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Growth Factors Volume 20, 2002 - Issue 1
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Research Article

Expression of Pleiotrophin in Hepatic Nonparenchymal Cells and Preneoplastic Nodules in Carbon Tetrachloride-induced Fibrotic Rat Liver

T. Kohashi Laboratory of Developmental Biology, Department of Biological Science, Graduate School of Science, Hiroshima University, 1-3-1, Kagamiyama, Higashihiroshima, Hiroshima 739-8526, Japan
,
Y. Tateaki Laboratory of Developmental Biology, Department of Biological Science, Graduate School of Science, Hiroshima University, 1-3-1, Kagamiyama, Higashihiroshima, Hiroshima 739-8526, Japan
,
C. Tateno Tissue Regeneration Project, Hiroshima Prefecture Collaboration of Regional Entities for the Advancement of Technological Excellence, Japan Science and Technology Corporation, Hiroshima Prefectural Institute of Industrial Science and Technology, 3-10-32, Kagamiyama, Higashihiroshima, Hiroshima 739-0046, Japan
,
T. Asahara Second Department of Surgery, Hiroshima University School of Medicine, 1-2-3, Kasumi, Minami-ku, Hiroshima 734-8551, Japan
,
M. Obara Laboratory of Developmental Biology, Department of Biological Science, Graduate School of Science, Hiroshima University, 1-3-1, Kagamiyama, Higashihiroshima, Hiroshima 739-8526, Japan
&
K. Yoshizato Laboratory of Developmental Biology, Department of Biological Science, Graduate School of Science, Hiroshima University, 1-3-1, Kagamiyama, Higashihiroshima, Hiroshima 739-8526, Japan
Pages 53-60 | Published online: 11 Jul 2009

  • Chauhan, A.K., Li, Y.S. and Deuel, T.F. (1993) "Pleiotrophin transforms NIH 3T3 cells and induced tumors in nude mice", Proc. Natl Acad. Sci. USA 90, 679-682.
  • Choudhuri, R., Zhang, H.T., Donnini, S., Ziehe, M. and Bicknell, R. (1997) "An angiogenic role for the neurokines midkine and pleiotrophin in tumorigenesis", Cancer Res. 57, 1814-1819.
  • Corbley, M.J. (1997) 'Transformation by ras suppresses expression of the neurotrophic growth factor pleiotrophin", J. Biol. Chem. 272, 24696-24702.
  • Czubayko, F., Schulte, A.M., Berchem, G.J. and Wellstein, A. (1996) "Melanoma angiogenesis and metastasis modulated by ribozyme targeting of the secreted growth factor pleiotrophin", Proc. Natl Acad. Sci. USA 93, 14753-14758.
  • Fang, W., Hartmann, N., Chow, D.T., Riegel, A.T. and Wellstein, A. (1992) "Pleiotrophin stimulates fibroblasts and endothelial and epithelial cells and is expressed in human cancer", J. Biol. Chem. 267, 25889-25897.
  • Fink, L., Seeger, W, Ermert, L., Hanze, J., Stahl, U., Grimminger, F., Kummer, W. and Bohle, R.M. (1998) "Real-time quantitative RT-PCR after laser-assisted cell picking", Nat. Med. 4, 1329-1333.
  • Friedman, S.L. (1993) "Seminars in medicine of the Beth Israel Hospital, Boston. The cellular basis of hepatic fibrosis. Mechanisms and treatment strategies", N. Engl J. Med. 328, 1828-1835.
  • Friedman, S.L. (2000) "Molecular regulation of hepatic fibrosis, and integrated cellular response to tissue injury", J. Biol. Chem. 275, 2247-2250.
  • Carver, R.I., Radford, D.M., Keller, H.D., Wick, M.R. and Milner, P.G. (1994) "Midkine and pleiotrophin expression in normal and malignant breast tissue", Cancer 74, 1584-1590.
  • Gibson, U.E.M., Heid, C.A. and Williams, P.M. (1996) "A novel method for real time quantitative PCR", Genome Res. 6, 995-1000.
  • Heid, C.A., Stevens, J., Livak, K.J. and Williams, P.M. (1996) "Real time quantitative PCR", Genome Res. 6, 986-994.
  • Li, Y.S., Milner, P.G., Chauhan, A.K., Watson, M.A., Huffman, R.M., Kodner, C.M., Milbrandt, J. and Deuel, T.F. (1990) "Cloning and expression of a developmentally regulated protein that induces mitogenic and neunte outgrowth activity", Science 250, 1690-1694.
  • Li, Y.S., Gurrieri, M. and Deuel, T.F. (1992) "Pleiotrophin gene expression is highly restricted and is regulated by platelet-derived growth factor", Biochem. Biophys. Res. Commun. 184, 427-432.
  • Lopez de Leon, A. and Rojkind, M. (1985) "A simple micromethod for collagen and total protein determination in formalin-fixed paraffinembedded sections", J. Histochem. Cytochem. 33, 737-743.
  • MacSween, R.N.M., Anthony, P.P., Scheuer, P.J., Burt, A.D. and Portmann, B.C. (1994) Pathology of The liver, 3rd Ed. (Churchill Livingstone, New York), pp 397-424.
  • Marra, F., Gentilini, A., Pinzani, M., Choudhury, G.G., Parola, M., Herbst, H., Dianzani, M.U., Laffi, G., Abboud, H.E. and Gentilini, P. (1997) "Phosphatidylinositol 3-kinase is required for platelet-derived growth factor's actions on hepatic stellate cells", Gastmentemlogy 112, 1297-1306.
  • Matsumoto, K., Wanaka, A., Mori, T., Taguchi, A., Ishii, N., Murasmatsu, H., Muramatsu, T. and Tohyama, M. (1994) "Localization of pleiotrophin and midkine in the postnatal developing cerebellum", Neumsci. Lett. 178, 216-220.
  • Milhiet, P.E., Vacherot, F., Caruelle, J.P., Barritault, D., Caruelle, D. and Courty, J. (1998) "Upregulation of the angiogenic factor heparin affin regulatory peptide by progesterone in rat uterus", J. Endocrinol. 158, 389-399.
  • Milner, P.G., Li, Y.S., Hoffman, R.M., Kodner, C.M., Siegel, N.R. and Deuel, T.F. (1989) "A novel 17kD heparin-binding growth factor (HBGF-8) in bovine uterus: purification and N-terminal amino acid sequence", Biochem. Biophys. Res. Commun. 165, 1096-1103.
  • Muramatsu, H., Song, X., Koide, N., Hada, H., Tsuji, T., Kadomatsu, K., Inui, T., Kimura, T., Sakakibara, T. and Muramatsu, T. (1996) "Enzyme-linked immunoassay for midkine, and its application to evaluation of midkine levels in developing mouse brain and sera from patients with hepatocellular carcinomas", J. Biochem. 119, 1171-1175.
  • Nakanishi, T., Kadomatsu, K., Okamoto, T., Tomoda, Y. and Muramatsu, T. (1997) "Expression of midkine and pleiotrophin in ovarian tumors", Obstet. Gynecol. 90, 285-290.
  • Nakatsukasa, H., Nagy, P., Events, R.P., Hsia, C., Marsden, E. and Thorgeirsson, S.S. (1990) "Cellular distribution of transforming growth factor ß1 and procollagen type I, III and IV transcripts in carbon tetrachrolide-induced rat liver fibrosis", J. Clin. Invest. 85, 1833-1843.
  • Neubauer, K., Knittel, T., Aurisch, S., Fellmer, P. and Ramadori, G. (1996) "Glial fibrillary acidic protein--a cell type specific marker for Ito cells in vivo and in vitro", J. Hepatol. 24, 719-730.
  • Niki, T., De Bleser, P.J., Xu, G., Berg, K.V., Wisse, E. and Geerts, A. (1996) "Comparison of glial fibrillary acidic protein and desmin staining in normal and CCl4-induced fibrotic rat livers", Hepatology 23, 1538-1545.
  • Niki, T., Penky, M., Hellemans, K., De Bleser, P., Berg, K.V., Vaeyens, F., Quartier, E., Schuit, F. and Geerts, A. (1999) "Class VI intermediate filament protein nestin is induced during activation of rat hepatic stellate cells", Hepatology 29, 520-527.
  • Paradis, V., Dargere, D., Vidaud, M., Gouville, A.C., Huet, S., Martinez, V., Gauthier, J.M., Ba, N., Sobesky, R., Ratziu, V. and Bedossa, P. (1999) "Expression of connective tissue growth factor in experimental rat and human liver fibrosis", Hepatology 30, 968-976.
  • Pinzani, M. (1995) "Hepatic stellate (ITO) cells: expanding roles for a liver-specific pericyte", J. Hepatol 22, 700-706.
  • Pinzani, M., Guesualdo, L., Sabbath, G.M. and Abboud, H.E. (1989) "Effects of platelet-derived growth factor and other polypeptide mitogens on DNA synthesis and growth of cultured rat liver fatstoring cells", J. Clin. Invest. 84, 1786-1789.
  • Pinzani, M., Milani, S., Grappone, C., Weber, Jr., F.L., Gentilini, P. and Abboud, H.E. (1994) "Expression of platelet-derived growth factor in a model of acute liver injury", Hepatology 19, 701-707.
  • Ramadori, G., Veit, T., Schwogler, S., Dienes, H.P., Knittel, T., Rieder, H. and Meyer zum Buschenfelde, K.H. (1990) "Expression of the gene of alpha-smooth muscle-actin isoform in rat liver and rat fat-storing (ITO) cells", Virchows Arch. B Cell Pathol. Incl. Mol. Palhol. 59, 349-357.
  • Rauvala, H. (1989) "An 18-kd heparin-binding protein of developing brain that is distinct from fibroblast growth factors", EMBO J. 10, 2933-2941.
  • ReIf, M., Leleone, S., Scott, P.A., Fox, S., Smith, K., Leek, R., Moghaddam, A., Whitehouse, R., Bicknell, R. and Harris, A.L. (1997) "Expression of the angiogenic factor, acidic and basic fibroblast growth factor, tumor growth factor beta-1, platelet-derived endothelial cell growth factor, placenta growth factor, and pleiotrophin in human primary breast cancer and its relation to angiogenesis", Cancer Res. 57, 963-969.
  • Sakaida, I., Kubota, M., Kayano, K., Takenaka, K., Mori, K. and Okita, K. (1994) "Prevention of fibrosis reduces enzyme-altered lesions in the rat liver", Carcinogenesis 15, 2201-2206.
  • Sakaida, I., Hironaka, K., Uchida, K., Suzuki, C., Kayano, K. and Okita, K. (1998) "Fibrosis accelerates the development of enzyme-altered lesions in the rat liver", Hepatology 28, 1247-1252.
  • Sato, K., Kitahara, A., Satoh, K., Ishikawa, T., Tatematsu, M. and Ito, N. (1984) "The placental form of glutathione S-transferase as a new marker protein for preneoplasia in rat chemical hepatocarcinogenesis", Gann 75, 199-202.
  • Sato, M., Miyado, K., Okazaki, M and Kimura, M. (1997) "Regulation of osteoblast-specific factor-1 (OSF-1) mRNA expression by dual promoters as revealed by RT-PCR", Biochem. Biophys. Res. Commun. 238, 831-837.
  • Sato, H., Funahashi, M., Kristensen, D.B., Tateno, C. and Yoshizato, K. (1999) "Pleiotrophin as a Swiss 3T3 cell-derived potent mitogen for adult rat hepatocytes", Exp. Cell Res. 246, 152-164.
  • Satoh, K., Kitahara, A., Soma, Y., Inaba, Y., Hatayama, I. and Sato, K. (1985) "Purification, induction, and distribution of placental glutathione transferase: a new marker enzyme for preneoplastic cells in the rat chemical hepatocarcinogenesis", Proc. Natl Acad. Sci. USA 82, 3964-3968.
  • Silos-Santiago, I., Yeh, H.J., Gurrieri, M.A., Guillerman, R.P., Li, Y.S., Wolf, J., Snider, W. and Deuel, T.F. (1996) "Localization of pleiotrophin and its mRNA in subpopulations of neurons and their corresponding axonal tracts suggests important role in neural--glial interactions during development and in maturity", J. Neumbiol. 31, 283-296.
  • Souttou, B., Juhl, H., Hackenbrack, J., Rockseisen, M., Klomp, H.J., Raulais, D., Vigny, M. and Wellstein, A. (1998) "Relationship between serum concentrations of the growth factor pleiotrophin and pleiotrophin-positive tumors", J. Natl Cancer Inst. 90, 1468-1473.
  • Specht, K., Richter, T., Muller, U., Walch, A., Werner, M. and Hofler, H. (2001) "Quantitative gene expression analysis in microdissected archival formalin-fixed and paraffin-embedded tumor tissue", Am. J. Pathol 158, 419-429.
  • Sweat, F., Fuchtler, H. and Rosenthal, S.I. (1964) "Sirius red F3BA as a stain for connective tissue", Arch. Pathol. 78, 69-72.
  • Tatematsu, M., Mera, Y, Inoue, T., Satoh, K., Sato, K. and Ito, N. (1998) "Stable phenotypic expression of glutathione S-transferase placental type and unstable phenotypic expression of gamma-glutamyl transferase in rat liver preneoplastic and neoplastic lesions", Carcinogenesis 9, 215-220.
  • Wakisaka, S., Tabata, M.J., Maeda, T., Matsumoto, K., Wanaka, K., Muramatsu, H., Muramatsu, T. and Kurisu, K. (1998) "Immunohisto-chemical localization of pleiotrophin and midkine in the lingual epithelium of the adult rat", Arch. Histol. Cytol. 61, 475-480.
  • Waldrop, F.S. and Puchtler, H. (1982) "Light microscopic distinction of collagens in hepatic cirrhosis", Histochemistry 74, 487-491.
  • Weiner, F.R., Giambrone, M.A., Czaja, M.J., Shah, A., Annoni, G., Takahashi, S., Eghbali, M. and Zern, M.A. (1990) "Ito-cell gene expression and collagen regulation", Hepatology 11, 111-117.
  • Yeh, H.J., He, Y.Y., Xu, J., Hsu, C.Y. and Deuel, T.F. (1998) "Upregulation of pleiotrophin gene expression in developing microvasculature, macrophages and astrocytes after acute ischemic brain injury", J. Neurosci. 18, 3699-3707.
  • Zhang, N., Zhong, R. and Deuel, T.F. (1999) "Domain structure of pleiotrophin required for transformation", J. Biol. Chem. 274, 12959-12962.

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