A synthetic, bioactive PDGF mimetic with binding to both α-PDGF and β-PDGF receptors

References

• Assouline M, Chew SJ, Thompson HW, Beuerman R. Effect of growth factors on collagen lattice contraction by human keratocytes. Invest Ophthalmol Vis Sci 1992; 33(5)1742–1755
   PubMed Web of Science ®Google Scholar
• Engstrom U, Engstrom A, Ernlund A, Westermark B, Heldin CH. Identification of a peptide antagonist for platelet-derived growth factor. J Biol Chem 1992; 267(23)16581–16587
   PubMed Web of Science ®Google Scholar
• Fenstermaker RA, Poptic E, Bonfield TL, Knauss TC, Corsillo L, Piskurich JF, Kaetzel CS, Jentoft JE, Gelfand C, DiCorleto PE, et al. A cationic region of the platelet-derived growth factor (PDGF) A-chain (Arg159-Lys160-Lys161) is required for receptor binding and mitogenic activity of the PDGF-AA homodimer. J Biol Chem 1993; 268(14)10482–10489
   PubMed Web of Science ®Google Scholar
• Fredriksson L, Li H, Eriksson U. The PDGF family: Four gene products form five dimeric isoforms. Cytokine Growth Factor Rev 2004; 15(4)197–204
   PubMed Web of Science ®Google Scholar
• Gilbertson DG, Duff ME, West JW, Kelly JD, Sheppard PO, Hofstrand PD, Gao Z, Shoemaker K, Bukowski TR, Moore M, et al. Platelet-derived growth factor C (PDGF-C), a novel growth factor that binds to PDGF alpha and beta receptor. J Biol Chem 2001; 276(29)27406–27414
   PubMed Web of Science ®Google Scholar
• Heldin CH. Development and possible clinical use of antagonists for PDGF and TGF-beta. Ups J Med Sci 2004; 109(3)165–178
   PubMed Web of Science ®Google Scholar
• Hoch RV, Soriano P. Roles of PDGF in animal development. Development 2003; 130(20)4769–4784
   PubMed Web of Science ®Google Scholar
• Kreysing J, Ostman A, van de Poll M, Backstrom G, Heldin CH. Identification of three amino acid residues in the B-chain of platelet-derived growth factor with different importance for binding to PDGF alpha- and beta-receptors. FEBS Lett 1996; 385(3)181–184
   PubMed Web of Science ®Google Scholar
• LaRochelle WJ, Pierce JH, May-Siroff M, Giese N, Aaronson SA. Five PDGF B amino acid substitutions convert PDGF A to a PDGF B-like transforming molecule. J Biol Chem 1992; 267(24)17074–17077
   PubMed Web of Science ®Google Scholar
• Lawlor MA, Feng X, Everding DR, Sieger K, Stewart CE, Rotwein P. Dual control of muscle cell survival by distinct growth factor-regulated signalling pathways. Mol Cell Biol 2000; 20(9)3256–3265
   PubMed Web of Science ®Google Scholar
• Lin X, Zamora PO, Albright S, Glass JD, Pena LA. Multidomain synthetic peptide B2A2 synergistically enhances BMP-2 in vitro. J Bone Miner Res 2005; 20(4)693–703
   PubMed Web of Science ®Google Scholar
• Lin X, Pena LA, Zamora PO, Campion SL, Takahashi K. Augmentation of demineralized bone matrix (DBM) mineralization by a synthetic growth factor mimetic. J Orthop Res 2006a; 24(11)2051–2058
   PubMed Web of Science ®Google Scholar
• Lin X, Takahashi K, Campion SL, Liu Y, Gustavsen GG, Pena LA, Zamora PO. Synthetic peptide F2A4-K-NS mimics fibroblast growth factor-2 in vitro and is angiogenic in vivo. Int J Mol Med 2006b; 17(5)833–839
   PubMed Web of Science ®Google Scholar
• Lin X, Elliot JJ, Carnes DL, Fox WC, Pena LA, Campion SL, Takahashi K, Atkinson BL, Zamora PO. Augmentation of osseous phenotypes in vivo with a synthetic peptide. J Orthop Res 2006c
   Web of Science ®Google Scholar
• Lin X, Takahashi K, Liu Y, Zamora PO. Enhancement of cell attachment and tissue integration by a IKVAV containing multi-domain peptide. Biochim Biophys Acta 2006d; 1760(9)1403–1410
   PubMed Web of Science ®Google Scholar
• Matsumoto H, Nasu K, Nishida M, Ito H, Bing S, Miyakawa I. Regulation of proliferation, motility, and contractility of human endometrial stromal cells by platelet-derived growth factor. J Clin Endocrinol Metab 2005; 90(6)3560–3567
   PubMed Web of Science ®Google Scholar
• Miller MS. Use of topical recombinant human platelet-derived growth factor-BB (becaplermin) in healing of chronic mixed arteriovenous lower extremity diabetic ulcers. J Foot Ankle Surg 1999; 38(3)227–231
   PubMedGoogle Scholar
• Nagai MK, Embil JM. Becaplermin: Recombinant platelet-derived growth factor, a new treatment for healing diabetic foot ulcers. Expert Opin Biol Ther 2002; 2(2)211–218
   PubMed Web of Science ®Google Scholar
• Nash TJ, Howlett CR, Martin C, Steele J, Johnson KA, Hicklin DJ. Effect of platelet-derived growth factor on tibial osteotomies in rabbits. Bone 1994; 15(2)203–208
   PubMed Web of Science ®Google Scholar
• Nevins M, Giannobile WV, McGuire MK, Kao RT, Mellonig JT, Hinrichs JE, McAllister BS, Murphy KS, McClain PK, Nevins ML, et al. Platelet-derived growth factor stimulates bone fill and rate of attachment level gain: Results of a large multicenter randomized controlled trial. J Periodontol 2005; 76(12)2205–2215
   PubMed Web of Science ®Google Scholar
• Oefner C, D'Arcy A, Winkler FK, Eggimann B, Hosang M. Crystal structure of human platelet-derived growth factor BB. Embo J 1992; 11(11)3921–3926
   PubMed Web of Science ®Google Scholar
• Rolny C, Spillman D, Lindahl U, Claesson-Welsh L, Hosang M. Heparin amplifies platelet-derived growth factor (PDGF)-BB-induced PDGF alpha-receptor but not PDGF beta-receptor tyrosine phosphorylation in heparan sulfate-deficient cells. Effects on signal transduction and biological responses. J. Biol Chem 2002; 277(22)19315–21
   PubMed Web of Science ®Google Scholar
• Schilling D, Reid IJ, Hujer A, Morgan D, Demoll E, Bummer P, Fenstermaker RA, Kaetzel DM. Loop III region of platelet-derived growth factor (PDGF) B-chain mediates binding to PDGF receptors and heparin. Biochem J 1998; 333(Pt 3)637–644
   PubMedGoogle Scholar
• Smiell JM, Wieman TJ, Steed DL, Perry BH, Sampson AR, Schwab BH. Efficacy and safety of becaplermin (recombinant human platelet-derived growth factor-BB) in patients with nonhealing, lower extremity diabetic ulcers: A combined analysis of four randomized studies. Wound Repair Regen 1999; 7(5)335–346
   PubMed Web of Science ®Google Scholar