Cyclins: Roles in mitogenic signaling and oncogenic transformation

References

• Albanese C, Johnson J, Watanabe G, et al. Transforming p21ras mutants and c-Ets-2 activate the cyclin D1 promoter through distinguishable regions. J Biol Chem 1995; 270: 23589–23597
   PubMed Web of Science ®Google Scholar
• Besson A, Assoian RK, Roberts JM. Regulation of the cytoskeleton: An oncogenic function for CDK inhibitors?. Nat Rev Cancer 2004; 4: 948–955
   PubMed Web of Science ®Google Scholar
• Bill HM, Knudsen B, Moores SL, et al. Epidermal growth factor receptor-dependent regulation of integrin-mediated signaling and cell cycle entry in epithelial cells. Mol Cell Biol 2004; 24: 8586–8599
   PubMed Web of Science ®Google Scholar
• Bodrug S, Warner BJ, Bath ML, et al. Cyclin D1 transgene impedes lymphocyte maturation and collaborates in lymphomagenesis with the myc gene. EMBO J 1994; 13: 2124–2130
   PubMed Web of Science ®Google Scholar
• Bortner DM, Rosenberg MP. Induction of mammary gland hyperplasia and carcinomas in transgenic mice expressing human cyclin E. Mol Cell Biol 1997; 17: 453–459
   PubMed Web of Science ®Google Scholar
• Bowe DB, Kenney NJ, Adereth Y, et al. Suppression of Neu-induced mammary tumor growth in cyclin D1-deficient mice is compensated for by cyclin E. Oncogene 2002; 21: 291–298
   PubMed Web of Science ®Google Scholar
• Butt AJ, McNeil CM, Musgrove EA, et al. Downstream targets of growth factor and oestrogen signalling and endocrine resistance: The potential roles of c-Myc, cyclin D1 and cyclin E. Endocr Relat Cancer 2005; 12: S47–S59
   PubMed Web of Science ®Google Scholar
• Cheng M, Sexl V, Sherr CJ. Assembly of cyclin D-dependent kinase and titration of p27Kip1 regulated by mitogen-activated protein kinase kinase (MEK1). Proc Natl Acad Sci USA 1998; 95: 1091–1096
   PubMed Web of Science ®Google Scholar
• Coqueret O. Linking cyclins to transcriptional control. Gene 2002; 299: 35–55
   PubMed Web of Science ®Google Scholar
• D'Amico M, Hulit J, Amanatullah DF, et al. The integrin-linked kinase regulates the cyclin D1 gene through glycogen synthase kinase 3beta and cAMP-responsive element-binding protein-dependent pathways. J Biol Chem 2000; 275: 32649–32657
   PubMed Web of Science ®Google Scholar
• Desai KV, Xiao N, Wang W, et al. Initiating oncogenic event determines gene-expression patterns of human breast cancer models. Proc Natl Acad Sci USA 2002; 99: 6967–6972
   PubMed Web of Science ®Google Scholar
• Diehl JA, Cheng M, Roussel MF, et al. Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization. Genes Dev 1998; 12: 3499–3511
   PubMed Web of Science ®Google Scholar
• Frei C. Cyclin D/Cdk4: New insights from Drosophila. Cell Cycle 2004; 3: 558–560
   PubMed Web of Science ®Google Scholar
• Gabrielli BG, Sarcevic B, Sinnamon J, et al. A cyclin D-Cdk4 activity required for G2 phase cell cycle progression is inhibited in ultraviolet radiation-induced G2 phase delay. J Biol Chem 1999; 274: 13961–13969
   PubMed Web of Science ®Google Scholar
• Garriga J, Grana X. Cellular control of gene expression by T-type cyclin/CDK9 complexes. Gene 2004; 337: 15–23
   PubMed Web of Science ®Google Scholar
• Geng Y, Yu Q, Sicinska E, et al. Cyclin E ablation in the mouse. Cell 2003; 114: 431–443
   PubMed Web of Science ®Google Scholar
• Gille H, Downward J. Multiple ras effector pathways contribute to G(1) cell cycle progression. J Biol Chem 1999; 274: 22033–22040
   PubMed Web of Science ®Google Scholar
• Guo Y, Stacey DW, Hitomi M. Post-transcriptional regulation of cyclin D1 expression during G2 phase. Oncogene 2002; 21: 7545–7556
   PubMed Web of Science ®Google Scholar
• Harbour JW, Dean DC. Rb function in cell-cycle regulation and apoptosis. Nat Cell Biol 2000; 2: E65–E67
   PubMed Web of Science ®Google Scholar
• Harbour JW, Luo RX, Dei Santi A, et al. Cdk phosphorylation triggers sequential intramolecular interactions that progressively block Rb functions as cells move through G1. Cell 1999; 98: 859–869
   PubMed Web of Science ®Google Scholar
• Horton LE, Templeton DJ. The cyclin box and C-terminus of cyclins A and E specify CDK activation and substrate specificity. Oncogene 1997; 14: 491–498
   PubMed Web of Science ®Google Scholar
• Huang S, Chen CS, Ingber DE. Control of cyclin D1, p27(Kip1), and cell cycle progression in human capillary endothelial cells by cell shape and cytoskeletal tension. Mol Biol Cell 1998; 9: 3179–3193
   PubMed Web of Science ®Google Scholar
• Joyce D, Bouzahzah B, Fu M, et al. Integration of Rac-dependent regulation of cyclin D1 transcription through a nuclear factor-kappaB-dependent pathway. J Biol Chem 1999; 274: 25245–25249
   PubMed Web of Science ®Google Scholar
• Kalish LH, Kwong RA, Cole IE, et al. Deregulated cyclin D1 expression is associated with decreased efficacy of the selective epidermal growth factor receptor tyrosine kinase inhibitor gefitinib in head and neck squamous cell carcinoma cell lines. Clin Cancer Res 2004; 10: 7764–7774
   PubMed Web of Science ®Google Scholar
• Karsunky H, Geisen C, Schmidt T, et al. Oncogenic potential of cyclin E in T-cell lymphomagenesis in transgenic mice: Evidence for cooperation between cyclin E and Ras but not Myc. Oncogene 1999; 18: 7816–7824
   PubMed Web of Science ®Google Scholar
• Kitagawa M, Higashi H, Jung H-K, et al. The consensus motif for phosphorylation by cyclin D1-Cdk4 is different from that for phosphorylation by cyclin A/E-Cdk2. EMBO J 1996; 15: 7060–7069
   PubMed Web of Science ®Google Scholar
• Koziczak M, Hynes NE. Cooperation between fibroblast growth factor receptor-4 and ErbB2 in regulation of cyclin D1 translation. J Biol Chem 2004; 279: 50004–50011
   PubMed Web of Science ®Google Scholar
• LaBaer J, Garrett MD, Stevenson LF, et al. New functional activities for the p21 family of CDK inhibitors. Genes Dev 1997; 11: 847–862
   PubMed Web of Science ®Google Scholar
• Lamb J, Ramaswamy S, Ford HL, et al. A mechanism of cyclin D1 action encoded in the patterns of gene expression in human cancer. Cell 2003; 114: 323–334
   PubMed Web of Science ®Google Scholar
• Lavoie JN, L'Allemain G, Brunet A, et al. Cyclin D1 expression is regulated positively by the p42/p44MAPK and negatively by the p38/HOGMAPK pathway. J Biol Chem 1996; 271: 20608–20616
   PubMed Web of Science ®Google Scholar
• Lazarov M, Kubo Y, Cai T, et al. CDK4 coexpression with Ras generates malignant human epidermal tumorigenesis. Nat Med 2002; 8: 1105–1114
   PubMed Web of Science ®Google Scholar
• Lee RJ, Albanese C, Fu M, et al. Cyclin D1 is required for transformation by activated Neu and is induced through an E2F-dependent signaling pathway. Mol Cell Biol 2000; 20: 672–683
   PubMed Web of Science ®Google Scholar
• Lents NH, Keenan SM, Bellone C, et al. Stimulation of the Raf/MEK/ERK cascade is necessary and sufficient for activation and Thr-160 phosphorylation of a nuclear-targeted CDK2. J Biol Chem 2002; 277: 47469–47475
   PubMed Web of Science ®Google Scholar
• Liang J, Slingerland JM. Multiple roles of the PI3K/PKB (Akt) pathway in cell cycle progression. Cell Cycle 2003; 2: 339–345
   PubMed Web of Science ®Google Scholar
• Lovec H, Grzeschiczek A, Kowalski M-B, et al. Cyclin D1/bcl-1 cooperates with myc genes in the generation of B-cell lymphoma in transgenic mice. EMBO J 1994; 13: 3487–3495
   PubMed Web of Science ®Google Scholar
• Lukas J, Bartkova J, Bartek J. Convergence of mitogenic signalling cascades from diverse classes of receptors at the cyclin D-cyclin-dependent kinase-pRb-controlled G1 checkpoint. Mol Cell Biol 1996; 16: 6917–6925
   PubMed Web of Science ®Google Scholar
• Lukas J, Bartkova J, Rodhe M, et al. Cyclin D1 is dispensible for G1 control in retinoblastoma gene-deficient cells independently of cdk4 activity. Mol Cell Biol 1995; 15: 2600–2611
   PubMed Web of Science ®Google Scholar
• Lundberg AS, Weinberg RA. Functional inactivation of the retinoblastoma protein requires sequential modification by at least two distinct cyclin-cdk complexes. Mol Cell Biol 1998; 18: 753–761
   PubMed Web of Science ®Google Scholar
• Malumbres M, Barbacid M. To cycle or not to cycle: A critical decision in cancer. Nat Rev Cancer 2001; 1: 222–231
   PubMed Web of Science ®Google Scholar
• Malumbres M, Pellicer A. RAS pathways to cell cycle control and cell transformation. Front Biosci 1998; 3: d887–d912
   PubMed Web of Science ®Google Scholar
• Malumbres M, Perez De Castro I, Hernandez MI, et al. Cellular response to oncogenic ras involves induction of the Cdk4 and Cdk6 inhibitor p15(INK4b). Mol Cell Biol 2000; 20: 2915–2925
   PubMedGoogle Scholar
• Mettouchi A, Klein S, Guo W, et al. Integrin-specific activation of Rac controls progression through the G(1) phase of the cell cycle. Mol Cell 2001; 8: 115–127
   PubMed Web of Science ®Google Scholar
• Minella AC, Welcker M, Clurman BE. Ras activity regulates cyclin E degradation by the Fbw7 pathway. Proc Natl Acad Sci USA 2005; 102: 9649–9654
   PubMedGoogle Scholar
• Mirza AM, Gysin S, Malek N, et al. Cooperative regulation of the cell division cycle by the protein kinases RAF and AKT. Mol Cell Biol 2004; 24: 10868–10881
   PubMed Web of Science ®Google Scholar
• Morgan DO. Cyclin-dependent kinases: Engines, clocks, and microprocessors. Annu Rev Cell Dev Biol 1997; 13: 261–291
   PubMed Web of Science ®Google Scholar
• Muise-Helmericks RC, Grimes HL, Bellacosa A, et al. Cyclin D expression is controlled post-transcriptionally via a phosphatidylinositol 3-kinase/Akt-dependent pathway. J Biol Chem 1998; 273: 29864–29872
   PubMed Web of Science ®Google Scholar
• Murray AW. Recycling the cell cycle: Cyclins revisited. Cell 2004; 116: 221–234
   PubMed Web of Science ®Google Scholar
• Ohanna M, Sobering AK, Lapointe T, et al. Atrophy of S6K1(-/-) skeletal muscle cells reveals distinct mTOR effectors for cell cycle and size control. Nat Cell Biol 2005; 7: 286–294
   PubMed Web of Science ®Google Scholar
• Olson MF, Ashworth A, Hall A. An essential role for Rho, Rac, and Cdc42 GTPases in cell cycle progression through G1. Science 1995; 269: 1270–1272
   PubMed Web of Science ®Google Scholar
• Page K, Li J, Hodge JA, et al. Characterization of a Rac1 signaling pathway to cyclin D(1) expression in airway smooth muscle cells. J Biol Chem 1999; 274: 22065–22071
   PubMed Web of Science ®Google Scholar
• Radeva G, Petrocelli T, Behrend E, et al. Overexpression of the integrin-linked kinase promotes anchorage-independent cell cycle progression. J Biol Chem 1997; 272: 13937–13944
   PubMed Web of Science ®Google Scholar
• Ren S, Rollins BJ. Cyclin C/cdk3 promotes Rb-dependent G0 exit. Cell 2004; 117: 239–251
   PubMed Web of Science ®Google Scholar
• Resnitzky D. Ectopic expression of cyclin D1 but not cyclin E induces anchorage-independent cell cycle progression. Mol Cell Biol 1997; 17: 5640–5647
   PubMed Web of Science ®Google Scholar
• Richter JD, Sonenberg N. Regulation of cap-dependent translation by eIF4E inhibitory proteins. Nature 2005; 433: 477–480
   PubMed Web of Science ®Google Scholar
• Rimerman RA, Gellert-Randelman A, Diehl JA. Wnt and MEK1 cooperate to promote cyclin D1 accumulation and cellular transformation. J Biol Chem 2000; 275: 14736–14742
   PubMed Web of Science ®Google Scholar
• Robles AI, Conti CJ. Early overexpression of cyclin D1 protein in mouse skin carcinogenesis. Carcinogenesis 1995; 16: 781–786
   PubMedGoogle Scholar
• Robles AI, Larcher F, Whalin RB, et al. Expression of cyclin D1 in epithelial tissues of transgenic mice results in epidermal hyperproliferation and severe thymic hyperplasia. Proc Natl Acad Sci USA 1996; 93: 7634–7638
   PubMed Web of Science ®Google Scholar
• Robles AI, Rodriguez-Puebla ML, Glick AB, et al. Reduced skin tumor development in cyclin D1-deficient mice highlights the oncogenic ras pathway in vivo. Genes Dev 1998; 12: 2469–2474
   PubMed Web of Science ®Google Scholar
• Roovers K, Assoian RK. Effects of rho kinase and actin stress fibers on sustained extracellular signal-regulated kinase activity and activation of G(1) phase cyclin-dependent kinases. Mol Cell Biol 2003a; 23: 4283–4294
   PubMed Web of Science ®Google Scholar
• Roovers K, Klein EA, Castagnino P, et al. Nuclear translocation of LIM kinase mediates Rho–Rho kinase regulation of cyclin D1 expression. Dev Cell 2003b; 5: 273–284
   PubMed Web of Science ®Google Scholar
• Rosenwald IB, Lazaris-Karatzas A, Sonenberg N, et al. Elevated levels of cyclin D1 protein in response to increased expression of eukaryotic initiation factor 4E. Mol Cell Biol 1993; 13: 7358–7363
   PubMed Web of Science ®Google Scholar
• Rousseau D, Kaspar R, Rosenwald I, et al. Translation initiation of ornithine decarboxylase and nucleocytoplasmic transport of cyclin D1 mRNA are increased in cells overexpressing eukaryotic initiation factor 4E. Proc Natl Acad Sci USA 1996; 93: 1065–1070
   PubMed Web of Science ®Google Scholar
• Sarcevic B, Lilischkis R, Sutherland RL. Differential phosphorylation of T-47D human breast cancer cell substrates by D1-, D3-, E-, and A-cyclin-CDK complexes. J Biol Chem 1997; 272: 33327–33337
   PubMed Web of Science ®Google Scholar
• Schwartz MA, Assoian RK. Integrins and cell proliferation: Regulation of cyclin-dependent kinases via cytoplasmic signaling pathways. J Cell Sci 2001; Pt 14: 2553–2560
   Google Scholar
• Senderowicz AM. Small-molecule cyclin-dependent kinase modulators. Oncogene 2003; 22: 6609–6620
   PubMed Web of Science ®Google Scholar
• Serrano M, Gómez-Lahoz E, DePinho RA, et al. Inhibition of Ras-induced proliferation and cellular transformation by p16INK4. Science 1995; 267: 249–252
   PubMed Web of Science ®Google Scholar
• Sherr CJ, Roberts JM. CDK inhibitors: Positive and negative regulators of G1 phase progression. Genes Dev 1999; 13: 1501–1512
   PubMed Web of Science ®Google Scholar
• Sherr CJ, Roberts JM. Living with or without cyclins and cyclin-dependent kinases. Genes Dev 2004; 18: 2699–2711
   PubMed Web of Science ®Google Scholar
• Shi Y, Sharma A, Wu H, et al. Cyclin D1 and c-Myc internal ribosome entry site (IRES)-dependent translation is regulated by AKT activity and enhanced by rapamycin through a p38 MAPK and ERK-dependent pathway. J Biol Chem 2005; 280: 10964–10973
   PubMed Web of Science ®Google Scholar
• Shtutman M, Zhurinsky J, Simcha I, et al. The cyclin D1 gene is a target of the beta-catenin/LEF-1 pathway. Proc Natl Acad Sci USA 1999; 96: 5522–5527
   PubMed Web of Science ®Google Scholar
• Tetsu O, McCormick F. Proliferation of cancer cells despite CDK2 inhibition. Cancer Cell 2003; 3: 233–245
   PubMed Web of Science ®Google Scholar
• Wang TC, Cardiff RD, Zukerberg L, et al. Mammary hyperplasia and carcinoma in MMTV-cyclin D1 transgenic mice. Nature 1994; 369: 669–671
   PubMed Web of Science ®Google Scholar
• Weber JD, Raben DM, Phillips PJ, et al. Sustained activation of extracellular-signal-regulated kinase 1 (ERK1) is required for the continued expression of cyclin D1 in G1 phase. Biochem J 1997; 326: 61–68
   PubMed Web of Science ®Google Scholar
• Welcker M, Singer J, Loeb KR, et al. Multisite phosphorylation by Cdk2 and GSK3 controls cyclin E degradation. Mol Cell 2003; 12: 381–392
   PubMed Web of Science ®Google Scholar
• Welsh CF. Rho GTPases as key transducers of proliferative signals in G1 cell cycle regulation. Breast Cancer Res Treat 2004; 84: 33–42
   PubMed Web of Science ®Google Scholar
• Welsh CF, Roovers K, Villanueva J, et al. Timing of cyclin D1 expression within G1 phase is controlled by Rho. Nat Cell Biol 2001; 3: 950–957
   PubMed Web of Science ®Google Scholar
• Westwick JK, Lambert QT, Clark GJ, et al. Rac regulation of transformation, gene expression, and actin organization by multiple, PAK-independent pathways. Mol Cell Biol 1997; 17: 1324–1335
   PubMed Web of Science ®Google Scholar
• Winston JT, Coats SR, Wang YZ, et al. Regulation of the cell cycle machinery by oncogenic ras. Oncogene 1996; 12: 127–134
   PubMed Web of Science ®Google Scholar
• Yang C, Ionescu-Tiba V, Burns K, et al. The role of the cyclin D1-dependent kinases in ErbB2-mediated breast cancer. Am J Pathol 2004; 164: 1031–1038
   PubMed Web of Science ®Google Scholar
• Yu Q, Geng Y, Sicinski P. Specific protection against breast cancers by cyclin D1 ablation. Nature 2001, 411: 1017–1021
   PubMedGoogle Scholar
• Zhao J, Pestell R, Guan JL. Transcriptional activation of cyclin D1 promoter by FAK contributes to cell cycle progression. Mol Biol Cell 2001; 12: 4066–4077
   PubMed Web of Science ®Google Scholar