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Research Article

Epidermal Growth Factor Receptor: Association of Extracellular Domain Negatively Regulates Intracellular Kinase Activation in the Absence of Ligand

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Pages 15-30 | Received 25 Jan 2003, Published online: 07 Aug 2009

REFERENCES

  • Alroy, I. and Yarden, Y. (1997) “The ErbB signaling network in embryogenesis and oncogenesis: signal diversification through combinatorial ligand–receptor interactions”, FEBS Lett. 410, 83–86.
  • Aroian, R.V. and Sternberg, P.W. (1991) “Multiple functions of let-23, a Caenorhabditis elegans receptor tyrosine kinase gene required for vulval induction”, Genetics 128, 251–267.
  • Blume-Jensen, P. and Hunter, T. (2001) “Oncogenic kinase signalling”, Nature 411, 355–365.
  • Burke, C.L. and Stern, D.F. (1998) “Activation of Neu (ErbB-2) mediated by disulfide bond-induced dimerization reveals a receptor tyrosine kinase dimer interface”, Mol. Cell. Biol. 18, 5371–5379.
  • Carraway, III, K.L. and Cantley, L.C. (1994) “A neu acquaintance for erbB3 and erbB4: a role for receptor heterodimerization in growth signaling”, Cell 78, 5–8.
  • Chantry, A. (1995) “The kinase domain and membrane localization determine intracellular interactions between epidermal growth factor receptors”, J. Biol. Chem. 270, 3068–3073.
  • Chen, R.H. and Derynck, R. (1994) “Homomeric interactions between type II transforming growth factor-beta receptors”, J. Biol. Chem. 269, 22868–22874.
  • Chen, R.H., Moses, H.L., Maruoka, E.M., Derynck, R. and Kawabata, M. (1995) “Phosphorylation-dependent interaction of the cytoplasmic domains of the type I and type II transforming growth factor-beta receptors”, J. Biol. Chem. 270, 12235–12241.
  • D’Andrea, A.D., Lodish, H.F. and Wong, G.G. (1989) “Expression cloning of the murine erythropoietin receptor”, Cell 57, 277–285.
  • Ekstrand, A.J., Sugawa, N., James, C.D. and Collins, V.P. (1992) “Amplified and rearranged epidermal growth factor receptor genes in human glioblastomas reveal deletions of sequences encoding portions of the N-and/or C-terminal tails”, Proc. Natl Acad. Sci. USA 89, 4309–4313.
  • Fowler, K.J., Walker, F., Alexander, W., Hibbs, M.L., Nice, E.C., Bohmer, R.M., Mann, G.B., Thumwood, C., Maglitto, R. and Danks, J.A. (1995) “A mutation in the epidermal growth factor receptor in waved-2 mice has a profound effect on receptor biochemistry that results in impaired lactation”, Proc. Natl Acad. Sci. USA 92, 1465–1469.
  • Frederick, L., Wang, X.Y., Eley, G. and James, C.D. (2000) “Diversity and frequency of epidermal growth factor receptor mutations in human glioblastomas”, Cancer Res. 60, 1383–1387.
  • Gadella, T.W. Jr, and Jovin, T.M. (1995) “Oligomerization of epidermal growth factor receptors on A431 cells studied by time-resolved fluorescence imaging microscopy. A stereochemical model for tyrosine kinase receptor activation”, J. Cell. Biol. 129, 1543–1558.
  • Heldin, C.H. (1995) “Dimerization of cell surface receptors in signal transduction”, Cell 80, 213–223.
  • Henis, Y.I., Moustakas, A., Lin, H.Y. and Lodish, H.F. (1994) “The types II and III transforming growth factor-beta receptors form homo oligomers”, J. Cell. Biol. 126, 139–154.
  • Huang, H.S., Nagane, M., Klingbeil, C.K., Lin, H., Nishikawa, R., Ji, X.D., Huang, C.M., Gill, G.N., Wiley, H.S. and Cavenee, W.K. (1997) “The enhanced tumorigenic activity of a mutant epidermal growth factor receptor common in human cancers is mediated by threshold levels of constitutive tyrosine phosphorylation and unattenuated signaling”, J. Biol. Chem. 272, 2927–2935.
  • Jiang, G. and Hunter, T. (1999) “Receptor signaling: when dimerization is not enough”, Curr. Biol. 9, R568–R571.
  • Kishimoto, T., Taga, T. and Akira, S. (1994) “Cytokine signal transduction”, Cell 76, 253–262.
  • de Larco, J.E. and Todaro, G.J. (1978) “Growth factors from murine sarcoma virus-transformed cells”, Proc. Natl Acad. Sci. USA 75, 4001–4005.
  • Lemmon, M.A. and Schlessinger, J. (1994) “Regulation of signal transduction and signal diversity by receptor oligomerization”, Trends Biochem. Sci. 19, 459–463.
  • Libermann, T.A., Nusbaum, H.R., Razon, N., Kris, R., Lax, I., Soreq, H., Whittle, N., Waterfield, M.D., Ullrich, A. and Schlessinger, J. (1985) “Amplification, enhanced expression and possible rearrangement of EGF receptor gene in primary human brain tumours of glial origin”, Nature 313, 144–147.
  • Lin, C.R., Chen, W.S., Kruiger, W., Stolarsky, L.S., Weber, W., Evans, R.M., Verma, I.M., Gill, G.N. and Rosenfeld, M.G. (1984) “Expression cloning of human EGF receptor complementary DNA: gene amplification and three related messenger RNA products in A431 cells”, Science 224, 843–848.
  • Livnah, O., Stura, E.A., Johnson, D.L., Middleton, S.A., Mulcahy, L.S., Wrighton, N.C., Dower, W.J., Jolliffe, L.K. and Wilson, I.A. (1996) “Functional mimicry of a protein hormone by a peptide agonist: the EPO receptor complex at 2.8 A”, Science 273, 464–471.
  • Livnah, O., Stura, E.A., Middleton, S.A., Johnson, D.L., Jolliffe, L.K. and Wilson, I.A. (1999) “Crystallographic evidence for preformed dimers of erythropoietin receptor before ligand activation”, Science 283, 987–990.
  • Malden, L.T., Novak, U., Kaye, A.H. and Burgess, A.W. (1988) “Selective amplification of the cytoplasmic domain of the epidermal growth factor receptor gene in glioblastoma multiforme”, Cancer Res. 48, 2711–2714.
  • Merlino, G.T., Xu, Y.H., Ishii, S., Clark, A.J., Semba, K., Toyoshima, K., Yamamoto, T. and Pastan, I. (1984) “Amplification and enhanced expression of the epidermal growth factor receptor gene in A431 human carcinoma cells”, Science 224, 417–419.
  • Moriki, T., Maruyama, H. and Maruyama, I.N. (2001) “Activation of preformed EGF receptor dimers by ligand-induced rotation of the transmembrane domain”, J. Mol. Biol. 311, 1011–1026.
  • Nicholson, S.E., Starr, R., Novak, U., Hilton, D.J. and Layton, J.E. (1996) “Tyrosine residues in the granulocyte colony-stimulating factor (G-CSF) receptor mediate G-CSF-induced differentiation of murine myeloid leukemic (M1) cells”, J. Biol. Chem. 271, 26947–26953.
  • Price, J.V., Clifford, R.J. and Schupbach, T. (1989) “The maternal ventralizing locus torpedo is allelic to faint little ball, an embryonic lethal, and encodes the Drosophila EGF receptor homolog”, Cell 56, 1085–1092.
  • Remy, I., Wilson, I.A. and Michnick, S.W. (1999) “Erythropoietin receptor activation by a ligand-induced conformation change”, Science 283, 990–993.
  • Sako, Y., Minoghchi, S. and Yanagida, T. (2000) “Single-molecule imaging of EGFR signalling on the surface of living cells”, Nat. Cell. Biol. 2, 168–172.
  • Schejter, E.D. and Shilo, B.Z. (1989) “The Drosophila EGF receptor homolog (DER) gene is allelic to faint little ball, a locus essential for embryonic development”, Cell 56, 1093–1104.
  • Schlessinger, J. and Ullrich, A. (1992) “Growth factor signaling by receptor tyrosine kinases”, Neuron 9, 383–391.
  • Sherrill, J.M. and Kyte, J. (1996) “Activation of epidermal growth factor receptor by epidermal growth factor”, Biochemistry 35, 5705–5718.
  • Sibilia, M. and Wagner, E.F. (1995) “Strain-dependent epithelial defects in mice lacking the EGF receptor”, Science 269, 234–238.
  • Sorokin, A., Lemmon, M.A., Ullrich, A. and Schlessinger, J. (1994) “Stabilization of an active dimeric form of the epidermal growth factor receptor by introduction of an inter-receptor disulfide bond”, J. Biol. Chem. 269, 9752–9759.
  • Syed, R.S., Reid, S.W., Li, C., Cheetham, J.C., Aoki, K.H., Liu, B., Zhan, H., Osslund, T.D., Chirino, A.J., Zhang, J., Finer-Moore, J., Elliott, S., Sitney, K., Katz, B.A., Matthews, D.J., Wendoloski, J.J., Egrie, J. and Stroud, R.M. (1998) “Efficiency of signalling through cytokine receptors depends critically on receptor orientation”, Nature 395, 511–516.
  • Threadgill, D.W., Dlugosz, A.A., Hansen, L.A., Tennenbaum, T., Lichti, U., Yee, D., LaMantia, C., Mourton, T., Herrup, K. and Harris, R.C. (1995) “Targeted disruption of mouse EGF receptor: effect of genetic background on mutant phenotype”, Science 269, 230–234.
  • Ullrich, A., Coussens, L., Hayflick, J.S., Dull, T.J., Gray, A., Tam, A.W., Lee, J., Yarden, Y., Libermann, T.A. and Schlessinger, J. (1984) “Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells”, Nature 309, 418–425.
  • van der G.P., Hunter T. and Lindberg R.A. (1994) “Receptor protein-tyrosine kinases and their signal transduction pathways”, Annu. Rev. Cell. Biol. 10, 251–337.
  • Wells, R.G., Gilboa, L., Sun, Y., Liu, X., Henis, Y.I. and Lodish, H.F. (1999) “Transforming growth factor-beta induces formation of a dithiothreitol-resistant type I/Type II receptor complex in live cells”, J. Biol. Chem. 274, 5716–5722.
  • Wong, A.J., Bigner, S.H., Bigner, D.D., Kinzler, K.W., Hamilton, S.R. and Vogelstein, B. (1987) “Increased expression of the epidermal growth factor receptor gene in malignant gliomas is invariably associated with gene amplification”, Proc. Natl Acad. Sci. USA 84, 6899–6903.
  • Wong, A.J., Ruppert, J.M., Bigner, S.H., Grzeschik, C.H., Humphrey, P.A., Bigner, D.S. and Vogelstein, B. (1992) “Structural alterations of the epidermal growth factor receptor gene in human gliomas”, Proc. Natl Acad. Sci. USA 89, 2965–2969.
  • Xu, Y.H., Ishii, S., Clark, A.J., Sullivan, M., Wilson, R.K., Ma, D.P., Roe, B.A., Merlino, G.T. and Pastan, I. (1984) “Human epidermal growth factor receptor cDNA is homologous to a variety of RNAs overproduced in A431 carcinoma cells”, Nature 309, 806–810.
  • Yamamoto, T., Nishida, T., Miyajima, N., Kawai, S., Ooi, T. and Toyoshima, K. (1983) “The erbB gene of avian erythroblastosis virus is a member of the src gene family”, Cell 35, 71–78.
  • Zhu, H.J. and Sizeland, A.M. (1999a) “A pivotal role for the transmembrane domain in transforming growth factor-beta receptor activation”, J. Biol. Chem. 274, 11773–11781.
  • Zhu, H.J. and Sizeland, A.M. (1999b) “Extracellular domain of the transforming growth factor-beta receptor negatively regulates ligand-independent receptor activation”, J. Biol. Chem. 274, 29220–29227.

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