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Inhalation Toxicology
International Forum for Respiratory Research
Volume 28, 2016 - Issue 9
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Research Article

Comparison of cell counting methods in rodent pulmonary toxicity studies: automated and manual protocols and considerations for experimental design

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Pages 410-420 | Received 12 Jan 2016, Accepted 10 May 2016, Published online: 02 Jun 2016

References

  • Afshari A, Zeidler-Erdely PC, McKinney W, et al. (2014). Development and characterization of a resistance spot welding aerosol generator and inhalation exposure system. Inhal Toxicol 26:708–19
  • Antonini JM, Afshari AA, Stone S, et al. (2006). Design, construction, and characterization of a novel robotic welding fume generator and inhalation exposure system for laboratory animals. J Occup Environ Hyg 3:194–203
  • Antonini JM, Lawryk NJ, Krishna Murthy GG, Brain JD. (1999). Effect of welding fume solubility on lung macrophage viability and function in vitro. J Toxicol Environ Health A 58:343–63
  • Antonini JM, Roberts JR, Stone S, et al. (2011). Persistence of deposited metals in the lungs after stainless steel and mild steel welding fume inhalation in rats. Arch Toxicol 85:487–98
  • Antonini JM, Stone S, Roberts JR, et al. (2007). Effect of short-term stainless steel welding fume inhalation exposure on lung inflammation, injury, and defense responses in rats. Toxicol Appl Pharmacol 223:234–45
  • Berger SA, Waitman DA, Baruch R. (1992). Coulter counter identifies Cryptococcus neoformans as leukocytes a case of pseudopleocytosis. Am J Clin Pathol 97:663–4
  • Cherniack RM, Banks DE, Bell DY, et al. (1990). Bronchoalveolar lavage constitutents in healthy individuals, idiopathic pulmonary fibrosis, and selected comparison groups. Am Rev Respir Dis 141:S169–202
  • Erdely A, Dahm M, Chen BT, et al. (2013). Carbon nanotube dosimetry: from workplace exposure assessment to inhalation toxicology. Part Fibre Toxicol 10:53
  • Haley PJ, Muggenburg BA, Weissman DN, Bice DE. (1991). Comparative morphology and morphometry of alveolar macrophages from six species. Am J Anat 191:401–7
  • Hyde DM, Tyler NK, Putney LF, et al. (2004). Total number and mean size of alveoli in mammalian lung estimated using fractionator sampling and unbiased estimates of the Euler characteristic of alveolar openings. Anat Rec Part A 274A:216–26
  • Krombach F, Munzing S, Allmeling A-M, et al. (1997). Cell size of alveolar macrophages: an interspecies comparison. Environ Health Perspect 105:1261–3
  • Lee YCG, Lane KB, Light RW. (2001). Coulter counter registers talc particles as leukocytes. Chest 119:669–70
  • Lopez A, Yong S, Sharma A, Bailey D. (1986). Effect of sex, age, number of bronchoalveolar lavages and quantitation methods on the bronchoalveolar cell counts in rats. Can J Vet Res 50:101–5
  • Marshall BA, Theil KS, Brandt JT. (1990). Abnormalities of leukocyte histograms resulting from microorganisms. Am J Clin Pathol 93:526–32
  • McKinney W, Chen B, Frazer D. (2009). Computer controlled multi-walled carbon nanotube inhalation exposure system. Inhal Toxicol 21:1053–61
  • Porter DW, Hubbs AF, Mercer RR, et al. (2010). Mouse pulmonary dose- and time course responses induced by exposure to multi-walled carbon nanotubes. Toxicology 269:136–47
  • Porter DW, Hubbs AF, Chen BT, et al. (2012). Acute pulmonary dose-responses to inhaled multi-walled carbon nanotubes. Nanotoxicology 7:1179–94
  • Stevens WW, Kim TS, Pujanauski LM, et al. (2007). Detection and quantitation of eosinophils in the murine respiratory tract by flow cytometry. J Immunol Methods 327:63–74
  • Whittington RJ, Comer DAM. (1984). Discrepancy between hemocytometer and electronic counts of blood cells. J Wildl Dis 20:258–60
  • Zeidler-Erdely PC, Battelli LA, Stone S, et al. (2011). Short-term inhalation of stainless steel welding fume causes sustained lung toxicity but no tumorigenesis in lung tumor susceptible A/J mice. Inhal Toxicol 23:112–20
  • Zeidler-Erdely PC, Meighan TG, Erdely A, et al. (2013). Lung tumor promotion by chromium-containing welding particulate matter in a mouse model. Part Fibre Toxicol 10:45
  • Zeidler-Erdely PC, Meighan TG, Erdely A, et al. (2014). Effects of acute inhalation of aerosols generated during resistance spot welding with mild-steel on pulmonary, vascular and immune responses in rats. Inhal Toxicol 26:697–707

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