102
Views
19
CrossRef citations to date
0
Altmetric
Original

Stability of local brain levels of insulin-like growth factor-I in two well-characterized models of decreased plasma IGF-I

, , , , &
Pages 181-188 | Received 10 Nov 2008, Accepted 02 Mar 2009, Published online: 11 Jul 2009

References

  • Bondy CA, Werner H, Roberts CT, Jr, LeRoith D. Cellular pattern of insulin-like growth factor-I (IGF-I) and type I IGF receptor gene expression in early organogenesis: Comparison with IGF-II gene expression. Mol Endocrinol 1990; 4: 1386–1398
  • Breese CR, D'Costa A, Rollins YD, Adams C, Booze RM, Sonntag WE, Leonard S. Expression of insulin-like growth factor-1 (IGF-1) and IGF-binding protein 2 (IGF-BP2) in the hippocampus following cytotoxic lesion of the dentate gyrus. J Comp Neurol 1996; 369: 388–404
  • Carter CS, Ramsey MM, Ingram RL, Cashion AB, Cefalu WT, Wang ZQ, Sonntag WE. Models of growth hormone and IGF-1 deficiency: Applications to studies of aging processes and life-span determination. J Gerontol A Biol Sci Med Sci 2002a; 57: B177–B188
  • Carter CS, Ramsey MM, Sonntag WE. A critical analysis of the role of growth hormone and IGF-1 in aging and lifespan. Trends Genet 2002b; 18: 295–301
  • D'Ercole AJ, Stiles AD, Underwood LE. Tissue concentrations of somatomedin C: Further evidence for multiple sites of synthesis and paracrine or autocrine mechanisms of action. Proc Natl Acad Sci USA 1984; 81: 935–939
  • Delafontaine P, Lou H, Alexander RW. Regulation of insulin-like growth factor I messenger RNA levels in vascular smooth muscle cells. Hypertension 1991; 18: 742–747
  • Jafferali S, Dumont Y, Sotty F, Robitaille Y, Quirion R, Kar S. Insulin-like growth factor-I and its receptor in the frontal cortex, hippocampus, and cerebellum of normal human and alzheimer disease brains. Synapse 2000; 38: 450–459
  • Le Grevès M, Le Grevès P, Nyberg F. Age-related effects of IGF-I on the NMDA-, GH- and IGF-I-receptor mRNA transcripts in the rat hippocampus. Brain Res Bull 2005; 65: 369–374
  • Le Roith D, Bondy C, Yakar S, Liu JL, Butler A. The somatomedin hypothesis. Endocr Rev 2001; 22: 53–74
  • Lichtenwalner RJ, Forbes ME, Bennett SA, Lynch CD, Sonntag WE, Riddle DR. Intracerebroventricular infusion of insulin-like growth factor-I ameliorates the age-related decline in hippocampal neurogenesis. Neuroscience 2001; 107: 603–613
  • Markowska AL, Mooney M, Sonntag WE. Insulin-like growth factor-1 ameliorates age-related behavioral deficits. Neuroscience 1998; 87: 559–569
  • Masoro EJ. Overview of caloric restriction and ageing. Mech Ageing Dev 2005; 126: 913–922
  • Molina DP, Weiner JL, Ariwodola SJ, Sonntag WE, Adams MM, Brunso-Bechtold JK. Effect of growth hormone (GH) supplementation on age-related changes in excitatory synaptic transmission in CA1. Soc Neurosci Abstr 2008; 537: 18
  • Nieto-Bona MP, Garcia-Segura LM, Torres-Alemán I. Transynaptic modulation by insulin-like growth factor I of dendritic spines in Purkinje cells. Int J Dev Neurosci 1997; 15: 749–754
  • Nyberg F. Growth hormone in the brain: Characteristics of specific brain targets for the hormone and their functional significance. Front Neuroendocrinol 2000; 21: 330–348
  • Pan W, Kastin AJ. Interactions of IGF-I with the blood–brain barrier in vivo and in situ. Neuroendocrinology 2000; 72: 171–178
  • Ramsey MM, Adams MM, Ariwodola OJ, Sonntag WE, Weiner JL. Functional characterization of des-IGF-1 action at excitatory synapses in the CA1 region of rat hippocampus. J Neurophysiol 2005; 94: 247–254
  • Reinhardt RR, Bondy CA. Insulin-like growth factors cross the blood–brain barrier. Endocrinology 1994; 135: 1753–1761
  • Shi L, Linville MC, Tucker EW, Sonntag WE, Brunso-Bechtold JK. Differential effects of aging and insulin-like growth factor-1 on synapses in CA1 of rat hippocampus. Cereb Cortex 2004; 15: 571–577, Epub 2004 Aug 18
  • Sonntag WE, Lynch CD, Cooney PT, Hutchins PM. Decreases in cerebral microvasculature with age are associated with the decline in growth hormone and insulin-like growth factor 1. Endocrinology 1997; 138: 3515–3520
  • Sonntag WE, Lynch CD, Bennett SA, Khan AS, Thornton PL, Cooney PT, Ingram RL, McShane T, Brunso-Bechtold JK. Alterations in insulin-like growth factor-1 gene and protein expression and type 1 insulin-like growth factor receptors in the brains of ageing rats. Neuroscience 1999; 88: 269–279
  • Sonntag WE, Bennett SA, Khan AS, Thornton PL, Xu X, Ingram RL, Brunso-Bechtold JK. Age and insulin-like growth factor-1 modulate N-methyl-d-aspartate receptor subtype expression in rats. Brain Res Bull 2000; 51: 331–338
  • Sonntag WE, Carter CS, Ikeno Y, Ekenstedt K, Carlson CS, Loeser RF, Chakrabarty S, Lee S, Bennett C, Ingram R, Moore T, Ramsey M. Adult-onset growth hormone and insulin-like growth factor 1 deficiency reduces neoplastic disease, modifies age-related pathology, and increases life span. Endocrinology 2005a; 146: 2920–2932
  • Sonntag WE, Ramsey M, Carter CS. Growth hormone and insulin-like growth factor-1 (IGF-1) and their influence on cognitive aging. Ageing Res Rev 2005b; 4: 195–212
  • Walter HJ, Berry M, Hill DJ, Logan A. Spatial and temporal changes in the insulin-like growth factor (IGF) axis indicate autocrine/paracrine actions of IGF-I within wounds of the rat brain. Endocrinology 1997; 138: 3024–3034
  • Xu X, Sonntag WE. Growth hormone and aging: Regulation, signal transduction and replacement therapy. Trends Endocrinol Metab 1996; 7: 145–150
  • Yamamoto H, Murphy LJ. Enzymatic conversion of IGF-I to des(1-3)IGF-I in rat serum and tissues: A further potential site of growth hormone regulation of IGF-I action. J Endocrinol 1995; 146: 141–148

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.