Stimulation of extracellular signal-regulated kinases and proliferation in the human gastric cancer cells KATO-III by obestatin

References

• Bagrodia S, Chackalaparampil I, Kmiecik TE, Shalloway D. Altered tyrosine 527 phosphorylation and mitotic activation of p60c-src. Nature 1991; 349: 172–175
   PubMedGoogle Scholar
• Batterham RL, Cowley MA, Small CJ, Herzog H, Cohen MA, Dakin CL, Wren AM, Brynes AE, Low MJ, Ghatei MA, Cone RD, Bloom SR. Gut hormone PYY(3–36) physiologically inhibits food intake. Nature 2002; 418: 650–654
   PubMed Web of Science ®Google Scholar
• Batterham RL, Cohen MA, Ellis SM, Le Roux CW, Withers DJ, Frost GS, Ghatei MA, Bloom SR. Inhibition of food intake in obese subjects by peptide YY3-36. N Engl J Med 2003; 349: 941–948
   PubMed Web of Science ®Google Scholar
• Boggiano MM, Chandler PC, Oswald KD, Rodgers RJ, Blundell JE, Ishii Y, Beattie AH, Holch P, Allison DB, Schindler M, Arndt K, Rudolf K, Mark M, Schoelch C, Joost HG, Klaus S, Thöne-Reineke C, Benoit SC, Seeley RJ, Beck-Sickinger AG, Koglin N, Raun K, Madsen K, Wulff BS, Stidsen CE, Birringer M, Kreuzer OJ, Deng XY, Whitcomb DC, Halem H, Taylor J, Dong J, Datta R, Culler M, Ortmann S, Castañeda TR, Tschöp M. PYY3-36 as an anti-obesity drug target. Obes Rev 2005; 6: 307–322
   Google Scholar
• Brandt DT, Goerke A, Heuer M, Gimona M, Leitges M, Kremmer E, Lammers R, Haller H, Mischak H. Protein kinase C delta induces Src kinase activity via activation of the protein tyrosine phosphatase PTP alpha. J Biol Chem 2003; 278: 34073–34078
   PubMed Web of Science ®Google Scholar
• Bresciani E, Rapetti D, Dòna F, Bulgarelli I, Tamiazzo L, Locatelli V, Torsello A. Obestatin inhibits feeding but does not modulate GH and corticosterone secretion in the rat. J Endocrinol Invest 2006; 29: RC16–RC18
   Google Scholar
• Camiña JP, Campos JF, Caminos JE, Dieguez C, Casanueva FF. Obestatin-mediated proliferation of human retinal pigment epithelial cells: Regulatory mechanisms. J Cell Physiol 2007; 211: 1–9
   PubMedGoogle Scholar
• Carlini VP, Schioth HB, Debarioglio SR. Obestatin improves memory performance and causes anxiolytic effects in rats. Biochem Biophys Res Commun 2007; 352: 907–912
   PubMed Web of Science ®Google Scholar
• Coll AP, Farooqi IS, Challis BG, Yeo GS, O'Rahilly S. Proopiomelanocortin and energy balance: Insights from human and murine genetics. J Clin Endocrinol Metab 2004; 89: 2557–2562
   PubMed Web of Science ®Google Scholar
• Chartrel N, Alvear-Perez R, Leprince J, Iturrioz X, Reaux-Le Goazigo A, Audinot V, Chomarat P, Coge F, Nosjean O, Rodriguez M, Galizzi JP, Boutin JA, Vaudry H, Llorens-Cortes C. Comment on “Obestatin, a peptide encoded by the ghrelin gene, opposes ghrelin's effects on food intake”. Science 2007; 315: 766
   Google Scholar
• Cummings DE, Overduin J. Gastrointestinal regulation of food intake. J Clin Invest 2007; 117: 13–23
   PubMed Web of Science ®Google Scholar
• Dun SL, Brailoiu GC, Brailoiu E, Yang J, Chang JK, Dun NJ. Distribution and biological activity of obestatin in the rat. J Endocrinol 2006; 191: 481–489
   PubMedGoogle Scholar
• Frame MC. Src in cancer: Deregulation and consequences for cell behaviour. Biochim Biophys Acta 2002; 1602: 114–130
   PubMed Web of Science ®Google Scholar
• Gould KL, Woodgett JR, Cooper JA, Buss JE, Shalloway D, Hunter T. Protein kinase C phosphorylates pp60src at a novel site. Cell 1985; 42: 849–857
   PubMedGoogle Scholar
• Gourcerol G, Million M, Adelson DW, Wang Y, Wang L, Rivier J, St-Pierre DH, Taché Y. Lack of interaction between peripheral injection of CCK and obestatin in the regulation of gastric satiety signaling in rodents. Peptides 2006; 27: 2811–2819
   PubMed Web of Science ®Google Scholar
• Hawes BE, Luttrell LM, van Biesen T, Lefkowitz RJ. Phosphatidylinositol 3-kinase is an early intermediate in the G beta gamma-mediated mitogen-activated protein kinase signaling pathway. J Biol Chem 1996; 271: 12133–12136
   PubMedGoogle Scholar
• Holst B, Egerod KL, Schild E, Vickers SP, Cheetham S, Gerlach LO, Storjohann L, Stidsen CE, Jones R, Beck-Sickinger AG, Schwartz TW. GPR39 signaling is stimulated by zinc ions but not by obestatin. Endocrinology 2007; 148: 13–20
   PubMed Web of Science ®Google Scholar
• Kaech S, Covic L, Wyss A, Ballmer-Hofer K. Association of p60c-src with polyoma virus middle-T antigen abrogating mitosis-specific activation. Nature 1991; 350: 431–433
   PubMedGoogle Scholar
• Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H, Kangawa K. Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 1999; 402: 656–660
   PubMed Web of Science ®Google Scholar
• Lagaud GJ, Young A, Acena A, Morton MF, Barrett TD, Shankley NP. Obestatin reduces food intake and suppresses body weight gain in rodents. Biochem Biophys Res Commun 2007; 357: 264–269
   PubMedGoogle Scholar
• Moyers JS, Bouton AH, Parsons SJ. The sites of phosphorylation by protein kinase C and an intact SH2 domain are required for the enhanced response to beta-adrenergic agonists in cells overexpressing c-src. Mol Cell Biol 1993; 13: 2391–2400
   PubMedGoogle Scholar
• Nogueiras R, Pfluger P, Tovar S, Arnold M, Mitchell S, Morris A, Perez-Tilve D, Vazquez MJ, Wiedmer P, Castañeda TR, DiMarchi R, Tschöp M, Schurmann A, Joost HG, Williams LM, Langhans W, Dieguez C. Effects of obestatin on energy balance and growth hormone secretion in rodents. Endocrinology 2007; 148: 21–26
   PubMed Web of Science ®Google Scholar
• Parker PJ, Murray-Rust J. PKC at a glance. J Cell Sci 2004; 117: 131–132
   PubMed Web of Science ®Google Scholar
• Piiper A, Elez R, You SJ, Kronenberger B, Loitsch S, Roche S, Zeuzem S. Cholecystokinin stimulates extracellular signal-regulated kinase through activation of the epidermal growth factor receptor. Yes and protein kinase C. Signal amplification at the level of Raf by activation of protein kinase Cepsilon. J Biol Chem 2003; 278: 7065–7072
   Google Scholar
• Raffin-Sanson ML, de Keyzer Y, Bertagna X. Proopiomelanocortin, a polypeptide precursor with multiple functions: From physiology to pathological conditions. Eur J Endocrinol 2003; 149: 79–90
   PubMedGoogle Scholar
• Roskoski R, Jr. Src kinase regulation by phosphorylation and dephosphorylation. Biochem Biophys Res Commun 2005; 331: 1–14
   PubMed Web of Science ®Google Scholar
• Samson WK, White MM, Price C, Ferguson AV. Obestatin acts in brain to inhibit thirst. Am J Physiol Regul Integr Comp Physiol 2007; 292: R637–R643
   PubMed Web of Science ®Google Scholar
• Seoane LM, Al-Massadi O, Pazos Y, Pagotto U, Casanueva FF. Central obestatin administration does not modify either spontaneous or ghrelin-induced food intake in rats. J Endocrinol Invest 2006; 29: RC13–RC15
   Google Scholar
• Szentirmai E, Krueger JM. Obestatin alters sleep in rats. Neurosci Lett 2006; 404: 222–226
   PubMed Web of Science ®Google Scholar
• Thomas SM, Brugge JS. Cellular functions regulated by Src family kinases. Annu Rev Cell Dev Biol 1997; 13: 513–609
   PubMed Web of Science ®Google Scholar
• Tremblay F, Perreault M, Klaman LD, Tobin JF, Smith E, Gimeno RE. Normal food intake and body weight in mice lacking the G protein-coupled receptor GPR39. Endocrinology 2007; 148: 501–506
   Google Scholar
• van der Lely AJ, Tschöp M, Heiman ML, Ghigo E. Biological, physiological, pathophysiological and pharmacological aspects of ghrelin. Endocr Rev 2004; 25: 426–457
   PubMed Web of Science ®Google Scholar
• Yamamoto D, Ikeshita N, Daito R, Herningtyas EH, Toda K, Takahashi K, Iida K, Takahashi Y, Kaji H, Chihara K, Okimura Y. Neither intravenous nor intracerebroventricular administration of obestatin affects the secretion of GH, PRL, TSH and ACTH in rats. Regul Pept 2007; 138: 141–144
   Google Scholar
• Yart A, Chap H, Raynal P. Phosphoinositide 3-kinases in lysophosphatidic acid signaling: Regulation and cross-talk with the Ras/mitogen-activated protein kinase pathway. Biochim Biophys Acta 2002; 1582: 107–111
   Google Scholar
• Yeatman TJ. A renaissance for SRC. Nat Rev Cancer 2004; 4: 470–480
   PubMed Web of Science ®Google Scholar
• Zhang JV, Ren PG, Avsian-Kretchmer O, Luo CW, Rauch R, Klein C, Hsueh AJ. Obestatin, a peptide encoded by the ghrelin gene, opposes ghrelin's effects on food intake. Science 2005; 310: 996–999
   PubMed Web of Science ®Google Scholar
• Zheng XM, Wang Y, Pallen CJ. Cell transformation and activation of pp60c-src by overexpression of a protein tyrosine phosphatase. Nature 1992; 359: 336–339
   PubMed Web of Science ®Google Scholar
• Zheng XM, Resnick RJ, Shalloway D. Mitotic activation of protein–tyrosine phosphatase alpha and regulation of its Src-mediated transforming activity by its sites of protein kinase C phosphorylation. J Biol Chem 2002; 277: 21922–21929
   PubMedGoogle Scholar
• Zizzari P, Longchamps R, Epelbaum J, Bluet-Pajot MT. Obestatin partially affects ghrelin stimulation of food intake and growth hormone secretion in rodents. Endocrinology 2007; 148: 1648–1653
   PubMed Web of Science ®Google Scholar