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Original

The antifibrogenic effect of hepatocyte growth factor (HGF) on renal tubular (HK-2) cells is dependent on cell growth

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Pages 173-180 | Received 30 Jun 2008, Accepted 10 Feb 2009, Published online: 11 Jul 2009

References

  • Branton MH, Kopp JB. TGF-β and fibrosis. Microbes Infect 1999; 1: 1349–1365
  • Brinkmann V, Foroutan H, Sachs M, Weidner KM, Birchmeier W. Hepatocyte growth factor/scatter factor induces a variety of tissue-specific morphogenic programs in epithelial cells. J Cell Biol 1995; 131: 1573–1586
  • Cosio FG. Cell matrix adhesion receptors: Relevance to glomerular pathology. Am J Kidney Dis 1992; 20: 294–305
  • De Caestecker MP, Parks WT, Frank CJ, Castagnino P, Bottaro DP, Roberts AB, Lechleider RJ. Smad2 transduces common signals from receptor serine–threonine and tyrosine kinases. Gene Dev 1998; 12: 1587–1592
  • Esposito C, Fornoni A, Cornacchia F, Bellotti N, Fasoli G, Foschi A, Mazzucchelli I, Mazzullo T, Semeraro L, Dal Canton A. Cyclosporine induces different responses in human epithelial, endothelial and fibroblast cell cultures. Kidney Int 2000; 58: 123–130
  • Esposito C, Parrilla B, De Mauri A, Cornacchia F, Fasoli G, Foschi A, Mazzullo T, Plati AR, Scudellaro R, Dal Canton A. Hepatocyte growth factor (HGF) modulates matrix turnover in human glomeruli. Kidney Int 2005; 67: 2143–2150
  • Flaumenhaft R, Rifkin DB. The extracellular regulation of growth factor action. Mol Biol Cell 1992; 3: 1057–1065
  • Folkman J, Moscona A. Role of cell shape in growth control. Nature 1978; 273: 345–349
  • He CJ, Striker LJ, Tsokos M, Yang CW, Peten EP, Striker GE. Relationships between mesangial cell proliferation and type I and IV collagen mRNA levels in vitro. Am J Physiol 1995; 269: C554–C562
  • He CJ, Esposito C, Phillips C, Zalups RK, Henderson DA, Striker GE, Striker LJ. Dissociation of glomerulosclerosis, glomerular hypertrophy and cell proliferation in mouse strains heterozygous for a mutation (Os) which induces a 50% reduction in nephron number. J Clin Invest 1996; 97: 1242–1249
  • Inoue T, Okada H, Kobayashi T, Watanabe Y, Kanno Y, Kopp JB, Nishida T, Takigawa M, Ueno M, Nakamura T, Suzuki H. Hepatocyte growth factor counteracts transforming growth factor-β1, through attenuation of connective tissue growth factor induction, and prevent renal fibrogenesis in 5/6 nephrectomised mice. FASEB J 2003; 17: 268–272
  • Liu Y, Centracchio JN, Lin L, Sun AM, Dworkin LD. Constitutive expression of HGF modulates renal epithelial cell phenotype and induces c-met and fibronectine expression. Exp Cell Res 1998; 242: 174–178
  • Madri JA, Marx M. Matrix composition, organisation and soluble factors: Modulators of microvascular cell differentiation in vitro. Kidney Int 1992; 41: 560–566
  • Matsumoto K, Nakamura T. Hepatocyte growth factor (HGF) as a tissue organizer for organogenesis and regeneration. Biochem Biophys Res Commun 1997; 239: 639–644
  • Mizuno S, Matsumoto K, Nakamura T. Hepatocyte growth factor suppresses interstitial fibrosis in a mouse model of obstructive nephropathy. Kidney Int 2001; 59: 1304–1314
  • Nakamura T, Teramoto H, Ichihara A. Purification and characterization of a growth factor from rat platelets for mature parenchymal hepatocytes in primary cultures. Proc Natl Acad Sci USA 1986; 83: 6489–6493
  • Naldini L, Vigna E, Narsimhan R, Gaudino P, Zarnegar R, Michalopoulos GA, Comoglio PM. Hepatocyte growth factor (HGF) stimulates the tyrosine kinase activity of the receptor encoded by the proto-oncogene c-met. Oncogene 1991; 6: 501–504
  • Okada H, Danoff TM, Kalluri R, Neilson EG. Early role of Fsp1 in epithelial–mesenchymal transformation. Am J Physiol 1997; 273: F563–F574
  • Rampino T, Cancarini G, Gregorini M, Guallini P, Maggio M, Ranghino A, Soccio G, Dal Canton A. Hepatocyte growth factor/scatter factor released during peritonitis is active on mesothelial cells. Am J Pathol 2001; 159: 1275–1285
  • Steuli CH, Schmidhauser C, Kobrin M, Bissell MJ, Derynck R. Extracellular matrix regulates expression of the TGF-β gene. J Cell Biol 1993; 120: 253–260
  • Stoker M, Gherardi E, Perryman M, Gray J. Scatter factor is a fibroblast-derived modulator of epithelial cell mobility. Nature (Lond) 1987; 327: 238–242
  • Takayama H, LaRochelle WJ, Sabnis SG, Otsuka T, Merlino G. Renal tubular hyperplasia, polycystic disease and glomerulosclerosis in transgenic mice over expressing hepatocyte growth factor/scatter factor. Lab Invest 1997; 77: 131–138
  • Wang SN, Hirschberg R. Growth factor ultrafiltration in experimental diabetic nephropathy contributes to interstitial fibrosis. Am J Physiol Renal Physiol 2000; 278: F554–F560
  • Weidner KM, Sachs M, Birchmeier W. The MET receptor tyrosine kinase transduces motility, proliferation and morphogenic signals of scatter factor/hepatocyte growth factor in epithelial cells. J Cell Biol 1993; 121: 145–154
  • Wolthuis A, Boes A, Grond J. Cell density modulates growth, extracellular matrix and protein synthesis of cultured rat mesangial cells. Am J Pathol 1993; 1: 1209–1219
  • Yang J, Liu Y. Blockage of tubular epithelial to myofibroblast transition by hepatocyte growth factor prevents renal interstitial fibrosis. J Am Soc Nephrol 2002; 13: 96–107
  • Yang J, Liu Y. Delayed administration of hepatocyte growth factor reduces renal fibrosis in obstructive nephropathy. Am J Physiol Renal Physiol 2003; 284: F349–F357
  • Yang J, Dai C, Liu Y. Hepatocyte growth factor suppresses renal interstitial myofibroblast activation and intercepts Smad signal transduction. Am J Pathol 2003; 163: 621–632
  • Yang J, Zhang X, Li Y, Liu Y. Downregulation of Smad transcriptional co repressor SnoN and Ski in the fibrotic kidney: An amplification mechanism for TGF-β signalling. J Am Soc Nephrol 2003; 14: 3167–3177
  • Yang J, Dai C, Liu Y. A novel mechanism by which hepatocyte growth factor blocks tubular epithelial to mesenchymal transition. J Am Soc Nephrol 2005; 16: 68–78
  • Yang H, Magilnik N, Noureddin M, Mato JM, Lu SC. Effect of hepatocyte growth factor on methionine adenosyltransferase genes and growth is cell density-dependent in HepG2 cells. J Cell Physiol 2007; 210: 766–773
  • Yung S, Chen XR, Tsang RC, Zhang Q, Chan TM. Reduction of perlecan synthesis and induction of TGF-β in human peritoneal mesothelial cells due to high dialysate glucose concentration: Implication in peritoneal dialysis. J Am Soc Nephrol 2004; 15: 1178–1188

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