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Inhalation Toxicology
International Forum for Respiratory Research
Volume 21, 2009 - Issue sup1
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Research Article

Low cytotoxicity of solid lipid nanoparticles in in vitro and ex vivo lung models

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Pages 104-109 | Received 23 Apr 2009, Accepted 27 Apr 2009, Published online: 30 Jun 2009

References

  • Agu, R. U., Ugwoke, M. I., Armand, M., Kinget, R., and Verbeke, N. (2001). The lung as a route for systemic delivery of therapeutic proteins and peptides. Respir Res 2, 198–209.
  • Bailey, M. M., and Berkland, C. J. (2009). Nanoparticle formulations in pulmonary drug delivery. Med Res Rev 29, 196–212.
  • Bosquillon, C., Preat, V., and Vanbever, R. (2004). Pulmonary delivery of growth hormone using dry powders and visualization of its local fate in rats. J Controlled Release 96, 233–244.
  • Goris, K., Uhlenbruck, S., Schwegmann-Wessels, C., Kohl, W., Niedorf, F., Stern, M., Hewicker-Trautwein, M., Bals, R., Taylor, G., Braun, A., Bicker, G., Kietzmann, M., and Herrler, G. (2009). Differential sensitivity of differentiated epithelial cells to respiratory viruses reveals different viral strategies of host infection. J Virol 83, 1962–1968.
  • Held, H. D., Martin, C., and Uhlig, S. (1999). Characterization of airway and vascular responses in murine lungs. Br J Pharmacol 126, 1191–1199.
  • Henjakovic, M., Martin, C., Hoymann, H. G., Sewald, K., Ressmeyer, A. R., Dassow, C., Pohlmann, G., Krug, N., Uhlig, S., and Braun, A. (2008a). Ex vivo lung function measurements in precision-cut lung slices (PCLS) from chemical allergen-sensitized mice represent a suitable alternative to in vitro studies. Toxicol Sci 106, 444–453.
  • Henjakovic, M., Sewald, K., Switalla, S., Kaiser, D., Muller, M., Veres, T. Z., Martin, C., Uhlig, S., Krug, N., and Braun, A. (2008b). Ex vivo testing of immune responses in precision-cut lung slices. Toxicol Appl Pharmacol 231, 68–76.
  • Martin, C., Uhlig, S., and Ullrich, V. (1996). Videomicroscopy of methacholine-induced contraction of individual airways in precision-cut lung slices. Eur Respir J 9, 2479–2487.
  • Melani, A. S. (2007). Inhalatory therapy training: A priority challenge for the physician. Acta Biomed 78, 233–245.
  • Mosmann, T. (1983). Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays. J Immunol Methods 65, 55–63.
  • Müller, R. H., and Lucks, S. (1996). Arzneistoffträger aus festen Lipidteilchen (feste Lipidnanosphären) (SLN). European Patent 0605497.
  • Müller, R. H., Mehnert, W., Lucks, J. S., Schwarz, C., zur Mühlen, A., Weyhers, H., Freitas, C., and Rühl, D. (1995). Solid lipid nanoparticles (SLN) : An alternative colloidal carrier system for controlled drug delivery. Eur J Pharm Biopharm. 41, 62–69.
  • Parrish, A. R., Gandolfi, A. J., and Brendel, K. (1995). Precision-cut tissue slices: applications in pharmacology and toxicology. Life Sci 57, 1887–1901.
  • Schubert, M. A., and Muller-Goymann, C. C. (2005). Characterisation of surface-modified solid lipid nanoparticles (SLN): Influence of lecithin and nonionic emulsifier. Eur J Pharm Biopharm. 61, 77–86.
  • Shen, Z. C., Zhang, Q., Wei, S. L., and Nagai, T. (1999). Proteolytic enzymes as a limitation for pulmonary absorption of insulin: In vitro and in vitro investigations. International Journal of Pharmaceutics 192, 115–121.
  • Valavanidis, A., Fiotakis, K., and Vlachogianni, T. (2008). Airborne particulate matter and human health: Toxicological assessment and importance of size and composition of particles for oxidative damage and carcinogenic mechanisms. J Environ Sci Health C Environ Carcinogen Ecotoxicol Rev 26, 339–362.
  • Videira, M. A., Botelho, M. F., Santos, A. C., Gouveia, L. F., de Lima, J. J., and Almeida, A. J. (2002). Lymphatic uptake of pulmonary delivered radiolabelled solid lipid nanoparticles. J Drug Target 10, 607–613.
  • Videira, M. A., Gano, L., Santos, C., Neves, M., and Almeida, A. J. (2006). Lymphatic uptake of lipid nanoparticles following endotracheal administration. J Microencapsul 23, 855–862.
  • Wittmaack, K. (2007). In search of the most relevant parameter for quantifying lung inflammatory response to nanoparticle exposure: Particle number, surface area, or what? Environ Health Perspect 115, 187–194.
  • Worle-Knirsch, J. M., Kern, K., Schleh, C., Adelhelm, C., Feldmann, C., and Krug, H. F. (2007). Nanoparticulate vanadium oxide potentiated vanadium toxicity in human lung cells. Environ Sci Technol. 41, 331–336.
  • Yuan, H., Miao, J., Du, Y. Z., You, J., Hu, F. Q., and Zeng, S. (2008). Cellular uptake of solid lipid nanoparticles and cytotoxicity of encapsulated paclitaxel in A549 cancer cells. Int J Pharm 348, 137–145.

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