Toxicological Comparisons of Three Styles of a Commercial U.S. Cigarette (Marlboro®) with the 1R4F Reference Cigarette

REFERENCES

• AALAS. American Association for Laboratory Animals Science Policy on the Humane Care and Use of Laboratory Animals. Laboratory Animal Science 1991; 41: 91
   Google Scholar
• Adams J. D., O'Mara-Adams K. J., Hoffmann D. Toxic and carcinogenic agents in undiluted mainstream smoke and sidestream smoke of different types of cigarettes. Carcinogenesis 1987; 8: 729–731
   PubMed Web of Science ®Google Scholar
• Bradford J. A., Harlan W. R., Hanmer H. R. Nature of cigaret smoke. Technic of experimental smoking. Industrial and Engineering Chemistry 1936; 28: 836–839
   Google Scholar
• Byrd G. D., Fowler K. W., Hicks R. D., Lovette M. E., Borgerding M. F. Isotope dilution gas chromatography-mass spectrometry in the determination of benzene, toluene, styrene and acrylonitrile in mainstream cigarette smoke. Journal of Chromatography 1990; 503: 359–368
   PubMed Web of Science ®Google Scholar
• Carmines E. L. Evaluation of the potential effects of ingredients added to cigarettes. Part 1: Cigarette design, testing approach, and review of results. Food and Chemical Toxicology 2002; 40: 77–91
   PubMed Web of Science ®Google Scholar
• Chen P. X., Moldoveanu S. C. Mainstream smoke chemical analyses for 2R4F Kentucky reference cigarette. Beiträge zur Tabakforschung International 2003; 20: 448–458
   Google Scholar
• Chepiga T. A., Morton M. J., Murphy P. A., Avalos J. T., Bombick B. R., Doolittle D. J., Borgerding M. F., Swauger J. E. A comparison of the mainstream smoke chemistry and mutagenicity of a representative sample of the US cigarette market with two Kentucky reference cigarettes (K1R4F and K1R5F). Food and Chemical Toxicology 2000; 38: 949–962
   PubMed Web of Science ®Google Scholar
• Coggins C. R. E., Ayres P. H., Mosberg A. T., Burger G. T., Sagartz J. W., Hayes A. W. Comparative inhalation study in rats, using a second prototype of a cigarette that heats rather than burns tobacco. Inhalation Toxicology 1989a; 1: 197–226
   Google Scholar
• Coggins C. R. E., Ayres P. H., Mosberg A. T., Sagartz J. W., Burger G. T., Hayes A. W. Ninety-day inhalation study in rats, comparing smoke from cigarettes that heat tobacco with those that burn tobacco. Fundamental and Applied Toxicology 1989b; 13: 460–483
   PubMedGoogle Scholar
• Coggins C. R. E., Duchosal F., Musy C., Ventrone R. Measurement of respiratory patterns in rodents, using whole-body plethysmography and a pneumotachograph. Laboratory Animals 1981; 15: 137–140
   PubMed Web of Science ®Google Scholar
• Coggins C. R. E., Fouillet X. L. M., Lam R., Morgan K. T. Cigarette smoke induced pathology of the rat respiratory tract: a comparison of the effects of the particulate and vapour phases. Toxicology 1980; 16: 83–101
   PubMed Web of Science ®Google Scholar
• Counts M. E., Hsu F. S., Laffoon S. W., Dwyer R. W., Cox R. H. Mainstream smoke constituent yields and predicting relationships from a worldwide market sample of cigarette brands: ISO smoking conditions. Regulatory Toxicology and Pharmacology 2004; 39: 111–134
   PubMed Web of Science ®Google Scholar
• Counts M. E., Morton M. J., Laffoon S. W., Cox R. H., Lipowicz P. J. Smoke composition and predicting relationships for international commercial cigarettes smoked with three machine-smoking conditions. Regulatory Toxicology and Pharmacology 2005; 41: 185–227
   PubMed Web of Science ®Google Scholar
• Diana J. N., Vaught A. Research Cigarettes. University of Kentucky Printing Services, Lexington, KY 1990
   Google Scholar
• Feldman D. B., Seely J. C. Necropsy guide: rodents and the rabbit. CRC Press, Boca Raton, FL 1988
   Google Scholar
• Friedrichs B., Miert E., Vanscheeuwijck P. Lung inflammation in rats following subchronic exposure to cigarette mainstream smoke. Experimental Lung Research 2006; 32: 151–179
   PubMed Web of Science ®Google Scholar
• Gaworski C. L., Dozier M. M., Heck J. D., Gerhart J. M., Rajendran N., David R. M., Brennecke L. H., Morrissey R. Toxicologic evaluation of flavor ingredients added to cigarette tobacco: 13-week inhalation exposures in rats. Inhalation Toxicology 1998; 10: 357–381
   Web of Science ®Google Scholar
• Harrison P. T. An ethanol-acetic acid-formol saline fixative for routine use with special application to the fixation of non-perfused rat lung. Laboratory Animals 1984; 18: 325–331
   PubMed Web of Science ®Google Scholar
• Haussmann H.-J., Anskeit E., Becker D., Kuhl P., Stinn W., Teredesai A., Voncken P., Walk R.-A. Comparison of fresh and room-aged cigarette sidestream smoke in a subchronic inhalation study on rats. Toxicological Sciences 1998; 41: 100–116
   PubMed Web of Science ®Google Scholar
• Higuchi M. A., Sagartz J., Shreve W. K., Ayres P. H. Comparative subchronic inhalation study of smoke from the 1R4F and 2R4F reference cigarettes. Inhalation Toxicology 2004; 16: 1–20
   PubMed Web of Science ®Google Scholar
• Hotchkiss J. A., Evans W. A., Chen B. T., Finch G. L., Harkema J. R. Regional differences in the effects of mainstream cigarette smoke on stored mucosubstances and DNA synthesis in F344 rat nasal respiratory epithelium. Toxicology and Applied Pharmacology 1995; 131: 316–324
   PubMed Web of Science ®Google Scholar
• ISO. International Standard ISO 10315. Cigarettes—determination of nicotine in smoke condensates—gas chromatographic method. GenevaSwitzerland 1989
   Google Scholar
• ISO. International Standard ISO 3308. Routine analytical cigarette-smoking machine. Definitions and standard conditions. Third edition. GenevaSwitzerland 1991a
   Google Scholar
• ISO. International Standard ISO 3402. Tobacco and tobacco products. Atmosphere for conditioning and testing. Third edition. GenevaSwitzerland 1991b
   Google Scholar
• ISO. International Standard ISO 8454. Cigarettes—determination of carbon monoxide in the vapour phase of cigarette smoke—NDIR method. Second edition. GenevaSwitzerland 1995a
   Google Scholar
• ISO. International Standard ISO 10362-2. Cigarettes determination of water in smoke condensates—Part 2. Karl Fischer method. GenevaSwitzerland 1995b
   Google Scholar
• ISO. International Standard ISO 4387. Cigarettes—determination of total and nicotine free dry paniculate matter using a routine analytical smoking machine. GenevaSwitzerland 2000
   Google Scholar
• Klimisch H.-J., Meißner K., Wernicke H. Quantitative determination of carbon monoxide in blood by gaschromatography. Zeitschrift fur Klinical Chemie und Klinical Biochemie 1974; 12: 535–538
   PubMedGoogle Scholar
• Langard S., Nordhagen A.-L. Small animal inhalation chambers and the significance of dust ingestion from the contaminated coat when exposing rats to zinc chromate. Acta Pharmacologica et Toxicologica 1980; 46: 43–46
   PubMedGoogle Scholar
• Lemus R., Carmines E. L., Van Miert E., Coggins C. R. E., Anskeit E., Gerstenberg B., Meisgen T. J., Schramke H., Stabbert R., Volkel H., Terpstra P. M. Toxicological comparisons of cigarettes containing different amounts of vanillin. Inhalation Toxicology 2007; 19: 683–699
   PubMed Web of Science ®Google Scholar
• Lewis D. J. Factors affecting the distribution of tobacco smoke-induced lesions in the rodent larynx. Toxicology Letters 1981; 9: 189–194
   PubMed Web of Science ®Google Scholar
• Lewis D. J. Morphological assessment of pathological changes within the rat larynx. Toxicologic Pathology 1991; 19: 352–357
   PubMed Web of Science ®Google Scholar
• Loeb W. F., Quimby F. W. Clinical chemistry of laboratory animals, Second ed. Pergamon Press, New York 1999
   Google Scholar
• Maxwell J. C. 2004 Maxwell Tobacco Fact Book. SpecComm International Inc, Raleigh, NC 2004
   Google Scholar
• Nanni E. J., Lovette M. E., Hicks R. D., Fowler K. W., Borgerding M. F. Separation and quantitation of phenolic compounds in mainstream cigarette smoke by capillary gas chromatography with mass spectrometry in the selected-ion mode. Journal of Chromatography 1990; 505: 365–374
   PubMed Web of Science ®Google Scholar
• OECD. OECD Guidelines for the testing of chemicals. ParisFrance 1981, No. 413. Subchronic inhalation toxicity: 90-day study
   Google Scholar
• OECD. OECD guidelines for testing of chemicals. ParisFrance 1997, No. 471. Bacterial reverse mutation test
   Google Scholar
• Patskan G., Reininghaus W. Toxicological evaluation of an electrically heated cigarette. Part 1: Overview of technical concepts and summary of findings. Journal of Applied Toxicology 2003; 23: 323–328
   PubMed Web of Science ®Google Scholar
• Ritter D., Knebel J., Aufderheide M. Comparative assessment of toxicities of mainstream smoke from commercial cigarettes. Inhalation Toxicology 2004; 16: 691–700
   PubMed Web of Science ®Google Scholar
• Roemer E., Stabbert R., Rustemeier K., Veltel D. J., Meisgen T. J., Reininghaus W., Carchman R. A., Gaworski C. L., Podraza K. F. Chemical composition, cytotoxicity and mutagenicity of smoke from US commercial and reference cigarettes smoked under two sets of machine smoking conditions. Toxicology 2004; 195: 31–52
   PubMed Web of Science ®Google Scholar
• Roemer E., Tewes F. J., Meisgen T. J., Veltel D. J., Carmines E. L. Evaluation of the potential effects of ingredients added to cigarettes. Part 3: In vitro genotoxicity and cytotoxity. Food and Chemical Toxicology 2002; 40: 105–111
   PubMed Web of Science ®Google Scholar
• Rustemeier K., Stabbert R., Haussmann H.-J., Roemer E., Carmines E. L. Evaluation of the potential effects of ingredients added to cigarettes. Part 2: Chemical composition of mainstream smoke. Food and Chemical Toxicology 2002; 40: 93–104
   PubMed Web of Science ®Google Scholar
• Stabbert R., Voncken P., Rustemeier K., Haussmann H.-J., Roemer E., Schaffernicht H., Patskan G. Toxicological evaluation of an electrically heated cigarette. Part 2. Chemical composition of mainstream smoke. Journal of Applied Toxicology 2003; 23: 329–339
   PubMed Web of Science ®Google Scholar
• Steele R. H., Payne V. M., Fulp C. W., Rees D. C., Lee C. K., Doolittle D. J. A comparison of the mutagenicity of mainstream cigarette smoke condensates from a representative sample of the U.S. cigarette market with a Kentucky reference cigarette (1R4F). Mutation Research 1995; 342: 179–190
   PubMed Web of Science ®Google Scholar
• Stinn W., Teredesai A., Anskeit E., Rustemeier K., Schepers G., Schnell P., Haussmann H.-J., Carchman R. A., Coggins C. R. E., Reininghaus W. Chronic nose-only inhalation study in rats, comparing room-aged sidestream smoke and diesel engine exhaust. Inhalation Toxicology 2005; 17: 549–576
   PubMed Web of Science ®Google Scholar
• Stöber W., Flachsbart H. Size-separating precipitation of aerosols in a spinning spiral duct. Journal of Environmental Science & Technology 1969; 3: 1280–1296
   Web of Science ®Google Scholar
• Terpstra P. M., Teredesai A., Vanscheeuwijck P. M., Verbeeck J., Schepers G., Radtke F., Kuhl P., Gomm W., Anskeit E., Patskan G. Toxicological evaluation of an electrically heated cigarette. Part 4: subchronic inhalation toxicology. Journal of Applied Toxicology 2003; 23: 349–362
   PubMed Web of Science ®Google Scholar
• Tewes F. J., Meisgen T. J., Veltel D. J., Roemer E., Patskan G. Toxicological evaluation of an electrically heated cigarette. Part 3: genotoxicity and cytotoxicity of mainstream smoke. Journal of Applied Toxicology 2003; 23: 341–348
   PubMed Web of Science ®Google Scholar
• Vanscheeuwijck P. M., Teredesai A., Terpstra P. M., Verbeek J., Kuhl P., Gerstenberg B., Gebel S., Carmines E. L. Evaluation of the potential effects of ingredients added to cigarettes. Part 4: subchronic inhalation toxicity. Food and Chemical Toxicology 2002; 40: 113–131
   PubMed Web of Science ®Google Scholar
• Young J. T. Histopathological examination of the rat nasal cavity. Fundamental and Applied Toxicology 1981; 1: 309–312
   PubMedGoogle Scholar