Early suppression of NFκB and IL-8 in bronchial epithelium after ozone exposure in healthy human subjects

References

• Aris RM, Christian D, Hearne PQ, Kerr K, Finkbeiner WE, Balmes JR. 1993. Ozone-induced airway inflammation in human subjects as determined by airway lavage and biopsy. Am Rev Respir Dis 148(5):1363–1372.
   PubMed Web of Science ®Google Scholar
• Beg AA, Ruben SM, Scheinman RI, Haskill S, Rosen CA, Baldwin AS Jr., 1992. I kappa B interacts with the nuclear localization sequences of the subunits of NF-kappa B: A mechanism for cytoplasmic retention. Genes Dev 6(10):1899–1913.
   PubMedGoogle Scholar
• Behndig AF, Mudway IS, Brown JL, Stenfors N, Helleday R, Duggan ST, Wilson SJ, Boman C, Cassee FR, Frew AJ, Kelly FJ, Sandstrom T, Blomberg A. 2006. Airway antioxidant and inflammatory responses to diesel exhaust exposure in healthy humans. Eur Respir J 27(2):359–365.
   PubMedGoogle Scholar
• Biswas SK, McClure D, Jimenez LA, Megson IL, Rahman I. 2005. Curcumin induces glutathione biosynthesis and inhibits NF-kappaB activation and interleukin-8 release in alveolar epithelial cells: Mechanism of free radical scavenging activity. Antioxid Redox Signal 7(1–2):32–41.
   PubMedGoogle Scholar
• Blomberg A, Mudway IS, Nordenhall C, Hedenstrom H, Kelly FJ, Frew AJ, Holgate ST, Sandstrom T. 1999. Ozone-induced lung function decrements do not correlate with early airway inflammatory or antioxidant responses. Eur Respir J 13(6):1418–1428.
   PubMed Web of Science ®Google Scholar
• Bosson J, Stenfors N, Bucht A, Helleday R, Pourazar J, Holgate ST, Kelly FJ, Sandstrom T, Wilson S, Frew AJ, Blomberg A. 2003. Ozone-induced bronchial epithelial cytokine expression differs between healthy and asthmatic subjects. Clin Exp Allergy 33(6):777–782.
   PubMedGoogle Scholar
• Brunekreef B, Holgate ST. 2002. Air pollution and health. Lancet 360(9341):1233–1242.
   PubMedGoogle Scholar
• Cappello C, Saugel B, Huth KC, Zwergal A, Krautkramer M, Furman C, Rouis M, Wieser B, Schneider HW, Neumeier D, Brand K. 2007. Ozonized low density lipoprotein (ozLDL) inhibits NFkB and IRAK-1-associated signaling. Arterioscler Thromb Vasc Biol 27(1):226–232.
   PubMedGoogle Scholar
• Chang MM, Wu R, Plopper CG, Hyde DM. 1998. IL-8 is one of the major chemokines produced by monkey airway epithelium after ozone-induced injury. Am J Physiol 275(3 Pt 1):L524–L532.
   Google Scholar
• Coffey MJ, Wheeler CS, Gross KB, Eschenbacher WL, Sporn PH, Peters-Golden M. 1996. Increased 5-lipoxygenase metabolism in the lungs of human subjects exposed to ozone. Toxicology 114(3):187–197.
   PubMedGoogle Scholar
• Devlin RB, McDonnell WF, Mann R, Becker S, House DE, Schreinemachers D, Koren HS. 1991. Exposure of humans to ambient levels of ozone for 6.6 hours causes cellular and biochemical changes in the lung. Am J Respir Cell Mol Biol 4(1):72–81.
   PubMedGoogle Scholar
• Fakhrzadeh L, Laskin JD, Laskin DL. 2004. Ozone-induced production of nitric oxide and TNF-alpha and tissue injury are dependent on NF-kappaB p50. Am J Physiol Lung Cell Mol Physiol 287(2):L279–L285.
   Google Scholar
• Folinsbee LJ, Horstman DH, Kehrl HR, Harder S, Abdul-Salaam S, Ives PJ. 1994. Respiratory responses to repeated prolonged exposure to 0.12 ppm ozone. Am J Respir Crit Care Med 149(1):98–105.
   PubMedGoogle Scholar
• Frampton MW, Pryor WA, Cueto R, Cox C, Morrow PE, Utell MJ. 1999. Aldehydes (nonanal and hexanal) in rat and human bronchoalveolar lavage fluid after ozone exposure. Res Rep Health Eff Inst (90):1–15; discussion 17–18.
   PubMedGoogle Scholar
• Frevert CW, Kinsella MG, Vathanaprida C, Goodman RB, Baskin DG, Proudfoot A, Wells TN, Wight TN, Martin TR. 2003. Binding of interleukin-8 to heparan sulfate and chondroitin sulfate in lung tissue. Am J Respir Cell Mol Biol 28(4):464–472.
   PubMedGoogle Scholar
• Ganchi PA, Sun SC, Greene WC, Ballard DW. 1992. I kappa B/MAD-3 masks the nuclear localization signal of NF-kappa B p65 and requires the transactivation domain to inhibit NF-kappa B p65 DNA binding. Mol Biol Cell 3(12):1339–1352.
   PubMedGoogle Scholar
• Hoogewerf AJ, Kuschert GS, Proudfoot AE, Borlat F, Clark-Lewis I, Power CA, Wells TN. 1997. Glycosaminoglycans mediate cell surface oligomerization of chemokines. Biochemistry 36(44):13570–13578.
   PubMedGoogle Scholar
• Janic B, Umstead TM, Phelps DS, Floros J. 2005. Modulatory effects of ozone on THP-1 cells in response to SP-A stimulation. Am J Physiol Lung Cell Mol Physiol 288(2):L317–L325.
   Google Scholar
• Jaspers I, Chen LC, Flescher E. 1998. Induction of interleukin-8 by ozone is mediated by tyrosine kinase and protein kinase A but not by protein kinase C. J Cell Physiol 177(2):313–323.
   PubMedGoogle Scholar
• Jaspers I, Flescher E, Chen LC. 1997. Ozone-induced IL-8 expression and transcription factor binding in respiratory epithelial cells. Am J Physiol 272(3 Pt 1):L504–L511.
   Google Scholar
• Kabe Y, Ando K, Hirao S, Yoshida M, Handa H. 2005. Redox regulation of NF-kappaB activation: Distinct redox regulation between the cytoplasm and the nucleus. Antioxid Redox Signal 7(3–4):395–403.
   PubMedGoogle Scholar
• Kafoury RM, Pryor WA, Squadrito GL, Salgo MG, Zou X, Friedman M. 1998. Lipid ozonation products activate phospholipases A2, C and D. Toxicol Appl Pharmacol 150(2):338–349.
   PubMedGoogle Scholar
• Koptides M, Umstead TM, Floros J, Phelps DS. 1997. Surfactant protein A activates NF-kappa B in the THP-1 monocytic cell line. Am J Physiol 273(2 Pt 1):L382–L388.
   Google Scholar
• Koren HS, Devlin RB, Graham DE, Mann R, McGee MP, Horstman DH, Kozumbo WJ, Becker S, House DE, McDonnell WF, et al. 1989. Ozone-induced inflammation in the lower airways of human subjects. Am Rev Respir Dis 139(2):407–415.
   PubMed Web of Science ®Google Scholar
• Krishna MT, Blomberg A, Biscione GL, Kelly F, Sandstrom T, Frew A, Holgate S. 1997. Short-term ozone exposure upregulates P-selectin in normal human airways. Am J Respir Crit Care Med 155(5):1798–1803.
   PubMed Web of Science ®Google Scholar
• Kuschert GS, Coulin F, Power CA, Proudfoot AE, Hubbard RE, Hoogewerf AJ, Wells TN. 1999. Glycosaminoglycans interact selectively with chemokines and modulate receptor binding and cellular responses. Biochemistry 38(39):12959–12968.
   PubMedGoogle Scholar
• Laskin DL, Fakhrzadeh L, Heck DE, Gerecke D, Laskin JD. 2002. Upregulation of phosphoinositide 3-kinase and protein kinase B in alveolar macrophages following ozone inhalation. Role of NF-kappaB and STAT-1 in ozone-induced nitric oxide production and toxicity. Mol Cell Biochem 234–235(1–2):91–98.
   Google Scholar
• Laskin DL, Sunil V, Guo Y, Heck DE, Laskin JD. 1998. Increased nitric oxide synthase in the lung after ozone inhalation is associated with activation of NF-kappa B. Environ Health Perspect 106(suppl. 5):1175–1178.
   PubMedGoogle Scholar
• Mogel M, Kruger E, Krug HF, Seidel A. 1998. A new coculture-system of bronchial epithelial and endothelial cells as a model for studying ozone effects on airway tissue. Toxicol Lett 96–97:25–32.
   PubMed Web of Science ®Google Scholar
• Mudway IS, Blomberg A, Frew AJ, Holgate ST, Sandstrom T, Kelly FJ. 1999. Antioxidant consumption and repletion kinetics in nasal lavage fluid following exposure of healthy human volunteers to ozone. Eur Respir J 13(6):1429–1438.
   PubMedGoogle Scholar
• Mudway IS, Kelly FJ. 2000. Ozone and the lung: A sensitive issue. Mol Aspects Med 21(1–2):1–48.
   PubMedGoogle Scholar
• Mudway IS, Stenfors N, Blomberg A, Helleday R, Dunster C, Marklund SL, Frew AJ, Sandstrom T, Kelly FJ. 2001. Differences in basal airway antioxidant concentrations are not predictive of individual responsiveness to ozone: A comparison of healthy and mild asthmatic subjects. Free Radic Biol Med 31(8):962–974.
   PubMed Web of Science ®Google Scholar
• Pendino KJ, Laskin JD, Shuler RL, Punjabi CJ, Laskin DL. 1993. Enhanced production of nitric oxide by rat alveolar macrophages after inhalation of a pulmonary irritant is associated with increased expression of nitric oxide synthase. J Immunol 151(12):7196–7205.
   PubMedGoogle Scholar
• Pourazar J, Mudway IS, Samet JM, Helleday R, Blomberg A, Wilson SJ, Frew AJ, Kelly FJ, Sandstrom T. 2005. Diesel exhaust activates redox-sensitive transcription factors and kinases in human airways. Am J Physiol Lung Cell Mol Physiol 289(5):L724–L730.
   Google Scholar
• Punjabi CJ, Laskin JD, Pendino KJ, Goller NL, Durham SK, Laskin DL. 1994. Production of nitric oxide by rat type II pneumocytes: Increased expression of inducible nitric oxide synthase following inhalation of a pulmonary irritant. Am J Respir Cell Mol Biol 11(2):165–172.
   PubMedGoogle Scholar
• Rahman I. 2005. Redox signaling in the lungs. Antioxid Redox Signal 7(1–2):1–5.
   PubMedGoogle Scholar
• Reynaert NL, van der Vliet A, Guala AS, McGovern T, Hristova M, Pantano C, Heintz NH, Heim J, Ho YS, Matthews DE, Wouters EF, Janssen-Heininger YM. 2006. Dynamic redox control of NF-kappaB through glutaredoxin-regulated S-glutathionylation of inhibitory kappaB kinase beta. Proc Natl Acad Sci USA 103(35):13086–13091.
   PubMed Web of Science ®Google Scholar
• Roos-Engstrand E, Wallin A, Bucht A, Pourazar J, Sandstrom T, Blomberg A. 2005. Increased expression of p38 MAPK in human bronchial epithelium after lipopolysaccharide exposure. Eur Respir J 25(5):797–803.
   PubMedGoogle Scholar
• Salvi S, Blomberg A, Rudell B, Kelly F, Sandstrom T, Holgate ST, Frew A. 1999. Acute inflammatory responses in the airways and peripheral blood after short-term exposure to diesel exhaust in healthy human volunteers. Am J Respir Crit Care Med 159(3):702–709.
   PubMedGoogle Scholar
• Salvi SS, Nordenhall C, Blomberg A, Rudell B, Pourazar J, Kelly FJ, Wilson S, Sandstrom T, Holgate ST, Frew AJ. 2000. Acute exposure to diesel exhaust increases IL-8 and GRO-alpha production in healthy human airways. Am J Respir Crit Care Med 161(2 Pt 1):550–557.
   PubMedGoogle Scholar
• Stenfors N, Pourazar J, Blomberg A, Krishna MT, Mudway I, Helleday R, Kelly FJ, Frew AJ, Sandstrom T. 2002. Effect of ozone on bronchial mucosal inflammation in asthmatic and healthy subjects. Respir Med 96(5):352–358.
   PubMed Web of Science ®Google Scholar
• Torres A, Utell MJ, Morow PE, Voter KZ, Whitin JC, Cox C, Looney RJ, Speers DM, Tsai Y, Frampton MW. 1997. Airway inflammation in smokers and nonsmokers with varying responsiveness to ozone. Am J Respir Crit Care Med 156(3 Pt 1):728–736.
   PubMed Web of Science ®Google Scholar
• Voter KZ, Whitin JC, Torres A, Morrow PE, Cox C, Tsai Y, Utell MJ, Frampton MW. 2001. Ozone exposure and the production of reactive oxygen species by bronchoalveolar cells in humans. Inhal Toxicol 13(6):465–483.
   PubMedGoogle Scholar
• Wang G, Umstead TM, Phelps DS, Al-Mondhiry H, Floros J. 2002. The effect of ozone exposure on the ability of human surfactant protein a variants to stimulate cytokine production. Environ Health Perspect 110(1):79–84.
   PubMedGoogle Scholar