Advanced search
Publication Cover
Inhalation Toxicology
International Forum for Respiratory Research
Volume 21, 2009 - Issue sup1
Submit an article Journal homepage
250
Views
47
CrossRef citations to date
0
Altmetric
Research Article

A role for nanoparticle surface reactivity in facilitating pulmonary toxicity and development of a base set of hazard assays as a component of nanoparticle risk management

David B. WarheitDuPont Haskell Global Centers for Health and Environmental Sciences, Newark, Delaware, USACorrespondencedavid.b.warheit@ usa.dupont.com
,
Kenneth L. ReedDuPont Haskell Global Centers for Health and Environmental Sciences, Newark, Delaware, USA
&
Christie M. SayesDuPont Haskell Global Centers for Health and Environmental Sciences, Newark, Delaware, USA
Pages 61-67 | Received 01 Apr 2009, Accepted 02 Apr 2009, Published online: 30 Jun 2009

References

  • Clouter A, Brown D, Hohr D, Borm P, and Donaldson K. (2001) Inflammatory effects of respirable quartz collected in workplaces versus standard DQ12 quartz: Particle surface correlates. Toxicol. Sci. 63:90–98.
  • Donaldson K, Stone V, Clouter A, Renwick L, and MacNee W. (2001) Ultrafine particles. Occup. Environ. Med. 2001; 58:211–216.
  • Harington JS, Macnab GM, Miller K, and King PC. (1971) Enhancement of haemolytic activity of asbestos by heat-labile factors in fresh serum. Med. Lav. 62:171–176.
  • Nano Risk Framework (2007) www.nanoriskframework.com.
  • Nolan RP, Langer AM, Harington JS, Oster G, and Selikoff IJ. (1981) Quartz hemolysis as related to its surface functionalities. Environ. Res. 26: 503–520.
  • Oberdorster G. (2000) Toxicology of ultrafine particles: In vivo studies. Philos. Trans. R. Soc. London A 358:2719–2740.
  • Rajh T, Nedeljkovic M, Chen LX, Poluektov O, Thurnauer MC. (1999) Improving optical and charge separation properties of nanocrystalline TiO2 by surface modification with vitamin C. J. Phys. Chem. B 103:3515.
  • Warheit DB, Webb TR, Sayes CM, Colvin VL, and Reed KL. (2006) Pulmonary instillation studies with nanoscale TiO2 rods and dots in rats: Toxicity is not dependent upon particle size and surface area. Toxicol. Sci. 91:227–236.
  • Warheit DB, Webb TR, Colvin VL, Reed KL, and Sayes CM. (2007a) Pulmonary bioassay studies with nanoscale and fine quartz particles in rats: Toxicity is not dependent upon particle size but on surface characteristics. Toxicol. Sci. 95:270–280.
  • Warheit DB, Webb TR, Reed KL, Frerichs S, and Sayes CM. (2007b) Pulmonary toxicity study in rats with three forms of ultrafine-TiO2 particles: Differential responses related to surface properties. Toxicology 230:90–104.
  • Warheit DB, Hoke RA, Finlay C, Donner EM, Reed KL, and Sayes CM. (2007c) Development of a base set of toxicity tests using ultrafine TiO2 particles as a component of nanoparticle risk management. Toxicol. Lett. 171:99–110.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.