REFERENCES
- Andersen M. E., Sarangapani R., Reitz R. H., Gallavan R. H., Dobrev I. D., Plotzke K. P. Physiological modeling reveals novel pharmacokinetic behavior for inhaled octamethylcyclotetrasiloxane in rats. Toxicol. Sci. 2001; 60: 214–231
- Brown R. P., Delp M. D., Lindstedt S. L., Rhomberg L. R., Beliles R. P. Physiological parameter values for physiologically based pharmacokinetic models. Toxicol. Ind. Health 1997; 13: 407–484
- Clewell H. J., III, Gentry P. R., Gearhart J. M., Covington T. R., Banton M. I., Andersen M. E. Development of a physiologically based pharmacokinetic model of isopropanol and its metabolite acetone. Toxicol. Sci. 2001; 63: 160–172
- Dennison J. E., Andersen M. E., Yang R. S. H. Characterization of the pharmacokinetics of gasoline using PBPK modeling with a complex mixtures chemical lumping approach. Inhal. Toxicol. 2003; 15: 961–986
- Dobrev I. D., Reddy M. B., Plotzke K. P., Varaprath S., McNett D. A., Durham J., Andersen M. E. Closed chamber inhalation pharmacokinetic studies with hexamethyldisiloxane in the rat. Inhal. Toxicol. 2003; 15: 589–617
- Filser J. G. The closed chamber technique± Uptake, endogenous production, excretion, steady-state kinetics and rates of metabolism of gases and vapors. Arch. Toxicol. 1992; 66: 1–10
- Gargas M. L., Andersen M. E., Clewell H. J., III. A physiologically based simulation approach for determining metabolic constants from gas uptake data. Toxicol. Appl. Pharmacol. 1986; 86: 341–352
- Gargas M. L., Clewell H. J., III, Andersen M. E. Gas uptake inhalation techniques and the rates of metabolism of chloromethanes, chloroethanes, and chloroethylenes in the rat. Inhal. Toxicol. 1990; 2: 285–309
- McKim J. M., Jr., Kolesar G. B., Jean P. A., Meeker L. S., Wilga P. C., Schoonhoven R., Swenberg J. A., Goodman J. I., Gallavan R. H., Meeks R. G. Repeated inhalation exposure to octamethylcyclotetrasiloxane produces hepatomegaly, transient hepatic hyperplasia, and sustained hypertrophy in female Fischer 344 rats in a manner similar to phenobarbital. Toxicol. Appl. Pharmacol. 2001; 172: 83–92
- McKim J. M., Jr., Wilga P. C., Kolesar G. B., Choudhuri S., Madan A., Dochterman L. W., Breen J. G., Parkinson A., Mast R. W., Meeks R. G. Evaluation of octamethylcyclotetrasiloxane (D4) as an inducer of rat hepatic microsomal cytochrome P450, UDP-glucuronosyltransferase, and epoxide hydrolase: A 28-day inhalation study. Toxicol. Sci. 1998; 41: 29–41
- Nakajima T., Wang R. S., Elovaara E., Gonzalez F. J., Gelboin H. V., Vainio H., Aoyama T. CYP2C11 and CYP2B1 are major cytochrome P450 forms involved in styrene oxidation in liver and lung microsomes from untreated rats, respectively. Biochem. Pharmacol. 1994; 48: 637–42
- Nong A., Charest-Tardif G., Tardif R., Lewis D. F., Sweeney L. M., Gargas M. L., Krishnan K. Physiologically based modeling of the inhalation pharmacokinetics of ethylbenzene in B6C3F1 mice. J. Toxicol. Environ. Health A 2007; 70: 1838–1848
- Plotzke K. P., Crofoot S. D., Ferdinandi E. S., Beattie J. G., Reitz R. H., McNett D. A., Meeks R. G. Disposition of radioactivity in fischer 344 rats after single and multiple inhalation exposure to [14C]Octamethylcyclotetrasiloxane ([14C]D4). Drug Metab. Dispos. 2000; 28: 192–204
- Plotzke K. P. Compare the absorption potential of14C-octamethylcyclotetrasiloxane (D4) in Fischer 344 rats when delivered in various carriers. Dow Corning Corporation, Midland, MI 1998
- Powley M. W., Carlson G. P. Cytochromes P450 involved with benzene metabolism in hepatic and pulmonary microsomes. J. Biochem. Mol. Toxicol. 2000; 14: 303–309
- Reddy M. B., Dobrev I. D., Plotzke K. P., Andersen M. E., Reitz R. H., Morrow P., Utell M. A physiologically based pharmacokinetic model for inhalation of octamethylcyclotetrasiloxane (D4) in Human during rest and exercise. Toxicol. Sci. 2003; 72: 3–18
- Sarangapani R., Teeguarden J., Andersen M. E., Reitz R. H., Plotzke K. P. Route-specific differences in distribution characteristics of octamethylcyclotetrasiloxane in rats: analysis using physiologically based pharmacokinetic model. Toxicol. Sci. 2003; 71: 41–52
- Sarangapani R., Teeguarden J., Plotzke K. P., McKim J. M., Jr., Andersen M. E. Dose-response modeling of cytochrome P450 induction in rats by octamethylcyclotetrasiloxane. Toxicol. Sci. 2002a; 67: 159–72
- Sarangapani R., Teeguarden J., Cruzan G., Clewell H. J., III, Andersen M. E. Physiologically based pharmacokinetic modeling of styrene and styrene oxide respiratory-tract dosimetry in rodents and humans. Inhal. Toxicol. 2002b; 14: 789–834
- Semino G., Lilly P., Andersen M. E. A pharmacokinetic model describing pulsatile uptake of orally administered carbon tetrachloride. Toxicology 1997; 117: 25–33