Effects of Metals within Ambient Air Particulate Matter (PM) on Human Health

References

• I. Y. Adamson, H. Prieditis, C. Hedgecock, and R. Vincent. 2000. Zinc is the toxic factor in the lung response to an atmospheric particulate sample. Toxicol. Appl. Pharmacol. 166:111–119.
   PubMed Web of Science ®Google Scholar
• M. O. Amdur, J. Bayles, V. Ugro, and D. W. Underhill. 1978. Comparative irritant potency of sulfate salts. Environ. Res. 16:1–8.
   PubMed Web of Science ®Google Scholar
• M. O. Amdur, and L. C. Chen. 1989. Furnace generated acid aerosols: Speciation and pulmonary effects. Environ. Health Perspect. 79:147–150.
   PubMed Web of Science ®Google Scholar
• J. M. Antonini, J. R. Roberts, M. R. Jernigan, H. M. Yang, J. Y. Ma, and R. W. Clarke. 2002. Residual oil fly ash increases the susceptibility to infection and severely damages the lungs after pulmonary challenge with a bacterial pathogen. Toxicol. Sci. 70:110–119.
   PubMed Web of Science ®Google Scholar
• J. M. Antonini, M. D. Taylor, S. S. Leonard, N. J. Lawryk, X. Shi, R. W. Clarke, and J. R. Roberts. 2004. Metal composition and solubility determine lung toxicity induced by residual oil fly ash collected from different sites within a power plant. Mol. Cell. Biochem. 255:257–265.
   PubMed Web of Science ®Google Scholar
• R. U. Ayres, and U. E. Simonis. 1994. Industrial metabolism. United Nations University Press, New York.
   Google Scholar
• J. R. F. Batalha, P. H. N. Saldiva, R. W. Clarke, B. A. Coull, R. C. Stearns, J. Lawrence, G. G. Krishna-Murthy, P. Koutrakis, and J. J. Godleski. 2002. Concentrated ambient air particles induce vasoconstriction of small pulmonary arteries in rats. Environ. Health Perspect. 110:1191–1197.
   PubMed Web of Science ®Google Scholar
• B. R. Ball, K. R. Smith, J. M. Veranth, and A. E. Aust. 2000. Bioavailability of iron from coal fly ash: mechanisms of mobilization and of biological effects. Inhal. Toxicol. 12 (Suppl. 4):209–225.
   PubMedGoogle Scholar
• S. Becker, L. A. Dailey, J. M. Soukup, S. C. Grambow, R. B. Devlin, and Y.-C. T. Huang. 2005. Seasonal variations in air pollution particle-induced inflammatory mediator release and oxidative stress. Environ. Health Perspect. 113:1032–1038.
   PubMed Web of Science ®Google Scholar
• S. Becker, J. M. Soukup, M. I. Gilmour, and R. B. Devlin. 1996. Stimulation of human and rat alveolar macrophages by urban air particulates: Effects on oxidant radical generation and cytokine production. Toxicol. Appl. Pharmacol. 141:637–648.
   PubMed Web of Science ®Google Scholar
• R. T. Burnett, J. Brook, T. Dann, C. Delocla, O. Philips, S. Cakmak, R. Vincent, M. S. Goldberg, and D. Krewski. 2000. Association between particulate- and gas-phase components of urban air pollution and daily mortality in eight Canadian cities. Inhal. Toxicol. 12 (suppl. 4):15–39.
   PubMed Web of Science ®Google Scholar
• R. T. Burnett, D. Stieb, J. R. Brook, S. Cakmak, R. Dales, M. Raizenne, R. Vincent, and T. Dann. 2004. Associations between short-term changes in nitrogen dioxide and mortality in Canadian cities. Arch. Environ. Health 59:228–236.
   PubMed Web of Science ®Google Scholar
• M. J. Campen, D. L. Costa, and W. P. Watkinson. 2000. Cardiac and thermoregulatory toxicity of residual oil fly ash in cardiopulmonary-compromised rats. In Inhalation Toxicology: Proceedings of the third colloquium on particulate air pollution and human health (second special issue), June, 1999; Durham, NC, ed. R. F. Phalen. Inhal. Toxicol. 12 (suppl. 2):7–22.
   PubMedGoogle Scholar
• M. J. Campen, J. P. Nolan, M. C. J. Schladweiler, U. P. Kodavanti, P. A. Evansky, D. L. Costa, and W. P. Watkinson. 2001. Cardiovascular and thermoregulatory effects of inhaled PM-associated transition metals: A potential interaction between nickel and vanadium sulfate. Toxicol. Sci. 64:243–252.
   PubMed Web of Science ®Google Scholar
• J. D. Carter, A. J. Ghio, J. M. Samet, and R. B. Devlin. 1997. Cytokine production by human epithelial cells after exposure to an air pollution particle is metal-dependent. Toxicol. Appl. Pharmacol. 146:180–188.
   PubMed Web of Science ®Google Scholar
• H. Chen, T. Davidson, S. Singleton, M. D. Garrick, and M. Costa. 2005. Nickel decreases cellular iron level and converts cytosolic aconitase to iron-regulatory protein 1 in A549 cells. Toxicol. Appl. Pharmacol. 206:275–287.
   PubMed Web of Science ®Google Scholar
• L. C. Chen, and J. S. Hwang. 2005. Effects of subchronic exposures to concentrated ambient particles (CAPs) in mice. IV. Characterization of acute and chronic effects of ambient air fine particulate matter exposures on heart-rate variability. Inhal. Toxicol. 17:209–216.
   PubMed Web of Science ®Google Scholar
• L. C. Chen, and C. Nadziejko. 2005. Effects of subchronic exposures to concentrated ambient particles (CAPs) in mice. V. CAPs exacerbate aortic plaque development in hyperlipidemic mice. Inhal. Toxicol. 17:217–224.
   PubMed Web of Science ®Google Scholar
• K.-J. Chuang, C.-C. Chan, T.-C. Su, L.-Y. Lin, and C.-T. Lee. 2007. Associations between particulate sulfate and organic carbon exposures and heart rate variability in patients with or at risk for cardiovascular diseases. J. Occup. Environ. Med. 49:610–617.
   PubMed Web of Science ®Google Scholar
• R. W. Clarke, B. Coull, U. Reinisch, P. Catalano, C. R. Killingsworth, P. Koutrakis, I. Kavouras, G. G. Murthy, J. Lawrence, E. Lovett, J. M. Wolfson, R. L. Verrier, and J. J. Godleski. 2000. Inhaled concentrated ambient particles are associated with hematologic and bronchoalveolar lavage changes in canines. Environ. Health Perspect. 108:1179–1187.
   PubMed Web of Science ®Google Scholar
• D. L. Costa, J. R. Lehmann, D. Winsett, J. Richards, A. D. Ledbetter, and K. L. Dreher. 2006. Comparative pulmonary toxicological assessment of oil combustion particles following inhalation or instillation exposure. Toxicol. Sci. 91:237–246.
   PubMed Web of Science ®Google Scholar
• D. L. Costa, and K. L. Dreher. 1997. Bioavailable transition metals in particulate matter mediate cardiopulmonary injury in healthy and compromised animal models. In Proceedings of the sixth international meeting on the toxicology of natural and man-made fibrous and non-fibrous particles, September 1996, Lake Placid, NY, eds. K. E. Driscoll and G. Oberdörster. Environ. Health Perspect. Suppl. 105 (5):1053–1060.
   PubMedGoogle Scholar
• B. Coutant, and S. Stetzer. 2001. Evaluation of PM_2.5 speciation sampler performance and related sample collection and stability issues: Final report. Research Triangle Park, NC: U.S. Environmental Protection Agency, Office of Air Quality Planning and Standards, report EPA-454/R-01-008. http://www.epa.gov/ttn/amtic/pmspec.html [accessed 5 April 2002].
   Google Scholar
• B. Coutant, X. Zhang, and T. Pivetz. 2001. Summary statistics and data displays for the speciation minitrends study: Final report. Research Triangle Park, NC: U.S. Environmental Protection Agency, Office of Air Quality Planning and Standards, contract 68-D-98-030.
   Google Scholar
• J. Creason, L. Neas, D. Walsh, R. Williams, L. Sheldon, D. Liao, and C. Shy. 2001. Particulate matter and heart rate variability among elderly retirees: The Baltimore 1998 PM study. J. Environ. Exp. Anal. Environ. Epidemiol. 11:116–122.
   PubMedGoogle Scholar
• T. L. Davidson, H. Chen, D. M. Di Toro, G. D'Angelo, and M. Costa. 2006. Soluble nickel inhibits HIF-prolyl-hydroxylases creating persistent hypoxic signaling in A549 cells. Mol. Carcinogen. 45:479–489.
   PubMedGoogle Scholar
• T. Davidson, H. Chen, M. D. Garrick, G. D'Angelo, and M. Costa. 2005. Soluble nickel interferes with cellular iron homeostasis. Mol. Cell. Biochem. 279:157–162.
   PubMed Web of Science ®Google Scholar
• D. W. Dockery, C. A. PopeIII, X. Xu, J. W. Spengler, J. H. Ware, M. E. Fay, B. G. Ferris, and F. E. Speizer. 1993. An association between air pollution and mortality in six U.S. cities. N. Engl. J. Med. 329:1753–1759.
   PubMed Web of Science ®Google Scholar
• F. Dominici, R. D. Peng, K. Ebisu, S. L. Zeger, J. M. Samet, and M. L. Bell. 2007a. Does the effect of PM10 on mortality depend on PM nickel and vanadium? A reanalysis of the NMMAPS data. Environ. Health Perspect. 115:1701–1703.
   PubMed Web of Science ®Google Scholar
• F. Dominici, R. D. Peng, S. L. Zeger, R. H. White, and J. M. Samet. 2007b. Particulate air pollution and mortality in the United States: Did the risks change from 1987 to 2000?. Am. J. Epidemiol 166:880–888.
   PubMed Web of Science ®Google Scholar
• K. Donaldson, D. M. Brown, C. Mitchell, M. Dineva, P. H. Beswick, P. Gilmour, and W. MacNee. 1997. Free radical activity of PM10: Iron-mediated generation of hydroxyl radicals. In Proceedings of the sixth international meeting on the toxicology of natural and man-made fibrous and non-fibrous particles; September 1996; Lake Placid, NY, eds. K. E. Driscoll and G. Oberdörster. Environ. Health Perspect. Suppl. 105 (5):1285–1289.
   PubMedGoogle Scholar
• K. L. Dreher, R. H. Jaskot, J. R. Lehmann, J. H. Richards, J. K. McGee, A. J. Ghio, and D. L. Costa. 1997. Soluble transition metals mediate residual oil fly ash induced acute lung injury. J. Toxicol. Environ. Health 50:285–305.
   PubMed Web of Science ®Google Scholar
• J. A. Dye, K. B. Adler, J. H. Richards, and K. L. Dreher. 1997. Epithelial injury induced by exposure to residual oil fly-ash particles: Role of reactive oxygen species?. Am. J. Respir. Cell Mol. Biol. 17:625–633.
   PubMed Web of Science ®Google Scholar
• J. A. Dye, K. B. Adler, J. H. Richards, and K. L. Dreher. 1999. Role of soluble metals in oil fly ash-induced airway epithelial injury and cytokine gene expression. Am. J. Physiol. 277:L498–L510.
   PubMed Web of Science ®Google Scholar
• J. A. Dye, J. R. Lehmann, J. K. McGee, D. W. Winsett, A. D. Ledbetter, J. I. Everitt, A. J. Ghio, and D. L. Costa. 2001. Acute pulmonary toxicity of particulate matter filter extracts in rats: coherence with epidemiological studies in Utah Valley residents. Environ. Health Perspect. Suppl. 109 (3):395–403.
   PubMedGoogle Scholar
• S. T. Ebelt, W. E. Wilson, and M. Brauer. 2005. Exposure to ambient and nonambient components of particulate matter. Epidemiology 16:396–405.
   PubMed Web of Science ®Google Scholar
• A. Fernandez, J. O. L. Wendt, R. Cenni, R. S. Young, and M. L. Witten. 2002. Resuspension of coal and coal/municipal sewage sludge combustion generated fine particles for inhalation health effects studies. Sci. Total Environ. 287:265–274.
   PubMed Web of Science ®Google Scholar
• J. M. Fine, T. Gordon, L. C. Chen, P. Kinney, G. Falcone, and W. S. Beckett. 1997. Metal fume fever: characterization of clinical and plasma IL-6 responses in controlled human exposures to zinc oxide fume at and below the threshold limit value. J. Occup. Environ. Med. 39:722–726.
   PubMed Web of Science ®Google Scholar
• M. Finkelstein, M. Jerrett, and M. R. Sears. 2004. Traffic air pollution and mortality rate advancement periods. Am. J. Epidemiol. 160:173–177.
   PubMed Web of Science ®Google Scholar
• M. Finkelstein, M. Jerrett, and M. R. Sears. 2005. Environmental inequality and circulatory disease mortality gradients. J. Epidemiol. Commun. Health 59:481–487.
   PubMed Web of Science ®Google Scholar
• M. W. Frampton, A. J. Ghio, J. M. Samet, J. L. Carson, J. D. Carter, and R. B. Devlin. 1999. Effects of aqueous extracts of PM10 filters from the Utah Valley on human airway epithelial cells. Am. J. Physiol. 277:L960–L967.
   PubMed Web of Science ®Google Scholar
• S. Y. Gardner, J. R. Lehmann, and D. L. Costa. 2000. Oil fly ash-induced elevation of plasma fibrinogen levels in rats. Toxicol. Sci. 56:175–180.
   PubMed Web of Science ®Google Scholar
• S. H. Gavett, N. Haykal-Coates, L. B. Copeland, J. Heinrich, and M. I. Gilmour. 2003. Metal composition of ambient PM2.5 influences severity of allergic airways disease in mice. Environ. Health Perspect. 111:1471–1477.
   PubMed Web of Science ®Google Scholar
• S. H. Gavett, S. L. Madison, K. L. Dreher, D. W. Winsett, J. K. McGee, and D. L. Costa. 1997. Metal and sulfate composition of residual oil fly ash determines airway hyperreactivity and lung injury in rats. Environ. Res. 72:162–172.
   PubMed Web of Science ®Google Scholar
• U. Gehring, J. Heinrich, U. Kramer, V. Grote, M. Hochadel, D. Sugiri, M. Kraft, K. Rauchfuss, H. G. Eberwein, and H.-E. Wichmann. 2006. Long-term exposure to ambient air pollution and cardiopulmonary mortality in women. Epidemiology 17:545–551.
   PubMed Web of Science ®Google Scholar
• A. J. Ghio, and R. B. Devlin. 2001. Inflammatory lung injury after bronchial instillation of air pollution particles. Am. J. Respir. Crit. Care Med. 164:704–708.
   PubMed Web of Science ®Google Scholar
• A. J. Ghio, J. H. Richards, K. L. Dittrich, and J. M. Samet. 1998a. Metal storage and transport proteins increase after exposure of the rat lung to an air pollution particle. Toxicol. Pathol. 26:388–394.
   PubMed Web of Science ®Google Scholar
• A. J. Ghio, J. Stonehuerner, L. A. Dailey, and J. D. Carter. 1999d. Metals associated with both the water-soluble and insoluble fractions of an ambient air pollution particle catalyze an oxidative stress. Inhal. Toxicol. 11:37–49.
   PubMed Web of Science ®Google Scholar
• A. J. Ghio, C. Kim, and R. B. Devlin. 2000. Concentrated ambient air particles induce mild pulmonary inflammation in healthy human volunteers. Am. J. Respir. Crit. Care Med. 162:981–988.
   PubMed Web of Science ®Google Scholar
• A. J. Ghio, C. A. Piantadosi, X. Wang, L. A. Dailey, J. D. Stonehuerner, M. C. Madden, F. Yang, K. G. Dolan, M. D. Garrick, and L. M. Garrick. 2005. Divalent metal transporter-1 decreases metal-related injury in the lung. Am. J. Physiol. Lung Cell. Mol. Physiol. 289:L460–467.
   Google Scholar
• P. S. Gilmour, D. M. Brown, T. G. Lindsay, P. H. Beswick, W. MacNee, and K. Donaldson. 1996. Adverse health effects of PM10 particles: Involvement of iron in generation of hydroxyl radical. Occup. Environ. Med. 53:817–822.
   PubMed Web of Science ®Google Scholar
• P. S. Gilmour, M. C. Schladweiler, A. Nyska, J. K. McGee, J. K. Thomas, R. H. Jaskot, J. Schmid, and U. P. Kodavanti. 2006. Systemic imbalance of essential metals and cardiac gene expression in rats following acute pulmonary zinc exposure. J. Toxicol. Environ. Health A 69:2011–2032.
   PubMed Web of Science ®Google Scholar
• P. S. Gilmour, A. Nyska, M. C. Schladweiler, J. K. McGee, J. G. Wallenborn, J. H. Richards, and U. P. Kodavanti. 2006. Cardiovascular and blood coaguative effects of pulmonary zinc exposure. Toxicol. Appl. Pharmacol. 211:41–52.
   PubMed Web of Science ®Google Scholar
• D. R. Gold, A. A. Litonjua, A. Zanobetti, B. A. Coull, J. Schwartz, G. MacCallum, R. L. Verrier, B. D. Nearing, M. J. Canner, H. Suh, and P. H. Stone. 2005. Air pollution and ST-segment depression in elderly subjects. Environ. Health Perspect. 113:883–887.
   PubMed Web of Science ®Google Scholar
• C.-A. W. Goldsmith, A. Imrich, H. Danaee, Y. Y. Ning, and L. Kobzik. 1998. Analysis of air pollution particulate-mediated oxidant stress in alveolar macrophages. J. Toxicol. Environ. Health A 54:529–545.
   PubMed Web of Science ®Google Scholar
• B. S. Glenn, K. Bandeen-Roche, B.-K. Lee, V. M. Weaver, A. C. Todd, and B. S. Schwartz. 2006. Changes in systolic blood pressure associated with lead in blood and bone. Epidemiology 17:538–544.
   PubMedGoogle Scholar
• T. Grahame, and G. Hidy. 2004. Using factor analysis to attribute health impact to particulate pollution sources. Inhal. Toxicol. 16 (Suppl.1):143–152.
   PubMedGoogle Scholar
• A. Gunnison, and L. C. Chen. 2005. Effects of subchronic exposures to concentrated ambient particles (CAPs) in mice. VI. Gene expression in heart and lung tissue. Inhal. Toxicol. 17:225–233.
   PubMed Web of Science ®Google Scholar
• S. A. Gurgueira, J. Lawrence, B. Coull, G. G. Murthy, and B. Gonzalez-Flecha. 2002. Rapid increases in the steady-state concentration of reactive oxygen species in the lungs and heart after particulate air pollution inhalation. Environ. Health Perspect. 110:749–755.
   PubMed Web of Science ®Google Scholar
• K. Hamada, C.-A. Goldsmith, A. Goldman, and L. Kobzik. 2000. Resistance of very young mice to inhaled allergen sensitization Is overcome by coexposure to an air-pollutant aerosol. Am. J. Respir. Crit. Care Med. 161:1285–1293.
   PubMed Web of Science ®Google Scholar
• A. J. Hedley, P. Y. K. Chau, and C. M. Wong. 2004. The change in sub-species of particulate matter [PM10] before and after an intervention to restrict sulphur content of fuel in Hong Kong. Poster presented at Better Air Quality/Asian Development Bank meeting at Agra, India.
   Google Scholar
• A. J. Hedley, C. M. Wong, T. Q. Thach, S. Ma, T. H. Lam, and H. R. Anderson. 2002. Cardiorespiratory and all-cause mortality after restrictions on sulphur content of fuel in Hong Kong: An intervention study. Lancet 360:1646–1652.
   PubMed Web of Science ®Google Scholar
• J. D. Herner, P. G. Green, and M. J. Kleeman. 2006. Measuring the trace elemental composition of size-resolved airborne particles. Environ. Sci. Technol. 40:1925–1933.
   PubMed Web of Science ®Google Scholar
• G. Hoek, B. Brunekreef, S. Goldbohm, P. Fischer, and P. A. van den Brandt. 2002. Association between mortality and indicators of traffic-related air pollution in the Netherlands: A cohort study. Lancet 360:1203–1209. (online)
   PubMed Web of Science ®Google Scholar
• P. K. Hopke, K. Ito, T. Mar, W. F. Christensen, D. J. Eatough, R. C. Henry, E. Kim, F. Laden, R. Lall, T. V. Larson, H. Liu, L. Neas, J. Pinto, M. Stölzel, H. Suh, P. Paatero, and G. D. Thurston. 2006. PM source apportionment and health effects: 1. Intercomparison of source apportionment results. J. Expso. Anal. Environ. Epidemiol. 16:275–286.
   PubMed Web of Science ®Google Scholar
• Y.-C. T. Huang, A. J. Ghio, J. Stoneheurner, J. McGee, D. Carter, S. C. Grambow, and R. B. Devlin. 2003. The role of soluble components in ambient air fine particles-induced changes in human lungs and blood. Inhal. Toxicol. 15:327–342.
   PubMed Web of Science ®Google Scholar
• J. S. Hwang, C. Nadziejko, and L. C. Chen. 2005. Effects of subchronic exposures to concentrated ambient particles (CAPs) in mice. III. Acute and chronic effects of CAPs on heart rate, heart-rate fluctuation, and body temperature. Inhal. Toxicol. 17:199–207.
   PubMed Web of Science ®Google Scholar
• K Ito, N. Xue, and G. Thurston. 2004. Spatial variation of PM2.5 chemical species and source-apportioned mass concentrations in New York City. Atmos. Environ. 38:5269–5282.
   Web of Science ®Google Scholar
• K. Ito, W. F. Christensen, D. J. Eatough, R. C. Henry, E Kim, F. Laden, R. Lall, T. V. Larson, L. Neas, P. K. Hopke, and G. D. Thurston. 2006. PM source apportionment and health effects: 2. An investigation of inter-method variability in associations between source-apportioned fine particle mass and daily mortality in Washington, DC. J. Expos. Anal. Environ. Epidemiol. 16:300–310.
   Google Scholar
• N. B. Jain, V. Potula, J. Schwartz, P. S. Vokonas, R. O. Wright, H. Nie, and H. Hu. 2007. Lead levels and ischemic heart disease in a prospective study of middle-aged and elderly men: The VA normative aging study. Environ. Health Perspect. 115:871–875.
   PubMed Web of Science ®Google Scholar
• N. A. H. Janssen, J. Schwartz, A. Zanobetti, and H. Suh. 2002. Air conditioning and source-specific particles as modifiers of the effect of PM10 on hospital admissions for heart and lung disease. Environ. Health Perspect. 110:43–49.
   PubMed Web of Science ®Google Scholar
• A. Jemal, B. I. Graubard, S. S. Devesa, and K. M. Flegal. 2002. The association of blood lead level and cancer mortality among whites in the United States. Environ. Health Perspect. 110:325–329.
   PubMed Web of Science ®Google Scholar
• M. B. Kadiiska, A. J. Ghio, and R. P. Mason. 2004. ESR investigation of the oxidative damage in lungs caused by asbestos and air pollution particles. Spectrochim. Acta 60:1371–1377.
   PubMed Web of Science ®Google Scholar
• M. B. Kadiiska, R. P. Mason, K. L. Dreher, D. L. Costa, and A. J. Ghio. 1997. In vivo evidence of free radical formation in the rat lung after exposure to an emission source air pollution particle. Chem. Res. Toxicol. 10:1104–1108.
   PubMed Web of Science ®Google Scholar
• T. Kennedy, A. J. Ghio, W. Reed, J. Samet, J. Zagorski, J. Quay, J. Carter, L. Dailey, J. R. Hoidal, and R. B. Devlin. 1998. Copper-dependent inflammation and nuclear factor-6B activation by particulate air pollution. Am. J. Respir. Cell Mol. Biol. 19:366–378.
   PubMed Web of Science ®Google Scholar
• Y. M. Kim, W. Reed, W. Wu, P. A. Bromberg, L. M. Graves, and J. M. Samet. 2006. Zn2 +-induced IL-8 expression involves AP-1, JNK, and ERK activities in human airway epithelial cells. Am. J. Physiol. Lung Cell. Mol. Physiol. 290:L1028–1035.
   Google Scholar
• U. P. Kodavanti, R. H. Jaskot, D. L. Costa, and K. L. Dreher. 1997. Pulmonary proinflammatory gene induction following acute exposure to residual oil fly ash: Roles of particle-associated metals. Inhal. Toxicol. 9:679–701.
   Web of Science ®Google Scholar
• U. P. Kodavanti, R. Hauser, D. C. Christiani, Z. H. Meng, J. McGee, A. Ledbetter, J. Richards, and D. L. Costa. 1998. Pulmonary responses to oil fly ash particles in the rat differ by virtue of their specific soluble metals. Toxicol. Sci. 43:204–212.
   PubMed Web of Science ®Google Scholar
• U. P. Kodavanti, M. C. Jackson, A. D. Ledbetter, J. R. Richards, S. Y. Gardner, W. P. Watkinson, M. J. Campen, and D. L. Costa. 1999. Lung injury from intratracheal and inhalation exposures to residual oil fly ash in a rat model of monocrotaline-induced pulmonary hypertension. J. Toxicol. Environ. Health A 57:543–563.
   PubMed Web of Science ®Google Scholar
• U. P. Kodavanti, M. C. Schladweiler, A. D. Ledbetter, W. P. Watkinson, M. J. Campen, D. W. Winsett, J. R. Richards, K. M. Crissman, G. E. Hatch, and D. L. Costa. 2000a. The spontaneously hypertensive rat as a model of human cardiovascular disease: Evidence of exacerbated cardiopulmonary injury and oxidative stress from inhaled emission particulate matter. Toxicol. Appl. Pharmacol. 164:250–263.
   PubMed Web of Science ®Google Scholar
• U. P. Kodavanti, R. Mebane, A. Ledbetter, T. Krantz, J. McGee, M. C. Jackson, L. Walsh, H. Hilliard, B. Y. Chen, J. Richards, and D. L. Costa. 2000b. Variable pulmonary responses from exposure to concentrated ambient air particles in a rat model of bronchitis. Toxicol. Sci. 54:441–451.
   PubMed Web of Science ®Google Scholar
• U. P. Kodavanti, M. C. J. Schladweiler, J. R. Richards, and D. L. Costa. 2001. Acute lung injury from intratracheal exposure to fugitive residual oil fly ash and its constituent metals in normo- and spontaneously hypertensive rats. Inhal. Toxicol. 13:37–54.
   PubMed Web of Science ®Google Scholar
• U. P. Kodavanti, M. C. Schladweiler, A. D. Ledbetter, R. Hauser, D. C. Christiani, J. McGee, J. R. Richards, and D. L. Costa. 2002a. Temporal association between pulmonary and systemic effects of particulate matter in healthy and cardiovascular compromised rats. J. Toxicol. Environ. Health A 65:1545–1569.
   PubMed Web of Science ®Google Scholar
• U. P. Kodavanti, C. F. Moyer, A. D. Ledbetter, M. C. Schladweiler, D. L. Costa, R. Hauser, D. C. Christiani, and A. Nyska. 2003. Inhaled environmental combustion particles cause myocardial injury in the Wistar Kyoto rat. Toxicol. Sci. 71:237–245.
   PubMed Web of Science ®Google Scholar
• U. P. Kodavanti, M. C. Schladweiler, A. D. Ledbetter, J. K. McGee, L. Walsh, P. S. Gilmour, J. W. Highfill, D. Davies, K. E. Pinkerton, J. H. Richards, K. J. Crissman, D. Andrews, and D. L. Costa. 2005. Consistent pulmonary and systemic responses from inhalation of fine concentrated ambient particles: Roles of rat strains used and physiochemical properties. Environ. Health Perspect. 113:1561–1568.
   PubMed Web of Science ®Google Scholar
• C.-B. Kweon, S. Okada, J. C. Stetter, C. G. Christenson, M. M. Shafer, J. J. Schauer, and D. E. Foster. 2003. Effect of fuel composition and detailed chemical/physical characteristics of diesel exhaust. 112 (Part 4):1668–1687. SAE Transactions; Society of Automotive Engineers, New York City.
   Google Scholar
• F. Laden, L. M. Neas, D. W. Dockery, and J. Schwartz. 2000. Association of fine particulate matter from different sources with daily mortality in six U.S. cities. Environ. Health Perspect. 108:941–947.
   PubMed Web of Science ®Google Scholar
• S. Lagorio, F. Forastiere, R. Pistelli, I. Iavarone, P. Michelozzi, V. Fano, A. Marconi, G. Ziemacki, and B. D. Ostro. 2006. Air pollution and lung function among susceptible adult subjects: A panel study. Environ. Health Global Access Sci. Source 5:1–12.
   PubMedGoogle Scholar
• A. L. Lambert, W. Dong, M. K. Selgrade, and M. I. Gilmour. 2000. Enhanced allergic sensitization by residual oil fly ash particles is mediated by soluble metal constituents. Toxicol. Appl. Pharmacol. 165:84–93.
   PubMed Web of Science ®Google Scholar
• A. L. Lambert, W. Dong, D. W. Winsett, M. K. Selgrade, and M. I. Gilmour. 1999. Residual oil fly ash exposure enhances allergic sensitization to house dust mite. Toxicol. Appl. Pharmacol. 158:269–277.
   PubMed Web of Science ®Google Scholar
• T. Lanki, J. J. de Hartog, J. Heinrich, G. Hoek, N. A. H. Janssen, A. Peters, M. Stolzel, K. L. Timonen, M. Vallius, E. Vanninen, and J. Pekkanen. 2006. Can we identify sources of fine particles responsible foe exercise-induced ischemia on days with elevated air pollution? The ULTRA study. Environ. Health Perspect. 114:655–660.
   PubMed Web of Science ®Google Scholar
• J. C. Lay, W. D. Bennett, C. S. Kim, R. B. Devlin, and P. A. Bromberg. 1998. Retention and intracellular distribution of instilled iron oxide particles in human alveolar macrophages. Am. J. Respir. Cell Mol. Biol. 18:687–695.
   PubMed Web of Science ®Google Scholar
• J. C. Lay, K. L. Zeman, A. J. Ghio, and W. D. Bennett. 2001. Effects of inhaled iron oxide particles on alveolar epithelial permeability in normal subjects. Inhal. Toxicol. 13:1065–1078.
   PubMed Web of Science ®Google Scholar
• P. K. H. Lee, J. R. Brook, E. Dabek-Zlotorzynska, and S. A. Mabury. 2003. Identification of the major sources contributing to PM2.5 observed in Toronto. Environ. Sci. Technol 37:4831–4840.
   PubMed Web of Science ®Google Scholar
• X. Y. Li, P. S. Gilmour, K. Donaldson, and W. MacNee. 1997. In vivo and in vitro proinflammatory effects of particulate air pollution (PM10). In Proceedings of the sixth international meeting on the toxicology of natural and man-made fibrous and non-fibrous particles; September 1996; Lake Placid, NY, eds. K. E. Driscoll and G. Oberdörster. Environ. Health Perspect. Suppl. 105 (5):1279–1283.
   PubMedGoogle Scholar
• Z. Li, X. Hyseni, J. D. Carter, J. M. Soukup, L. A. Dailey, and Y.-C. T. Huang. 2006. Pollutant particles enhanced H2O2 production from NAD(P)H oxidase and mitochondria in human pulmonary artery endothelial cells. Am. J. Physiol. Cell Physiol. 291:C357–365.
   PubMed Web of Science ®Google Scholar
• J. J. N. Lingard, A. S. Tomlin, A. G. Clarke, K. Healey, A. W. M. Hay, C. P. Wild, and M. N. Routledge. 2005. A study of trace metal concentration of urban airborne particulate matter and its role in free radical activity as measured by plasmid strand break assay. Atmos. Environ. 39:2377–2384.
   Web of Science ®Google Scholar
• F. W. Lipfert, J. D. Baty, J. P. Miller, and R. E. Wyzga. 2006. PM2.5 constituents and related air quality variables as predictors of survival in a cohort of U.S. military veterans. Inhal. Toxicol. 18:645–657.
   PubMed Web of Science ®Google Scholar
• M. Lippmann, K Ito, J. H. Hwang, P. Maciejczyk, and L. C. Chen. 2006. Cardiovascular effects of nickel in ambient air. Environ. Health Perspect. 114:1662–1669.
   PubMed Web of Science ®Google Scholar
• M. Lippmann, and G. D. Thurston. 1996. Sulfate concentrations as an indicator of ambient particulate matter air pollution for health risk evaluations. J. Expos. Anal. Environ. Epidemiol. 6:123–146.
   PubMedGoogle Scholar
• M. Lippmann, T. Gordon, and L. C. Chen. 2005a. Effects of subchronic exposures to concentrated ambient particles (CAPs) in mice. I. Introduction, objectives, and experimental plan. Inhal. Toxicol. 17:177–187.
   PubMed Web of Science ®Google Scholar
• M. Lippmann, T. Gordon, and L. C. Chen. 2005b. Effects of subchronic exposures to concentrated ambient particles in mice. IX. Integral assessment and human health implications of subchronic exposures of mice to CAPs. Inhal. Toxicol. 17:255–261.
   PubMed Web of Science ®Google Scholar
• M. Lippmann, J. S. Hwang, P. Maciejczyk, and L. C. Chen. 2005c. PM source apportionment for short-term cardiac function changes in ApoE-/-mice. Environ. Health Perspect. 113:1575–1579.
   PubMed Web of Science ®Google Scholar
• M. Lippmann, K. Ito, J. S. Hwang, P. Maciejczyk, and L. C. Chen. 2006. Cardiovascular effects of nickel in ambient air. Environ. Health Perspect. 114:1662–1669.
   PubMed Web of Science ®Google Scholar
• M. Lustberg, and E. Silbergeld. 2002. Blood lead levels and mortality. Arch. Intern. Med. 162:2443–2449.
   PubMed Web of Science ®Google Scholar
• P. B. Maciejczyk, and L. C. Chen. 2005. Effects of subchronic exposures to concentrated ambient particles (CAPs) in mice: VIII. Source-related daily variations in in vitro responses to CAPs. Inhal. Toxicol. 17:243–253.
   PubMed Web of Science ®Google Scholar
• S. R. Magari, J. Schwartz, P. L. Williams, R. Hauser, T. G. Smith, and D. C. Christiani. 2002. The association of particulate air metal concentrations with heart rate variability. Environ. Health Perspect. 110:875–880.
   PubMed Web of Science ®Google Scholar
• T. F. Mar, G. A. Norris, T. V. Larson, W. E. Wilson, and J. Q. Koenig. 2003. Air pollution and cardiovascular mortality in Phoenix, 1995–1997. In Revised analyses of time-series studies of air pollution and health. Special report, pp. 177–182. Boston, MA: Health Effects Institute. http://www.healtheffects.org/Pubs/TimeSeries.pdf [accessed 18 October, 2004].
   Google Scholar
• T. F. Mar, K. Ito, J. Q. Koenig, T. V. Larson, D. J. Eatough, R. C. Henry, E. Kim, F. Laden, R. Lall, L. Neas, M Stolzel, P Paatero, P. K. Hopke, and G. D. Thurston. 2006. PM source apportionment and health effects: 3. Investigation of inter-method variations in associations between estimated source contributions of PM2.5 and daily mortality in Phoenix, AZ. J. Expos. Anal. Environ. Epidemiol. 16:311–320.
   Google Scholar
• J. L. Mauderly, and J. C. Chow. 2008. Health effects of organic aerosols. Inhal. Toxicol. 20:257–288.
   PubMed Web of Science ®Google Scholar
• A. Menke, P. Muntner, V. Batuman, E. K. Silbergeld, and E. Guallar. 2006. Blood lead below 0.48 μmol/L (10 μg/dL) and mortality among US adults. Epidemiology 114:1388–1394.
   Google Scholar
• K. B. Metzger, P. E. Tolbert, M. Klein, J. L. Peel, W. D. Flanders, K. Todd, J. A. Mulholland, P. B. Ryan, and H. Frumkin. 2004. Ambient air pollution and cardiovascular emergency department visits. Epidemiology 15 (1):46–56.
   PubMedGoogle Scholar
• M. Morishita, J. G. Wagner, F. J. Marsik, E. J. Timm, J. T. Dvonch, and J. R. Harkema. 2004. Pulmonary retention of particulate matter is associated with airway inflammation in allergic rats exposed to air pollution in urban Detroit. Inhal. Toxicol. 16:663–674.
   PubMed Web of Science ®Google Scholar
• M. Morishita, G. J. Keeler, J. G. Wagner, and J. R. Harkema. 2006. Source identification of ambient PM2.5 during summer inhalation exposure studies in Detroit. Atmos. Environ. 40:3823–3834.
   Web of Science ®Google Scholar
• B. A. Muggenburg, J. M. Benson, E. B. Barr, J. Kubatko, and L. P. Tilley. 2003. Short-term inhalation of particulate transition metals has little effect on the electrocardiograms of dogs having preexisting cardiac abnormalities. Inhal. Toxicol. 15:357–371.
   PubMed Web of Science ®Google Scholar
• S. S. Nadadur, and U. P. Kodavanti. 2002. Altered gene expression profiles of rat lung in response to an emission particulate and its metal constituents. J. Toxicol. Environ. Health A 65:1333–1350.
   PubMed Web of Science ®Google Scholar
• S. S. Nadadur, M. C. J. Schladweiler, and U. P. Kodavanti. 2000. A pulmonary rat gene array for screening altered expression profiles in air pollutant-induced lung injury. Inhal. Toxicol. 12:1239–1254.
   PubMed Web of Science ®Google Scholar
• P. Nafstad, L. L. Haheim, B. Oftedal, F. Gram, I. Holme, I. Hjermann, and P. Leren. 2003. Lung cancer and air pollution: A 27 year follow up of 16,209 Norwegian men. Thorax 58:1071–1076.
   PubMed Web of Science ®Google Scholar
• P. Nafstad, L. L. Haheim, T. Wisloff, F. Gram, B. Oftedal, I. Holme, I. Hjermann, and P. Leren. 2004. Urban air pollution and mortality in a cohort of Norwegian men. Environ. Health Perspect. 112:610–615.
   PubMed Web of Science ®Google Scholar
• National Research Council, Committee on Research Priorities for Airborne Particulate Matter. 2001Research priorities for airborne particulate matter: III. Early research progress. Washington, DC: National Academy Press.
   Google Scholar
• B. Ostro, W.-Y. Feng, R. Broadwin, S. Green, and M. Lipsett. 2007. The effects of components of fine particulate air pollution on mortality in California: Results from CALFINE. Environ. Health Perspect. 115:13–19.
   PubMed Web of Science ®Google Scholar
• H. Özkaynak, and G. D. Thurston. 1987. Associations between 1980 U.S. mortality rates and alternative measures of airborne particle concentration. Risk Anal. 7:449–460.
   PubMed Web of Science ®Google Scholar
• H. Özkaynak, J. Xue, H. Zhou, and M. Raizenne. 1996. Associations between daily mortality and motor vehicle pollution in Toronto, Canada. Boston: Harvard University School of Public Health, Department of Environmental Health, March 25.
   Google Scholar
• P. Penttinen, M. Vallius, P. Tittanen, J. Ruuskanen, and J. Pekkanen. 2006. Source-specific fine particles in urban air and respiratory function among adult asthmatics. Inhal. Toxicol. 18:191–198.
   PubMed Web of Science ®Google Scholar
• C. A. PopeIII. 1989. Respiratory disease associated with community air pollution and a steel mill, Utah Valley. Am. J. Public Health 79:623–628.
   PubMed Web of Science ®Google Scholar
• C. A. PopeIII. 1991. Respiratory hospital admissions associated with PM10 pollution in Utah, Salt Lake, and Cache Valleys. Arch. Environ. Health 46:90–97.
   PubMed Web of Science ®Google Scholar
• C. A. PopeIII, J. Schwartz, and M. R. Ransom. 1992. Daily mortality and PM10 pollution in Utah Valley. Arch. Environ. Health 47:211–217.
   PubMed Web of Science ®Google Scholar
• C. A. PopeIII, M. J. Thun, M. M. Namboodiri, D. W. Dockery, J. S. Evans, F. E. Speizer, and C. W. HeathJr.. 1995. Particulate air pollution as a predictor of mortality in a prospective study of U.S. adults. Am. J. Respir. Crit. Care Med. 151:669–674.
   PubMed Web of Science ®Google Scholar
• C. A. PopeIII, D. L. Rodermund, and M. M. Gee. 2007. Mortality effects of a copper smelter strike and reduced ambient sulfate particulate matter air pollution. Environ. Health Perspect. 115:679–683.
   PubMed Web of Science ®Google Scholar
• R. J. Pritchard, A. J. Ghio, J. R. Lehmann, D. W. Winsett, J. S. Tepper, P. Park, M. I. Gilmour, K. L. Dreher, and D. L. Costa. 1996. Oxidant generation and lung injury after particulate air pollution exposure increase with the concentrations of associated metals. Inhal. Toxicol. 8:457–477.
   Web of Science ®Google Scholar
• Z. Ramadan, X.-H. Song, and P. Hopke. 2000. Identification of sources of Phoenix aerosol by positive matrix factorization. J. Air Waste Manage. Assoc. 50:1308–1320.
   Web of Science ®Google Scholar
• T. Reponen, S. A. Grinshpun, S. Trakumas, Wang Z.-M. Martuzevicius, G. LeMasters, J. E. Lockey, and P. Biswas. 2003. Concentration gradient patterns of aerosol particles near interstate highways in the Greater Cincinnati airshed. J. Environ. Monit. 5:557–562.
   PubMed Web of Science ®Google Scholar
• M. Riediker, R. B. Devlin, T. R. Griggs, M. C. Herbst, P. A. Bromberg, R. W. Williams, and W. E. Cascio. 2004b. Cardiovascular effects in patrol officers are associated with fine particulate matter from brake wear and engine emissions. Particle Fibre Technology 1:2. (open access).
   PubMed Web of Science ®Google Scholar
• C. R. Rhoden, J. Lawrence, J. J. Godleski, and B. Gonzalez-Flecha. 2004. N-Acetylsteine prevents lung inflammation after short-term exposure to concentrated ambient particles. Toxicol. Sci. 79:296–303.
   PubMed Web of Science ®Google Scholar
• W. Roemer, G. Hoek, B. Brunekreef, J. Clench—Aas, B. Forsberg, J. Pekkanen, and A. Schutz. 2000. PM10 elemental composition and acute respiratory health effects in European children. Eur. Respir. J. 15:553–559.
   PubMed Web of Science ®Google Scholar
• P. H. N. Saldiva, R. W. Clarke, B. A. Coull, R. C. Stearns, J. Lawrence, C. G. Krishna Murthy, E. Diaz, P. Koutrakis, H. Suh, A. Tsuda, and J. J. Godleski. 2002. Ling inflammation induced by concentrated ambient air particles is related to particle composition. Am. J. Respir. Crit. Care Med. 165:1610–1617.
   PubMed Web of Science ®Google Scholar
• K. Salnikow, X. Li, and M. Lippmann. 2004. Effect of nickel and iron co-exposure on human lung cells. Toxicol. Appl. Pharmacol. 196:258–265.
   PubMed Web of Science ®Google Scholar
• S. Salvi, A. Blomberg, B. Rudell, F. Kelly, T. Sandstrom, S. T. Holgate, and A. Frew. 1999. Acute inflammatory responses in the airways and peripheral blood after short-term exposure to diesel exhaust in healthy human volunteers. Am. J. Respir. Crit. Care Med. 159:702–709.
   PubMed Web of Science ®Google Scholar
• J. M. Samet, W. Reed, A. J. Ghio, R. B. Devlin, J. D. Carter, L. A. Dailey, P. A. Bromberg, and M. C. Madden. 1996. Induction of prostaglandin H synthase 2 in human airway epithelial cells exposed to residual oil fly ash. Toxicol. Appl. Pharmacol. 141:159–168.
   PubMed Web of Science ®Google Scholar
• J. M. Samet, J. Stonehuerner, W. Reed, R. B. Devlin, L. A. Dailey, T. P. Kennedy, P. A. Bromberg, and A. J. Ghio. 1997. Disruption of protein tyrosine phosphate homeostasis in bronchial epithelial cells exposed to oil fly ash. Am. J. Physiol. 272:L426–L432.
   PubMed Web of Science ®Google Scholar
• R. B. Schlesinger, and F. Cassee. 2003. Atmospheric secondary inorganic particulate matter: The toxicological perspective as a basis for health effects risk assessment. Inhal. Toxicol. 15:197–235.
   PubMed Web of Science ®Google Scholar
• R. B. Schlesinger. 2007. The health impact of common inorganic components of fine particulate matter (PM2.5) in ambient air: A critical review. Inhal. Toxicol 19 (10):811–832.
   PubMedGoogle Scholar
• S. E. Schober, L. B. Mirel, B. I. Graubard, D. J. Brody, and K. M. Flegal. 2006. Blood lead levels and death from all causes, cardiovascular disease, and cancer. Environ. Health Perspect. 114:1538–1541.
   PubMed Web of Science ®Google Scholar
• J. Schwartz. 2003a. Daily deaths associated with air pollution in six US cities and short-term mortality displacement in Boston. In Revised analyses of time-series studies of air pollution and health. Special report, pp. 219–226. Boston: Health Effects Institute. http://www.healtheffects.org/Pubs/TimeSeries.pdf [accessed 18 October, 2004].
   Google Scholar
• J. Schwartz, A. Litonjua, H. Suh, M. Verrier, A. Zanobetti, M. Syring, B. Nearing, R. Verrier, P. Stone, G. MacCallum, F. E. Speizer, and D. E. Gold. 2005. Traffic related pollution and heart rate variability in a panel of elderly subjects. Thorax 60:455–461.
   PubMed Web of Science ®Google Scholar
• J. C. Seagrave, and K. J. Nikula. 2000. Multiple modes of responses to air pollution particulate materials in A549 alveolar type II cells. In PM2000: Particulate matter and health, ed. L. D. Grant. Inhal. Toxicol. 12 (suppl. 4):247–260.
   PubMedGoogle Scholar
• J. Seagrave, J. D. McDonald, E. Bedrick, E. S. Edgerton, A. P. Gigliotti, J. J. Jansen, L. Ke, L. P. Naeher, S. K. Seilkop, M. Zheng, and J. L. Mauderly. 2006. Lung toxicity of ambient particulate matter from southeastern U.S. sites with different contributing sources: relationships between composition and effects. Environ. Health Perspect. 114:1387–1393.
   PubMed Web of Science ®Google Scholar
• A. H. Sinclair, and D. Tolsma. 2004. Associations and lags between air pollution and acute respiratory visits in an ambulatory care setting: 25-Month results from the aerosol research and inhalation epidemiological study. J. Air Waste Manage. Assoc. 54:1212–1218.
   Web of Science ®Google Scholar
• A. Skukla, C. Timblin, K. BeruBe, T. Gordon, W. McKinney, K. Driscoll, P. Vacek, and B. T. Mossman. 2000. Inhaled particulate matter causes expression of nuclear factor (NF)-κ B related genes and oxidant-dependent NF-κ B activation in vitro. Am. J. Respir. Cell Mol. Biol. 23:182–187.
   PubMedGoogle Scholar
• K. R. Smith, J. M. Veranth, A. A. Hu, J. S. Lighty, and A. E. Aust. 2000. Interleukin-8 levels in human lung epithelial cells are increased in response to coal fly ash and vary with the bioavailability of iron, as a function of particle size and source of coal. Chem. Res. Toxicol. 13:118–125.
   PubMed Web of Science ®Google Scholar
• K. R. Smith, J. M. Veranth, J. S. Lighty, and A. E. Aust. 1998. Mobilization of iron from coal fly ash was dependent upon the particle size and the source of coal. Chem. Res. Toxicol. 11:1494–1500.
   PubMed Web of Science ®Google Scholar
• K. R. Smith, and A. E. Aust. 1997. Mobilization of iron from urban particulates leads to generation of reactive oxygen species in vitro and induction of ferritin synthesis in human lung epithelial cells. Chem. Res. Toxicol. 10:828–834.
   PubMed Web of Science ®Google Scholar
• M. Sorensen, R. P. F. Schins, O. Hertel, and S. Loft. 2005. Transition metals in personal samples of PM2.5 and oxidative stress in human volunteers. Cancer Epidemiol. Biomarkers Prevent. 14 (5):1340–1343.
   PubMedGoogle Scholar
• P. A. Steerenberg, C. E. Withagen, J. A. Dormans, W. J. van Dalen, H. van Loveren, and F. R. Casee. 2003. Adjuvant activity of various diesel exhaust and ambient particles in two allergic models. J. Toxicol. Environ. Health A 66:1421–1439.
   PubMed Web of Science ®Google Scholar
• Q. Sun, A. Wang, X. Jin, A. Natanzon, D. Duquaine, R. D. Brook, J. G. S. Auinaldo, Z. A. Fayad, V. Fuster, M. Lippmann, L. C. Chen, and S. Rajagopalan. 2005. Long-term air pollution exposure and acceleration of atherosclerosis and vascular inflammation in an animal model. J. Am. Med. Assoc. 294:3003–3010.
   PubMed Web of Science ®Google Scholar
• G. D. Thurston, H. Ozkaynak, and A. Schatz. 1984. A chemical characterization and source apportionment of the IP Network fine particle data. Paper 84-58.5. Presented at the 77th Annual Meeting of the Air Pollution Control Association, San Francisco, CA, June.
   Google Scholar
• G. D. Thurston, and K. Ito. 2001. Epidemiological studies of acute ozone exposures and mortality. J. Expos. Anal. Environ. Epidemiol. 11 (4):286–294.
   PubMedGoogle Scholar
• G. D. Thurston, K. Ito, T. Mar, W. F. Christensen, D. J. Eatough, R. C. Henry, E. Kim, F. Laden, R. Lall, T. V. Larson, H. Liu, L. Neas, J. Pinto, M. Stolzel, H. Suh, and P. K. Hopke. 2005. Workshop report: Workshop on source apportionment of particulate matter health effects—Intercomparison of results and implications. Environ. Health Perspect. 113:1768–1774.
   PubMed Web of Science ®Google Scholar
• F. C. Tsai, M. G. Apte, and J. M. Daisey. 2000. An exploratory analysis of the relationship between mortality and the chemical composition of airborne particulate matter. Inhal. Toxicol. 12 (suppl.):121–135.
   PubMedGoogle Scholar
• B. Urch, J. R. Brook, D. Wasserstein, R. D. Brook, S. Rajagopalan, P. Corey, and F. Silverman. 2004. Relative contributions of PM2.5 chemical constituents to acute arterial vasoconstriction in humans. Inhal. Toxicol. 16:345–352.
   PubMed Web of Science ®Google Scholar
• B. Urch, F. Silverman, P. Corey, J. R. Brook, K. Z. Lukic, S. Rajagopalan, and R. D. Brook. 2005. Acute blood pressure responses in healthy adults during controlled air pollution exposures. Environ. Health Perspect. 113 (8):1052–1055.
   PubMedGoogle Scholar
• U.S. Environmental Protection Agency. 2004. Air quality criteria for particulate matter. Research Triangle Park, NC: National Center for Environmental Assessment-RTP Office, report EPA/600/P-99/002aF, October.
   Google Scholar
• J. M. Veranth, T. A. Moss, J. C. Chow, R. Labban, W. K. Nichols, J. C. Walton, J. G. Watson, and G. S. Yost. 2006. Correlation of in vitro cytokine responses with the chemical composition of soil-derived particulate matter. Environ. Health Perspect. 114:341–349.
   PubMed Web of Science ®Google Scholar
• B. Veronesi, O. Makwana, M. Pooler, and L. C. Chen. 2005. Effects of subchronic exposures to concentrated ambient particles. VII. Degeneration of dopaminergic neurons in Apo E-/-mice. Inhal. Toxicol. 17:235–241.
   PubMed Web of Science ®Google Scholar
• P. S. Vinzents, P. Meller, M. Sorensen, L. E. Knudsen, O. Hertel, F. P. Jensen, B. Schibye, and S. Loft. 2005. Personal exposure to ultrafine particles and oxidative DNA damage. Environ. Health Perspect. 113:1485–1490.
   PubMed Web of Science ®Google Scholar
• W. P. Watkinson, M. J. Campen, and D. L. Costa. 1998. Cardiac arrhythmia induction after exposure to residual oil fly ash particles in a rodent model of pulmonary hypertension. Toxicol. Sci. 41:209–216.
   PubMed Web of Science ®Google Scholar
• W. P. Watkinson, M. J. Campen, J. P. Nolan, U. P. Kodavanti, K. L. Dreher, W.-Y. Su, J. W. Highfill, and D. L. Costa. 2000a. Cardiovascular effects following exposure to particulate matter in healthy and cardiopulmonary-compromised rats. Relationships between acute and chronic effects of air pollution, eds. U. Heinrich, and U. Mohr, pp. 447–463. Washington, DC: ISLI Press.
   Google Scholar
• W. P. Watkinson, M. J. Campen, K. L. Dreher, W.-Y. Su, U. P. Kodavanti, J. W. Highfill, and D. L. Costa. 2000b. Thermoregulatory effects following exposure to particulate matter in healthy and cardiopulmonary-compromised rats. J. Therm. Biol. 25:131–137.
   Web of Science ®Google Scholar
• W. P. Watkinson, M. J. Campen, J. P. Nolan, and D. L. Costa. 2001. Cardiovascular and systemic responses to inhaled pollutants in rodents: Effects of ozone and particulate matter. Environ. Health Perspect. 109 (suppl. 4):539–546.
   PubMed Web of Science ®Google Scholar
• G. A. Wellenius, P. H. N. Saldiva, J. R. F. Batalha, G. G. K. Murthy, B. A. Coull, R. L. Verrier, and J. J. Godleski. 2002. Electrocardiographic changes during exposure to residual oil fly ash (ROFA) particles in a rat model of myocardial infarction. Toxicol. Sci. 66:327–335.
   PubMed Web of Science ®Google Scholar
• G. A. Wellenius, B. A. Coull, J. J. Godleski, P. Koutrakis, K. Okaba, S. T. Savage, J. E. Lawrence, G. G. K. Murthy, and R. L. Verrier. 2002. Inhalation of concentrated ambient air particles exacerbates myocardial ischemia in conscious dogs. Environ. Health Perspect. 111:402–408.
   Web of Science ®Google Scholar
• M. R. Wilson, J. H. Lightbody, K. Donaldson, J. Sales, and V. Stone. 2002. Interactions between ultrafine particles and transition metals in vivo and in vitro. Toxicol. Appl. Pharmacol. 184:172–179.
   PubMed Web of Science ®Google Scholar
• World Bank Group. 1998. Pollution prevention and abatement handbook. World Bank Group, Washington, DC.
   Google Scholar
• W. Wu, J. M. Samet, A. J. Ghio, and R. B. Devlin. 2001. Activation of the EGF receptor signaling pathway in human airway epithelial cells exposed to Utah Valley PM. Am. J. Physiol. 281:L483–L489.
   PubMed Web of Science ®Google Scholar
• W. Wu, X. Wang, W. Zhang, W. Reed, J. M. Samet, Y. E. Whang, and A. J. Ghio. 2003. Zinc-induced PTEN protein degradation through the proteasome pathway in human airway epithelial cells. J. Biol. Chem. 278:28258–28263.
   PubMed Web of Science ®Google Scholar
• W. Wu, R. A. Silbajoris, Y. E. Whang, L. M. Graves, P. A. Bromberg, and J. M. Samet. 2005. p38 and EGF receptor kinase-mediated activation of the phosphatidylinositol 3-kinase/Akt pathway is required for Zn2 +-induced cyclooxygenase-2 expression. Am. J. Physiol. Lung Cell. Mol. Physiol. 289:L883–889.
   Google Scholar
• Y.-M. Zhou, C.-Y. Zhong, I. M. Kennedy, and K. E. Pinkerton. 2003. Pulmonary responses of acute exposure to ultrafine iron particles in healthy adult rats. Environ. Toxicol. 18:227–235.
   PubMedGoogle Scholar