Chimeric vitronectin:insulin-like growth factor proteins enhance cell growth and migration through co-activation of receptors

References

• Ainscough SL, Barnard Z, et al. Vitronectin supports migratory responses of corneal epithelial cells to substrate bound IGF-I and HGF, and facilitates serum-free cultivation. Exp Eye Res 2006; 83(6)1505–1514
   PubMed Web of Science ®Google Scholar
• Balan V, Nelson DR, et al. Modulation of interferon-specific gene expression by albumin-interferon-alpha in interferon-alpha-experienced patients with chronic hepatitis C. Antivir Ther 2006; 11(7)901–908
   Google Scholar
• Bayne ML, Applebaum J, et al. The C region of human insulin-like growth factor (IGF) I is required for high affinity binding to the type 1 IGF receptor. J Biol Chem 1989; 264(19)11004–11008
   Google Scholar
• Bayne ML, Applebaum J, et al. The roles of tyrosines 24, 31, and 60 in the high affinity binding of insulin-like growth factor-I to the type 1 insulin-like growth factor receptor. J Biol Chem 1990; 265(26)15648–15652
   Google Scholar
• Bjerrum OJ, Schafer-Nielsen C. Buffer systems and transfer parameters for semidry electroblotting with a horizontal apparatus. Electrophoresis '86, MJ Dunn. VCH Publishers, Deerfield Beach, FL 1986; 315–327
   Google Scholar
• Brewster L, Brey EM, et al. Improving endothelial healing with novel chimeric mitogens. Am J Surg 2006; 192(5)589–593
   Google Scholar
• Brewster LP, Brey EM, et al. Heparin-independent mitogenicity in an endothelial and smooth muscle cell chimeric growth factor (S130K-HBGAM). Am J Surg 2004; 188(5)575–579
   Google Scholar
• Cascieri MA, Chicchi GG, et al. Mutants of human insulin-like growth factor I with reduced affinity for the type 1 insulin-like growth factor receptor. Biochemistry 1988; 27(9)3229–3233
   Google Scholar
• Clemmons DR, Maile LA. Interaction between insulin-like growth factor-I receptor and alphaVbeta3 integrin linked signaling pathways: Cellular responses to changes in multiple signaling inputs. Mol Endocrinol 2005; 19(1)1–11
   PubMed Web of Science ®Google Scholar
• Clemmons DR, Horvitz G, et al. Synthetic alphaVbeta3 antagonists inhibit insulin-like growth factor-I-stimulated smooth muscle cell migration and replication. Endocrinology 1999; 140(10)4616–4621
   Google Scholar
• Congote LF. Increased heparin binding by site directed mutagenesis of a recombinant chimera of bombyxin and insulin-like growth factor II. Biochim Biophys Acta 1995; 1243(3)538–542
   Google Scholar
• Congote LF, Li Q. Accurate processing and secretion in the baculovirus expression system of an erythroid-cell-stimulating factor consisting of a chimaera of insulin-like growth factor II and an insect insulin-like peptide. Biochem J 1994; 299(Pt 1)101–107
   Google Scholar
• Cory AH, Owen TC, et al. Use of an aqueous soluble tetrazolium/formazan assay for cell growth assays in culture. Cancer Commun 1991; 3(7)207–212
   PubMed Web of Science ®Google Scholar
• Dawson RA, Upton Z, et al. Preparation of cultured skin for transplantation using insulin-like growth factor I in conjunction with insulin-like growth factor binding protein 5, epidermal growth factor, and vitronectin. Transplantation 2006; 81(12)1668–1676
   PubMed Web of Science ®Google Scholar
• Denley A, Cosgrove LJ, et al. Molecular interactions of the IGF system. Cytokine Growth Factor Rev 2005; 16(4–5)421–439
   Google Scholar
• Difalco MR, Congote LF. Preparation of a recombinant chimaera of insulin-like growth factor II and interleukin 3 with high proliferative potency for haemopoietic cells. Biochem J 1997; 326(Pt 2)407–413
   Google Scholar
• Doerr ME, Jones JI. The roles of integrins and extracellular matrix proteins in the insulin-like growth factor I-stimulated chemotaxis of human breast cancer cells. J Biol Chem 1996; 271(5)2443–2447
   PubMed Web of Science ®Google Scholar
• Edman P. Method for determination of the amino acid sequence in peptides. Acta Chemi Scand 1950; 4: 283
   Google Scholar
• Eliceiri BP. Integrin and growth factor receptor crosstalk. Circ Res 2001; 89(12)1104–1110
   PubMed Web of Science ®Google Scholar
• Ewing NP, Cassady CJ. Dissociation of multiply charged negative ions for hirudin (54–65), fibrinopeptide B, and insulin A (oxidized). J Am Soc Mass Spectrom 2001; 12(1)105–116
   Google Scholar
• Fincham VJ, James M, et al. Active ERK/MAP kinase is targeted to newly forming cell-matrix adhesions by integrin engagement and v-Src. Embo J 2000; 19(12)2911–2923
   PubMed Web of Science ®Google Scholar
• Fryklund L, Sievertsson H. Primary structure of somatomedin B: A growth hormone-dependent serum factor with protease inhibiting activity. FEBS Lett 1978; 87(1)55–60
   Google Scholar
• Geisse S, Gram H, et al. Eukaryotic expression systems: A comparison. Protein Expr Purif 1996; 8(3)271–282
   PubMed Web of Science ®Google Scholar
• Giancotti FG, Ruoslahti E. Integrin signaling. Science 1999; 285(5430)1028–1032
   PubMed Web of Science ®Google Scholar
• Harrison RL, Jarvis DL. Protein N-glycosylation in the baculovirus-insect cell expression system and engineering of insect cells to produce “mammalianized” recombinant glycoproteins. Adv Virus Res 2006; 68: 159–191
   PubMed Web of Science ®Google Scholar
• Hollier B, Harkin DG, et al. Responses of keratinocytes to substrate-bound vitronectin: Growth factor complexes. Exp Cell Res 2005; 305(1)221–232
   PubMed Web of Science ®Google Scholar
• Hollier BG, Kricker JA, et al. The PI3-K/AKT pathway mediates substrate-bound IGF-I:IGFBP:Vitronectin complex stimulated breast cell migration. Endocrinology 2007, Submitted
   Google Scholar
• Hu YC. Baculovirus as a highly efficient expression vector in insect and mammalian cells. Acta Pharmacol Sin 2005; 26(4)405–416
   Google Scholar
• Huang C, Jacobson K, et al. MAP kinases and cell migration. J Cell Sci 2004; 117(Pt 20)4619–4628
   PubMed Web of Science ®Google Scholar
• Hudson PJ. Recombinant antibody fragments. Curr Opin Biotechnol 1998; 9(4)395–402
   PubMedGoogle Scholar
• Huston JS, Levinson D, et al. Protein engineering of antibody binding sites: Recovery of specific activity in an anti-digoxin single-chain Fv analogue produced in Escherichia coli. Proc Natl Acad Sci USA 1988; 85(16)5879–5883
   PubMed Web of Science ®Google Scholar
• Hyde C, Hollier B, et al. Insulin-like growth factors (IGF) and IGF-binding proteins bound to vitronectin enhance keratinocyte protein synthesis and migration. J Invest Dermatol 2004; 122(5)1198–1206
   PubMed Web of Science ®Google Scholar
• Ishikawa T, Eguchi M, et al. Establishment of a functionally active collagen-binding vascular endothelial growth factor fusion protein in situ. Arterioscler Thromb Vasc Biol 2006; 26(9)1998–2004
   Google Scholar
• Josic D, Kannicht C, et al. Vitronectin in clotting factor IX concentrates. Haemophilia 2001; 7(3)250–257
   Google Scholar
• Keyhanfar M, Booker GW, et al. Precise mapping of an IGF-I-binding site on the IGF-1R. Biochem J 2007; 401(1)269–277
   Google Scholar
• Klemke RL, Yebra M, et al. Receptor tyrosine kinase signaling required for integrin alpha v beta 5-directed cell motility but not adhesion on vitronectin. J Cell Biol 1994; 127(3)859–866
   PubMed Web of Science ®Google Scholar
• Klemke RL, Cai S, et al. Regulation of cell motility by mitogen-activated protein kinase. J Cell Biol 1997; 137(2)481–492
   PubMedGoogle Scholar
• Kortt AA, Lah M, et al. Single-chain Fv fragments of anti-neuraminidase antibody NC10 containing five- and ten-residue linkers form dimers and with zero-residue linker a trimer. Protein Eng 1997; 10(4)423–433
   Google Scholar
• Kricker JA, Towne CL, et al. Structural and functional evidence for the interaction of insulin-like growth factors (IGFs) and IGF binding proteins with vitronectin. Endocrinology 2003; 144(7)2807–2815
   PubMed Web of Science ®Google Scholar
• Laemmli UK. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 1970; 227(5259)680–685
   PubMed Web of Science ®Google Scholar
• Leavesley DI, Schwartz MA, et al. Integrin beta 1- and beta 3-mediated endothelial cell migration is triggered through distinct signaling mechanisms. J Cell Biol 1993; 121(1)163–170
   PubMed Web of Science ®Google Scholar
• Ling Y, Maile LA, et al. Tyrosine phosphorylation of the beta3-subunit of the alphaVbeta3 integrin is required for embrane association of the tyrosine phosphatase SHP-2 and its further recruitment to the insulin-like growth factor I receptor. Mol Endocrinol 2003; 17(9)1824–1833
   Google Scholar
• Lynn GW, Heller WT, et al. A model for the three-dimensional structure of human plasma vitronectin from small-angle scattering measurements. Biochemistry 2005; 44(2)565–574
   Google Scholar
• Maile LA, Badley-Clarke J, et al. Structural analysis of the role of the beta 3 subunit of the alpha V beta 3 integrin in IGF-I signaling. J Cell Sci 2001; 114(Pt 7)1417–1425
   Google Scholar
• Maile LA, Busby WH, et al. Insulin-like growth factor-I signaling in smooth muscle cells is regulated by ligand binding to the 177CYDMKTTC184 sequence of the beta3-subunit of alphaVbeta3. Mol Endocrinol 2006; 20(2)405–413
   PubMedGoogle Scholar
• Majack RA, Cook SC, et al. Control of smooth muscle cell growth by components of the extracellular matrix: Autocrine role for thrombospondin. Proc Natl Acad Sci USA 1986; 83(23)9050–9054
   PubMed Web of Science ®Google Scholar
• Michieli P, Cavassa S, et al. An HGF-MSP chimera disassociates the trophic properties of scatter factors from their pro-invasive activity. Nat Biotechnol 2002; 20(5)488–495
   Google Scholar
• Miyamoto S, Teramoto H, et al. Integrins can collaborate with growth factors for phosphorylation of receptor tyrosine kinases and MAP kinase activation: Roles of integrin aggregation and occupancy of receptors. J Cell Biol 1996; 135(6 Pt 1)1633–1642
   Google Scholar
• Morris CA, Underwood PA, et al. Relative topography of biologically active domains of human vitronectin. Evidence from monoclonal antibody epitope and denaturation studies. J Biol Chem 1994; 269(38)23845–23852
   Google Scholar
• Noble A, Towne C, et al. Insulin-like growth factor-II bound to vitronectin enhances MCF-7 breast cancer cell migration. Endocrinology 2003; 144(6)2417–2424
   PubMed Web of Science ®Google Scholar
• Nurcombe V, Smart CE, et al. The proliferative and migratory activities of breast cancer cells can be differentially regulated by heparan sulfates. J Biol Chem 2000; 275(39)30009–30018
   Google Scholar
• Plopper GE, McNamee HP, et al. Convergence of integrin and growth factor receptor signaling pathways within the focal adhesion complex. Mol Biol Cell 1995; 6(10)1349–1365
   Google Scholar
• Rahman S, Patel Y, et al. Novel hepatocyte growth factor (HGF) binding domains on fibronectin and vitronectin coordinate a distinct and amplified Met-integrin induced signalling pathway in endothelial cells. BMC Cell Biol 2005; 6(1)8
   Google Scholar
• Sandoval C, Curtis H, et al. Enhanced proliferative effects of a baculovirus-produced fusion protein of insulin-like growth factor and alpha(1)-proteinase inhibitor and improved anti-elastase activity of the inhibitor with glutamate at position 351. Protein Eng 2002; 15(5)413–418
   PubMedGoogle Scholar
• Sandoval C, Stojanova A, et al. The fusion of IGF I with stromal cell-derived factor I or alpha1 proteinase inhibitor alters their mitogenic or chemotactic activities while keeping their ability to inhibit HIV-1-gp120 binding. Biochem Pharmacol 2003; 65(12)2055–2063
   Google Scholar
• Schleicher I, Parker A, et al. Surface modification by complexes of vitronectin and growth factors for serum-free culture of human osteoblasts. Tissue Eng 2005; 11(11–12)1688–1698
   PubMedGoogle Scholar
• Schvartz I, Seger D, et al. Vitronectin. Int J Biochem Cell Biol 1999; 31(5)539–544
   Google Scholar
• Sunstrom NA, Gay RD, et al. Insulin-like growth factor-I and transferrin mediate growth and survival of Chinese hamster ovary cells. Biotechnol Prog 2000; 16(5)698–702
   Google Scholar
• Tai YT, Podar K, et al. Insulin-like growth factor-1 induces adhesion and migration in human multiple myeloma cells via activation of beta1-integrin and phosphatidylinositol 3′-kinase/AKT signaling. Cancer Res 2003a; 63(18)5850–5858
   PubMed Web of Science ®Google Scholar
• Tai YT, Podar K, et al. CD40 induces human multiple myeloma cell migration via phosphatidylinositol 3-kinase/AKT/NF-kappa B signaling. Blood 2003b; 101(7)2762–2769
   PubMed Web of Science ®Google Scholar
• Turner DJ, Ritter MA, et al. Importance of the linker in expression of single-chain Fv antibody fragments: Optimisation of peptide sequence using phage display technology. J Immunol Methods 1997; 205(1)43–54
   Google Scholar
• Upton Z, Webb H, et al. Identification of vitronectin as a novel insulin-like growth factor-II binding protein. Endocrinology 1999; 140(6)2928–2931
   PubMed Web of Science ®Google Scholar
• Upton Z, Cuttle L, et al. Topical application of nanogram amounts of a novel vitronectin: Growth factor complex significantly enhances wound healing in vivo. J Invest Dermatol 2007, Submitted
   Google Scholar
• Vuori K, Ruoslahti E. Association of insulin receptor substrate-1 with integrins. Science 1994; 266(5190)1576–1578
   Google Scholar
• Wilkins MR, Gasteiger E, et al. Protein identification and analysis tools in the ExPASy server. Methods Mol Biol 1999; 112: 531–552
   PubMedGoogle Scholar
• Yamboliev IA, Gerthoffer WT. Modulatory role of ERK MAPK-caldesmon pathway in PDGF-stimulated migration of cultured pulmonary artery SMCs. Am J Physiol Cell Physiol 2001; 280(6)C1680–C1688
   PubMed Web of Science ®Google Scholar
• Yamboliev IA, Chen J, et al. PI 3-kinases and Src kinases regulate spreading and migration of cultured VSMCs. Am J Physiol Cell Physiol 2001; 281(2)C709–C718
   Google Scholar
• Zheng B, Clemmons DR. Blocking ligand occupancy of the alphaVbeta3 integrin inhibits insulin-like growth factor I signaling in vascular smooth muscle cells. Proc Natl Acad Sci USA 1998; 95(19)11217–11222
   PubMedGoogle Scholar