181
Views
0
CrossRef citations to date
0
Altmetric
Research Paper

Differential effects of epidermal growth factor (EGF) receptor ligands on receptor binding, downstream signalling pathways and DNA synthesis in hepatocytes

, , , , , & show all
Pages 239-248 | Received 22 Dec 2017, Accepted 13 Mar 2018, Published online: 27 Mar 2018

References

  • Barnard JA, Graves-Deal R, Pittelkow MR, DuBois R, Cook P, Ramsey GW, Bishop PR, et al. 1994. Auto- and cross-induction within the mammalian epidermal growth factor-related peptide family. J Biol Chem 269:22817–22822.
  • Beerli RR, Hynes NE. 1996. Epidermal growth factor-related peptides activate distinct subsets of ErbB receptors and differ in their biological activities. J Biol Chem 271:6071–6076.
  • Berasain C, Castillo J, Perugorría MJ, Prieto J, Avila MA. 2007. Amphiregulin: A new growth factor in hepatocarcinogenesis. Cancer Lett 254:30–41.
  • Berasain C, Avila MA. 2014. Amphiregulin. Semin Cell Dev Biol 28:31–41.
  • Berry MN, Friend DS. 1969. High-yield preparation of isolated rat liver parenchymal cells: A biochemical and fine structural study. J Cell Biol 43:506–520.
  • Carver RS, Stevenson MC, Scheving LA, Russell WE. 2002. Diverse expression of ErbB receptor proteins during rat liver development and regeneration. Gastroenterology 123:2017–2027.
  • Ceresa BP, Peterson JL. 2014. Cell and molecular biology of epidermal growth factor receptor. Int Rev Cell Mol Biol 313:145–178.
  • Christoffersen T, Refsnes M, Bronstad GO, Østby E, Huse J, Haffner F, Sand TE, et al. 1984. Changes in hormone responsiveness and cyclic AMP metabolism in rat hepatocytes during primary culture and effects of supplementing the medium with insulin and dexamethasone. Eur J Biochem 138:217–226.
  • Dahlhoff M, Wolf E, Schneider MR. 2014. The ABC of BTC: Structural properties and biological roles of betacellulin. Semin Cell Dev Biol 28:42–48.
  • Dajani OF, Meisdalen K, Guren TK, Aasrum M, Tveteraas IH, Lilleby P, Thoresen GH, et al. 2008. Prostaglandin E2 upregulates EGF-stimulated signaling in mitogenic pathways involving Akt and ERK in hepatocytes. J Cell Physiol 214:371–380.
  • Faria JAQA, de Andrade C, Goes AM, Rodrigues MA, Gomes DA. 2016. Effects of different ligands on epidermal growth factor receptor (EGFR) nuclear translocation. Biochem Biophys Res Commun 478:39–45.
  • Freed DM, Bessman NJ, Kiyatkin A, Salazar-Cavazos E, Byrne PO, Moore JO, Valley CC, et al. 2017. EGFR ligands differentially stabilize receptor dimers to specify signaling kinetics. Cell 171:683–695.
  • French AR, Tadaki DK, Niyogi SK, Lauffenburger DA. 1995. Intracellular trafficking of epidermal growth factor family ligands is directly influenced by the pH sensitivity of the receptor/ligand interaction. J Biol Chem 270:4334–4340.
  • Gladhaug IP, Refsnes M, Sand TE, Christoffersen T. 1988. Effects of butyrate on epidermal growth factor receptor binding, morphology, and DNA synthesis in cultured rat hepatocytes. Cancer Res 48:6560–6564.
  • Guren TK, Thoresen GH, Dajani OF, Taraldsrud E, Moberg ER, Christoffersen T. 1996. Epidermal growth factor behaves as a partial agonist in hepatocytes: Effects on DNA synthesis in primary culture and competition with transforming growth factor alpha. Growth Factors 13:171–179.
  • Harlow E, Lane D. 1988. Antibodies: A laboratory manual. Cold Spring Harbor, New York: Cold Spring Harbor Laboratory.
  • Hisaka T, Yano H, Haramaki M, Utsunomiya I, Kojiro M. 1999. Expressions of epidermal growth factor family and its receptor in hepatocellular carcinoma cell lines: Relationship to cell proliferation. Int J Oncol 14:453–460.
  • Jones JT, Akita RW, Sliwkowski MX. 1999. Binding specificities and affinities of egf domains for ErbB receptors. FEBS Lett 447:227–231.
  • Jorissen RN, Walker F, Pouliot N, Garrett TP, Ward CW, Burgess AW. 2003. Epidermal growth factor receptor: Mechanisms of activation and signalling. Exp Cell Res 284:31–53.
  • Kawasaki T, Tamura S, Kiso S, Doi Y, Yoshida Y, Kamada Y, Saeki A, et al. 2005. Effects of growth factors on the growth and differentiation of mouse fetal liver epithelial cells in primary cultures. J Gastroenterol Hepatol 20:857–864.
  • Kholodenko BN, Hancock JF, Kolch W. 2010. Signalling ballet in space and time. Nat Rev Mol Cell Biol 11:414–426.
  • Kidger AM, Keyse SM. 2016. The regulation of oncogenic Ras/ERK signalling by dual-specificity mitogen activated protein kinase phosphatases (MKPs). Semin Cell Dev Biol 50:125–132.
  • Klapper LN, Glathe S, Vaisman N, Hynes NE, Andrews GC, Sela M, Yarden Y. 1999. The ErbB-2/HER2 oncoprotein of human carcinomas may function solely as a shared coreceptor for multiple stroma-derived growth factors. Proc Natl Acad Sci USA 96:4995–5000.
  • Knudsen SL, Mac AS, Henriksen L, van Deurs B, Grøvdal LM. 2014. EGFR signaling patterns are regulated by its different ligands. Growth Factors 32:155–163.
  • Liu S, Wierød L, Skarpen E, Grøsvik H, Duan G, Huitfeldt HS. 2013. EGF activates autocrine TGFα to induce prolonged EGF receptor signaling and hepatocyte proliferation. Cell Physiol Biochem 32:511–522.
  • Macdonald-Obermann JL, Pike LJ. 2014. Different epidermal growth factor (EGF) receptor ligands show distinct kinetics and biased or partial agonism for homodimer and heterodimer formation. J Biol Chem 289:26178–26188.
  • MacRae Dell K, Nemo R, Sweeney WE, Jr, Avner ED. 2004. EGF-related growth factors in the pathogenesis of murine ARPKD. Kidney Int 65:2018–2029.
  • Maeda K, Kato Y, Sugiyama Y. 2002. pH-dependent receptor/ligand dissociation as a determining factor for intracellular sorting of ligands for epidermal growth factor receptors in rat hepatocytes. J Control Release 82:71–82.
  • Marshall CJ. 1995. Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation. Cell 80:179–185.
  • Normanno N, De Luca A, Bianco C, Strizzi L, Mancino M, Maiello MR, Carotenuto A, et al. 2006. Epidermal growth factor receptor (EGFR) signaling in cancer. Gene 366:2–16.
  • Ødegård J, Aasrum M, Tveteraas IH, Bharath SP, Sandnes D, Christoffersen T. 2012. Role of ErbB2 in the prostaglandin E2-induced enhancement of the mitogenic response to epidermal growth factor in cultured hepatocytes. Biochem Biophys Res Commun 421:255–260.
  • Olayioye MA, Neve RM, Lane HA, Hynes NE. 2000. The ErbB signaling network: Receptor heterodimerization in development and cancer. EMBO J 19:3159–3167.
  • Refsnes M, Thoresen GH, Dajani OF, Christoffersen T. 1994. Stimulation of hepatocyte DNA synthesis by prostaglandin E2 and prostaglandin F2 alpha: Additivity with the effect of norepinephrine, and synergism with epidermal growth factor. J Cell Physiol 159:35–40.
  • Roepstorff K, Grandal MV, Henriksen L, Knudsen SL, Lerdrup M, Grøvdal L, Willumsen BM, van Deurs B. 2009. Differential effects of EGFR ligands on endocytic sorting of the receptor. Traffic 10:1115–1127.
  • Roskoski R. Jr. 2014. The ErbB/HER family of protein-tyrosine kinases and cancer. Pharmacol Res 79:34–74.
  • Sagmeister S, Drucker C, Losert A, Grusch M, Daryabeigi A, Parzefall W, Rohr-Udilova N, et al. 2008. HB-EGF is a paracrine growth stimulator for early tumor prestages in inflammation-associated hepatocarcinogenesis. J Hepatol 49:955–964.
  • Sanders JM, Wampole ME, Thakur ML, Wickstrom E. 2013. Molecular determinants of epidermal growth factor binding: A molecular dynamics study. PLoS One 8:e54136.
  • Scheving LA, Buchanan R, Krause MA, Zhang X, Stevenson MC, Russell WE. 2007. Dexamethasone modulates ErbB tyrosine kinase expression and signaling through multiple and redundant mechanisms in cultured rat hepatocytes. Am J Physiol Gastrointest Liver Physiol 293:G552–G559.
  • Scheving LA, Zhang L, Stevenson MC, Kwak ES, Russell WE. 2006. The emergence of ErbB2 expression in cultured rat hepatocytes correlates with enhanced and diversified EGF-mediated signaling. Am J Physiol Gastrointest Liver Physiol 291:G16–G25.
  • Schlessinger J. 2002. Ligand-induced, receptor-mediated dimerization and activation of EGF receptor. Cell 110:669–672.
  • Seglen PO. 1976. Preparation of isolated rat liver cells. Methods Cell Biol 13:29–83.
  • Shaul YD, Seger R. 2007. The MEK/ERK cascade: From signaling specificity to diverse functions. Biochim Biophys Acta 1773:1213–1226.
  • Singh B, Carpenter G, Coffey RJ. 2016. EGF receptor ligands: Recent advances. F1000Research 5:2270.
  • Thoresen GH, Guren TK, Christoffersen T. 2003. Role of ERK, p38 and PI3-kinase in EGF receptor-mediated mitogenic signalling in cultured rat hepatocytes: Requirement for sustained ERK activation. Cell Physiol Biochem 13:229–238.
  • Thoresen GH, Guren TK, Sandnes D, Peak M, Agius L, Christoffersen T. 1998. Response to transforming growth factor alpha (TGFalpha) and epidermal growth factor (EGF) in hepatocytes: Lower EGF receptor affinity of TGFalpha is associated with more sustained activation of p42/p44 mitogen-activated protein kinase and greater efficacy in stimulation of DNA synthesis. J Cell Physiol 175:10–18.
  • Waterman H, Sabanai I, Geiger B, Yarden Y. 1998. Alternative intracellular routing of ErbB receptors may determine signaling potency. J Biol Chem 273:13819–13827.
  • Wee P, Wang Z. 2017. Epidermal growth factor receptor cell proliferation signaling pathways. Cancers (Basel) 9:E52.
  • Wills MK, Jones N. 2012. Teaching an old dogma new tricks: Twenty years of Shc adaptor signalling. Biochem J 447:1–16.
  • Wilson KJ, Mill C, Lambert S, Buchman J, Wilson TR, Hernandez-Gordillo V, Gallo RM, et al. 2012. EGFR ligands exhibit functional differences in models of paracrine and autocrine signaling. Growth Factors 30:107–116.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.