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Inhalation Toxicology
International Forum for Respiratory Research
Volume 21, 2009 - Issue 11
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Research Article

Two-year inhalation study of carcinogenicity and chronic toxicity of 1,4-dioxane in male rats

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Pages 889-897 | Received 01 Oct 2008, Accepted 17 Nov 2008, Published online: 17 Aug 2009

References

  • Acheson ED. (1976). Nasal cancer in the furniture and boot and shoe manufacturing industries. Prev Med 5:295–315.
  • Acheson ED, Cowdell RH, Hadfield E, Macbeth RG. (1968). Nasal cancer in woodworkers in the furniture industry. Br Med J 2:587–596.
  • American Conference of Governmental Industrial Hygienists. (2001). 1,4-Dioxane. In Documentation of the threshold limit values (TLVs) and biological exposure indices (BEIs) [CD-ROM 2007]. Cincinnati, OH: ACGIH.
  • Argus MF, Arcos JC, Hoch-Ligeti C. (1965). Studies on the carcinogenic activity of protein-denaturing agents: Hepatocarcinogenicity of dioxane. J Natl Cancer Inst 35:949–958.
  • Argus MF, Sohal RS, Bryant GM, Hoch-Ligeti C, Arcos J.E. (1973). Dose response and ultrastructural alterations in dioxane carcinogenesis. Influence of methylcholanthrene on acute toxicity. Eur J Cancer 9:237–243.
  • Bannasch P, Griesemer RA, Anders F, Becker R, Cabral JR, Della Porta G, Feron VJ, Henschler D, Ito N, Kroes R, Magee PN, McKnight B, Mohr U, Montesano R, Napalkov NP, Nesnow S, Pegg AE, Rao GN, Turusov VS, Wahrendorf J, Wilbourn J. (1986). Long-term assays for carcinogenicity in animals. In Long-term and short-term assays for carcinogens: A critical appraisal, eds. R Montesano, H Bartsch, H Vainio, J Wilbourn, H, Yamasaki, pp. 13–83. IARC scientific publications No. 83. Lyon: IARC.
  • Boatman RJ, Knaak JB. (2001). Dioxane. In Patty’s toxicology, 5th ed., vol. 7, eds. E Bingham, B Cohrssen, CH Powell, pp. 177–187. New York: John Wiley & Sons.
  • Bond JA. (1993). Metabolism of xenobiotics by the respiratory tract. In Toxicology of the lung, 2nd ed., eds. DE Gardner, JD Crapo, RO McClellan, pp. 187–215. New York: Raven Press.
  • Buffler PA, Wood SM, Suarez L, Kilian DJ. (1978). Mortality follow-up of workers exposed to 1,4-dioxane. J Occup Med 20:255–259.
  • Deutsche Forschungsgemeinschaft. (2003). 1,4-Dioxane. Occupational toxicants. In Critical data evaluation for MAK values and classification of carcinogens, vol. 20, ed. H Greim, pp. 105–133. Weinheim, Germany: Wiley–VCH.
  • European Chemicals Bureau. (2002). European Union Risk Assessment Report, vol. 21, 1,4-Dioxane. Institute for Health and Consumer Protection, European Chemicals Bureau, Ispra, Italy.
  • Goldsworthy TL, Monticello TM, Morgan KT, Bermudez E, Wilson DM, Jackh R, Butterworth B. (1991). Examination of potential mechanisms of carcinogenicity of 1,4-dioxane in rat nasal epithelial cells and hepatocytes. Arch Toxicol 65:1–9.
  • Harkema JR. (1991). Comparative aspects of nasal airway anatomy: Relevance to inhalation toxicology. Toxicol Pathol 19:321–336.
  • Haschek WM, Witschi HR. (1991). Respiratory system. In Handbook of toxicologic pathology, eds. WM Haschek, CG Rousseaux, pp. 761–827. San Diego: Academic Press.
  • Hoch-Ligeti C, Argus MF, Arcos JE. (1970). Induction of carcinomas in the nasal cavity of rats by dioxane. Br J Cancer 24:164–167.
  • International Agency for Research on Cancer. (1999). 1,4-Dioxane. Re-evaluation of some organic chemicals, hydrazine and hydrogen peroxide. IARC Monogr Eval Carcinogen Risk Hum 71:589–602.
  • International Programme on Chemical Safety. (1994). Assessing human health risks of chemicals: Derivation of guidance values for health-based exposure limits. Environmental health criteria 170. Geneva: WHO. http://www.inchem.org/documents/ehc/ehc/ehc170.htm (accessed August 21, 2008).
  • Japan Chemical Week. (2008). 1,4-Dioxane. In Chemical products handbook 15308, pp. 825–826. Tokyo: The Chemical Daily Co. (in Japanese).
  • Japan Society for Occupational Health. (1984). 1,4-Dioxane. Documentation for recommendation of occupational exposure limit value for 1,4-dioxane. Jpn J Ind Health 26:354–355. (in Japanese).
  • Johnstone RT. (1959). Death due to dioxane? AMA Arch Ind Health 20:445–447.
  • Kano H, Umeda Y, Saito M, Senoh H, Ohbayashi H, Aiso S, Yamazaki K, Nagano K, Fukushima S. (2008). Thirteen-week oral toxicity of 1,4-dioxane in rats and mice. J Toxicol Sci 33:141–153.
  • Kaplan EL, Meier P. (1958). Nonparametric estimation from incomplete observations. Am Stat Assoc. 53:457–481.
  • Kasai T, Saito M, Senoh H, Umeda Y, Aiso S, Ohbayashi S, Nishizawa T, Kagano K, Fukushima S. (2008). Thirteen-week inhalation toxicity of 1,4-dioxane in rats. Inhal Toxicol 20:961–971.
  • Kociba RJ, McCollister SB, Park C, Torkelson TR. (1974). 1,4-Dioxane—I. Results of a 2-year ingestion study in rats. Toxicol Appl Pharmacol 30:275–286.
  • Lewis RJ. (1993). Hawley’s condensed chemical dictionary, 12th ed., p. 426. New York: Van Nostrand Reinhold.
  • Mauderly JL, Tesarek JE, Sifford LJ, Sifford LJ. (1979). Respiratory measurements of unsedated small laboratory mammals using nonrebreathing valves. Lab Anim Sci 29:323–329.
  • Mirkova ET. (1994). Activity of the rodent carcinogen 1,4-dioxane in the mouse bone marrow micronucleus assay. Mutat Res 322:142–144.
  • Monticello TM, Morgan KT, Uraih L. (1990). Nonneoplastic nasal lesions in rats and mice. Environ Health Perspect 85:249–274.
  • Morgan KT, Monticello TM. (1990). Airflow gas deposition and lesion distribution in the nasal passages. Environ Health Perspect 88: 209–218.
  • Morgan KT, Jiang X-Z, Starr TB, Kerns WD. (1986). More precise localization on nasal tumors associated with chronic exposure of F-344 rats to formaldehyde gas. Toxicol Appl Pharmacol 82:264–271.
  • Morita T, Hayashi M. (1998). 1,4-Dioxane is not mutagenic in five in vitro assays and mouse peripheral blood micronucleus assay but is in mouse liver micronucleus assay. Environ Mol Mutagen 32:269–280.
  • Nagano K, Katagiri T, Aiso S, Senoh H, Sakura Y, Takeuchi T. (1997). Spontaneous lesions of nasal cavity in aging F344 rats and BDF1 mice. Exp Toxicol Pathol 49:97–104.
  • Nannelli A, De Rubertis A, Longo V, Gervasi PG. (2005). Effects of dioxane on cytochrome P450 enzymes in liver kidney lung and nasal mucosa of rat. Arch Toxicol 79:74–82.
  • National Cancer Institute. (1978). Bioassay of 1,4-dioxane for possible carcinogenicity. Technical Report Series No. 80. DHEW Publication No. (NIH) 78-1330. Bethesda, MD: NIH.
  • National Institute for Occupational Safety and Health. (1977). Criteria for a recommended standard occupational exposure to dioxane. U.S. Department of Health Education and Welfare Center for Disease Control. Cincinnati, OH: NIOSH.
  • National Research Council. (1977). Guide for the care and use of laboratory animals. DHEW Publication No. (NIH) 77-23. Bethesda, MD: NIH.
  • O’Neil MJ. (2006). The Merck Index, 14th ed., p. 559. Whitehouse Station, NJ: Merck & Co.
  • Organization for Economic Co-operation and Development. (1981). Test guideline 453, Combined chronic toxicity/carcinogenicity studies. Paris: OECD.
  • Peto R, Pike MC, Armitage P, Breslow NE, Cox DR, Howard SV, Mantel N, McPherson K, Peto J, Smith PG. (1977). Design and analysis of randomized clinical trials requiring prolonged observation of each patient. II. Analysis and examples. Br J Cancer 35:1–39.
  • Peto R, Pike MC, Day NE, Gray RG, Lee PN, Parish S, Peto J, Richards S, Wahrendorf J. (1980). Guidelines for simple sensitive significance tests for carcinogenic effects in long-term animal experiments. In Long-term and short-term screening assays for carcinogens: A critical appraisal. IARC monographs, suppl. 2, pp. 311–426. Lyon: IARC.
  • Reitz RH, McCroskey PS, Park CN, Andersen ME, Gargas ML. (1990). Development of a physiologically based pharmacokinetic model for risk assessment with 1,4-dioxane. Toxicol Appl Pharmacol 105:37–54.
  • Roy SK, Thilagar AK, Eastmond DA. (2005). Chromosome breakage is primarily responsible for the micronuclei induced by 1,4-dioxane in the bone marrow and liver of young CD-1 mice. Mutat Res 586:28–37.
  • Sontag JM, Page NP, Saffiotti U. (1976). Guidelines for carcinogen bioassay in small rodents. NCI-CG-TR-1. Washington, DC: Department of Health Education and Welfare.
  • Stickney JA, Sager SL, Clarkson JR, Smith LA, Locey BJ, Bock MJ, Hartung R, Olp SF. (2003). An updated evaluation of the carcinogenic potential of 1,4-dioxane. Regul Toxicol Pharmacol 38:183–195.
  • Torjussen W, Solberg LA, Hogetveit AC. (1979). Histopathological changes of the nasal mucosa in active and retired nickel workers. Br J Cancer 40:568–580.
  • Torkelson TR, Leong BKJ, Kociba RJ, Richter WA, Gehring PJ. (1974). 1,4-Dioxane—II. Results of a 2-year inhalation study in rats. Toxicol Appl Pharmacol 30:287–298.
  • Witschi HR, Last JA. (2001). Toxic responses of the respiratory system. In Casarett and Doull’s toxicology, 6th ed., ed. CD Klassen, pp. 515–534. New York: McGraw-Hill.
  • Yamazaki K, Ohno H, Asakura M, Narumi A, Ohbayashi H, Fujita H, Ohnishi M, Katagiri T, Senoh H, Yamanouchi K, Nakayama E, Yamamoto S, Noguchi T, Nagano K, Enomoto M, Sakabe H. (1994). Two-year toxicological and carcinogenesis studies of 1,4-dioxane in F344 rats and BDF1 mice—Drinking studies. In Proceedings of the second Asia–Pacific symposium on environmental and occupational health, ed. K Sumino, pp. 193–198. Kobe: International Center for Medical Research, Kobe University School of Medicine.

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