitizing and non-sensitizing chemicals. Toxicology 1997; 117: 229–237, [CROSSREF], [CSA]
  • Arts J. H. E., Kuper C. F., Spoor S. M., Bloksma N. Airway morphology and function of rats following dermal sensitization and respiratory challenge with low molecular weight chemicals. Toxicol. Appl. Pharmacol. 1998; 152: 66–76, [CROSSREF], [CSA]
  • Arts J. H. E., de Koning M. W., Bloksma N., Kuper C. F. Respiratory irritation by trimellitic anhydride in Brown Norway and Wistar rats. Inhal. Toxicol. 2001; 13: 719–728, [CROSSREF], [CSA]
  • Arts J. H. E., Bloksma N., Leusink-Muis T., Kuper C. F. Respiratory allergy and pulmonary irritation to trimellitic anhydride in Brown Norway rats. Toxicol. Appl. Pharmacol. 2003; 187: 38–49, [CROSSREF], [CSA]
  • Arts J. H. E., de Koning M. W., Bloksma N., Kuper C. F. Respiratory allergy to trimellitic anhydride in rats: Concentration-response relationship during elicitation. Inhal. Toxicol. 2004; 16: 259–269, [CROSSREF]
  • Cui Z. H., Sjöstrand M., Pullerits T., Andius P., Skoogh B.-E., Lötvall J. Bronchial hyperresponsiveness, epithelial damage, and airway eosinophilia after single and repeated allergen exposure in a rat model of anhydride-induced asthma. et al, 1997
  • Dearman R. J., Kimber I. Respiratory sensitization hazard identification. Comments Toxicol. 1999; 7: 43–57
  • Directive 86/609/EEC. Guideline of the Council dated November 24, 1986 on the Reconciliation of Legal and Administrative Regulations of the Member Countries for the Protection of Animals used for Studies and other Scientific Purposes. J. Eur. Commun. Legal Spec. 1986; 29: 1–28, L358
  • Elwood W., Lötvall J. O., Barnes P. J., Chung K. F. Characterization of allergen-induced bronchial hyperresponsiveness and airway inflammation in actively sensitized Brown Norway rats. J. Allergy Clin. Immunol. 1991; 88: 951–960, [CSA]
  • Ferreira H. H. A., Bevilacqua E., Gagioti S., De Luca I. M. S., Zanardo R. C. O., Teixeira C. E., Sannomiya P., Antunes E., DeNucci G. Nitric oxide modulates eosinophil infiltration in antigen-induced airway inflammation in rats. Eur. J. Pharmacol. 1998; 358: 253–259, [CROSSREF]
  • Gad S. C., Weil C. S. Statistics for toxicologists. Principles and methods of toxicology, A. W. Hayes. Raven Press, New York 1982; p. 280
  • Haczku A., Moqbel R., Elwood W., Sun J., Bay A. B., Barnes P. J., Chung K. F. Effect of prolonged repeated exposure to ovalbumin in sensitized Brown Norway rats. Am. J. Respir. Crit. Care Med. 1994; 150: 23–27, [CSA]
  • Hilton J., Dearman R. J., Basketter D. A., Kimber I. Identification of chemical respiratory allergens: Dose-response relationships in the mouse IgE test. Toxicol. Methods 1995; 5(1)51–60
  • Iijima H., Duguet A., Eum S.-Y., Hamid Q., Eidelman D. H. Nitric oxide and protein nitration are eosinophil dependent in allergen-challenged mice. Am. J. Respir. Crit. Care Med. 2001; 163: 1233–1240, [CSA]
  • Johnson V. J., Matheson J. M., Luster M. I. Animal models for diisocyanate asthma: Answers for lingering questions. Curr. Opin. Allergy Clin. Immunol. 2004; 4: 105–110, [CROSSREF], [CSA]
  • Karol M. H., Thorne P. S. Pulmonary hypersensitivity and hyperreactivity: Implications for assessing allergic responses. Toxicology of the lung, D. E. Gardner, J. D. Crapo, E. J. Massaro. Raven Press, New York 1988; 427–448
  • Kilgour J. D., Rattray N. J., Foster J., Soames A., Hext P. M. Pulmonary responses and recovery following single and repeated inhalation exposure of rats to polymeric methylene diphenyl diisocyanate aerosols. J. Appl. Toxicol. 2002; 22: 371–385, [CROSSREF], [CSA]
  • Kimber I., Dearman R. J. Toxicology of chemical respiratory hypersensitivity, et al. Taylor & Francis, London 1997
  • Kips J. C., Anderson G. P., Fredberg J. J., Herz U., Inman M. D., Jordana M., Kemeny D. M., Lötvall J., Pauwels R. A., Plopper C. G., Schmidt D., Sterk P. J., van Oosterhout A. J. M., Vargaftig B. B., Chung K. F. Murine models of asthma. Eur. Respir. J. 2003; 22: 374–382, [CROSSREF]
  • Kumar R. K., Foster P. S. Translational review—Modeling allergic asthma in mice—Pitfalls and opportunities. Am. J. Respir. Cell Mol. Biol. 2002; 27: 267–272, [CSA]
  • Kumar R. K., Temelkovski J., Mc Neil H. P., Hunter N. Airway inflammation in a murine model of chronic asthma: Evidence for a local humoral immune response. Clin. Exp. Allergy 2000; 30: 1486–1492, [CROSSREF], [CSA]
  • Leigh R., Ellis R., Wattie J., Southam D. S., de Hoogh M., Gauldie J., O'Byrne M., Imman M. D. Dysfunction and remodeling of the mouse airway persist after resolution of acute allergen-induced airway inflammation. Am. J. Respir. Cell Mol. Biol. 2002; 27: 526–535, [CSA]
  • Lindén A., Adachi M. Neutrophilic airway inflammation and IL-17. Allergy 2002; 57: 769–775, [CROSSREF], [CSA]
  • Matheson J. M., Lange R. W., Lemus R., Karol M. H., Luster M. I. Importance of inflammatory and immune response components in a mouse model of airway reactivity to toluene diisocyanate (TDI). Clin. Exp. Allergy 2001; 31: 1067–1076, [CROSSREF], [CSA]
  • Mauderly J. L. Respiration of F344 rats in nose-only inhalation exposure tubes. J. Appl. Toxicol. 1986; 6: 25–30
  • Palmans E., Kips J. C., Pauwels R. A. Prolonged allergen exposure induces structural airway changes in sensitized rats. Am. J. Respir. Crit. Care Med. 2000; 161: 627–635, [CSA]
  • Palmans E., Pauwels R. A., Kips J. C. Repeated allergen exposure changes collagen composition in airways of sensitized Brown Norway rats. Eur. Respir. J. 2002a; 20: 280–285, [CROSSREF]
  • Palmans E., Vanacker N. J., Pauwels R. A., Kips J. C. Effect of age on allergen-induced structural airway changes in Brown Norway rats. Am. J. Respir. Crit. Care Med. 2002b; 165: 1280–1284, [CROSSREF], [CSA]
  • Pauluhn J. Assessment of respiratory hypersensitivity in guinea pigs sensitized to toluene diisocyanate: Improvements on analysis of response. Fundam. Appl. Toxicology 1997; 40: 211–219, [CROSSREF], [CSA]
  • Pauluhn J. Acute inhalation toxicity of polymeric diphenyl-methane-4,4′-diisocyanate (MDI) in rats: Time course of changes in bronchoalveolar lavage. Arch. Toxicol. 2000; 74: 257–269, [CROSSREF]
  • Pauluhn J. Short-term inhalation toxicity of polyisocyanate aerosols in rats: Comparative assessment of irritant-threshold concentrations by bronchoalveolar lavage. Inhal. Toxicol. 2002; 14: 287–301, [CROSSREF], [CSA]
  • Pauluhn J. Respiratory hypersensitivity to trimellitic anhydride in Brown Norway rats: Analysis of dose-response following topical induction and time course following repeated inhalation challenge. Toxicology 2003; 194: 1–17, [CROSSREF], [CSA]
  • Pauluhn J. Comparative analysis of pulmonary irritation by measurements of Penh and protein in bronchoalveolar lavage fluid in Brown Norway rats and Wistar rats exposed to irritant aerosols. Inhal. Toxicol. 2004; 16: 159–175, [CROSSREF], [CSA]
  • Pauluhn J., Eben A. Validation of a non-invasive technique to assess immediate or delayed onset of airway hypersensitivity in guinea-pigs. J. Appl. Toxicol. 1991; 11: 423–431, [CSA]
  • Pauluhn J., Dearman R., Doe J., Hext P., Landry T. D. Respiratory hypersensitivity to diphenylmethane-4,4′-diisocyanate in guinea pigs: Comparison with trimellitic anhydride. Inhal. Toxicol. 1999; 11: 187–214, [CROSSREF], [CSA]
  • Pauluhn J., Thiel A., Emura M., Mohr U. Respiratory sensitization to diphenyl-methane-4,4′-diisocyanate (MDI) in guinea pigs: Impact of particle size on induction and elicitation of response. Toxicol. Sci. 2000; 56: 105–113, [CROSSREF], [CSA]
  • Pauluhn J., Eidmann P., Freyberger A., Wasinska-Kempka G., Vohr H.-W. Respiratory hypersensitivity to trimellitic anhydride in Brown Norway rats: A comparison of endpoints. J. Appl. Toxicol. 2002; 22: 89–97, [CROSSREF], [CSA]
  • Schneider T., van Velzen D., Moqbel R., Issekutz A. C. Kinetics and quantification of eosinophil and neutrophil recruitment to allergic lung inflammation in a Brown Norway rat model. Am. J. Respir. Cell Mol. Biol. 1997; 17: 702–712, [CSA]
  • Temelkovski J., Hogan S. P., Shepherd D. P., Foster P. S., Kumar R. K. An improved murine model of asthma: Selective airway inflammation, epithelial lesions and increased methacholine responsiveness following chronic exposure to aerosolised antigen. Thorax 1998; 53: 849–856
  • van der Vliet A., Eiserich J. P., Shigenaga M. K., Cross C. E. Reactive nitrogen species and tyrosine nitration in the respiratory tract. Epiphenomena or a pathobiologic mechanism of disease?. Am. J. Respir. Crit. Care Med. 1999; 160: 1–9, [CSA]
  • Warbrick E. V., Dearman R. J., Kimber I. IgG and IgE antibody responses following exposure of Brown Norway rats to trimellitic anhydride: Comparison of inhalation and topical exposure. Toxicology 2002; 172: 157–168, [CROSSREF], [CSA]

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.