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Growth Factors Volume 20, 2002 - Issue 1
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Research Article

Hierarchy of Stroma-derived Factors in Supporting Growth of Stroma-dependent Hemopoietic Cells: Membrane-bound SCF is Sufficient to Confer Stroma Competence to Epithelial Cells

Jutta Friel Heinrich-Pette-Institut for Experimental Virology and Immunology, Hamburg University, Martinistraße 52, 20251 Hamburg, Germany
,
Katsuhiko Itoh Heinrich-Pette-Institut for Experimental Virology and Immunology, Hamburg University, Martinistraße 52, 20251 Hamburg, Germany
,
Ulla Bergholz Heinrich-Pette-Institut for Experimental Virology and Immunology, Hamburg University, Martinistraße 52, 20251 Hamburg, Germany
,
Manfred Jücker Department of Cellular Signal Transduction, Institute of Medical Biochemistry and Molecular Biology, University Hospital, Martinistraße 51, 20246 Hamburg, Germany
,
Carol Stocking Heinrich-Pette-Institut for Experimental Virology and Immunology, Hamburg University, Martinistraße 52, 20251 Hamburg, Germany
,
Paul Harrison Cancer Research Campaign Beatson Laboratories, The Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Bearsden, Glasgow G61 1BD, UK
&
Wolfram Ostertag Heinrich-Pette-Institut for Experimental Virology and Immunology, Hamburg University, Martinistraße 52, 20251 Hamburg, Germany
 show all
Pages 35-51 | Published online: 11 Jul 2009

  • Anderson, D.M., Lyman, S.D., Bird, A., Wignall, J.M., Eisenman, I., Rauch, C., March, C.J., Boswee, H.S., Gimpel, S.D., Cosman, D. and Williams, D.E. (1990) "Molecular cloning of mast cell growth factor, that is active in both membrane bound and soluble forms", Cell 63, 235.
  • Chabot, B., Stephenson, D.A., Chapman, V.M., Besmer, P. and Bernstein, A. (1988) "The proto-oncogene c-kit encoding a transmembrane tyrosine kinase receptor maps to the mouse W locus", Nature 335, 88.
  • Delwiche, E, Raines, E., Powell, I., Ross, R. and Adamson, J. (1985) "Platelet-derived growth factor enhances in vitro erythropoiesis via stimulation of mesenchymal cells", J. Clin. Investig. 76, 137.
  • Dexter, T.M. and Moore, M.A.S. (1977) "In vitro duplication and cure of hematopoietic defects in genetically anemic mice", Nature 269, 412.
  • Dorshkind, K. (1990) "Regulation of hemopoiesis by bone marrow stromal cells and their products", Ann. Rev, Immunol. 8, 111.
  • Eaves, C.J., Cashman, J.D., Kay, R.T., Dougherty, G.J., Otsuka, T., Gaboury, L.A., Hogge, D.E., Lansdorp, P.M., Eaves, A.E. and Humphries, R.K. (1991) "Mechanisms that regulate the cell cycle status of very primitive hematopoietic cells in long term human marrow cultures II. Analysis of positive and negative regulators produced by stromal cells within the adherent layer", Blood 78, 110.
  • Flanagan, J.G., Chan, D.C. and Leder, P. (1991) 'Transmembrane form of the kit ligand growth factor is determined by alternative splicing and is missing in the Sld mutant", Cell 64, 1025.
  • Friel, I., Heberlein, C., Itoh, K. and Ostertag, W. (1997) "Role of the stem cell factor (SCF) receptor and the alternative forms of its ligand (SCF) in the induction of long term growth by stroma cells. XVIII symposium of the IACR on leukemia and related diseases", Leukemia 11, 493.
  • Fujita, J., Onoue, H., Nakamaya, H. and Kanakura, Y. (1988) "In vitro duplication and in vivo cure of mast-cell deficiency of Sl/Sld mutant mice by cloned 3T3 fibroblasts", Proc. Natl. Acad. Sci. USA 86, 2888.
  • Hall, D.J., Jones, S.D., Kaplan, D.R., Whitman, M., Rollins, B.J. and Stiles, C.D. (1989) "Evidence for a novel signal transduction pathway activated by platelet-derived growth factor and by double-stranded RNA", Mol. Cell Biol. 9, 1705.
  • Ikuta, K. and Weissman, I.L. (1992) "Evidence that hematopoietic stem cells express mouse c-kit but do not depend on Steel factor for their generation", Proc. Natl Acad. Sci. USA 89, 1502.
  • Itoh, K., Tezuka, H., Sakoda, H., Konno, M., Nagata, K., Uchiyama, T., Uchino, H. and Mori, K.J. (1989) "Reproducible establishment of hemopoietic supportive stromal cell lines from murine bone marrow", Exp. Hematol. 17, 145.
  • Itoh, K., Friel, J., Kluge, N., Kondo-Takaori, A., Kawamata, S., Uciyama, T. and Ostertag, W. (1996) "A novel hematopoietic multilineage clone, Myl-D-7, is stromal cell-dependent and supported by an alternative mechanism(s) independent of stem cell factor/c-kit interaction", Blood 87, 3218.
  • Itoh, K., Friel, J., Laker, C., Zeller, W., Just, U., Bittner, S., Nibbs, R.J.B., Harrison, P.R., Nishikawa, S.-I., Mori, K.J. and Ostertag, W. (1997) "The role of soluble growth factors in inducing transient growth and clonal extinction of stroma cell dependent erthryoblastic leukemia cells", Leukemia 11, 1753.
  • Just, U., Friel, J., Heberlein, C., Tamura, T., Baccarini, M., Tessmer, U., Klingler, K. and Ostertag, W. (1993) "Upregulation of lineage specific receptors and ligands in multipotential progenitor cells is part of an endogenous program of differentiation", Growth Factors 9, 291.
  • Kapur, R., Majumdar, M., Xiao, X., McAndrews-Hill, M., Schindler, K. and Williams, D.A. (1998) "Signaling through the interaction of membrane-restricted stem cell factor and c-kit receptor tyrosine kinase: genetic evidence for a differential role in erythropoiesis", Blood 91, 819.
  • Kim, C.H. and Broxmeyer, H.E. (1998) "In vitro behavior of hematopoietic progenitor cells under the influence of chemoattractants: stromal cell-derived factor-1, Steel factor, and the bone marrow environment", Blood 91, 100.
  • Kitamura, T., Tange, T., Terasawa, T., Chiba, S., Kuwaki, T., Miyagawa, K., Piao, Y.F., Miyazono, K., Urabe, A. and Takaku, F. (1989) "Establishment and characterization of a unique human cell line that proliferates dependently in GM-CSF, IL-3, or Erythropoietin", J. Cell Physiol. 140, 323.
  • Kodoma, H., Nose, M., Niida, S., Nishikawa, S. and Nishikawa, S. (1994) "Involvement of the c-kit receptor in the adhesion of hematopoietic stem cells to stromal cells", Exp. Hematol. 22, 979.
  • Laker, C., Stocking, C., Bergholz, U., Hess, N., DeLamarter, J.F. and Ostertag, W. (1987) "Autocrine stimulation after transfer of the granulocyte macrophage colony-stimulating factor gene and autonomous growth are distinct but interdependent steps in the oncogenic pathway", Proc. Natl. Acad. Sci USA 84, 8458.
  • Lee, D.C., Rose, T.M., Webb, N.R. and Todaro, G.J. (1985) "Cloning and sequence analysis of a cDNA for rat transforming growth factor-a", Nature 313, 489.
  • Lemoli, R.M., Fogli, M., Fortuna, A., Motta, M.R., Rizzi, S., Benini, C. and Tura, S. (1993) "Interleukin-11 stimulates the proliferation of human hematopoietic CD34+ CD34+ CD33- DR- cells and synergizes with stem cell factor, interleukin-3 and granulocyte-macrophage colony-stimulating factor", Exp. Hematol. 21, 1668.
  • Lerner, N.B., Nocka, K.H., Cole, S.R., Qiu, F., Strife, A., Ashman, L.K. and Besmer, P. (1991) "Monoclonal antibody YB5.B8 identifies the human c-kit protein product", Blood 77, 1876.
  • Long, M.W., Bridell, R., Walter, A.W, Bruno, E. and Huffman, R. (1992) "Human hematopoietic stem cell adhere to cytokines and matrix molecules", J. Clin. Investig. 90, 251.
  • Majumdar, M.K., Feug, L., Medlock, E., Toksoz, D. and Williams, D.A. (1994) "Identification and mutation of primary and secondary proteolytic cleavage sites in murine stem cell factor cDNA yields biologically active, cell-associated protein", J. Biol. Chem. 269, 1237.
  • Mayarai, H., Little, M.-T., Dragowska, W., Thombury, G. and Lansdorp, P.M. (1995) "Differential effects of the hematopoietic inhibitors MIP-1a, TGF-ß, and TNF-a on cytokine-induced proliferation of subpopulations of CD34+ cells purified from cord blood and fetal liver", Exp. Hanatol. 23, 422.
  • Mayani, H. and Lansdorp, P.M. (1998) "Biology of human umbilical cord blood-derived hematopoietic stem/progenitor cells", Stem Cells 16, 153.
  • McCulloch, E.A., Siminovitch, L., Till, J.E., Russel, E.S. and Bernstein, S.E. (1965) "The cellular basis of the genetically determined hemopoietic defect in anemia mice of genotype Sl/Sl ", Blood 269, 399.
  • McNiece, I.K., Langley, K.E. and Zsebo, K.M. (1991) "Recombinant human stem cell factor synergizes with GM-CSF, G-CSF, IL-3 and Epo to stimulate human progenitor cells of the myeloid and the erythroid lineages", Blood 19, 226.
  • Michalevicz, R., Katz, F., Stroobant, P., Janossy, G., Tindle, R.W. and Hoffbrand, A.V. (1986) "Platelet-derived growth factor stimulates growth of highly enriched multipotent haematopoietic progenitors", Br. J. Haanatol. 63, 591.
  • Miyazawa, K., Williams, D.A., Gotoh, A., Nishimaki, I., Broxmeyer, H.E. and Toyama, K. (1995) "Membrane-bound steel factor induces more persistent tyrosine kinase activation and longer life span of c-kit gene-encoded protein than its soluble form", Blood 85, 641.
  • Nocka, K., Majumder, S., Chabot, B., Ray, P., Cervone, M., Bernstein, A. and Besmer, P. (1989) "Expression of c-kit gene products in known cellular targets of W mutations in normal and W mutant mice--evidence for an impaired c-kit kinase in mutant mice", Genes Den 3, 816.
  • Ogawa, M., Matsuzaki, Y, Nishikawa, S., Hayashi, S., Kunisada, T., Sudo, T., Kina, T., Nakauchi, H. and Nishikawa, S. (1991) "Expression and function of c-kit in hemopoietic progenitor cells", J. Exp. Med. 174, 63.
  • O'Prey, J., Leslie, N., Itoh, K., Ostertag, W., Bartholomew, C. and Harrison, P. (1998) "Both stroma and stem cell factor maintain long term growth of ELM erythroleukemia cells, but only stroma prevents erythroid differentiation in response to erythropoietin and interlsukin-3". Blood 91, 1548.
  • Ramsfjell, V, Borge, O.J., Cui, L. and Jacobson, S.E.W. (1997) "Thrombopoietin directly and potently stimulates multilineage growth and progenitor cell expansion from primitive (CD34+ CD38-) human bone marrow progenitor cells: distinct and key interactions with the ligands for c-kit and fit 3, and inhibitory effects of TGF-ß and TNF-a", J. Immunol. 158, 5169.
  • Rapp, U.R., Jorma, K.-O. and Heine, U.I. (1979) "Establishment and characterization of the epithelial mouse embryo cell line MMC-E", Cancer Res. 39, 4111.
  • Rettenmier, C. W, Roussel, M.F., Ashmun, R.A., Ralph, R., Price, K. and Sherr, C.J. (1987) "Synthesis of membrane-bound colony-stimulating factor (CSF-1) and down-modulation of CSF-1 receptors in NIH 3T3 cells transformed by cotransfection of the human CSF-1 and c-fms (CSF-1 receptor) genes", Mol. Cell Biol. 7, 2378.
  • Roberts, R., Gallagher, J., Spooncer, E., Allen, T.D., Bloomfield, F. and Dexter, T.M. (1988) "Heparan sulphate bound growth factors: a mechanism for stromal cell mediated haemopoiesis", Nature 332, 376.
  • Stocking, C., Bergholz, U., Friel, J., Klingler, K., Wagener, T., Starke, C., Kitamura, T, Miyajima, A. and Ostertag, W. (1993) "Distinct classes of factor-independent mutants can be isolated after retroviral mutagenesis of a human myeloid stem cell line", Growth Factors 8, 197.
  • Sutherland, H.J., Hogge, D.E., Cook, D. and Eaves, C.J. (1993) "Alternative mechanisms with and without steel factor support primitive human hematopoiesis", Blood 81, 1465.
  • Toksoz, D., Zsebo, K.M, Smith, K.A., Hu, S., Brankow, D., Suggs, S.V., Martin, F.H. and Williams, D.A. (1992) "Support of human hematopoiesis in long term bone marrow cultures by murine stromalof the human homolog of the steel gene product", Proc. Natl. Acad. Sci. USA 89, 7350.
  • Yan, X.Q., Brady, G. and Iscove, N.N. (1993) "Platelet-derived growth factor (PDGF) activates primitive hematopoietic precursors (pre-CFCmulti) by upregularing IL-1 in PDGF receptor-expressing macrophages", J. Immunol. 150, 1.
  • Zsebo, K.M., Williams, D.A., Gassier, E.N., Broudy, V.C., Martin, F.H., Atkins, H.L., Hsu, R.-Y, Birkett, N.C., Okino, K.H., Murdock, D.C.,Jacobsen, F.W., Langley, K.E., Smith, K.A., Takeishi, T., Cattanach, B.M., Galli, S.J. and Suggs, S.V. (1990) "Stem cell factor is encoded at the Sl locus of the mouse and is the ligand for the c-kit tyrosine kinase receptor", Cell 63, 213.

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